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| 1 | Upper gastrointestinal tract capsule endoscopy using a nurse-led protocol: First reported experience显示文摘AIM To test the feasibility and performance of a novel upper gastrointestinal(GI) capsule endoscope using a nurse-led protocol. METHODS We conducted a prospective cohort analysis of patients who declined gastroscopy(oesophagogastroduodenoscopy, OGD) but who consented to upper GI capsule endoscopy. Patients swallowed the upper GI capsule following ingestion of 1 liter of water(containing simethicone). A series of positional changes were used to exploit the effects of water flow and move the upper GI capsule from one gravity-dependent area to another using a nurse-led protocol. Capsule transit time, video reading time, mucosal visualisation, pathology detection and patient tolerance was evaluated.RESULTS Fifty patients were included in the study. The mean capsule transit times in the oesophagus and stomach were 28 s and 68 min respectively. Visualisation of the following major anatomical landmarks was achieved(graded 1-5: Poor to excellent): Oesophagus, 4.8(± 0.5); gastro-oesophageal junction(GOJ), 4.8(± 0.8); cardia, 4.8(± 0.8); fundus, 3.8(± 1.2); body, 4.5(± 1); antrum, 4.5(± 1); pylorus, 4.7(± 0.8); duodenal bulb, 4.7(± 0.7); second part of the duodenum(D2), 4.7(± 1). The upper GI capsule reached D2 in 64% of patients. The mean video reading time was 48 min with standard playback mode and 20 min using Quickview(P = 0.0001). No pathology was missed using Quickview. Procedural tolerance was excellent. No complications were seen with the upper GI capsule. CONCLUSION The upper GI capsule achieved excellent views of the upper GI tract. Future studies should compare the diagnostic accuracy between upper GI capsule and OGD. | Hey-Long Ching Ailish Healy Victoria Thurston Melissa F Hale Reena Sidhu Mark E McAlindon | 2018 | World Journal of Gastroenterology2018，24，26： | 9 |
| 2 | Capsule endoscopy:Current practice and future directions显示文摘Capsule endoscopy(CE)has transformed investigation of the small bowel providing a non-invasive,well tolerated means of accurately visualising the distal duodenum,jejunum and ileum.Since the introduction of small bowel CE thirteen years ago a high volume of literature on indications,diagnostic yields and safety profile has been presented.Inclusion in national and international guidelines has placed small bowel capsule endoscopy at the forefront of investigation into suspected diseases of the small bowel.Most commonly,small bowel CE is used in patients with suspected bleeding or to identify evidence of active Crohn’s disease(CD)(in patients with or without a prior history of CD).Typically,CE is undertaken after upper and lower gastrointestinal flexible endoscopy has failed to identify a diagnosis.Small bowel radiology or a patency capsule test should be considered prior to CE in those at high risk of strictures(such as patients known to have CD or presenting with obstructive symptoms)to reduce the risk of capsule retention.CE also has a role in patients with coeliac disease,suspected small bowel tumours and other small bowel disorders.Since the advent of small bowel CE,dedicated oesophageal and colon capsule endoscopes have expanded the fields of application to include the investigation of upper and lower gastrointestinal disorders.Oesophageal CE may be used to diagnose oesophagitis,Barrett’s oesophagus and varices but reliability in identifying gastroduodenal pathology is unknown and it does not have biopsy capability.Colon CE provides an alternative to conventional colonoscopy for symptomatic patients,while a possible role in colorectal cancer screening is a fascinating prospect.Current research is already addressing the possibility of controlling capsule movement and developing capsules which allow tissue sampling and the administration of therapy. | Melissa F Hale Reena Sidhu Mark E McAlindon | 2014 | World Journal of Gastroenterology2014，20，24： | 9 |
| 3 | 施万细胞在阴茎和外周神经再生中的作用显示文摘施万细胞(SCs)是外周神经系统中主要的胶质细胞。施万细胞最终发育为形成髓鞘的细胞和不形成髓鞘的细胞,前者包绕直径较大的神经,后者则包绕直径较小的神经。他们在神经损伤后的再生中发挥重要作用,包括海绵体神经损伤导致的勃起功能障碍(ED)。尽管前列腺癌根治术手术技术有所提高,但是仍有相当一部分患者术后出现ED。这是由于术中牵拉损伤或局部炎症反应改变了自主神经的微环境,最终导致终末器官-阴茎的病理生理改变。该综述目的是总结现有的如下方面相关文献:(1)外周神经特别是阴茎神经中施万细胞的起源和发育;(2)外周神经特别是阴茎神经损伤后的Wallerian变性和施万细胞的可塑性;(3)施万细胞如何通过分泌神经生长因子促进神经再生;(4)以施万细胞作为治疗靶点促进神经再生的技术。我们搜索了Pubmed,发现了为数众多的与上述主题相关的动物实验和人体研究,这提示施万细胞有望成为神经源性ED治疗的新靶点。 | Lin Wang Melissa T Sanford Zhongcheng Xin Guiting Lin Tom F Lue | 2015 | Asian Journal of Andrology2015，17，5： | 7 |
| 4 | Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies显示文摘The antibody repertoire of Bos taurus is characterized by a subset of variable heavy(VH)chain regions with ultralong third complementarity determining regions(CDR3)which,compared to other species,can provide a potent response to challenging antigens like HIV env.These unusual CDR3 can range to over seventy highly diverse amino acids in length and form uniqueβ-ribbon‘stalk’and disulfide bonded‘knob’structures,far from the typical antigen binding site.The genetic components and processes for forming these unusual cattle antibody VH CDR3 are not well understood.Here we analyze sequences of Bos taurus antibody VH domains and find that the subset with ultralong CDR3 exclusively uses a single variable gene,IGHV1-7(VHBUL)rearranged to the longest diversity gene,IGHD8-2.An eight nucleotide duplication at the 3′end of IGHV1-7 encodes a longer V-region producing an extended Fβ-strand that contributes to the stalk in a rearranged CDR3.A low amino acid variability was observed in CDR1 and CDR2,suggesting that antigen binding for this subset most likely only depends on the CDR3.Importantly a novel,potentially AID mediated,deletional diversification mechanism of the B.taurus VH ultralong CDR3 knob was discovered,in which interior codons of the IGHD8-2 region are removed while maintaining integral structural components of the knob and descending strand of the stalk in place.These deletions serve to further diversify cysteine positions,and thus disulfide bonded loops.Hence,both germline and somatic genetic factors and processes appear to be involved in diversification of this structurally unusual cattle VH ultralong CDR3 repertoire. | Thaddeus C Deiss Melissa Vadnais Feng Wang Patricia L Chen Ali Torkamani Waithaka Mwangi Marie-Paule Lefranc Michael F Criscitiello Vaughn V Smider | 2019 | Cellular & Molecular Immunology2019，16，1： | 4 |
| 5 | Global cancer sta- tistics显示文摘 | Ahmedin Jemal DVM Bray F Melissa M | 2011 | Cancer J Clin2011，61，2： | 1 |
| 6 | Global cancer sta-tistics显示文摘 | Jemal A Bray F Melissa M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 7 | Cardi- ovascular effects of strenuous exercise in adult recreational hockey: the hockey heart study显示文摘 | MELISSA S F LAURIE Q JAMES H RIMMER | 2002 | CMAJ2002，166，3： | 1 |
| 8 | Global cancer statistics 显示文摘 | Jemal A Bray F Melissa M | | CACancer J Clin0，61，2： | 1 |
| 9 | Design and projec- ted performance of a flapping foil AUV显示文摘 | STEPHEN L VICTOR P MELISSA F | 2004 | IEEE Journal of Oceanic Engineering2004，29，3： | 1 |
| 10 | Quantitation of the hydroxyl radical by reaction with dimethyl sulfoxide 显示文摘 | Melissa G S Babbs F C | 1990 | Archives of Biochemistry and Biophysics1990，278，2： | 1 |
| 11 | Global Cancer Statistics显示文摘 | Jemal A Bray F Melissa | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 12 | Quantitative determination of fluorinated alkyl substances by large-volume-injection liquid chromatography tandem mass spectrometry-characterization of municipal wastewaters显示文摘 | SCHULTZ Melissa M BAROFSKY Douglas F FIELD Jennifer A | 2006 | Environmental Science & Technology2006，40，1： | 1 |
| 13 | Continuous venous infusion 5 - Fu and interferon- a in pancreatic earcinoma显示文摘 | WiLLiam J J MeLissa Q F | 1998 | Am J Clin OncoL1998，21，： | 1 |
| 14 | Polyacrylam-ide added as a nitrogen source stimulates methanogenesisin consortia form various wastewaters显示文摘 | Melissa E H Michael D M Phillip M F | 2005 | Water Re-search2005，39，14： | 1 |
| 15 | Not just a grain of rice: the quest for quality显示文摘 | Melissa A F Susan R M Robert D H | 2009 | J Trends in Plant Sci2009，14，3： | 1 |
| 16 | Escape from immune surveillance does not result in tolerance to tumor-associated antigens显示文摘 | Melchionda F McKirdy MK Melissa F | 2004 | J Immunother2004，27，5： | 1 |
| 17 | Continuous venous infusion 5-Fu and interferon-a in pancreatic carcinoma 显示文摘 | William J J Melissa Q F | 1998 | Am J Clin Oncol1998，21，： | 1 |
| 18 | Ground- based observa- tions of the slowdown in ozone decline and onset of ozone increase显示文摘 | JAMES K A MELISSA F | 2009 | Journal of Geophysical Research2009，114，7： | 1 |
| 19 | Diastolic performance assessed by tissue Doppler after pediatric heart transplantation显示文摘 | Alfred A K Melissa F Mark M | 2004 | MSa J Heart Lung Transplant2004，23，： | 1 |
| 20 | Global cancer statistics 显示文摘 | Jemal A Bray F Melissa M | 2011 | CA Canc J Clin2011，61，2： | 1 |
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