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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 3 | 星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。 | Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 | 2019 | 神经损伤与功能重建2019，14，6： | 2 |
| 4 | Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis 显示文摘 | Matus S Burgos PV Bravo-Zehnder M | 2007 | J Exp Med2007，204，13： | 1 |
| 5 | Analysis of the grape MYBR2R3 subfamily reveals expanded wine quality-related clades and con-served gene structure organization across Vitis and Arabidopsis genomes显示文摘 | MATUS J T AQUEA M ARCE-JOHNSON P | 2008 | BMC Plant Biology2008，，： | 1 |
| 6 | Acid Initiation of Ammonia-Borane Dehydrogenation for Hydrogen Storage显示文摘 | STEPHENS F H BAKER R T MATUS M H | 2007 | Angew Chem Int Ed2007，46，5： | 1 |
| 7 | Genetic diversity in three groups of barley germplasm assessed by simple sequence repeats显示文摘 | Matus I A Hayes P M | 2002 | Genome2002，45，6： | 1 |
| 8 | Impact of management on vegetation dynamics and seed bank formation of inland dune grassland in Hungary显示文摘 | Matus G Papp M Tothmeresz B | 2005 | Flora2005，200，3： | 1 |
| 9 | 2011, The grapevine guard cell-related VvMYB60 transcription factor is in- volved in the regulation of stomatal activity and is dif- ferentially expressed in response to ABA and osmotic stress显示文摘 | Galbiati M Matus J T Francia P | 2011 | BMC Plant Biology2011，11，： | 1 |
| 10 | Identification of critical spans for monitoring systems in dynamic thermal rating显示文摘 | MATUS M SAEZ D FAVLEY M | 2012 | IEEE Transactions on Power Delivery2012，27，2： | 1 |
| 11 | Groth and characterization of cubic SiC single - ctystalline films on Si显示文摘 | Power J A Matus L G Kuczmarski M A | 1986 | Journal of The Elctrochemical Society1986，134，6： | 1 |
| 12 | Environmental and laboratory studies of the photodegradation of the pesfidde fenarimol显示文摘 | MATUS M SILUA A M BAURROUS H D | 1994 | Photochem Photobid Chart1994，80，： | 1 |
| 13 | Pseudomonas aeruginosa hypoxic or anaerobic bio-film infections within cystic fibrosis airways显示文摘 | Hassett D J Sutton M D Schurr M J Herr A B Caldwell C C Matu J 0 | 2009 | Trends Micro-biol2009，17，： | 1 |
| 14 | Critical role of transcription factorcyclic AMP response element modulator in beta 1 -adrenoceptor-medi-ated cardiac dysfunction 显示文摘 | Lewin G Matus M Basu A | 2009 | Circulation2009，119，1： | 1 |
| 15 | Spontaneous vaginal delivery 显示文摘 | Patterson DA Winslow M Matus CD | 2008 | Am Faro Physician2008，78，3： | 1 |
| 16 | High actin concentrations in brain dendritic spines and postsynaptic densities显示文摘 | MATUS A ACKERMANN M PEHLING G | 1982 | Proc Natl Acad Sci USA1982，79，23： | 1 |
| 17 | Transitivity as a Tool for Ideological Analysis 显示文摘 | Matu Peter M | 2008 | Journal of the World Studies2008，，1： | 1 |
| 18 | In vitro inhibitory activity of human vaginal lactobacilli against pathogenic bacteria associated with bacterial vaginosis in Kenyan women 显示文摘 | Matu M N Orinda G O Njagi E N | 2010 | Anaerobe2010，16，3： | 1 |
| 19 | The stress rheostat:an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration显示文摘 | Matus S Lisbona F Torres M | 2008 | Curr Mol Med2008，8，3： | 1 |
| 20 | Acid Initiation of Ammonia-Borane Dehydrogenation for Hydrogen Storage 显示文摘 | Stephens F H Baker R T Matus M H | 2007 | Angew Chem Int Ed2007，46，： | 1 |
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