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| 1 | First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus显示文摘Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal tract.The incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is striking.The progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with patients.This guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based recommendations.Comprehensive up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications. | Maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar Ahmed M Khassouan Zaher Koutoubi Rahul Nathwani Mazen S Taha Jimmy K Limdi | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 2 | Pharyngocutaneous fistula after laryngectomy:incidence,predisposing factors,and outcome显示文摘 | Nader S Soheila N Maryam K | 2008 | Arch Iranian Med2008，11，3： | 1 |
| 3 | Casting the Net : A Multimodal Network Perspective on User-System Interactions 显示文摘 | GERALD C K MARYAM A | 2008 | Information Systems Research2008，19，3： | 1 |
| 4 | Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism显示文摘We have recently developed an enzyme-directed immunostimulant(EDI)prodrug motif,which is metabolized to active immunostimulant by cancer cells and,following drug efflux,activates nearby immune cells,resulting in immunogenicity.In this study,we synthesized several EDI prodrugs featuring an imidazoquinoline immunostimulant resiquimod(a Toll-like receptor 7/8 agonist)covalently modified with glycosidase enzyme-directing groups selected from substrates of β-glucuronidase,α-mannosidase,or β-galactosidase.We compared the glycosidase-dependent immunogenicity elicited by each EDI in RAW-Blue macrophages following conversion to active immunostimulant by complementary glycosidase.At a cellular level,we examined EDI metabolism across three cancer cell lines(B16 melanoma,TC2 prostate,and 4T1 breast cancer).Comparing the relative immunogenicity elicited by each EDI/cancer cell combination,we found that B16 cells produced the highest EDI prodrug immunogenicity,achieving>95% of that elicited by unmodified resiquimod,followed by TC2 and 4T1 cells(40% and 30%,respectively).Immunogenicity elicited was comparable for a given cell type and independent of the glycosidase substrate in the EDIs or differences in functional glycosidase activity between cell lines.Measuring drug efflux of the immunostimulant payload and efflux protein expression revealed that EDI/cancer cell-mediated immunogenicity was governed by efflux potential of the cancer cells.We determined that,following EDI conversion,immunostimulant efflux occurred through both P-glycoprotein-dependent and P-glycoprotein-independent transport mechanisms.Overall,this study highlights the broad ability of EDIs to couple immunogenicity to the metabolism of many cancers that exhibit drug efflux and suggests that designing future generations of EDIs with immunostimulant payloads that are optimized for drug efflux could be particularly beneficial. | Austin T Ryan Anunay J Pulukuri Maryam Davaritouchaee Armina Abbasi Aaron T Hendricksen Larissa K Opp Anthony J Burt Amy E Nielsen Rock J Mancini | 2020 | Acta Pharmacologica Sinica2020，41，7： | 1 |
| 5 | Lavender and the nervous system显示文摘 | Hossein K P Maryam K G Ali G | 2013 | Evid-Based Comp Alt Med2013，2013，68： | 1 |
| 6 | Adaptive Kalman Filtering in Networked Systems with Random Sensor Delays, Multiple Packet Dropouts and Missing Measurements显示文摘 | Maryam M Yung F K Yeng C S | 2010 | IEEE Trans- actions on Signal Processing2010，58，3： | 1 |
| 7 | Determing of Factors Influencing the Success and Failure of HospitaI Information System and Their Evaluation Methods:A Systematic Review显示文摘 | Farahnaz S Khalil K Maryam A | 2013 | lran Red Cres Med2013，15，2： | 1 |
| 8 | Oxidative stress and ischemic myocardial syndromes 显示文摘 | Misra Mithilesh K Sarwat Maryam Bhakuni Pushpa Tuteja | 2009 | Med Sci Monit2009，15，10： | 1 |
| 9 | Pharyngocutaneous Fistula after Laryngectomy: Incidence, Predisposing Factors, and Outcome 显示文摘 | Nader S Soheila N Maryam K | 2008 | Arch Iranian Med2008，11，3： | 1 |
| 10 | Pharyngocutaneous Fistula after Laryngectomy:Incidence,Predisposing Factors,and Outcome显示文摘 | Nader S Soheila N Maryam K | 2008 | Arch Iranian Med2008，11，3： | 1 |
| 11 | Designing the fuzzy controller in mobile robot navigation with the presence of unknown obstacles 显示文摘 | MARYAM R MOHAMMAD H K MOHAMMAD A N | 2012 | International Journal of Intelligent Information Processing2012，3，1： | 1 |
| 12 | Characterization of the organic molecules deposited at gold surface by the electrochemical reaction of diazonium sahs显示文摘 | Maryam K Abbas A | 2010 | Journal of Electroanalytical Chemistry2010，647，： | 1 |
| 13 | Research note and report: Tourism development and dependency theory: mass tourism vs ecotourism显示文摘 | Maryam M K | 1997 | Annals of Tourism Research1997，24，4： | 1 |
| 14 | The Children’s Hospital of Philadelphia’s experience with donation after cardiac death显示文摘 | Maryam Y. Naim K Sarah Hoehn Richard D. Hasz Lori S. White Mark A. Helfaer Robert M. Nelson | 2008 | Critical Care Medicine2008，，6： | 1 |
| 15 | Sizing of 3-D Arbi-trary Defects Using Magnetic Flux Leakage Measurements显示文摘 | Maryam R Reza K A Slawomir K | 2010 | IEEE Transactions on magnetics2010，46，4： | 1 |
| 16 | The effects of peer education on health behaviors in girls with dysmenorrhea显示文摘 | Zahra A Maryam K Seyed RiM | 2011 | J Am Sci2011，7，1： | 1 |
| 17 | Self-management in primary dysmenorrhea: toward evidence-based education显示文摘 | Maryam K Zahra A Seyed RM | 2011 | Life SciJ2011，8，2： | 1 |
| 18 | Applying theory of planned behavior in predicting of patient safety behaviors of nurses 显示文摘 | Marzieh J Maryam K Maryam Y | 2013 | Mat Soc Med2013，，： | 1 |
| 19 | Determinants of immediate success for catheter ablation of atrioventricular nodal reentry tachycardia inpatients without junctional rhythm显示文摘 | ATAALLAH B TOORAJ K MARYAM M | 2014 | J Interv Card Electrophysiol2014，39，： | 1 |
| 20 | Investigation into the potential ability of Pickering emulsions ( food-grade particles ) to enhance the oxidative stability of oil-in-water emulsions 显示文摘 | MARYAM K KHORSHID F MINA A | 2012 | Journal of Colloid and Interface Science2012，366，1： | 1 |
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