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| 1 | Modulation of tau phosphorylation by environmental copper显示文摘Background:The transition metal copper enhances amyloidβaggregation and neurotoxicity,and in models of concomitant amyloid and tau pathology,copper also promotes tau aggregation.Since it is not clear if the effects of environmental copper upon tau pathology are dependent on the presence of pathological amyloidβ,we tested the effects of copper overload and complexing in disease models which lack pathological amyloidβ.Methods:We used cell culture and transgenic murine models to test the effects of environmental copper on tau phosphorylation.We used oral zinc acetate as a copper lowering agent in mice and examined changes in blood and brain metals through inductively coupled plasma mass spectroscopy.Behavioral effects of copper lowering were assessed with Morris water maze and novel object recognition tasks.Changes in tau phosphorylation were examined by phosphorylation specific antibodies on Western blots.Results:In human neuroblastoma cells,excess copper promoted tau phosphorylation and a copper complexing agent,tetrathiomolybdate,attenuated tau phosphorylation.In a transgenic mouse model expressing wild type human tau,copper-lowering by oral zinc suppressed plasma and brain levels of copper,and resulted in a marked attenuation of tau phosphorylation.No significant changes in behavior were observed with copper lowering,but a trend to improved recognition of the novel object was observed in zinc acetate treated mice.Conclusions:We propose that reduction of brain copper by blocking uptake of copper from the diet may be a viable strategy for modulating tau pathology in Alzheimer’s disease.The potential benefits of this approach are tempered by the absence of a behavioral benefit and by the health risks of excessive lowering of copper. | Kellen Voss Christopher Harris Martina Ralle Megan Duffy Charles Murchison Joseph F Quinn | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 2 | Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes显示文摘 | Giuseppe L Luca F Martina M | 2009 | Clin Chem Lab Med2009，47，3： | 1 |
| 3 | Factors influencing Comliance in Schizophrenia Patients显示文摘 | Wwolfgang F Martina H | 2003 | J Clin Psychiatry2003，64，： | 1 |
| 4 | Solid lipid nanoparticles as delivery systems for bromocriptine 显示文摘 | ELISABETTA E MARTINA F MATTEO M | 2008 | Pharm Res2008，25，7： | 1 |
| 5 | Review of PEM fuel cell durability:Degradation mechanisms and mitigation strategies显示文摘 | Wu J F Yuan X Z Martina J J | | 0，，01： | 1 |
| 6 | Carbon source dependence and photostimulation of conidiatiou in Hypocrea atroviridis显示文摘 | MARTINA A F CHRISTIAN P K IRINA S D | 2008 | Applied and Enviroumental Microbiology2008，74，1： | 1 |
| 7 | Using ecological models in research on health disparities显示文摘 | Elizabeth R Martina G Bunny F | 2005 | J Prof Nuts2005，21，4： | 1 |
| 8 | Magnetic Targeting of Magnetoliposomes to Solid Tumors with MR Imaging Monitoring in Mice : Feasibility 显示文摘 | Fortin-Ripoche J Martina M S Gazeau F | 2006 | Radiology2006，239，2： | 1 |
| 9 | Modelling respirometric tests for the assessment of kinetic and stoichiometric parameters on MBBR biofilm for municipal wastewater treatment显示文摘 | MARTINA F GIUSEPPE G GIANNI A | 2009 | Environmental Modelling & Software2009，5，5： | 1 |
| 10 | Endothelial VE-cadherin expression in human lungs 显示文摘 | Martina F Klaus-Michael DT Annette M | 2008 | Pathol Res Pract2008，204，10： | 1 |
| 11 | Effect of different variables on the efficiencyof the baker's yeast cell disruption process to obtain alcohol dehydrogenase activity显示文摘 | Martina S Davor V Zvjezdana F | 2013 | Appl Biochem Biotechnol2013，169，3： | 1 |
| 12 | Role of the IGF system in trophoblast invasion and pre-eclampsia 显示文摘 | Irwin J C Suen L F Martina N A | 1999 | Hum Reprod1999，14，2： | 1 |
| 13 | Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmit oyl glycol chitosan hydrogels显示文摘 | Martina L Wilsona C G Kooshab F | 2003 | Euro J Pharm Biopharm2003，，55： | 1 |
| 14 | Magnetic targeting of magnetoliposomes to solid tumors with MR imaging monitoring in mice: Feasibility显示文摘 | Fortin-Ripoche JP Martina MS Gazeau F | 2006 | Radiology2006，239，2： | 1 |
| 15 | Disproportionate body composition and neonatal outcome in offspring of mothers with and without gestational diabetes mellitus 显示文摘 | Martina P Helena F Ulf H | 2013 | Diabetes Care2013，36，11： | 1 |
| 16 | Efficient regioselective functionalizations of cyclodextrins carried out under microwaves or power ultrasound显示文摘 | Martina K Trotto F Robaldo B | 2007 | Teterahedron Lett2007，48，52： | 1 |
| 17 | Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat 显示文摘 | Angela C Sveva B Michela P Saverio S Andrea C Lisa G Jenny T Martina P Elisabetta L Gino G Igor V Emanuele C Annalisa A Laura I Giovanni F Z Anthony A Paolo D C and Saverio S | 2007 | Journal of Molecular and Cellular Cardiology2007，42，4： | 1 |
| 18 | Magnetic targeting of magnetoliposomes to solid tumors with MR imaging monitoring in mice:feasibility显示文摘 | Fortin-Ripoche JP Martina MS Gazeau F Ménager C Wilhelm C Bacri JC | | 0，，02： | 1 |
| 19 | The effect of heavy metals on laboratory populations of two poly- chaetes with comparisons to the water quality condi- tions and standards in Southern California marine wa- ters 显示文摘 | Reish D J Martina J M Piltzb F M | 1976 | Water Research1976，10，4： | 1 |
| 20 | Wire + arc additive manufacturing显示文摘 | Williams S W Martina F Addison A C | 2015 | Materials Science and Technology2015，，： | 1 |
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