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| 1 | Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients显示文摘T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease progression.Pro-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell function.Constitutive STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune diseases.We characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for M.tuberculosis-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 expression.Lentiviral modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after M.tuberculosis-specific stimulation compared to healthy contacts.In addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy contacts.Notably,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in T-cells.Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.SOCS3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 phosphorylation.SOCS3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 phosphorylation.We conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients. | Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 2 | Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma显示文摘瞄准:在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法:COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果:COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论:COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC,从而导致致癌作用。 | Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 3 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 4 | 青贮饲料中接种乳酸菌对黑白花奶牛甲烷排放和生产性能的影响显示文摘乳酸菌菌剂(LAB)通过增加青贮饲料中乳酸和其他有机酸类含量、降低饲料p H来提高饲料品质,防止酸败。本试验在青贮饲料中添加LAB,改变青贮饲料品质及其在瘤胃中的发酵条件,探索饲料中添加LAB对奶牛干物质采食量(DMI)、消化率、产奶量、牛奶品质和甲烷(CH4)排放量的影响。8头泌乳中期荷斯坦-黑白花杂交奶牛根据产奶量分成高产和低产两组,采用4×4拉丁方阵设计21 d试验。CH_4排放量采用间接量热法测量。各组青贮饲料(主要成分为黑麦草)分为空白组、长期添加LAB组、短期添加组(饲喂前16 h添加)和长短期综合添加组。所有饲料都由牧草青贮和复合物构成(干物质基础上的比例为7525)。长期添加组菌剂中植物乳杆菌、乳酸乳球菌和布氏乳杆菌比例为102070,短期添加组为乳酸乳球菌。试验结果表明,长期添加组和短期添加组对奶牛干物质摄入量(DMI)、中性洗涤纤维(NDF)、脂肪消化率、氮含量和能量平衡无显著影响,对乳成分(尤其是尿素)、乳脂肪、乳蛋白质和牛奶中微生物总数均无显著影响。但长期添加LAB使产奶量有增加趋势。长期添加组和短期添加组的奶牛中CH_4排放量无显著变化。其中,长期添加组中以k J·kg^(-1)为单位的代谢体重有提高趋势。试验结果得出引起动物生产性能改变的LAB最小添加量,包括长期和短期的。虽然其他研究表明青贮饲料中添加菌剂能对奶牛生产性能产生有利的显著影响,但本试验由于剂量、青贮饲料基底牧草选择和保存条件等因素的差异,未产生显著影响。 | Ellis J L Hindrichsen I K Klop G Kinley R D Milora N Bannink A Dijkstra J | 2016 | 饲料博览2016，0，9： | 3 |
| 5 | Localized S-inversion of time-domain electromagnetic data显示文摘 | ZHDANOV M S PAVLOV D A ELLIS R G | 2002 | Geophysics2002，67，： | 1 |
| 6 | Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury显示文摘 | Shaw G Yang C Ellis R | 2005 | Biochem Biophys Res Commun2005，336，4： | 1 |
| 7 | Developing Metacognitive Awareness-the Missing Dimension显示文摘 | Ellis G | 1999 | The Journal1999，，10： | 1 |
| 8 | Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase显示文摘 | Ellis D R Sors T G Brunk D G | 2004 | BMC Plant Biol2004，4，： | 1 |
| 9 | Effect of room temperature and dietary amino acid concentration on performance of lactating sows 显示文摘 | Johnston L J Ellis M Libal G W | 1999 | Journal of Animal Science1999，77，： | 1 |
| 10 | Protein complexes mediate signalling in plant responses to hormones, light, sucrose and pathogens 显示文摘 | Ellis C Turner J G Devoto A | 2002 | Plant Mol Biol2002，50，6： | 1 |
| 11 | Experimental infection of colostrum deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication 显示文摘 | Allan G M Mcneilly F Ellis J | 2000 | Arch Virol2000，145，11： | 1 |
| 12 | DNA assembly for synthetic biology: from parts to pathways and beyond 显示文摘 | Ellis T Adie T Baldwin G S | 2011 | Integrative Biology2011，3，2： | 1 |
| 13 | Mandibular motion after closed and open treatment of unilateral mandibular condylar process fractures 显示文摘 | Palmieri C Ellis E 3rd Throckmorton G | 1999 | J Oral Maxillofac Surg1999，57，7： | 1 |
| 14 | Effects of estradiol on lipoprotein lipase activity and lipid availability in exercised male rats显示文摘 | Ellis G S Lanza-Jacoby S Gow A | 1994 | J Appl Physiol1994，77，1： | 1 |
| 15 | psoriasis-recent advances in understanding its pathogenesis and treatment显示文摘 | Kruemer G Ellis S C N | 2005 | J Am Acad Dermatol2005，53，： | 1 |
| 16 | Natural killer cells and reproduction 显示文摘 | Moffett-King A Entrican G Ellis S | 2002 | Trends Immunol2002，23，7： | 1 |
| 17 | Porcine eircoviruses: a review 显示文摘 | Allan G M Ellis J A | 2000 | J Vet Diagn Invest2000，12，： | 1 |
| 18 | Interferometric attitude determination with the Global Positioning System显示文摘 | Ellis J F Greswell G A | 1979 | Journal of Guidance and Control1979，2，6： | 1 |
| 19 | Hyperphosphorylated neu-rofilament NF-H is a serum biomarker of axonal injury显示文摘 | Sham G Yang C Ellis R | 2005 | Biochem Biophys Res Commum2005，336，： | 1 |
| 20 | The origin of large local uplift in extensional regions显示文摘 | King G C P Ellis S | 1990 | Nature1990，348，： | 1 |
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