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| 1 | Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy显示文摘AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: 'intervascular background coloration'; 'proliferation of intrapapillary capillary loops(IPCL)'; and 'dilation', 'tortuosity', 'change in caliber', and 'various shapes(VS)' of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME. | Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya Masayuki Kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Preparation of particulate Li4Ti5O12 having excellent characteristics as an electrode active material for power storage ceils 显示文摘 | Nakahara K Nakajima R Matsushima T | 2003 | Journal of Power Sources2003，117，12： | 1 |
| 3 | Apoptosis induction by acyclic retinoid: a molecular basis of ' clonal deletion' therapy for hepatozellular carcinoma显示文摘 | Okuno M Sano T Matsushima Nishiwaki R | 2001 | Jpn J Clin Oncol2001，31，8： | 1 |
| 4 | Asymptomatic hyperglycaemia is associated with increased intimal plus medial thickness of the carotid artery显示文摘 | Yamasaki Y Kawamori R Matsushima H | | 0，，05： | 1 |
| 5 | Preparation of particulate Li4Ti5O12 having excellent characteristics as an eleclrode active material for power storage cells显示文摘 | Nakahara K Nakajima R Matsushima T | 2003 | J Power sources2003，117，12： | 1 |
| 6 | Inhibition of protein phosphatases by microcystins and nodularin associated with hepatoxicity显示文摘 | YOSHIZAWA S MATSUSHIMA R WATANABE M | 1990 | J Cancer Res Clin Oncol1990，116，： | 1 |
| 7 | Determination of S- 1 ( combined drug of tegafur), 5-chloro-2,4-dihydroxypyridine and potassium oxonate and 5-fluorouracil in human plasma and urine using high-performance liquid chromatography and gas chromatography-negative ion chemical ionization mass spectrometry显示文摘 | Matsushima E Yoshida K Kitamura R | 1997 | J Chromatogr B1997，691，1： | 1 |
| 8 | Mitochondrial transcription factor B2 is essential for metabolic function in Drosophila melanogaster devel- opment显示文摘 | ADAN C MATSUSHIMA Y HERNANDEZ- SIERRA R | 2008 | J Biol Chem2008，283，12： | 1 |
| 9 | Preparation of particulate Li4Ti5O12 having excellent characteristics as an electrode active material for power storage cells显示文摘 | NAKAHARA K NAKAJIMA R MATSUSHIMA T | 2003 | J Power Sources2003，117，1： | 1 |
| 10 | Analysis of organization-committed human error by extended CREAM 显示文摘 | Kubota R Kiyokawa K Arazoe M Ito H Iijima Y Matsushima H Shimokawa H | 2001 | Cognition Technology & Work2001，3，： | 1 |
| 11 | Droso- phila mitochondrail transcription factor B 1 modulates mi- tochondrial translation but not transcription or DNA copy number in Schneider cells 显示文摘 | MATSUSHIMA Y ADAN C GARESSE R | 2005 | J Biol Chem2005，280，16： | 1 |
| 12 | Ultrasonic butt welding of aluminum,aluminum alloy and stainless steel plate specimens显示文摘 | TSUJINO J HIDAI K HASEGAWA KANAI R MATSUURA H MATSUSHIMA K UEOKA T | | 0，，1： | 1 |
| 13 | Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity 显示文摘 | Yoshizawa S Matsushima R Watanabe M | 1990 | Cancer Res Clin Oncol1990，116，6： | 1 |
| 14 | Microsurgical anatomy of the posterior inferior cerebellar artery显示文摘 | Lister J R Rhoton A L Jr Matsushima T | 1982 | Neurosur gery1982，10，2： | 1 |
| 15 | Mechanism of Quenching of the Uranyl Fluorescence by Organic Compounds显示文摘 | Matsushima R J | 1972 | J Am Chem Soc1972，94，： | 1 |
| 16 | Analysis of extracellular alginate lyase and its gene from a marine bacterial strain, Pseudoalteromonas atlantiea ARO6显示文摘 | Matsushima R Danno H Uchida M | 2010 | Applied Mierobiology and Bioteehnology2010，86，2： | 1 |
| 17 | Enkephalin-,substance P and serotonin-like immunoreactive axonal varicosities in close apposition to perikarya of mesencephalic trigeminal nucleus neurons in the cat显示文摘 | Satoda T Matsushima R | 1989 | Brain Res1989，494，1： | 1 |
| 18 | Preparation of particulate Li4Ti5O12 having excellent characteristics as an electrode active material for power storage cells显示文摘 | Nakahara K Nakajima R Matsushima T | 2003 | J Power Sources2003，117，： | 1 |
| 19 | Asymptomatie hyperglycaemia is associated with increased intimal plus medial thickness of the carotid artery显示文摘 | Yamasaki Y Kawarnori R Matsushima H | 1995 | Diabetologia1995，，05： | 1 |
| 20 | An endoplasmic reticulum-derived structure that is induced under stress conditions in Arabidopsis显示文摘 | MATSUSHIMA R HAYASHI Y KONDO M | 2002 | Plant Physiol2002，130，： | 1 |
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