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| 1 | CYP72A67 Catalyzes a Key Oxidative Step in Medicago truncatula Hemolytic Saponin Biosynthesis显示文摘在 Medicago 类, triterpenic saponins 是 bioactive 第二等的代谢物组成地经由 isoprenoid 小径在天线和植物的地下的部分综合了。是的 saponins 的利用制药学,农业化肥并且在工业提起了的食物和化妆品,对识别酶的兴趣在他们的合成包含了。我们识别了一条反向的基因 TILLING 途径在 Medicago truncatula ethylmethanesulfonate (他们) 涉及 hemolytic sapogenin 生合成的细胞色素 P450 (CYP72A67 ) mutagenized 收集。在一个微体酵母系统的基因的基因、生物化学的分析,变异的互补,和表达式证明 CYP72A67 oleanolic 酸合成下游地为在 C-2 位置的 hydroxylation 负责。为有在多重碳位置的不同替换的底层的 CYP72A67 的亲密关系在一样的 invitro 酵母系统,并且在与二另外的 CYP450s (CYP72A68 ) 的关系被调查为 medicagenic 酸的生产负责,在 M.truncatula 叶子和根的主要 sapogenin。完整的亲族异种和野类型的植物与 Sinorhizobium meliloti 为他们的 sapogenin 侧面,涉及 sapogenin 合成的基因的表示模式,和对接种的反应被作比较。获得的结果允许我们在 M.truncatula 修订 hemolytic sapogenin 小径并且贡献加亮 sapogenin 合成的织物特性(叶子 / 根) 。 | Elisa Biazzi Maria Carelli Aldo Tava Pamela Abbruscato Ilaria Losini Pinarosa Avato Carla Scotti Ornella Calderini | 2015 | Molecular Plant2015，8，10： | 11 |
| 2 | Angiographic follow-up of cerebral aneurysms treated with Guglielmi detachable coils(GDCs): An analysis of 162 cases of 173 aneurysms显示文摘Objective To evaluate the mid- and long-term radiological outcomes of cerebral aneurysms with GDCs embolization.Methods One hundred and sixty-two patients with 173 aneurysms embolized with GDCs underwent angiographic follow-up from 1 to 54 months post-operatively and were retrospectively reviewed. Three neuro-radiologists reviewed each angiogram and made a comparison between initial and follow-up angiograms. Morphological outcomes were evaluated as follows: unchanged; progressive thrombosis; and re-opening or re-growth. Results Of 173 aneurysms with GDC embolization, 142 aneutysms had total or nearly total occlusion, 23 subtotal occlusion and 8 partial occlusion shown on initial angiograms. The incidence of re-opening was 17.1% (13/76) in less than 3 months, and 6.2% (6/97) between 3 and 6 months postoperatively. Four aneurysms showed recurrency(2.3%) on second follow-up angiography in one year after procedure and one-year cumulative recurrent rate was 13.3% of 56 aneurysms with the third follow-up angiography in the post-operation period of 12 to 54 months, four showed a little enlargement and the cmnulative recurrent rate so far was 20.2% (35/173). Conclusions The direct and main causes for aneurysmal recurrence are incomplete and loosening packing. The first angiographic follow-up is recommended to be performed at 3 months or earlier after the procedure, especially in aneurysms with initial incomplete occlusion. Re-treatment with balloon- or stent-assisted coil embolization is recommended in re-opening aneurysms. | LI Ming-hua GAO Bu-lang FANG Chun GU Bin-xian CHENG Ying-sheng WANG Wu Giuseppe Scotti | 2005 | 介入放射学杂志2005，14，5： | 6 |
| 3 | The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts显示文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China). | AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo | 2018 | Science China(Technological Sciences)2018，61，5： | 6 |
| 4 | Rethinking the Barcelona clinic liver cancer guidelines:Intermediate stage and Child-Pugh B patients are suitable for surgery?显示文摘According to Barcelona Clinic Liver Cancer recommendations,intermediate stage hepatocellular carcinomas(stage B)are excluded from liver resection and are referred to palliative treatment.Moreover,Child-Pugh B patients are not usually candidates for liver resection.However,many hepatobiliary centers in the world manage patients with intermediate stage hepatocellular carcinoma or Child-Pugh B cirrhosis with liver resection,maintaining that hepatic resection is not contraindicated in selected patients with non–early-stage hepatocellular carcinoma and without normal liver function.Several studies demonstrate that resection provides the best survival benefit for selected patients in very early/early and even in intermediate stages of Barcelona Clinic Liver Cancer classification,and this treatment gives good results in the setting of multinodular,large tumors in patients with portal hypertension and/or Child-Pugh B cirrhosis.In this review we explore this controversial topic,and we show through the literature analysis how liver resection may improve the short-and long-term survival rate of carefully selected Barcelona Clinic Liver Cancer B and Child-Pugh B hepatocellular carcinoma patients.However,other large clinical studies are needed to clarify which patients with intermediate stage hepatocellular carcinoma are most likely to benefit from liver resection. | Fabrizio Romano Marco Chiarelli Mattia Garancini Mauro Scotti Mauro Zago Gerardo Cioffi Matilde De Simone Ugo Cioffi | 2021 | World Journal of Gastroenterology2021，27，21： | 5 |
| 5 | Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?显示文摘BACKGROUND Distant metastases are found in approximately 35%of patients with gastric cancer at their first clinical observation,and of these,4%-14%involves the liver.Unfortunately,only 0.4%-2.3%of patients with metastatic gastric cancer are eligible for radical surgery.Although surgical resection for gastric cancer metastases is still debated,there have been changes in recent years,although several clinical issues remain to be defined and that must be taken into account before surgery is proposed.AIM To analyze the clinicopathological factors related to primary gastric tumor and metastases that impact the survival of patients with liver metastatic gastric cancer.METHODS We performed a systematic review of the literature from 2000 to 2018 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.The study protocol was based on identifying studies with clearly defined purpose,eligibility criteria,methodological analysis,and patient outcome.RESULTS We selected 47 studies pertaining to the purpose of the review,which involved a total of 2304 patients.Median survival was 7-52.3 mo,median disease-free survival was 4.7-18 mo.The 1-,2-,3-,and 5-year overall survival(OS)was 33%-90.1%,10%-60%,6%-70.4%,and 0%-40.1%,respectively.Only five papers reported the 10-year OS,which was 5.5%–31.5%.The general recurrence rate was between 55.5%and 96%,and that for hepatic recurrence was between 15%and 94%.CONCLUSION Serous infiltration and lymph node involvement of the primary cancer indicate an unfavorable prognosis,while the presence of single metastasis or≤3 metastases associated with a size of<5 cm may be considered data that do not contraindicate liver resection. | Fabio Uggeri Lorenzo Ripamonti Enrico Pinotti Mauro Alessandro Scotti Simone Famularo Mattia Garancini Luca Gianotti Marco Braga Fabrizio Romano | 2020 | World Journal of Clinical Oncology2020，11，7： | 3 |
| 6 | Aboveground nutrient components of Eucalyptus camaldulensis and E. grandis in semiarid Brazil under the nature and the mycorrhizal inoculation conditions显示文摘研究被进行评估未葬生物资源,养分含量和在桉树类 camaldulensis 和桉树类的 mycorrhizal 殖民的百分比宏大是在半干旱的区域的种植园(15 ° 09 ′
S 43 ° 49 ′
W ) 在在巴西的古代希腊的金额单位 Gerais 的状态的北方。结果证明总数未葬生物资源(干物质) 是 33.6 Mg · h 为 E 的 −1 。camaldulensis 和 53.1 Mg · h 为 E 的 −1 。宏大。茎木头,叶子,分支,和茎的生物资源为 E 吠叫。camaldulensis 占了 64.4% , 19.6% , 15.4% ,和 0.6% 全部的生物资源,分别地(桌子 2 ) ;同时总数的一个类似的分区未葬生物资源也被作出对有利的裁决 E。宏大。叶子的干物质和 E 的分支。camaldulensis 在叶子说明了 N, P, K, Ca, Mg,和 S 的 35% 全部的生物资源,和内容,分支总共占了 15.5% , 0.7% , 12.3% , 22.6% , 1.9% ,和 1.4% 那些未葬生物资源分别地。在箱子(bark 和木头) 中,滋养的累积一般来说更低。E 的养分含量。宏大被介绍很少变化与 E 的相比。camaldulensis。在箱子的优异部分局部性的伍德介绍了 P 的更高的集中, bark 包含了营养素的重要数量,特别在 E。宏大。这显示离开植物的废物具有在在这个半干旱的区域减少树生产率的损失的地点上的重要性。二种显示出 mycotrophy。 | Marcela C. Pagano Antonio F. Bellote Maria R. Scotti | 2009 | Journal of Forestry Research2009，20，1： | 2 |
| 7 | GTAW焊接过程中熔池发展的数值模拟及与实验结果的比较显示文摘用描述等离子弧和熔池中的流体流动和传热过程的数学模型对熔池的发展进行了数值模拟。模拟结果和文献中实验结果的比较表明 ,该数学模型能较好地预测熔池的形状和大小。 | 杨雪峰 Aristeuda Silveira Neto Américo Scotti | 2002 | 四川大学学报(工程科学版)2002，34，6： | 2 |
| 8 | Structure of human RNA N6- methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation 显示文摘 | Aik W Scotti JS Choi H | 2014 | Nucleic Acids Res2014，42，7： | 1 |
| 9 | Immobilization and properties of carminomycin 4-O-methyltranferase, the enzyme which catalyzes the final step in the biosynthesis of daunorubiein in Streptomyces peucetius显示文摘 | Scotti C Hutchinson C R | 1995 | Biotechnol Bioeng1995，48，2： | 1 |
| 10 | Postoperative pain after manual and mechanical glide path: a randomized clini- cal trial显示文摘 | Pasqualini D Mollo L Scotti N | 2012 | JEndod2012，38，1： | 1 |
| 11 | Psychometric properties of the PTSD Checklist-Civilian version显示文摘 | Ruggiero KJ Del Ben K Scotti JR | 2003 | J Trauma Stress2003，16，5： | 1 |
| 12 | Single nucleotide polymorphisms in several porcine cathepsin genes are associated with growth,carcass and production traits in Italian large white pigs显示文摘 | Russo V Fontanesi L Scotti E | 2008 | Journal of Animal Science2008，86，： | 1 |
| 13 | Treatment for children with posttraumatic stress disorder: current status and fu ture directions 显示文摘 | Ruggiero KJ MorrisTL Scotti JR | 2001 | Clin Psychol: Science and Practice2001，8，2： | 1 |
| 14 | The regional impact of monetary poliq显示文摘 | ScottI | 1955 | Quarterly Joumal of Economics1955，69，： | 1 |
| 15 | Internet use,abuse,and dependence among students at a southeastern regional university显示文摘 | Fortson BL Scotti JR Chen YC | | 0，，02： | 1 |
| 16 | Regional intensity attenuation models for France and the estimation of magnitude and location of historical earthquakes显示文摘 | Bakun W H Scotti O | | 0，，3： | 1 |
| 17 | Engineered decellularized matrices to instruct bone regeneration pro- cesses显示文摘 | Papadimitropoulos A Scotti C Bourgine P | 2015 | Bone2015，70，： | 1 |
| 18 | Differences of the porcine amelogenin X and Y chromosome genes(AMELX and AMELY)and their application for sex determination in pigs显示文摘 | Fontanesi L Scotti E V | 2008 | Molecular Reproduction&Development2008，75，11： | 1 |
| 19 | Theinfluence of doublepulse on porosity formation in aluminum GMAW 显示文摘 | Mendes da Silva C L Scotti A | 2006 | Journal of Materials Processing Technology2006，171，： | 1 |
| 20 | Generalized Smagorinsky Model for Anisotropic Grids显示文摘 | Scotti A Meneveau C | 1993 | Physics of Fluids1993，5，9： | 1 |
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