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| 1 | Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin显示文摘AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. | Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman | 2018 | World Journal of Gastroenterology2018，24，3： | 8 |
| 2 | Post-veraison sunlight exposure induces MYB-mediated transcriptional regulation of anthocyanin and flavonol synthesis in berry skins of Vitis vinifera显示文摘 | Matus J T Loyola R Vega A | 2009 | J Exp Bot2009，60，3： | 1 |
| 3 | MAPS:a novel brain microtubule-associated protein under strong developpmental regulation显示文摘 | RIEDERER B COHEN R MATUS A | 1986 | Neurocyto1986，15，： | 1 |
| 4 | Microtubule-Associated Proteins: Their Potential Role in Determining Neuronal Morphology显示文摘 | A Matus | 1988 | Annual Review of Neuroscience1988，，： | 1 |
| 5 | Growth of dendritic spines: a continuing story显示文摘 | Matus A | 2005 | Curr Opin Neurobiol2005，15，： | 1 |
| 6 | Allocation and cyc- ling of nitrogen in an alfalfa-bromegrass sward显示文摘 | Walley F L Tomm G O Matus A etal | 1996 | Agronomy Journal1996，88，5： | 1 |
| 7 | Microtubule-associated proteins and neuronal morphogenesis显示文摘 | MATUS A | 1991 | J Cell Sci1991，，： | 1 |
| 8 | Distribution of calpains Ⅰ and Ⅱ in rat brain显示文摘 | Hamakubo T Kannagi R Murachi T Matus A | 1986 | J Neurosci1986，6，11： | 1 |
| 9 | Broad phylogenomic sam-pling improves resolution of the animal tree of life显示文摘 | DUNN C W HEJNOL A MATUS D Q | 2008 | Nature2008，452，7188： | 1 |
| 10 | Genetic diversity in three groups of barley germplasm assessed by simple sequence repeats显示文摘 | Matus I A Hayes P M | 2002 | Genome2002，45，6： | 1 |
| 11 | Groth and characterization of cubic SiC single - ctystalline films on Si显示文摘 | Power J A Matus L G Kuczmarski M A | 1986 | Journal of The Elctrochemical Society1986，134，6： | 1 |
| 12 | Post-version sunlight exposure induces MYB-mediated ranseriptional regulation of anthocyanin and flavonol synthesis in berry skins of Vitis vinifera显示文摘 | Matus J T Loyola R Vega A | 2009 | Journal of Experimental Botany2009，60，3： | 1 |
| 13 | Environmental and laboratory studies of the photodegradation of the pesfidde fenarimol显示文摘 | MATUS M SILUA A M BAURROUS H D | 1994 | Photochem Photobid Chart1994，80，： | 1 |
| 14 | Pseudomonas aeruginosa hypoxic or anaerobic bio-film infections within cystic fibrosis airways显示文摘 | Hassett D J Sutton M D Schurr M J Herr A B Caldwell C C Matu J 0 | 2009 | Trends Micro-biol2009，17，： | 1 |
| 15 | Critical role of transcription factorcyclic AMP response element modulator in beta 1 -adrenoceptor-medi-ated cardiac dysfunction 显示文摘 | Lewin G Matus M Basu A | 2009 | Circulation2009，119，1： | 1 |
| 16 | Volatile anesthetics block actin-based motility in dendritic spines显示文摘 | Kaech S Brinkhaus H Matus A | 1999 | Proc Natl Acad Sci USA1999，96，10： | 1 |
| 17 | Increased genomic prediction accuracy in wheat breeding through spatial adjustment of field trial data 显示文摘 | Lado B Matus I Rodrlguez A | 2013 | G3 (Bethesda)2013，3，12： | 1 |
| 18 | High actin concentrations in brain dendritic spines and postsynaptic densities显示文摘 | MATUS A ACKERMANN M PEHLING G | 1982 | Proc Natl Acad Sci USA1982，79，23： | 1 |
| 19 | Allocation and cycling of nitrogen in an alfalfa-bromegrass sward显示文摘 | Walley F L Tomm G O Matus A | 1996 | Agronomy Journal1996，88，： | 1 |
| 20 | MARCKS for maintenance in dendritic spines 显示文摘 | Matus A | 2005 | Neu-ron2005，48，1： | 1 |
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