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| 1 | Titanium-coated polypropylene mesh as innovative bioactive material in conservatives mastectomies and pre-pectoral breast reconstruction显示文摘Breast reconstruction is rapidly evolving,thanks to the growing acceptance of synthetic meshes as innovative biomaterials.276 patients undergoing mastectomy(total of 328 mastectomies)were analyzed in a retrospective observational study to evaluate the pre-pectoral immediate breast reconstruction(IBR)using an implant wrapped with Titanium-Coated Polypropylene Mesh(TCPM)vs.patients treated with tissue expander(TE),equally placed pre-pectorally(and wrapped with the same TCPM in 74.3%of the control group’breasts).163 patients,of the study group(SG),underwent mastectomy and pre-pectoral IBR with implant wrapped with TCPM,in a one-step surgery,called direct-to-implant technique(DTI),while 113 patients control group(CG)underwent mastectomy and TE.DTI technique has been performed in 192 breasts of the SG while TE procedure in 136 breasts of the CG.The BREAST-Q questionnaire has been provided before the treatment and 2 years later.Baker scale has been used to evaluate capsular contracture.Oncologic,surgical,and aesthetic outcomes along with BREAST-Q scores were analyzed.Additionally,a histologic evaluation was conducted in 11 capsules’samples randomly chosen(6 derived from SG patients and 5 derived from CG).Complications were recorded in 43 cases(29SG-14CG):8 skin-nipple necrosis(5SG-3CG),8 wound dehiscence(6SG-2CG),3 hematomas(1SG-2CG),and 24 infections(8SG-16CG).Grade IV capsular contracture was detected in 9 breasts(1SG-8CG),whereas 254 breasts were grade I(110SG-144CG),33(10SG-23CG)grade II,and 32(4SG-28CG)grade III.Implant wrinkling was detected in 18 cases(10SG-8CG)after 30 months.The local tumor recurrence rate was 5.8%.Three recurrences were on the nipple-areola complex(1.9%).SG patients showed significantly higher rates in the BREAST-Q overall Satisfaction with Outcome(74.1),overall Satisfaction with Breasts(69.1),Psychosocial Well-being(81.9),and Sexual Well-being(63.1),versus CG’s patients(p<0.05).Histological analysis showed a process of normal tissue repair with a complete mesh integration and normal healing.Conservative mastectomies with pre-pectoral IBR assisted by TCPM proved themselves oncologically safe,biologically integrated into native tissues,and highly accepted in terms of quality of life guaranteeing a more natural and aesthetic breast appearance.Core tip:This retrospective observational study provided clinical and histological outcomes of the pre-pectoral IBR using an implant wrapped with TCPM vs.patients treated with TE,equally placed pre-pectorally.The efficacy of IBR using an implant wrapped with TCPM was confirmed by the cosmetic results obtained and by a rate of side effects comparable to TE.All the histological analyses performed confirmed the TCPM mesh complete integration with the physiological aspects of healing:The Collagen 1 and 3 expressions did not differ,between TCPM and NO TCPM samples to confirm a process of healing overlapping to perfect device incorporation and normal healing. | Pietro Gentile Marco Bernini Lorenzo Orzalesi Silvia Sordi Icro Meattini Francesca Lessi Ashutosh Kothari Claudio Calabrese | 2021 | Bioactive Materials2021，6，12： | 2 |
| 2 | Pegylated liposomal doxorubicin(eaelyxr)and oral vinorelbine in first-line metastatic breast cancer patients previously treated with anthracyclines显示文摘 | Livi L Meattini L Scotti V | 2011 | Chemother2011，23，3： | 1 |
| 3 | Simultaneous inte grated boost-intensity modulated radiotherapy (SIB-IMRT) in head and neck cancer显示文摘 | Franceschini D Paiar F Meattini I | 2013 | The Laryngoscope2013，123，： | 1 |
| 4 | Postoperative radiotherapy in stage I/II endometrial cancer: retrospective analysis of 883 patients treated at the University of Florence 显示文摘 | Scotti V Borghesi S Meattini I | 2010 | Int J Gynecol Cancer2010，20，9： | 1 |
| 5 | Post-operative radiotherapy in N2 non-small cell lung cancer:a retrospective analysis of 175 patients显示文摘 | SCOTTI V MEATTINI I SAIEVA C | | 0，，01： | 1 |
| 6 | The impact of young age on breast cancer outcome显示文摘 | Livi L Meattini I Saieva C | 2010 | Eur J Surg 0ncol2010，36，： | 1 |
| 7 | Role of radiotherapy boost in women with ductal carcinoma in situ: a single-center experience in a series of 389 patients显示文摘 | Meattini I Livi L Franceschini D | 2013 | Eur J Surg Onto2013，39，6： | 1 |
| 8 | Limited-stage small- cell lung cancer treated with early chemo-radiotherapy: the impact of effective chemotherapy 显示文摘 | Scotti V Meattini I Saieva C | 2012 | Tumori2012，98，1： | 1 |
| 9 | Radiotherapy boost doseescalation for invasive breast cancer after breast-conserving surgery: 2 093 patients treated with a prospective margin-directed policy显示文摘 | Livi L Meattini I Franceschini D | 2013 | Radiother Oncol2013，108，2： | 1 |
| 10 | Prognostic role of human epider- mal growth factor receptor 2 status in premenopausal early breast cancer treated with adjuvant tamoxifen 显示文摘 | Meattini I Livi L Saieva C | 2013 | Clin Breast Can2013，13，4： | 1 |
| 11 | Post-operative radiotherapy in N2 non-small cell lung cancer: a retrospective analysis of 175 patients显示文摘 | Scotti V Meattini I Saieva C | 2010 | RadiotherOncol2010，96，1： | 1 |
| 12 | Post-operative radiotherapy in N2 non-small cell lung cancer: a retrospective analysis of 175patients显示文摘 | Scotti V Meattini I Saieva C | 2010 | Radiother Oncol2010，96，1： | 1 |
| 13 | Impact of sentinel node tumor burden on outcome of invasive breast cancer patients显示文摘 | Meattini I Desideri I Saieva C | 2014 | Eur J Surg Oncol2014，40，10： | 1 |
| 14 | Stereotactic Radiotherapy for Adrenal Gland Metastases: University of Florence Experience显示文摘 | Franco Casamassima Lorenzo Livi Stefano Masciullo Claudia Menichelli Laura Masi Icro Meattini Ivano Bonucci Benedetta Agresti Gabriele Simontacchi Raffaela Doro | 2012 | International Journal of Radiation Oncology Biology Physics2012，，2： | 1 |
| 15 | Use of doxorubicin plus cyclophosphamide followed by docetaxel as adjuvant chemotherapy for breast cancer显示文摘 | Livi L Meattini I de Luca Cardillo C | 2011 | J Chemother2011，23，1： | 1 |
| 16 | Predictive factors foradditional non sentinel lymph node involvement in breast cancer patients with one positive sentinel node显示文摘 | Meattini I Saieva C Bertocci S | 2015 | Tumori2015，101，1： | 1 |
| 17 | Radiotherapy boost dose-escalation for invasive breast cancer after breast-con- serving surgery: 2093 patients treated with a prospective margin-directed policy 显示文摘 | Livi L Meattini I Franceschini D | 2013 | Radiother Oncol2013，108，2： | 1 |
| 18 | Aprepitant as prophylaxis of chemotherapy-induced nausea and vomiting in anthracyelines and cyclophosphamide-based regimen for adjuvant breast cancer显示文摘 | Meattini I Francolini G Scotti V | 2015 | Med Oncol2015，32，3： | 1 |
| 19 | Prognostic value of positive human epidermal growth factor receptor 2 status and negative hormone status in patients with T1a/T1b,lymph node-negative breast cancer显示文摘 | Livi L Meattini I Saieva C | 2012 | Cancer2012，118，13： | 1 |
| 20 | Prognostic role of human epidermal growth factor receptor 2 status in premcnopausal early breast cancer treated with adjuvant tamoxifen显示文摘 | Meattini I Livi L Saieva C | 2013 | Clinical Breast Cancer2013，13，4： | 1 |
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