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| 1 | Potential of (18)~F-FDG-PET as a valuable adjunct to clinical and response assessment in rheumatoid arthritis and seronegative spondyloarthropathies显示文摘AIM: To evaluate the role of fluorine-18-labeled fluorodeoxyglucose positron emission tomography (18F-FDG PET) in various rheumatic diseases and its potential in the early assessment of treatment response in a limited number of patients. METHODS: This study involved 28 newly diagnosed patients, of these 17 had rheumatoid arthritis (RA) and 11 had seronegative spondyloarthropathy (SSA). In the SSA group, 7 patients had ankylosing spondylitis, 3 had psoriatic arthritis, and one had non-specific SSA. Patients with RA were selected as per the American College of Rheumatology criteria. One hour after FDG injection, a whole body PET scan was performed from the skull vertex to below the knee joints using a GE Advance dedicated PET scanner. Separate scans were acquired for both upper and lower limbs. Post-treatment scans were performed in 9 patients in the RA group (at 6-9 wk from baseline) and in 1 patient with psoriatic arthropathy. The pattern of FDG uptake was analysed visually and quantified as maximum standardized uptake value (SUVmax) in a standard region of interest. Metabolic response on the scan was assessed qualitatively and quantitatively and was correlated with clinical assessment. RESULTS: The qualitative FDG uptake was in agreement with the clinically involved joints, erythrocyte sedimentation rate, C-reactive protein values and the clinical assessment by the rheumatologist. All 17 patients in the RA group showed the highest FDG avidity in painful/swollen/tender joints. The uptake pattern was homogeneous, intense and poly-articular in distribution. Hypermetabolism in the regional nodes (axillary nodes in the case of upper limb joint involvement and inguinal nodes in lower limb joints) was a constant feature in patients with RA. Multiple other extra-articular lesions were also observed including thyroid glands (in associated thyroiditis) and in the subcutaneous nodules. Treatment response was better appreciated using SUVmax values than visual interpretation, when compared with clinical evaluation. Four patients showed a favourable response, while 3 had stable disease and 2 showed disease progression. The resolution of regional nodal uptake (axillary or inguinal nodes based on site of joint involvement) in RA following disease modifying anti-rheumatoid drugs was noteworthy, which could be regarded as an additional parameter for identifying responding patients. In the SSA group, uptake in the affected joint was heterogeneous, low grade and nonsymmetrical. In particular, there was intense tendon and muscular uptake corresponding to symptomatic joints. The patients with psoriatic arthritis showed intense FDG uptake in the joints and soft tissue. CONCLUSION: 18F-FDG PET accurately delineates the ongoing inflammatory activity in various rheumatic diseases (both at articular and extra-articular sites) and relates well to clinical symptoms. Different metabolic patterns on FDG-PET scanning in RA and SSA can have important implications for their diagnosis and management in the future with the support of larger studies. FDG-PET molecular imaging is also a sensitive tool in the early assessment of treatment response, especially when using quantitative information. With these benefits, FDG-PET could play a pivotal clinical role in the management of inflammatory joint disorders in the future. | Vishu Vijayant Manjit Sarma Hrushikesh Aurangabadkar Lata Bichile Sandip Basu | 2012 | World Journal of Radiology2012，4，12： | 5 |
| 2 | 2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia显示文摘 | Dinesh Khanna John D. Fitzgerald Puja P. Khanna Sangmee Bae Manjit K. Singh Tuhina Neogi Michael H. Pillinger Joan Merill Susan Lee Shraddha Prakash Marian Kaldas Maneesh Gogia Fernando Perez‐Ruiz Will Taylor Frédéric Lioté Hyon Choi Jasvinder A. Singh Ni | 2012 | Arthritis Care Res2012，，10： | 4 |
| 3 | Hydrophobic protein in colorectal cancer in relation to tumor stages and grades显示文摘AIM: To identify differentially expressed hydrophobic proteins in colorectal cancer. METHODS: Eighteen pairs of colorectal cancerous tissues in addition to tissues from normal mucosa were analysed. Hydrophobic proteins were extracted from the tissues, separated using 2-D gel electrophoresis and analysed using Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS). Statistical analysis of the proteins was carried out in order to determine the significance of each protein to colorectal cancer (CRC) and also their relation to CRC stages, grades and patients’ gender. RESULTS: Thirteen differentially expressed proteins which were expressed abundantly in either cancerous or normal tissues were identified. A number of these proteins were found to relate strongly with a particular stage or grade of CRC. In addition, the association of these proteins with patient gender also appeared to be significant.CONCLUSION: Stomatin-like protein 2 was found to be a promising biomarker for CRC, especially in female patients. The differentially expressed proteins identified were associated with CRC and may act as drug target candidates. | Lay-Chin Yeoh Chee-Keat Loh Boon-Hui Gooi Manjit Singh Lay-Harn Gam | 2010 | World Journal of Gastroenterology2010，16，22： | 3 |
| 4 | 2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis显示文摘 | Dinesh Khanna Puja P. Khanna John D. Fitzgerald Manjit K. Singh Sangmee Bae Tuhina Neogi Michael H. Pillinger Joan Merill Susan Lee Shraddha Prakash Marian Kaldas Maneesh Gogia Fernando Perez‐Ruiz Will Taylor Frédéric Lioté Hyon Choi Jasvinder A. Singh Ni | 2012 | Arthritis Care Res2012，，10： | 2 |
| 5 | Effect of E-Learning on Public Health and Environment During COVID-19 Lockdown显示文摘E-learning is the most promising venture in the entire world. During the COVID-19 lockdown, e-learning is successfully providing potential information to the students and researchers. In developing nations like India, with limited resources, e-learning tools and platforms provide a chance to make education available to middle and low income households. This paper gives insights about three different online services, namely Google Classroom,Zoom, and Microsoft Teams being used by three different educational institutions. We aim to analyze the efficiency and acceptability of e-learning tools among Indian students during the COVID-19 lockdown. The paper also aims to evaluate the impact of e-learning on the environment and public health during COVID-19 lockdown. It is found that e-learning has potential to reduce carbon emissions, which has beneficial impact on the environment. However, the mental health is impacted as e-learning may lead to self-isolation and reduction in academic achievements that may lead to anxiety and mental depression. Due to usage of electronic devices for learning, the eyes and neck muscles may be put in strain, having deleterious effects on physical health. | Avani Agarwal Sahil Sharma Vijay Kumar Manjit Kaur | 2021 | Big Data Mining and Analytics2021，4，2： | 2 |
| 6 | Durability of cementing binders based on fly ash and other wastes显示文摘 | Manjit Singh Mridul Garg | 2006 | Construction and Building Materials2006，，11： | 1 |
| 7 | Seedyield components and stability analysis in buffel grass( Cenchrus c///ar/s) 显示文摘 | Rajora M P Manjit Singh Patidar S K | 2008 | Indian Jour- nal of Agricultural Sciences2008，78，3： | 1 |
| 8 | An improved process for the purification of phosphogypsum显示文摘 | Manjit Singh Mridul Garg C L Verma | 1996 | construction and building materials1996，10，8： | 1 |
| 9 | Effect of seed harvesting time on seed production and germination in buffelgrass (Cenchras ciliaris )geno- type CAZRI 358 显示文摘 | Rajora M P Manjit S J S K | 2006 | Range Management and Agroforestry2006，27，1： | 1 |
| 10 | Cemenlilious binders from fly ash and oilier industrial wasles 显示文摘 | Manjit Singh Mridul Garg | 1999 | Cement and Concrete Research1999，29，2： | 1 |
| 11 | Chemometrics of differentially expressed proteins from colorectal cancer patients显示文摘AIM:To evaluate the usefulness of differentially expressed proteins from colorectal cancer (CRC) tissues for differentiating cancer and normal tissues.METHODS:A Proteomic approach was used to identify the differentially expressed proteins between CRC and normal tissues.The proteins were extracted using Tris buffer and thiourea lysis buffer (TLB) for extraction of aqueous soluble and membrane-associated proteins,respectively.Chemometrics,namely principal component analysis (PCA) and linear discriminant analysis (LDA),were used to assess the usefulness of these proteins for identifying the cancerous state of tissues.RESULTS:Differentially expressed proteins identified were 37 aqueous soluble proteins in Tris extracts and 24 membrane-associated proteins in TLB extracts.Based on the protein spots intensity on 2D-gel images,PCA by applying an eigenvalue > 1 was successfully used to reduce the number of principal components (PCs) into 12 and seven PCs for Tris and TLB extracts,respectively,and subsequently six PCs,respectively from both the extracts were used for LDA.The LDA classification for Tris extract showed 82.7% of original samples were correctly classified,whereas 82.7% were correctly classified for the cross-validated samples.The LDA for TLB extract showed that 78.8% of original samples and 71.2% of the cross-validated samples were correctly classified.CONCLUSION:The classification of CRC tissues by PCA and LDA provided a promising distinction between normal and cancer types.These methods can possibly be used for identification of potential biomarkers among the differentially expressed proteins identified. | Lay-Chin Yeoh Saravanan Dharmaraj Boon-Hui Gooi Manjit Singh Lay-Harn Gam | 2011 | World Journal of Gastroenterology2011，17，16： | 1 |
| 12 | Effect of phosphatic and fluoride impurities of phosphogypsum on the properties of selenite plaster显示文摘 | | 2003 | Cement and Concrete Research2003，33，： | 1 |
| 13 | Dynamic tensile deformation and fracture of metal cylinders at high strain rates显示文摘 | Manjit S Suneja H R | 2002 | International Journal of Impact Engineering2002，，27： | 1 |
| 14 | Results of chest wall resection and reconstruction with and without rigid prothesis显示文摘 | Michael JW Manjit SB Ennapadam V | 2006 | Ann Thorac Surg2006，81，1： | 1 |
| 15 | Retarding Action of Various Chemicals on Setting and Hardening Characteristics of Gypsum Plaster at Different pH显示文摘 | Manjit Singh Mridul Garg | 1997 | Cement and Concrete Research1997，27，6： | 1 |
| 16 | Activation of gypsum anhydrite-slag mixture显示文摘 | Manjit Singh Mridal Garg | 1995 | Cement and Concrete Research1995，25，： | 1 |
| 17 | Retarding action of various chemicals on setting and hardening characteristics of gypsum plaster at different pH显示文摘 | Manjit Singh and Mridul Garg | 1997 | Cement and Concrete Research1997，，6： | 1 |
| 18 | Retarding action of various chemicals on setting and hardening characteristics of gypsum piaster at different pH显示文摘 | Manjit Singh Mridul Garg | 1997 | Cement and Concrete Kesearch1997，27，6： | 1 |
| 19 | The impact of complications on outcomes after resection for esophageal and gastroesophageal junction carcinoma显示文摘 | Nabil P Rizk Peter B Bach Deborah Schrag Manjit S Bains Alan D Turnbull Martin Karpeh Murray F Brennan Valerie W Rusch | 2004 | Journal of the American College of Surgeons2004，，1： | 1 |
| 20 | Genetic analysis of grain filling rate and duration in maize显示文摘 | Guilin Wang Manjit S K Orlando M | 1999 | Field Crops Research1999，61，： | 1 |
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