|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Potential beneficial effects of butyrate in intestinal and extraintestinal diseases显示文摘The multiple beneficial effects on human health of the short-chain fatty acid butyrate,synthesized from nonabsorbed carbohydrate by colonic microbiota,are well documented.At the intestinal level,butyrate plays a regulatory role on the transepithelial fluid transport,ameliorates mucosal inflammation and oxidative status,reinforces the epithelial defense barrier,and modulates visceral sensitivity and intestinal motility.In addition,a growing number of studies have stressed the role of butyrate in the prevention and inhibition of colorectal cancer.At the extraintestinal level,butyrate exerts potentially useful effects on many conditions,including hemoglobinopathies,genetic metabolic diseases,hypercholesterolemia,insulin resistance,and ischemic stroke.The mechanisms of action of butyrate are different;many of these are related to its potent regulatory effects on gene expression.These data suggest a wide spectrum of positive effects exerted by butyrate,with a high potential for a therapeutic use in human medicine. | Roberto Berni Canani Margherita Di Costanzo Ludovica Leone Monica Pedata Rosaria Meli Antonio Calignano | 2011 | World Journal of Gastroenterology2011，17，12： | 52 |
| 2 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 3 | Current role of modern radiotherapy techniques in the management of breast cancer显示文摘Breast cancer is the most common type of malignancy in females. Advances in systemic therapies and radiotherapy(RT) provided long survival rates in breast cancer patients. RT has a major role in the management of breast cancer. During the past 15 years several developments took place in the field of imaging and irradiation techniques, intensity modulated RT, hypofractionation and partial-breast irradiation. Currently, improvements in the RT technology allow us a subsequent decrease in the treatment-related complications such as fibrosis and long-term cardiac toxicity while improving the loco-regional control rates and cosmetic results. Thus, it is crucial that modern radiotherapy techniques should be carried out with maximum care and efficiency. Several randomized trials provided evidence for the feasibility of modern radiotherapy techniques in the management of breast cancer. However, the role of modern radiotherapy techniques in the management of breast cancer will continue to be defined by the mature results of randomized trials. Current review will provide an up-to-date evidence based data on the role of modern radiotherapy techniques in the management of breast cancer. | Gokhan Ozyigit Melis Gultekin | 2014 | World Journal of Clinical Oncology2014，5，3： | 6 |
| 4 | Prevalence of vacA, cagA and babA2 genes in Cuban Helicobacter pylori isolates显示文摘AIM: To investigate the prevalence of vacuolating cytotoxin (vacA), cytotoxin associated gene A (cagA) and blood adhesion binding antigen (babA2) genotypes of Helicobacter pylori (H pylori) isolates from Cuban dyspeptic patients. METHODS: DNA was extracted from H pylori-positive cultures taken from 130 dyspeptic patients. Genotyping was performed by PCR, using specifi c primers for vacA (s1, s2, m1, m2), cagA and babA2 genes. Endoscopic observations and histological examinations were used to determine patient pathologies. RESULTS: vacA alleles s1 , s2 , m1 and m2 were detected in 96 (73.8%), 34 (26.2%), 75 (57.7%) and 52 isolates (40%), respectively, while the cagA gene was detected in 95 isolates (73.2%). One hundred and seven isolates (82.3%) were babA2-positive. A signif icant correlation was observed between vacAs1m1 and cagA and between vacAs1m1 and babA2 genotypes (P < 0.001 and P < 0.05, respectively) and between babA2 genotype and cagA status (P < 0.05); but, no correlation was observed between vacAs1 and babA2 genotypes. Eighty fi ve (65.4%) and 73 (56.2%) strains were type 1 (vacAs1-cagA-positive) and 'triple- positive' (vacAs1-cagA-babA2-positive), respectively, and their presence was significantly associated with duodenal ulcer (P < 0.01 and P < 0.001, respectively). CONCLUSION: The distribution of the main virulence factors in the Cuban strains in this study resembled that of the Western-type strains, and the more virulent H pylori isolates were signifi cantly associated with duodenal ulcer, ulcer disease being the worst pathology observed in the group studied. | Lino E Torres Karelia Melián Arlenis Moreno Jordis Alonso Carlos A Sabatier Mayrín Hernández Ludisleydis Bermúdez Boris L Rodríguez | 2009 | World Journal of Gastroenterology2009，15，2： | 4 |
| 5 | Heterologous Expression of the Mevalonic Acid Pathway in Cyanobacteria Enhances Endogenous Carbon Partitioning to Isoprene显示文摘在 cyanobacterium Synechocystis PCC 6803 的异戌二烯 synthase 基因的 Heterologous 表示在这些微生物之上授与光合的异戌二烯(C5H8 ) 的性质烃生产。从 CO2 和 H2O 的异戌二烯的连续生产在光被完成,经由内长的 methylerythritol 磷酸盐(MEP ) 发生小径,与 Synechocystis 的生长一起。这个工作处理了光合的碳在 Synechocystis 在异戌二烯和生物资源之间划分的问题。证据被介绍显示出 heterologous genomic 集成和 mevalonic 酸(MVA ) 的细胞的表示在为碳流动扩大资助一条外国人小径到 isopentenyl-diphosphate (IPP ) 和 dimethylallyl-diphosphate (DMAPP ) 的 Synechocystis 的小径基因异戌二烯的先锋。在有 MVA 小径酶的联合的异戌二烯 synthase 的 Heterologous 表示由近似 2.5 褶层导致了光合的异戌二烯收益改进,与在仅仅与异戌二烯 synthase 基因转变的 cyanobacteria 测量了那相比。这些结果建议 MVA 小径介绍一在在到 IPP 和 DMAPP 的 Synechocystis 的内长的细胞的底层的流动的 bypass,克服本国的 MEP 小径的流动限制。工作在 Synechocystis 采用了新奇 chromosomal 集成和合成基因操纵子的表示,包括直到在一个单身的倡导者的控制下面的四基因,并且同时表示三操纵子。这是有七 recombinant 酶的一条全部 biosynthetic 小径 heterologously 在光合的微生物被表示了的第一次。它为有感染力的产品的可更新的产生在光合的途径的追求组成贡献到光合的微生物和一个范例的遗传工程工具箱。 | Fiona K. Bentley Andreas Zurbriggen Anastasios Melis | 2014 | Molecular Plant2014，7，1： | 4 |
| 6 | Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms显示文摘 | Anna Iacono Giuseppina Mattace Raso Roberto Berni Canani Antonio Calignano Rosaria Meli | 2011 | The Journal of Nutritional Biochemistry2011，，8： | 4 |
| 7 | Genotype × environment interaction effects on early fresh storage root yield and related traits in cassava显示文摘Cassava(Manihot esculenta Crantz) is an important root crop worldwide. It exhibits substantial differential genotypic responses to varying environmental conditions, a phenomenon termed genotype × environment interaction(GEI). A significant GEI presents challenges in the selection of superior genotypes. The objective of this study was to examine the effect of genotype,environment and GEI on early fresh storage root yield(FSRY) and related traits in cassava.Accordingly, 12 cassava genotypes were evaluated in a randomised complete block design at three contrasting locations(Jinja, Nakasongola and Namulonge) in Uganda. Trials were harvested nine months after planting and the data collected were analysed using the additive main effects and multiplicative interaction(AMMI) model. The AMMI analysis of variance showed significant variation among genotypes for early FSRY and all other traits assessed.Locations were significantly different for all traits except for cassava brown streak disease root necrosis. The GEI effect was non-significant for early FSRY, but significant for other traits. For early FSRY, 48.5% of the treatment sum of squares was attributable to genotypes, 27.3% to environments, and 24.1% to GEI, indicating a predominance of genotypic variation for this trait.Predominance of genotypic variation was also observed for all the other traits. A majority of the genotypes(67%) had low interaction effects with locations for early FSRY, with Akena, CT2, CT4 and NASE14 being the most stable genotypes for the trait. Significant negative correlation was observed between cassava mosaic disease severity and early FSRY and storage root number,indicating significant negative effects of cassava mosaic disease on early FSRY and stability in cassava. The information generated will inform future selection initiatives for superior early-yielding cassava genotypes combining resistance to cassava mosaic and brown streak diseases in Uganda. | Robooni Tumuhimbise Rob Melis Paul Shanahan Robert Kawuki | 2014 | The Crop Journal2014，2，5： | 3 |
| 8 | Revisiting Emergency Food Reserve Policy and Practiceunder Disaster and Extreme Climate Events显示文摘All food systems will continue to be affected by disasters and extreme climate events. Triggered by recent food crises around the world and climate change concerns,some governments have been trying to develop more robust and resilient food systems. One of the oldest options for many governments is to stockpile emergency food reserves for the purpose of food security and disaster preparedness. In the aftermath of the world food price crises in2007–2008 and 2011, some governments in Asia have been maintaining emergency food reserves to ensure greater supply and price stability. Disasters and extreme climate events help governments to justify emergency food reserves. This research examined emergency food reserve policies in Indonesia, the Philippines, and Malaysia.Emergency food reserves emerged as a practice where the shared objectives of development, disaster risk reduction,and climate change adaptation have been demonstrated by governments. The findings suggest that most governments maintain the strong view that adequate emergency food reserves can buffer national food price shocks and shocks from disasters and climate change, and soften disruptions in trade due to export bans during times of disasters and climate emergencies.Under global climate change scenarios, food security is at risk and volatile(Porter et al. 2014). The expected increase in climate extremes has generated anticipatory actions from governments, including a new push for EFR policy adoption. Triggered by recent disasters and climate change concerns, some governments have been trying to develop more robust and resilient food systems(Fan and Brzeska 2014; Porter et al. 2014). For many countries in Asia, this means the renewed adoption of EFR. Unfortunately, we argue that this is not well understood in climate change adaptation studies as well as contemporary disaster studies.The Association of Southeast Asian Nations(ASEAN)first initiated a Food Security Reserve Agreement in 1979,with the purpose of meeting emergency requirements(ASEAN 1979). Policymakers have been aware of the susceptibility of the region to natural hazards and the possibility of food shortages. But it took 30 years, until soon after the world food crisis in 2007–2008(Hadley and Fan 2010), for the association plus three additional East Asian nations(China, Japan, South Korea) to establish the ASEAN Plus Three Emergency Rice Reserve(APTERR)in 2009, as a mechanism to address potential food shortages in the region in the light of climate and market uncertainties. The final formal agreement was signed in October 2011 in Jakarta(APTERR 2017).The Association of Southeast Asian Nations also established the ASEAN Food Security Information System(AFSIS) that functions as a central information repository for five commodities—rice, maize, soybeans, sugar, and cassava. AFSIS not only monitors and analyzes production,import, export, inventory stock, price, food security ratio,and self-sufficiency ratio for these commodities but also provides data on losses from both floods and droughts in every member state(Lassa et al. 2016). In theory, AFSIS serves as an early warning mechanism for ASEAN to trigger the activation of APTERR's response mechanism(Saengbangka 2014, personal interview; AFSIS 2017).This article argues that EFR can function as a means of disaster risk reduction, including climate change adaptation, and aims to understand why governments in Asia are readopting emergency food reserves as national policies,with a focus on Indonesia, the Philippines, and Malaysia.We also explore how disasters and climate change strengthen or weaken government narratives in support of emergency food reserves. | Jonatan A.Lassa Paul Teng Mely Caballero-Anthony Maxim Shrestha | 2019 | International Journal of Disaster Risk Science2019，10，1： | 2 |
| 9 | The influence of cobalt on the electrochemical cycling stability of LaNi5-based hydride forming alloys 显示文摘 | Daniel Chartouni Felix Meli Andreas Zü ttel | 1996 | J Alloys Comp1996，241，： | 2 |
| 10 | Innate immunity–the hallmark of Helicobacter pylori infection in pediatric chronic gastritis显示文摘BACKGROUND Innate immunity was found to be associated with both persistence of Helicobacter pylori(H.pylori)infection and increased risk of gastric cancer.AIM To identify the risk factors associated with H.pylori infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in children.METHODS We performed a study of 155 children with digestive symptoms,who were divided into two groups according to the histopathological exam:Group 1–48 children with H.pylori-induced chronic gastritis,and Group 2–control group.RESULTS Rural area and poor living conditions were significantly associated with H.pylori chronic gastritis(P=0.0042/P<0.0001).Both positive immunoglobulin A anti H.pylori and the rapid urease test were significantly associated with H.pylori infection(P<0.0001).Significantly higher values of leukocytes and neutrophils within the peripheral blood were found in children with H.pylori chronic gastritis(P=0.111/P=0.284).We found a significant positive correlation between the variant TT genotype of TLR9 rs352140 polymorphism and both leucocytes and neutrophils(P=0.0225/P=0.0292).CONCLUSION Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation. | Lorena Elena Meliț Cristina Oana Mărginean Maria Oana Săsăran Simona Mocan Dana Valentina Ghiga Alina Bogliş Carmen Duicu | 2021 | World Journal of Clinical Cases2021，9，23： | 2 |
| 11 | Influence of red mud, zeolite and lime on heavy metal immobilization, culturable heterotrophic microbial populations and enzyme activities in a contaminated soil显示文摘 | Giovanni Garau Paola Castaldi Laura Santona Pietrino Deiana Pietro Melis | 2007 | Geoderma2007，，1： | 2 |
| 12 | 神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。 | 唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A | 2018 | 神经损伤与功能重建2018，13，2： | 2 |
| 13 | Monitoring of the formationand dissociation of polyethylenimine/DNA complexes by two photon fluorescence corrlation spectroscopy 显示文摘 | CLAMME J P AZOULAY J MELY Y | 2003 | Biophys J2003，84，3： | 1 |
| 14 | Characterization of brain tumors by MRS,DWI and Ki-67 labeling index显示文摘 | Calvar JA Meli FJ Romero C | 2005 | J Neurooncol2005，72，3： | 1 |
| 15 | Dendritic cells with a potent accessory activity are present in human exudative malignant pleural effusions显示文摘 | Gjomarkaj M Pace E Melis M | 1997 | Eur Respir J1997，10，3： | 1 |
| 16 | Plutonium and americium determination in mosses by laser ablation ICP-MS combined with isotope dilution technique显示文摘 | BOULYGA S F DESIDERI D MELI M A | 2003 | International Journal of Mass Spec- trometry2003，226，： | 1 |
| 17 | Neurotoxic effect of lead at low concentrations 显示文摘 | Mameli O Caria M A Melis F | 2001 | Brain Res Bull2001，55，2： | 1 |
| 18 | Evaluation of the interaction mechanisms between red muds and heavy metals 显示文摘 | Laura Santona Paola Castaldi Pietro Melis | 2006 | Journal of Hazardous Materials2006，136，： | 1 |
| 19 | Systemic levels of II-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis显示文摘 | Melis L Vandooren B Krui-Thof E | 2010 | Ann Rheum Dis2010，69，： | 1 |
| 20 | Neuronal injury in multiple sclerosis显示文摘 | Correale J Meli F Ysrraelit C | 2006 | Medicina (B Aires)2006，66，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员