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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis显示文摘AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent assay.RESULTS:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th patients.Between 1%and 26%of the peripheral bloo mononuclear cells(MNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the MNCs)could b detected in 91%of the patients.Additionally,18% of the patients showed a population of progenito cells(between 1%and 68%of the MNCs)that wa characterized by expression of breast cancer resistanc protein-1.Further phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for SDF-1.In line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells. | Ursula M Gehling Marc Willems Kathleen Schlagner Ralf A Benndorf Maura Dandri Jrg Petersen Martina Sterneck Joerg-Matthias Pollok Dieter K Hossfeld Xavier Rogiers | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 3 | 木质素腐植酸的结构特征显示文摘从木质素磺酸盐氧化和水解转化后的产物——木质素腐植酸盐中分离出腐植酸组分,并用化学和光谱学(UV/VIS,FT-IR,^(13)C-NMR光谱学)的方法对其组成和结构进行表征。同时,从褐煤和山地云杉林森林土有机层中分离出腐植酸,以作为对照。与其它来源的腐植酸相比,木质素腐植酸(LHHA)羧基含量相对较低,而其酸性在一定程度上是通过磺酸基所体现出来的。木质素及其相应腐殖质的^(13)C-NMR光谱在55.9 ppm处有明显的位移,这是其甲氧基碳的信号,而其它烷氧基碳的数量非常有限,如脂肪碳。由于这些类型的碳含量相对较低,木质素腐植酸的芳香度较高,为60.6%。相比天然的腐植酸,木质素磺酸盐经热处理后所得的木质素腐植酸盐则被认为是一种工业化生产的天然腐植物质的类似物。根据化学和光谱学数据评估结果,阐明了从木质素腐植酸盐提取的腐植酸的结构特征,且提出了其可能的化学结构,从而描述了分离组分的典型'平均'特征。 | FrantiSek Novák Martina Sestauberová Richard Hrabal 张水勤(译) 袁亮(译) 赵秉强(译) | 2016 | 腐植酸2016，0，1： | 3 |
| 4 | Detection of Listeria monocytogenes in food using a combined enrichment/real-time PCR method targeting the poCA gene显示文摘 | Peter R Martina K Martin W | 2006 | Research in Microbiology2006，，157： | 1 |
| 5 | Oestrogen receptor (ESR) polymorphisms and breast cancer susceptibility显示文摘 | Tone Ikdahl Anderson Ketil Riddervold Heimdal Martina Skrede Kjell Tveit K?re Berg Anne-Lise B?rresen | 1994 | Human Genetics1994，，6： | 1 |
| 6 | Emergence of carbapenem resistance in Acinetobacter baumannii in the Czech Republic is associated with the spread of multidrug resistant strains of European clone Ⅱ 显示文摘 | Alexandr N Lenka K Martina M | 2008 | d Antimicrob Chemother2008，62，3： | 1 |
| 7 | Loss of gene function as a consequence of human papillomavirus DNA integration显示文摘 | Martina SM Corina DC Katrin Beer-Grondke K | 2012 | Int J Cancer2012，131，5： | 1 |
| 8 | Symple- kin, a constitutive protein of karyo- and cytoplasmic particles involved in mRNA biogenesis in Xenopus laevis oocytes 显示文摘 | ILSE H MARTINA S ISABELLE K | 2000 | Mol Biol Cell2000，13，： | 1 |
| 9 | Auxin triggers a genetic switch显示文摘 | STEFFEN L IVE DE S MARTINA K | 2011 | Nature Cell Biology2011，13，5： | 1 |
| 10 | Electric Field-Induced Aligned Multi-Wall Carbon Nanotube Networks in Epoxy Composites显示文摘 | Martina C A Sandlera J K W Windlea A H | 2005 | Polymer2005，46，： | 1 |
| 11 | Evaluation of the incidence of carboplatin hypersensitivity reactions in cancer patients 显示文摘 | MARISA N ANURADHA K MARTINA L | 2006 | Gynecologic Oncology2006，103，2： | 1 |
| 12 | Tracking in multistatic passive radar systems using DAB/DVB-T illumination显示文摘 | Martina D Ulrich N and Wolfgang K | 2012 | Signal Processing2012，92，6： | 1 |
| 13 | Development of a biosensor specific for cysteine sulfoxides显示文摘 | Michael K Martina J Ingo K | 2003 | Biosensors & Bioelectronics2003，18，56： | 1 |
| 14 | Biosensoric detection of the cysteine sulphoxide alliin显示文摘 | Michael K Martina J Ingo K | 2003 | Senors & Actuators B2003，95，13： | 1 |
| 15 | Carbon source dependence and photostimulation of conidiatiou in Hypocrea atroviridis显示文摘 | MARTINA A F CHRISTIAN P K IRINA S D | 2008 | Applied and Enviroumental Microbiology2008，74，1： | 1 |
| 16 | Inhibition by Cyclosporine A of Adenosine Triphosphate-dependent Transport from the Hepatocyte into Bile显示文摘 | Martina K Cornelia K Matthias B | 1993 | Gastroenterology1993，104，： | 1 |
| 17 | Bacillus and Streptomyces Were Selected as Broad-Spectrum Antagonists Against Soilborne Pathogens from Arid Areas in Egypt 显示文摘 | MARTINA K ELAHAHAT M R MOHAMED A | 2013 | Federation of European Microbiological Societies Microbiol Letters2013，342，： | 1 |
| 18 | Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea 显示文摘 | Mueller C Scholer A Laule-Kilian K Martina B Schindler C Buser P Pfisterer M Perruchoud AP | 2004 | N Engl J Med2004，350，： | 1 |
| 19 | Exergy,waste accounting,and life-cycle analysis显示文摘 | AYRES R U AYRES L W MARTINAS K | 1998 | Energy1998，23，5： | 1 |
| 20 | Active site mutants of pyruvate decarboxylase from Zymomonas mobilis site-directed mutagenesis study of L112,I472,I476,E473 and N482显示文摘 | Siegert P Mesch K | 1998 | Eur J Biochem1998，257，： | 1 |
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