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| 1 | De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature显示文摘BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients. AIM To study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients. METHODS A systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood malignancy.RESULTS Emerging evidence suggests that the liver is an immunologically privileged organ able to support immunosuppression discontinuation in carefully selected recipients. Malignancies are often detected in liver transplant patients undergoing daily immunosuppression regimens. Post-transplant lymphoproliferative diseases and skin tumors are the most detected de novo malignancies in the pediatric and adult OLT population, respectively. To date, immunosuppression withdrawal has been achieved in up to 40% and 60% of well-selected adult and pediatric recipients, respectively. In both populations, a clear benefit of immunosuppression weaning protocols on de novo malignancies is difficult to ascertain because data have not been specified in most of the clinical experiences. CONCLUSION The selected populations of tolerant pediatric and adult liver transplant recipients greatly benefit from immunosuppression weaning. There is still no strong clinical evidence on the usefulness of immunosuppression withdrawal in OLT recipients on malignancies. An interesting focus is represented by the complete reconstitution of the immunological pathways that could help in decreasing the incidence of de novo malignancies and may also help in treating liver transplant patients suffering from cancer. | Tommaso Maria Manzia Roberta Angelico Carlo Gazia Ilaria Lenci Martina Milana Oludamilola T Ademoyero Domiziana Pedini Luca Toti Marco Spada Giuseppe Tisone Leonardo Baiocchi | 2019 | World Journal of Gastroenterology2019，25，35： | 3 |
| 2 | Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial显示文摘 | Ralf-Dieter Hofheinz Frederik Wenz Stefan Post Axel Matzdorff Stephan Laechelt J?rg T Hartmann Lothar Müller Hartmut Link Markus Moehler Erika Kettner Elisabeth Fritz Udo Hieber Hans Walter Lindemann Martina Grunewald Stephan Kremers Christian Constantin | 2012 | Lancet Oncology2012，，6： | 1 |
| 3 | Mouse cardiac surgery: Comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies显示文摘 | OLEG T JULIE R M MARTINA S | 2004 | Physiol Genomies2004，16，1： | 1 |
| 4 | A genome-wide association study of acenocoumarol maintenance dosage 显示文摘 | MARTINA T MARK E FERNANDO R | 2009 | Hu- man Molecular Gentics2009，18，19： | 1 |
| 5 | A VLP- based vaccine targeting domain Ⅲ of the West Nile virus E protein protects from lethal infection in mice 显示文摘 | Spohn G Jennings G T Martina B E | 2010 | Virol J2010，7，： | 1 |
| 6 | Relevance of BRAFV600E mutation testing versus RAS point muta- tions and RET/PTC rearrangements evaluation in the diagnosis of thyroid cancer显示文摘 | Martina R Mattia B Federico T | 2015 | Thyroid2015，25，2： | 1 |
| 7 | Botulinum Toxin A and B in sialorrhea: Long-term data and literature overview显示文摘 | Martina Petracca Arianna Guidubaldi Lucia Ricciardi Tàmara Ialongo Alessandra Del Grande Delia Mulas Enrico Di Stasio Anna Rita Bentivoglio | 2015 | Toxicon2015，，： | 1 |
| 8 | Finite element analysis on the Meppen-1I-4 slab test显示文摘 | Martina O Centrob V Schwoertzigb T | 2012 | Nuclear Engi- neering and Design2012，247，6： | 1 |
| 9 | Finite element analysis'on the VTT-IRSN flexural failure test显示文摘 | Martina O Centrob V Schwoertzigb T | 2012 | Nucle- ar Engineering and Design2012，252，12： | 1 |
| 10 | In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species显示文摘 | Martina BE Verjans GM Kuiken T | 2007 | Microbes Infect2007，9，1： | 1 |
| 11 | Moderate-to-severe blood pressure elevation at ED entry: hypertension or normotension? 显示文摘 | Dietefle T Schuurmans MM Slrobel W Battegay EJ Martina B | 2005 | Am J Emerg Med2005，23，： | 1 |
| 12 | A genome-wide association study of acenocoumaml maintenance dosage 显示文摘 | Martina T Mark E Fernando R | 2009 | Human Molecular Genetics2009，15，19： | 1 |
| 13 | Cervical length and risk of antepartum bleeding in women with complete placenta previa显示文摘 | Ghi T Contro E Martina T | 2009 | Ultrasound Obstet Gynecol2009，33，7： | 1 |
| 14 | Prolonged gonadotropin stimulation is associated with decreased ART success 显示文摘 | Chuang M Athena Z Martina T | 2010 | Assist Reprod Genet2010，27，3： | 1 |
| 15 | Cervical length and risk of antepatum bleeding in women with complete pla- centaprevia显示文摘 | Ghi T Contro E Martina T | 2009 | Ultrasound Obstet Gynecol2009，33，： | 1 |
| 16 | Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients 显示文摘 | GIUSEPPE L GIOVANNI T MARTINA M | 2009 | Arehives Pathol Laboratory Med2009，133，4： | 1 |
| 17 | Polypropylene-graft-maleic anhydride-nanocomposites : I-Characterization and thermal stability of nanocomposites produced under nitrogen and in air显示文摘 | Adams T Oliver W Martina M P | 2003 | Polymer Degradation and Stability2003，82，： | 1 |
| 18 | Grafting of abeixlmab to a microbubble-based ultrasound contrast agent for targeting to platelets expressing GP II b/III a--characterization and invitro testing显示文摘 | Della Martina A Allemann E Bettinger T | 2008 | Eur J Pharm Biophann2008，68，3： | 1 |
| 19 | Surface acoustic wave gas sensor based on conductivity changes显示文摘 | Ricco A J MartinA S J Zipperian T E | 1985 | Sensors and Actuators1985，，8： | 1 |
| 20 | Virology:SARS virus infection of cats and ferrets显示文摘 | Martina BE Haagmans BL Kuiken T | 2003 | Nature2003，425，6961： | 1 |
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