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| 1 | Virtual enterprise - organisation evolution and control显示文摘 | MARTINEZ M T FOULETIER P PARK K H | 2001 | Int J Production Economics2001，74，： | 3 |
| 2 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 3 | Synthetic small inhibiting RNAs:efficient tools to inactivate oncegenic muta-tions and restore p53 pathways显示文摘 | Martinez LA Nagnibneva I Lehrmann H | 2002 | Proc Natl Acad Sci USA2002，99，14： | 1 |
| 4 | Molecular beacons for bioanalytical applications 显示文摘 | Tan L Li Y Drake T J Moroz L Wang K Li J Munteanu A Yang C J Martinez K Tan W H | 2005 | Analyst2005，130，7： | 1 |
| 5 | Solubility of Lead, Zinc and Copper Added to Mineral Soils显示文摘 | Martinez C E Motto H L | 2000 | Environmental Pollution2000，107，： | 1 |
| 6 | Poly-lactic acid synthesis for application in biomedical devices-A review显示文摘 | Lasprilla A J R Martinez G A R Lunelli B H | 2012 | Biotechnology Advances2012，30，1： | 1 |
| 7 | Intraorol distraction for, andibularlerythening: a technical innovation 显示文摘 | Diner PA koUar EM Martinez H | 1996 | J Craniomaxillofac Surg1996，24，： | 1 |
| 8 | 8-GHz Static Frequency Divider in AlInAs/InGaAs HBT Technology显示文摘 | Fields Charles H Stephen Thomas III Shi Binqiang Young Kim Boegeman Mary Montes Rosanna Martinez Kramer Allan R and Meena Madhav A Low-Power 72 | 2001 | IEEE JOURNAL OF SOLID-STATE CIRCUITS2001，36，： | 1 |
| 9 | Health assessment at locallevel with unknown input excitation显示文摘 | Kathuda H Martinez R Hladar A | 2005 | StructuralEngineering2005，131，6： | 1 |
| 10 | Unified no- menclature for the winged helix/forkhead transcription factors显示文摘 | Kaestner K H Knochel W Martinez D E | 2000 | Genes Dev2000，14，2： | 1 |
| 11 | Recent Advances in the Covalent Modification of Graphene with Polymers 显示文摘 | Salavagione H J Martinez G Ellis G | 2011 | Macromolecular Rapid Communications2011，32，22： | 1 |
| 12 | Urinalysis:comparison between microscopic analysis and a new automated microscopy image-based urine sediment instrument显示文摘 | BOTTINI P V MARTINEZ M H GARLIPP C R | 2014 | Clin Lab2014，60，4： | 1 |
| 13 | Sperm capacitation in the porcine oviduct显示文摘 | Tienthai P Johannisson A Martinez R H | 2004 | Anim Reprod Sci2004，80，： | 1 |
| 14 | Comparative ecology of seed mass in Paychotria (Rubiaceae) Within and between species effects of seed mass on early performance显示文摘 | PAZ H MAZER S J MARTINEZ RAMOS M | 2005 | Functional Ecology2005，19，4： | 1 |
| 15 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 16 | Polymeric modification of graphene through esterification of graph- ite oxide and poly (vinyl alcohol)显示文摘 | alavagione H J Gomez M A Martinez G | 2009 | Macromolecules2009，42，17： | 1 |
| 17 | Evolution of the Si electrode/electrolyte interface in lithium batteries characteri- zed by XPS and AFM techniques: The influence of vinylene car- bonate additive 显示文摘 | MARTIN L MARTINEZ H ULLDEMOLINS M | 2012 | Solid State Ionics2012，215，： | 1 |
| 18 | The freetext matching algorithm:a computer program to extract diagnoses and causes of death from unstructured text in electronic health records显示文摘 | Shan AD Martinez C Hemingway H | 2012 | BMC Medical Informatics&Decision Making2012，12，： | 1 |
| 19 | Applicability of support vector machines and adaptive neurofuzzy inference system for modeling potato crop evapotranspiration显示文摘 | Tabari H Martinez C Ezani A | 2013 | Irrigation Science2013，31，4： | 1 |
| 20 | Microstructure evolution associated with adiabatic shear bands and shear band failure in baUistic plug formation in Ti-6A1-4V targets 显示文摘 | Murr L E Ramirez A C Gaytan S M Lopez M I Martinez E Y Hernandez D H Martinez E | 2009 | Materials Science and Engineering A2009，516，： | 1 |
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