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| 1 | Quantitative evaluationof DNA methylation by optimization of a differential-high reso-lution melt analysis protocol显示文摘 | Malentacchi F Forni G Vinci S | 2009 | Nucleic Acids Res2009，37，12： | 1 |
| 2 | Transforming growth factor-beta isoform and receptor expression in chondrosarcoma of bone显示文摘 | Masi L Malentacchi G Campanacci D | 2002 | Virchows Arch2002，440，5： | 1 |
| 3 | Quantitative analysis of carbonic anhydrase Ⅸ mRNA in human non-small cell lung cancer 显示文摘 | Simi L Venturini G Malentacchi F | 2006 | Lung Cancer2006，52，1： | 1 |
| 4 | Quantitative analysis of carbonic anhydrase IX mRNA in human non-small eel1 lung cancer 显示文摘 | Simi L Venturini G Malentacchi F | 2006 | Lung Cancer2006，52，1： | 1 |
| 5 | Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment:preliminary experience显示文摘 | Gelmini S Quattrone S Malentacchi F et a1 | | 0，，07： | 1 |
| 6 | Quantitative analysis of carbonic anhydrase Ⅸ mRNA in human non-small cell lung cancer显示文摘 | Simi L Venturini G Malentacchi F | 2006 | Lung Cancer2006，52，1： | 1 |
| 7 | Transforming growth factor-βisofoml and receptor expression in chondrosarcoma of bone 显示文摘 | Masi L Malentacchi C Campanacci D | 2002 | Virchows Arch2002，440，5： | 1 |
| 8 | Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience 显示文摘 | Gelmini S Quattrone S Malentacchi F | 2007 | Clin Chem Lab Med2007，45，7： | 1 |
| 9 | Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment:preliminary experience显示文摘 | GELMINI S QUATTRONE S MALENTACCHI F | | 0，，07： | 1 |
| 10 | Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers显示文摘 | Malentacchi F Marzocchini R Gelmini S | 2005 | Biochem Biophys Res Commun2005，334，3： | 1 |
| 11 | Quantitative analysis ofcarbonic anhydrase IX mRNA in human non-small cell lung cancer显示文摘 | Si mi L Venturini G Malentacchi F | 2006 | Lung Cancer2006，52，1： | 1 |
| 12 | Quantitative evaluation of DNA methylation by optimization of a differential-high resolution melt analysis protocol显示文摘 | Malentacchi F Fomi G Vinci S | 2009 | Nucleic Acids Res2009，37，12： | 1 |
| 13 | Quantitative evaluation of DNA methylation by optimization of a differential-high resolution melt analysis protocol显示文摘 | MALENTACCHI F FORNI G VINCI S | 2009 | Nucleic Acids Res2009，37，12： | 1 |
| 14 | Implementation of a proficiency testingfor the assessment of the preanalytical phase of blood samplesused for RNA based analysis显示文摘 | Gunther K Malentacchi F Verderio P | 2012 | Clin Chim Acta2012，413，78： | 1 |
| 15 | Alternative splicing variants of carbonic anhydrase IX in human non-small cell lung cancer显示文摘 | MALENTACCHI F SIMI L NANNELLI C | 2008 | Lung Cancer2008，3712，： | 1 |
| 16 | Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment:preliminary experience显示文摘 | Gelmini S Quattrone S Malentacchi F | 2007 | Clin Chem Lab Med2007，45，7： | 1 |
| 17 | Alternative splicing variants of carbonic anhydrase IX in human non-small cell lung cancer显示文摘 | Francesca Malentacchi Lisa Simi Caterina Nannelli Matteo Andreani Alberto Janni Silvia Pastorekova Claudio Orlando | 2008 | Lung Cancer2008，，3： | 1 |
| 18 | Quantitative analysis of carbonic anhydrase ⅨmRNA in human non-small cell lung cancer显示文摘 | Simi L Venturini G Malentacchi F | 2006 | Lung Cancer2006，52，1： | 1 |
| 19 | Quantitative e- valuation of DNA methylation by optimization of adifferential-high resolution melt analysis protocol显示文摘 | Malentacchi F Forni G Vinci S | 2009 | Nucleic Acids Res2009，37，12： | 1 |
| 20 | Multiplex gene expression profile in inflamed mucosa of patients with Crohn’s disease ileal localization: A pilot study显示文摘BACKGROUND Crohn’s disease (CD) is a complex disorder resulting from the interaction of genetic,environmental,and microbial factors.The pathogenic process may potentially affect any segment of the gastrointestinal tract,but a selective location in the terminal ileum was reported in 50% of patients.AIM To characterize clinical sub-phenotypes (colonic and/or ileal) within the same disease,in order to identify new therapeutic targets.METHODS 14 consecutive patients undergoing surgery for ileal CD were recruited for this study.Peripheral blood samples from each patient were collected and the main polymorphisms of the gene Card15/Nod2 (R702W,G908R,and 1007fs) were analyzed in each sample.In addition,tissue samples were taken from both the tract affected by CD and from the apparently healthy and disease-free margins (internal controls).We used a multiplex gene assay in specimens obtained from patients with ileal localization of CD to evaluate the simultaneous expression of 24 genes involved in the pathogenesis of the disease.We also processed surgery gut samples with routine light microscopy (LM) and transmission electron microscopy (TEM) techniques to evaluate their structural and ultrastructural features.RESULTS We found a significant increase of Th17 (IL17A and IL17F,IL 23R and CCR6) and Th1 (IFN-γ) gene expression in inflamed mucosa compared to non-inflamed sites of 14 CD patients.DEFB4 and HAMP,two genes coding for antimicrobial peptides,were also strongly activated in inflamed ileal mucosa,suggesting the overwhelming stimulation of epithelial cells by commensal microbiota.IFN-γ and CCR6 were more expressed in inflamed mucosa of CD patients with ileal localization compared with patients with colonic localization suggesting a more aggressive inflammation process in this site.Morphological analysis of the epithelial lining of Lieberkün crypts disclosed enhanced release activity from goblet mucocytes,whereas the lamina propria contained numerous cells pertaining to various lines.CONCLUSION We observed that the expression of ileal genes related to Th1 and Th17 activity is strongly activated as well as the expression of genes involved in microbiota regulation. | Francesco Giudici Letizia Lombardelli Edda Russo Tiziana Cavalli Daniela Zambonin Federica Logiodice Ornela Kullolli Lamberto Giusti Tatiana Bargellini Marilena Fazi Livia Biancone Stefano Scaringi Ann Maria Clemente Eloisa Perissi Giovanni Delfino Maria G Torcia Ferdinando Ficari Francesco Tonelli Marie-Pierre Piccinni Cecilia Malentacchi | 2019 | World Journal of Clinical Cases2019，7，17： | 1 |
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