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| 1 | Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes显示文摘Mitochondrial DNA(mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair system.This explains an increased mutation rate of mtDNA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDNA molecules within the same mitochondrion.In diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis. | Dimitry A Chistiakov Igor A Sobenin Yuri V Bobryshev Alexander N Orekhov | 2012 | World Journal of Cardiology2012，4，5： | 17 |
| 2 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 3 | Modeling Arctic Ocean heat transport and warming episodes in the 20th century caused by the intruding Atlantic Water显示文摘This study investigates the Arctic Ocean warming episodes in the 20th century using both a high-resolution coupled global climate model and historical observations .The model,with no flux adjustment,reproduces well the Atlantic Water core temperature(AWCT) in the Arctic Ocean and shows that four largest decadal-scale warming episodes occurred in the 1930s,70s,80s,and 90s,in agreement with the hydrographic observational data.The difference is that there was no pre-warming prior to the 1930s episode,while there were two pre-warming episodes in the 1970s and 80s prior to the 1990s,leading the 1990s into the largest and prolonged warming in the 20th century.Over the last century,the simulated heat transport via Fram Strait and the Barents Sea was estimated to be,on average,31.32 TW and 14.82 TW,respectively,while the Bering Strait also provides 15.94 TW heat into the western Arctic Ocean.Heat transport into the Arctic Ocean by the Atlantic Water via Fram Strait and the Barents Sea correlates significantly with AWCT(C=0.75 ) at 0- lag.The modeled North Atlantic Oscillation(NAO) index has a significant correlation with the heat transport(C=0.37).The observed AWCT has a significant correlation with both the modeled AWCT(C=0.49) and the heat transport(C=0.41). However,the modeled NAO index does not significantly correlate with either the observed AWCT(C=0.03) or modeled AWCT(C=0.16) at a zero-lag,indicating that the Arctic climate system is far more complex than expected. | Wang Jia Jin Meibing Jun Takahashi Tatsuo Suzuki Igor V Polyakov Kohei Mizobata Moto Ikeda Fancois J. Saucier Markus Meier | 2008 | Chinese Journal of Polar Science2008，19，2： | 2 |
| 4 | Gene selection from microarray data for cancer classification-a machinelearning approaeh显示文摘 | YU WANG IGOR V T MARK A H | 2005 | Computational Biology and Chemistry2005，，： | 1 |
| 5 | Effects of life history traits and sampling strategic on genetic diversity estimates obtained with RAPD markers in plants显示文摘 | NYBOM H IGOR V B | 2000 | Perspectives in Plant Ecology Evolution and Systematic2000，3，2： | 1 |
| 6 | Characterization and remediation of soils contaminated with uranium显示文摘 | MARIA G LUCIAN V P IGOR C | 2009 | Journal of Hazardous Materi- als2009，163，： | 1 |
| 7 | 3 ' -Minor groove binder-DNA probe increase sequence specificity at PCR extension temperatures显示文摘 | IGOR V K IRINA A A ALAN M | 2000 | Nucleic Acids Res2000，28，2： | 1 |
| 8 | Research of auto- collimating angular deformation measurement system for large-size objects control 显示文摘 | Tatiana V Turgalieva Igor A Konyakhin | | Optical Measurement Sys- tems for Industrial Inspection Ⅷ0，8788，87： | 1 |
| 9 | Lesst-Mean- Squares Phase Unwrapping by Use of an Incomplete Set of Residue Branch Cuts 显示文摘 | Igor V Lyuboshenko Henri Matre Alain Maruani | 2002 | Applied Optics2002，41，11： | 1 |
| 10 | QSPR modeling of cycloalkanes properties by correlation weighting of extended graph valence shells显示文摘 | Igor V N Ozad M N | 2003 | Journal of Molecular Structure (Theochem)2003，637，： | 1 |
| 11 | Genome sequence of the lignocellulose-biocenverting and xylose-fermenting yeast Pichia stipites显示文摘 | Jeffries T W Grigoriev Igor V Grimwood J | 2007 | Nature Biotechnology2007，25，3： | 1 |
| 12 | Antibiofic resistance of en- terococciand related bacteria in an urban wastewater treat- ment plant显示文摘 | Miguel F S Igor T Anto' nio V | 2006 | FEMS Microbiol Ecol2006，55，： | 1 |
| 13 | Evolutionary Stable Stock Markets 显示文摘 | Igor V Evstigneev Thorsten Hens & Klaus Reiner Schenk-Hoppe | 2006 | Economic Theory2006，，27： | 1 |
| 14 | AFM study of membrane proteins,cytochrome P450 2B4,and NADPH -cytochrome P450 reductase and their complex formation显示文摘 | OLGA I K IGOR V Y YURI O I | 1999 | Archives of Biochem and Biophysic1999，371，1： | 1 |
| 15 | Optical and mechanical properties of AIN thin films deposited by reactive magnetron sputtering显示文摘 | Igor V Svadkovski | 2006 | Journal of Xi''an Institute of Technology2006，26，3： | 1 |
| 16 | Development and Application of an Eight-Step Global Mechanism for CFD and CRN Simulations of Lean-Premixed Combustors 显示文摘 | Igor V Novosselov Philip C Mahe | 2008 | Journal of Engineering for Gas Turbines and Power2008，130，： | 1 |
| 17 | Prediction of Soil Properties by Digital Terrain Modeling显示文摘 | IGOR V FLORINSKY | 2002 | Envirnmental Modelling and Software2002，17，6： | 1 |
| 18 | Effects of life history traits and sampling strategies on genetic diversity estimates obtained with RAPD markers in plants显示文摘 | Nybom H Igor V B | 2000 | Perspectives in Plant Ecology Evolution and Systematics2000，3，2： | 1 |
| 19 | Study of high-power ka-band second-harmonic gyroklystron amplifier显示文摘 | Evgeny V Zasypkin Mark A Moiseev Igor G Gachev | 1996 | IEEE Trans Plasma Sci1996，24，3： | 1 |
| 20 | Liposome- encapsulated vincristine, vinblastine and vinorelbine:A comparative study of drug loading and retention显示文摘 | IGOR V ZHIGALTSEVA T MAURERB N | 2005 | J Controlled Release2005，104，1： | 1 |
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