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| 1 | 开放式空气中CO_2浓度增高(FACE)对水稻生长和发育的影响显示文摘人类活动导致的大气和气候变化将极大地改变作物的生长环境,其中最大的一个变化就是大气二氧化碳(CO2)浓度的迅速上升:从工业革命前的平均270μmol/mol上升到目前的381μmol/mol,到2050年至少超过550μmol/mol。FACE(Free-air CO2 enrichment,开放式空气中CO2浓度增高)试验是目前评估未来高浓度CO2对作物生长和产量实际影响的最佳方法。水稻无疑是人类最重要的食物来源,迄今为止人类利用FACE技术开展水稻响应和适应的研究已有10a(19982008年)的历史。以生长发育为主线,首次系统综述了10a水稻FACE试验在该领域的研究成果,总结了FACE情形下高浓度CO2(模拟本世纪中叶大气CO2浓度)对主要供试水稻品种(小区面积大于4m2)光合作用、生育进程、地上部生长、地下部生长、物质分配、籽粒灌浆、产量构成以及倒伏性状等影响的研究进展,比较了FACE与非FACE研究之间以及中国和日本FACE研究(世界上唯一的两个大型水稻FACE研究)之间的异同点。根据研究进展以及当前的技术水平,文章最后提出了该领域的3个优先课题:(1)FACE情形下杂交稻生产力响应高于预期的生物学机制;(2)FACE情形下CO2与主要栽培措施的互作效应;(3)FACE情形下CO2与主要空气污染物臭氧的互作效应。这些响应的机理性解析将有助于从根本上减少人类预测未来粮食安全的不确定性,进而更加有效地制订出应对全球变化的适应策略。 | 杨连新 王云霞 朱建国 Toshihiro Hasegawa 王余龙 | 2010 | 生态学报2010，30，6： | 62 |
| 2 | Ultrafast laser processing of materials: from science to industry显示文摘Processing of materials by ultrashort laser pulses has evolved significantly over the last decade and is starting to reveal its scientific,technological and industrial potential.In ultrafast laser manufacturing,optical energy of tightly focused femtosecond or picosecond laser pulses can be delivered to precisely defined positions in the bulk of materials via two-/multi-photon excitation on a timescale much faster than thermal energy exchange between photoexcited electrons and lattice ions.Control of photoionization and thermal processes with the highest precision,inducing local photomodification in sub-100-nm-sized regions has been achieved.State-of-the-art ultrashort laser processing techniques exploit high 0.1–1μm spatial resolution and almost unrestricted three-dimensional structuring capability.Adjustable pulse duration,spatiotemporal chirp,phase front tilt and polarization allow control of photomodification via uniquely wide parameter space.Mature opto-electrical/mechanical technologies have enabled laser processing speeds approaching meters-per-second,leading to a fast lab-to-fab transfer.The key aspects and latest achievements are reviewed with an emphasis on the fundamental relation between spatial resolution and total fabrication throughput.Emerging biomedical applications implementing micrometer feature precision over centimeter-scale scaffolds and photonic wire bonding in telecommunications are highlighted. | Mangirdas Malinauskas Albertas Žukauskas Satoshi Hasegawa Yoshio Hayasaki Vygantas Mizeikis Ričardas Buividas Saulius Juodkazis | 2016 | Light(Science & Applications)2016，5，1： | 37 |
| 3 | Brain Metastases Treated with Radio surgery Alone:An Alternative to Whole Brain Radiotherapy?显示文摘OBJECTIVE:Whole brain radiotherapy(WBRT)provides benefit for patients with b rain metastases but may result in neurological toxicity for patien ts with extended survival times.Ste reotactic radiosurgery in combination with WBRT has become an important approach,but the value of WBRT has been questioned.As an alternative to WBRT,we managed patients with stereotactic radiosurgery alone,evaluated pati ents’outcomes,and assessed prognostic factors for survival and tumor c ontrol.METHODS:One hundred seventy-two patients with b rain metastases were managed with ra diosurgery alone.One hundred twent y-one patients were evaluable with follow-up imaging after radiosurgery.The median patien t age was 60.5years(age range,16-86yr).The mean marginal tumor dose and volume were 18.5Gy (range,11-22Gy )and 4.4ml (range,0.1-24.9ml ).Eighty percent of patients had soli tary tumors.RESULTS:The overall median survival time was8months.The median survival time in patients with no evidence of primary tumor disease or stable disease was 13and 11months.The local tumor contr ol rate was 87%.At 2years,the rate of local control,remote brain control,and total intr acranial control were 75%,41%,and 27%,respectively.In multivariate a nalysis,advanced primary tumor status(P=0.0003),older age(P=0.008),lower Karnofsky Performance Scale score(P=0.01),and malignant melanoma (P=0.005)were significant for poorer surviva l.The median survival time was 28mon ths for patients younger than 60years of age,with Karnofsky Performance Scale score o f at least 90,and whose primary tumor status showed either no evidence of disease or stable disease.Tumor volume (P=0.02)alone was significant for local tumo r control,whereas no factor affecte d remote or intracranial tumor contr ol.Eleven patients developed complica tions,six of which were persistent.Nineteen(16.5%)of 116patients in whom the cause of death was obtained died as a result of cause s related to brain metastasis.CONCLUSION:Brain metastases were controlled we ll with radiosurgery alone as initial thera py.We advocate that WBRT should not be part of the initial treatment proto col for selected patients with one or two tumors with good control of their primary cancer,better Karnofsky Performance Scale score,and you nger age,all of which are predictors of longer | Toshinori Hasegawa Douglas Kondziolka John C.Flickinger Anand Germanwala L.Dade Lunsford | 2003 | 癌症2003，22，7： | 23 |
| 4 | Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer显示文摘AIM:To investigate human epidermal growth factor receptor 2(HER2)-phosphatidylinositol 3-kinase(PI3K)-vAkt murine thymoma viral oncogene homolog signaling pathway.METHODS:We analyzed 231 formalin-fixed,paraffinembedded gastric cancer tissue specimens from Japanese patients who had undergone surgical treatment.The patients' age,sex,tumor location,depth of invasion,pathological type,lymph node metastasis,and pathological stage were determined by a review of the medical records.Expression of HER2 was analyzed by immunohistochemistry(IHC) using the HercepTest TM kit.Standard criteria for HER2 positivity(0,1+,2+,and 3+) were used.Tumors that scored 3+ were considered HER2-positive.Expression of phospho Akt(pAkt) was also analyzed by IHC.Tumors were considered pAkt-positive when the percentage of positive tumor cells was 10% or more.PI3K,catalytic,alpha polypeptide(PIK3CA) mutations in exons 1,9 and 20 were analyzed by pyrosequencing.Epstein-Barr virus(EBV) infection was analyzed by in situ hybridization targeting EBV-encoded small RNA(EBER) with an EBER-RNA probe.Microsatellite instability(MSI) was analyzed by polymerase chain reaction using the mononucleotide markers BAT25 and BAT26.RESULTS:HER2 expression levels of 0,1+,2+ and 3+ were found in 167(72%),32(14%),12(5%) and 20(8.7%) samples,respectively.HER2 overexpression(IHC 3+) significantly correlated with intestinal histological type(15/20 vs 98 /205,P = 0.05).PIK3CA mutations were present in 20 cases(8.7%) and significantly correlated with MSI(10/20 vs 9/211,P < 0.01).The mutation frequency was high(21%) in T4 cancers and very low(6%) in T2 cancers.Mutations in exons 1,9 and 20 were detected in 5(2%),9(4%) and 7(3%) cases,respectively.Two new types of PIK3CA mutation,R88Q and R108H,were found in exon1.All PIK3CA mutations were heterozygous missense singlebase substitutions,the most common being H1047R(6/20,30%) in exon20.Eighteen cancers(8%) were EBV-positive and this positivity significantly correlated with a diffuse histological type(13/18 vs 93/198,P = 0.04).There were 7 cases of lymphoepithelioma-like carcinomas(LELC) and 6 of those cases were EBV-positive(percent/EBV:6/18,33%;percent/all LELC:6/7,86%).pAkt expression was positive in 119(53%) cases but showed no correlation with clinicopathological characteristics.pAkt expression was significantly correlated with HER2 overexpression(16/20 vs 103/211,P < 0.01) but not with PIK3CA mutations(12/20 vs 107/211,P = 0.37) or EBV infection(8/18 vs 103/211,P = 0.69).The frequency of pAkt expression was higher in cancers with exon20 mutations(100%) than in those with exon1(40%) or exon9(56%) mutations.One case showed both HER2 overexpression and EBV infection and 3 cases showed both PIK3CA mutations and EBV infection.However,no cases showed both PIK3CA mutations and HER2 overexpression.One EBVpositive cancer with PIK3CA mutation(H1047R) was MSI-positive.Three of these 4 cases were positive for pAkt expression.In survival analysis,pAkt expression significantly correlated with a poor prognosis(hazard ratio 1.75;95%CI:1.12-2.80,P = 0.02).CONCLUSION:HER2 expression,PIK3CA mutations and EBV infection in gastric cancer were characterized.pAkt expression significantly correlates with HER2 expression and with a poor prognosis. | Yasutaka Sukawa Hiroyuki Yamamoto Katsuhiko Nosho Hiroaki Kunimoto Hiromu Suzuki Yasushi Adachi Mayumi Nakazawa Takayuki Nobuoka Mariko Kawayama Masashi Mikami Takashi Matsuno Tadashi Hasegawa Koichi Hirata Kohzoh Imai Yasuhisa Shinomura | 2012 | World Journal of Gastroenterology2012，18，45： | 19 |
| 5 | Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid显示文摘背景:Methylmalonic 酸尿(MMA ) 是在中国的器官的酸尿的最经常的疾病。各种各样的生物化学的策略为 MMA 的出生前的诊断被跟随。然而,后来, MMA 影响的胎儿减少了 methylmalonic 酸的排泄,出生前的生物化学的诊断的困难是明显的。煤气的层析团分光术(GC/MS ) 和双人脚踏车团分光术(ESI/MS/MS ) 允许我们在影响胎儿识别疾病。这研究的目的是在 MMA 的出生前的诊断在羊膜的液体决定有机酸和全部的人半胱氨酸的分析的价值。方法:临床诊断并且有 MMA 的九个职业人员乐队的结果并且出生前在风险基于九个胎儿的生物化学的分析诊断因为 MMA 被调查。从在为 MMA 的风险的怀孕和新陈代谢的联盟者正常怀孕的羊膜的液体样品在 16 点被获得 - 24 星期怀孕期。Methylmalonic 酸和甲基枸橼酸被 GC/MS 测量, propionylcarnitine 被 ESI/MS/MS 分析,并且全部的人半胱氨酸由荧光极化免疫分析是坚定的。结果:在二怀孕, methylmalonic 酸的高水平,甲基枸橼酸, propionylcarnitine,和总数,人半胱氨酸在胎儿显示了联合 MMA 和 homocysteinemia。继续的怀孕和收到的维生素 B12 作为出生前的处理,和其它补充的母亲之一终止了她的怀孕。在一个,怀孕, methylmalonic 酸的显著地提高的层次,甲基枸橼酸,和 propionylcarnitine,和正常全部的人半胱氨酸铺平被发现在胎儿显示孤立的 MMA;流产在这个案例上被执行。在另外的六怀孕,上述提及的代谢物的所有层次是正常的建议胎儿没被 MMA 影响。diagnoses 被严峻的尿有机酸和血浆总数人半胱氨酸在交货以后证实。结论:MMA 的新陈代谢的畸形在怀孕期早发生。在羊膜的液体的全部的人半胱氨酸的水平可以是胎儿的联合 MMA 和 homocysteinemia 的另外的指示物。在羊膜的液体的全部的人半胱氨酸水平的决心可以为疾病的出生前的诊断成为一个方便、可靠的方法。 | ZHANG Yao YANG Yan-ling HASEGAWA Yuki YAMAGUCHI Seiji SHI Chun-yan SONG Jin-qing SAYAMI Sujan LIU Ping YAN Rong DONG Jin-hua QIN Jiong | 2008 | Chinese Medical Journal2008，，3： | 18 |
| 6 | The Phosphate Transporter PHT4;6 Is a Determinant of Salt Tolerance that Is Localized to the Golgi Apparatus of Arabidopsis显示文摘破坏 PHT4 的功能的插入变化;(At5g44370 ) 6 引起 NaCl 被主要的根的减少的生长根尖端描绘,提高的侧面的分叉,并且胀大的 Arabidopsis 幼苗的超敏性。变异的显型被蔗糖,然而并非由甘露糖醇的 equiosmolar 集中加重,并且在媒介由低无机的磷酸盐稀释了。蛋白质 PHT4; 6 属于分享重要顺序类似到哺乳动物的类型的 permeases 的主要 Facilitator 总科 -- 我 Pi transporters 和小囊的 glutamate transporters,并且是植物的通常认为的细胞内部的磷酸盐 transporters 的 PHT4 家庭的一个成员。PHT4; 6 本地化那 PHT4 到膜和运输研究显示的 Golgi; 6 便于 Pi 然而并非氯化物或无机的阴离子的选择运输。有显示根胀大的另外的异种的 Phenotypic 类似建议那 PHT4;在蛋白质 N-glycosylation 和房间的 6 可能的功能围生合成,它为盐忍耐是必要的。一起,我们的结果显示那 PHT4;从为再循环免除 glycosylation 的 Pi 的 Golgi lumenal 空间的 6 运输 Pi 处理。 | Beatriz Cubero Yuko Nakagawa Xing-Yu Jiang Ken-Ji Miura Fang Li Kashchandra G. Raghothama Ray A. Bressan Paul M. Hasegawa Jose M. Pardo | 2009 | Molecular Plant2009，2，3： | 15 |
| 7 | Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma显示文摘The prevalence of hepatocellular carcinoma(HCC)worldwide parallels that of persistent infection with the hepatitis B virus(HBV)and/or hepatitis C virus(HCV).According to recommendations by the World Health Organization guidelines for HBV/HCV,alpha-fetoprotein(AFP)testing and abdominal ultrasound should be performed in routine surveillance of HCC every 6 mo for high-risk patients.These examinations have also been recommended worldwide by many other HCC guidelines over the past few decades.In recent years,however,the role of AFP in HCC surveillance and diagnosis has diminished due to advances in imaging modalities.AFP was excluded from the surveillance and/or diagnostic criteria in the HCC guidelines published by the American Association for the Study of Liver Diseases in 2010,the European Association for the Study of the Liver in 2012,and the National Comprehensive Cancer Network in 2014.Other biomarkers,including the Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),des-γ-carboxyprothrombin,Dickkopf-1,midkine,and micro RNA,are being studied in this regard.Furthermore,increasing attention has focused on the clinical utility of biomarkers as pre-treatment predictors for tumor recurrence and as post-treatment monitors.Serum and tissue-based biomarkers and genomics may aid in the diagnosis of HCC,determination of patient prognosis,and selection of appropriate treatment.However,further studies are needed to better characterize the accuracy and potential role of these approaches in clinical practice. | Pei-Pei Song Ju-Feng Xia Yoshinori Inagaki Kiyoshi Hasegawa Yoshihiro Sakamoto Norihiro Kokudo Wei Tang | 2016 | World Journal of Gastroenterology2016，22，1： | 15 |
| 8 | 鼠Ⅱ型糖尿病减弱种植体骨整合能力的实验研究显示文摘目的:Ⅱ型糖尿病(成人非胰岛素依赖性糖尿病)是临床上的常见病,但有关此类病变对种植体骨整合能力影响的相关动物模型研究仍少见报道。为此本实验在Ⅱ型糖尿病鼠模型上,从组织学和组织形态测量学的角度检测钛种植体周围骨愈合的情况。方法:特制的中空钛种植体被植入普通雄鼠和经基因修饰的Ⅱ型糖尿病雄鼠的股骨。 | Hasegawa H Ozawa S Hashimoto K 王鹏 | 2008 | 口腔颌面外科杂志2008，18，5： | 13 |
| 9 | Reduced hemoglobin and increased C-reactive protein are associated with upper gastrointestinal bleeding显示文摘AIM: To investigate the early upper gastrointestinal endoscopy(endoscopy) significantly reduces mortality resulting from upper gastrointestinal(GI) bleeding. METHODS: Upper GI bleeding was defined as 1a, 1b, 2a, and 2b according to the Forrest classification. The hemoglobin(Hb), and C-reactive protein(CRP) were examined at around the day of endoscopy and 3 mo prior to endoscopy. The rate of change was calculated as follows:(the result of blood examination on the day of endoscopy- the results of blood examination 3 mo prior to endoscopy)/(results of blood examination 3 mo prior to endoscopy). Receiver operating characteristic curves were created to determine threshold values. RESULTS: Seventy-nine men and 77 women were enrolled. There were 17 patients with upper GI bleeding: 12 with a gastric ulcer, 3 with a duodenal ulcer, 1 with an acute gastric mucosal lesion, and 1 with gastric cancer. The area under the curve(AUC), threshold, sensitivity, and specificity of Hb around the day of endoscopy were 0.902, 11.7 g/dL, 94.1%, and 77.1%, respectively, while those of CRP were 0.722, 0.5 mg/dL, 70.5%, and 73%, respectively. The AUC, threshold, sensitivity, and specificity of the rate of change of Hb were 0.851,-21.3%, 76.4%, and 82.6%, respectively, while those of CRP were 0.901, 100%, 100%, and 82.5%, respectively. CONCLUSION: Predictors for upper GI bleeding were Hb < 11.7 g/dL, reduction rate in the Hb > 21.3% and an increase in the CRP > 100%, 3 mo before endoscopy. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Akira Togawa Yoshinori Shirai Noboru Ichiki Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Makoto Sueishi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 10 | Inhibitory effect of angiotensinⅡreceptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis显示文摘AIM: To investigate the efficacy of angiotensinⅡreceptor antagonist on hepatic stellate cells (HSCs) activation in the patients with non-alcoholic steatohepatitis (NASH). METHODS: Seven patients with NASH were prescribed losartan, a selective angiotensinⅡtype 1 receptor antagonist (50 mg/d) for 48 wk. Liver biopsies were performed both at the entry and end of the study in all patients. Quiescent and activated HSCs were identified by double immunostaining using anti-p75 andα-smooth muscle actin antibodies, and the number of each phenotype was counted. Similarly, the liver specimens obtained from the eight patients with non-alcoholic fatty liver (NAFL) were also examined as controls. RESULTS: In NASH hepatic tissues, activated HSCs were dominantly distributed as compared with those in NAFL. The 48-wk losartan treatment induced a remarkable decrease in activated HSCs and a mild increase in quiescent phenotypes. CONCLUSION: Our data suggest the crucial involvement of HSCs in anti-fibrotic effect of angiotensinⅡreceptor antagonist on patients with NASH. | Shiro Yokohama Yoshihiko Tokusashi Kimihide Nakamura Yosui Tamaki Satoshi Okamoto Mituyoshi Okada Kazunobu Aso Takenao Hasegawa Masaru Aoshima Naoyuki Miyokawa Masakazu Haneda Masashi Yoneda | 2006 | World Journal of Gastroenterology2006，12，2： | 10 |
| 11 | Reproducibility and Validity of a Chinese Food Frequency Questionnaire显示文摘Objectives This study was design to develop a semi-quantitative Chinese Food Frequency Questionnaire (FFQ) and to conduct a validation study for the questionnaire. Methods Based on the survey experience in recent years, a new Chinese food frequency questionnaire (FFQ) with 149 items in 17 food categories was developed. A validation study on this new FFQ was conducted in Jiangsu and Beijing of China between 1999 and 2001. The period of study covered 1 year and the FFQ was validated by comparing with data obtained by a six repeated 24-hour recalls for 3 consecutive days, or a totally 18-day 24- hour recall throughout the year. A total of 271 healthy adult subjects were enrolled in the study. Food and nutrient intakes measured by the 18-day dietary recalls and food frequency questionnaires (FFQs) were computed in the National Institute for Nutrition and Food Safety, China CDC using the existing nutrition database. The average daily intake of foods and nutrients over the 18-day recall was used to compare with FFQ1 and FFQ2, which was conducted at the beginning and the end of the year, respectively. All statistical analyses were carried out using SAS software version 6.12. | Water WILLETT Kyoko HASEGAWA | 2010 | Biomedical and Environmental Sciences2010，23，S1： | 9 |
| 12 | Natural regression of fibrosis in chronic hepatitis B显示文摘The fibrosis of liver cirrhosis was considered to be irreversible before the anti-viral drugs showed that it is reversible when they lead to continuous suppression of viral replication and inflammation. However, several reports previously showed that fibrosis of type B liver cirrhosis was almost completely absorbed after the natural remission of chronic inflammation. This phenomenon might not be limited to exceptional patients, but rather occur commonly, considering the dynamic clinical features of chronic hepatitis B(CHB), where inactive carrier stage normally follows aggravation of hepatitis and progression of fibrosis at the time of HBe Ag seroconversion. Thus, fibrosis levels of CHB as a hepatocellular carcinoma(HCC)-surveillance marker, particularly those of the inactive stage, could be underestimated, because some of them might have been(pre)cirrhotic in the past and recovered with the natural regression of fibrosis. We argue that cirrhosisinduced HCC mechanisms, rather than direct action of viral genome, may be more common than generally considered in CHB patients. This may have some impact on reconsidering the surveillance rationale for HCC in CHB, from where advanced HCCs tended to be missed. In addition, a molecular marker to assess the cancer-prone characteristics of the liver will definitely be needed to resolve the issue. | Shogo Ohkoshi Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa Kenya Kamimura Masahiko Yano | 2016 | World Journal of Gastroenterology2016，22，24： | 8 |
| 13 | Patient characteristics with high or low blood urea nitrogen in upper gastrointestinal bleeding显示文摘AIM: To examine characteristics of patients with blood urea nitrogen(BUN) levels higher and lower than the normal limit.METHODS: Patient records between April 2011 and March 2014 were analyzed retrospectively. During this time, 3296 patients underwent upper endoscopy. In total, 50 male(69.2 ± 13.2 years) and 26 female(72.3 ± 10.2 years) patients were assessed. Patients were divided into two groups based on BUN levels: higher than the normal limit(21.0 mg/d L)(H) and lower thanthe normal limit(L). One-way analysis of variance was performed to reveal differences in the variables between the H and L groups. Fisher's exact test was used to compare the percentage of patients with gastric ulcer or gastric cancer in the H and L groups.RESULTS: White blood cell count was higher in the H group than in the L group(P = 0.0047). Hemoglobin level was lower in the H group than in the L group(P = 0.0307). Glycated hemoglobin was higher in the H group than in the L group(P = 0.0264). The percentage of patients with gastric ulcer was higher in the H group(P = 0.0002). The H group contained no patients with gastric cancer.CONCLUSION: Patients with BUN ≥ 21 mg/d L might have more severe upper gastrointestinal bleeding. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Yoshinori Shirai Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Naoki Ishige | 2015 | World Journal of Gastroenterology2015，21，24： | 8 |
| 14 | Optimal treatment strategies for hepatic portal venous gas:A retrospective assessment显示文摘BACKGROUND Hepatic portal venous gas(HPVG)generally indicates poor prognoses in patients with serious intestinal damage.Although surgical removal of the damaged portion is effective,some patients can recover with conservative treatments.AIM To establish an optimal treatment strategy for HPVG,we attempted to generate computed tomography(CT)-based criteria for determining surgical indication,and explored reliable prognostic factors in non-surgical cases.METHODS Thirty-four cases of HPVG(patients aged 34-99 years)were included.Necessity for surgery had been determined mainly by CT findings(i.e.free-air,embolism,lack of contrast enhancement of the intestinal wall,and intestinal pneumatosis).The clinical data,including treatment outcomes,were analyzed separately for the surgical cases and non-surgical cases.RESULTS Laparotomy was performed in eight cases(surgical cases).Seven patients(87.5%)survived but one(12.5%)died.In each case,severe intestinal damage was confirmed during surgery,and the necrotic portion,if present,was removed.Non-occlusive mesenteric ischemia was the most common cause(n=4).Twentysix cases were treated conservatively(non-surgical cases).Surgical treatments had been required for twelve but were abandoned because of the patients’poor general conditions.Surprisingly,however,three(25%)of the twelve inoperable patients survived.The remaining 14 of the 26 cases were diagnosed originally as being sufficiently cured by conservative treatments,and only one patient(7%)died.Comparative analyses of the fatal(n=10)and recovery(n=16)cases revealed that ascites,peritoneal irritation signs,and shock were significantly more frequent in the fatal cases.The mortality was 90%if two or all of these three clinical findings were detected.CONCLUSION HPVG related to intestinal necrosis requires surgery,and our CT-based criteria are probably useful to determine the surgical indication.In non-surgical cases,ascites,peritoneal irritation signs and shock were closely associated with poor prognoses,and are applicable as predictors of patients’prognoses. | Masanori Gonda Tatsuya Osuga Yoshihiro Ikura Kazunori Hasegawa Kentaro Kawasaki Takatoshi Nakashima | 2020 | World Journal of Gastroenterology2020，26，14： | 8 |
| 15 | Endobronchial metastasis from adenocarcinoma of gastric cardia 7 years after potentially curable resection显示文摘Endobronchial metastasis(EBM) is a rare form of metas-tasis from extrapulmonary malignant tumors,although there are few reports of EBM from gastric cancer specifically.We report the case of a 51-year-old woman who had undergone gastrectomy for advanced gastric cancer seven years previously but was diagnosed with a solitary lung tumor by follow-up computed tomography.On diagnosis of primary lung cancer,she underwent pulmonary lobectomy,but immunohistochemical examination confirmed the resected tumor to be an EBM from the gastric cancer.Six months later,she was diagnosed with peritoneal metastases and underwent chemotherapy with gastric cancer regimen.She is still alive at 33 mo after the lobectomy.Generally,the prognosis for EBM is poor although multidisciplinary treatment can lead to long-term survival.Precise diagnosis on the basis of detailed pathological and immunohistochemical evaluation can contribute to deciding the most effective treatment and improving prognosis. | Takaaki Hanyu Tatsuo Kanda Atsushi Matsuki Go Hasegawa Kazuhito Yajima Masanori Tsuchida Shin-ichi Kosugi Makoto Naito Katsuyoshi Hatakeyama | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 7 |
| 16 | Neither Multiple Tumors Nor Portal Hypertension Are Surgical Contraindications for Hepatocellular Carcinoma显示文摘 | Takeaki Ishizawa Kiyoshi Hasegawa Taku Aoki Michiro Takahashi Yosuke Inoue Keiji Sano Hiroshi Imamura Yasuhiko Sugawara Norihiro Kokudo Masatoshi Makuuchi | 2008 | Gastroenterology2008，，7： | 7 |
| 17 | Prognostic Impact of Anatomic Resection for Hepatocellular Carcinoma显示文摘 | Kiyoshi Hasegawa Norihiro Kokudo Hiroshi Imamura Yutaka Matsuyama Taku Aoki Masami Minagawa Keiji Sano Yasuhiko Sugawara Tadatoshi Takayama Masatoshi Makuuchi | 2005 | Annals of Surgery2005，，2： | 6 |
| 18 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 6 |
| 19 | 劳力士学习中心显示文摘日本SANAA事务所设计的劳力士学习中心于2010年的2月22日开放。SANAA (Sejima And Nishizawa And Associates)是由建筑师妹岛和世和西泽立卫两人共同成立的建筑事务所,该事务所设计的劳力士学习中心建筑新颖大胆而且具有高度的实验性质,向人们展示了21世纪人类新的学习方式和交互性影响的意义。作为瑞士洛桑联邦理工学院(EPFL)的一部分, | Yumiko Yamada Rikiya Yamamoto Osamu Kato Naoto Noguchi Mizuko Kaji Takayuki Hasegawa Louis-Antoine Grego Tetsuo Kondo Matthias Haertel Catarina Canas 朱晓琳 | 2010 | 建筑技艺2010，16，5： | 6 |
| 20 | Arabidopsis CBL-Interacting Protein Kinases Regulate Carbon/Nitrogen-Nutrient Response by Phosphorylating Ubiquitin Liqase ATL31显示文摘响应可得到的碳(C) 和氮(N) 营养素的比率,植物调整他们的新陈代谢,生长,和发展,一个过程叫了 C/N-nutrient 反应。然而, C/N-nutrient 发信号的分子的基础仍然保持大部分不清楚。在这研究,我们识别了交往的三 CALCINEURIN 象 B 一样(CBL ) 蛋白质 KINASES (CIPK ) , CIPK7, CIPK12,和 CIPK14,在 Arabidopsis 在萌芽以后的生长期间给 C/N-nutrient 反应的管理者调音。CIPK7, CIPK12,和 CIPK14 的单个大美人的异种显示出超敏性到高 C/low N 条件,它在他们的三倍大美人的异种被提高,显示他们起一个否定作用并且部分至少在 C/N-nutrient 反应冗余地工作。而且,这些 CIPK 被发现调整 ATL31,经由 phosphorylation 依赖的 ubiquitination 涉及 C/N-nutrient 反应的 ubiquitin ligase 和 14-3-3 蛋白质的 proteasomal 降级的功能。CIPK7, CIPK12,和 CIPK14 身体上与 ATL31,和 CIPK14 交往了,与 CBL8 行动,直接以一种 Ca 2+-dependent 方式的 phosphorylated ATL31。进一步的分析证明这些 CIPK 为 ATL31 phosphorylation 和稳定被要求,它调停响应 C/N-nutrient 的 14-3-3 蛋白质的降级调节。这些调查结果提供新卓见进 C/N-nutrient 发信号由蛋白质 phosphorylation 调停了。 | Shigetaka Yasuda Shoki Aoyama Yoko Hasegawa Takeo Sato Junji Yamaguchi | 2017 | Molecular Plant2017，10，4： | 5 |
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