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| 1 | The Ubiquitin-Proteasome System and Its Role in Inflammatory and Autoimmune Diseases显示文摘通过 ubiquitin-proteasome 系统的蛋白质降级是细胞内部的蛋白质的 non-lysosomal 解朊作用的主要小径。它在象房间周期的规定那样的许多基本细胞的过程起重要作用有免疫力、煽动性的回答的前进,分割,开发和区别, apoptosis,房间 trafficking,和调整。这个系统的中央元素是到指向的蛋白质的 ubiquitin 的连接,它是然后由 26S proteasome 认出了的共有原子价,腺苷 triphosphate 依赖的、多催化的朊酶。损坏,氧化,否则象控制许多批评细胞的函数的规章的蛋白质一样的错误褶层蛋白质在这降级进程的目标之中。这个系统的错误导致细胞的动态平衡的 dysregulation 和多重疾病的发展。在这评论,我们在煽动性、自体免疫的疾病的开发描述了基本生物化学和 ubiquitin-proteasome 系统,和它的复杂角色的分子的生物学。另外,与 ubiquitin-proteasome 系统有关的治疗和潜在的治疗学的目标也被讨论。细胞与分子的免疫学。2006; 3 (4 ): 255-261。 | Jingsong Wang Michael A. Maldonado | 2006 | Cellular & Molecular Immunology2006，3，4： | 38 |
| 2 | Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia显示文摘瞄准:在更男的 ats 决定红 maca 的二篇不同摘录的效果。方法:Prostatic 增生与睾丸激素 enanthate (TE ) 在雄的老鼠被导致。Thestudy 包括了六个组:一个控制组(组 1 ),与 TE (组 2 )对待的一个组,与 TE 对待的二个组和红 maca 的水的摘录(组织 3 和 4 ),一个组对待红 maca (组 5 )的 withhydroalcoholic 摘录,一个组与 finasteride 对待( 0.1 mg , group6 )。在沸腾的时间的长度上的水的摘录依赖者的差别,是否为 2 个 or3 小时,为组, 3 和 4 被估计。红 maca 的摘录包含了 0.1 mg ofbenzylglucosinolate。此后,在红 maca 摘录的 benzylglucosinolates (0.02-0.08 mg ) 的不同剂量的剂量反应效果被估计。结果:前列腺重量在与红 maca 的水的摘录在沸腾的 2 和 3 个小时以后准备了的 freeze-dried 对待的老鼠是类似的。红 maca 的 Freeze-dried 水的摘录,红 maca 和 finasteride 的水疗院酒鬼摘录与职业人员静电干扰增生在老鼠减少了前列腺重量。没有差别在从水的摘录或红 maca 的水疗院酒鬼摘录获得的数据之间被观察。前列腺重量的剂量依赖者减小随红 macaextracts 的 benzylglucosinolates 的剂量的增加被观察。结论:现在的学习在 prostatichyperplasia 被 TE 在导致了的雄的老鼠给那个水疗院酒鬼或红 macacontaining 的水的摘录看了 benzylglucosinolate 罐头还原剂前列腺尺寸的 0.1 mg。 | Gustavo F. Gonzales Vanessa Vasquez Daniella Rodriguez Carmen Maldonado Juliet Mormontoy Jimmy Portella Monica Pajuelo León Villegas Manuel Gasco | 2007 | Asian Journal of Andrology2007，9，2： | 14 |
| 3 | Magnetic resonance imaging for prostate cancer before radical and salvage radiotherapy: What radiation oncologists need to know显示文摘External beam radiotherapy(EBRT) is one of the principal curative treatments for patients with prostate cancer(PCa). Risk group classification is based on prostate-specific antigen(PSA) level, Gleason score, and T-stage. After risk group determination, the treatment volume and dose are defined and androgen deprivation therapy is prescribed, if appropriate. Traditionally, imaging has played only a minor role in T-staging due to the low diagnostic accuracy of conventional imaging strategies such as transrectal ultrasound, computed tomography, and morphologic magnetic resonance imaging(MRI). As a result, a notable percentage of tumours are understaged, leading to inappropriate and imprecise EBRT. The development of multiparametric MRI(mp MRI), an imaging technique that combines morphologic studies with functional diffusion-weighted sequences and dynamic contrastenhanced imaging, has revolutionized the diagnosis and management of PCa. As a result, mpM RI is now used in staging PCa prior to EBRT, with possible implications for both risk group classification and treatment decisionmaking for EBRT. mpM RI is also being used in salvageradiotherapy(SRT), the treatment of choice for patients who develop biochemical recurrence after radical prostatectomy. In the clinical context of biochemical relapse, it is essential to accurately determine the site of recurrence-pelvic(local, nodal, or bone) or distant-in order to select the optimal therapeutic management approach. Studies have demonstrated the value of mpM RI in detecting local recurrences-even in patients with low PSA levels(0.3-0.5 ng/m L)-and in diagnosing bone and nodal metastasis. The main objective of this review is to update the role of mpM RI prior to radical EBRT or SRT. We also consider future directions for the use and development of MRI in the field of radiation oncology. | Felipe Cou?ago Gemma Sancho Violeta Catalá Diana Hernández Manuel Recio Sara Montemui?o Jhonathan Alejandro Hernández Antonio Maldonado Elia del Cerro | 2017 | World Journal of Clinical Oncology2017，8，4： | 4 |
| 4 | Natural orifice transluminal endoscopic surgery:The transvaginal route moving forward from cholecystectomy显示文摘The advent of minimally invasive surgery and the advances in endoluminal flexible endoscopy have converged to generate a new concept in digestive surgery,whose acronym natural orifice transluminal endoscopic surgery(NOTES),has become a familiar term in the surgical community.NOTES has been performed through the mouth,the bladder,the rectum and the vagina.Of these four approaches,the vagina has gained most popularity for several reasons.It is not only readily accessible and easy to decontaminate but it also provides safe entry and simple closure.The transvaginal approach has been described in the experimental and the clinical setting as an option for cholecystectomy,nephrectomy,splenectomy,segmental gastrectomy,retroperitoneal exploration and bariatric surgery.However,larger series are needed to delineate the exact risks of this approach,and to transcend cultural barriers that impede its wider introduction.Prospective randomized trials will shed light on the definitive role of the vaginal approach in minimal invasive surgery of the future. | Eduardo M Targarona Edgar Mauricio Maldonado Jose Antonio Marzol Franco Marinello | 2010 | World Journal of Gastrointestinal Surgery2010，2，6： | 4 |
| 5 | Clinical features and radiological manifestations of COVID-19 disease显示文摘Coronavirus disease 2019(COVID-19)was discovered after unusual cases of severe pneumonia emerged in December 2019 in Wuhan Province(China).Coronavirus is a family of single-stranded RNA viruses.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted from person to person.Although asymptomatic individuals can transmit the virus,symptomatic patients are more contagious.The incubation period ranges from 3-7 d and symptoms are mainly respiratory,including pneumonia or pulmonary embolism in severe cases.Elevated serum levels of interleukins(IL)-2,IL-6,IL-7 indicate the presence of cytokine release syndrome,which is associated with disease severity.The disease has three main phases:Viral infection,pulmonary involvement,and hyperinflammation.To date,no treatment has proved to be safe or effective.Chest X-ray and computed tomography(CT)are the primary imaging tests for diagnosis of SARS-CoV-2 pneumonia,follow-up,and detection of complications.The main radiological findings are ground-glass opacification and areas of consolidation.The long-term clinical course is unknown,although some patients may develop pulmonary fibrosis.Positron emission tomography-computed tomography(PETCT)is useful to assess pulmonary involvement,to define the affected areas,and to assess treatment response.The pathophysiology and clinical course of COVID-19 infection remain poorly understood.However,patterns detected on CT and PETCT may help to diagnose and guide treatment.In this mini review,we analyze the clinical manifestations and radiological findings of COVID-19 infection. | Pedro Landete Carlos Andres Quezada Loaiza Beatriz Aldave-Orzaiz Susana Hernandez Muniz Antonio Maldonado Enrique Zamora Allan Charles Sam Cerna Elia del Cerro Raquel Cano Alonso Felipe Counago | 2020 | World Journal of Radiology2020，12，11： | 2 |
| 6 | Toll‐Like Receptors and Cytokines are Upregulated during H elicobacter pylori Infection in Children显示文摘 | Hugo Lagunes‐Servin Javier Torres Carmen Maldonado‐Bernal Martha Pérez‐Rodríguez Sara Huerta‐Yépez Armando Madrazo de la Garza Leopoldo Mu?oz‐Pérez Lourdes Flores‐Luna Guillermo Ramón‐García Margarita Camorlinga‐Ponce | 2013 | Helicobacter2013，，6： | 2 |
| 7 | Role of platelets and breast cancer stem cells in metastasis显示文摘The high mortality rate of breast cancer is mainly caused by the metastatic ability of cancer cells,resistance to chemotherapy and radiotherapy,and tumor regression capacity.In recent years,it has been shown that the presence of breast cancer stem cells is closely associated with the migration and metastatic ability of cancer cells,as well as with their resistance to chemotherapy and radiotherapy.The tumor microenvironment is one of the main molecular factors involved in cancer and metastatic processes development,in this sense it is interesting to study the role of platelets,one of the main communicator cells in the human body which are activated by the signals they receive from the microenvironment and can generate more than one response.Platelets can ingest and release RNA,proteins,cytokines and growth factors.After the platelets interact with the tumor microenvironment,they are called'tumor-educated platelets.'Tumor-educated platelets transport material from the tumor microenvironment to sites adjacent to the tumor,thus helping to create microenvironments conducive for the development of primary and metastatic tumors.It has been observed that the clone capable of carrying out the metastatic process is a cancer cell with stem cell characteristics.Cancer stem cells go through a series of processes,including epithelial-mesenchymal transition,intravasation into blood vessels,movement through blood vessels,extravasation at the site of the establishment of a metastatic focus,and site colonization.Tumor-educated platelets support all these processes. | Gretel Mendoza-Almanza Luis Burciaga-Hernandez Vilma Maldonado Jorge Melendez-Zajgla Jorge Olmos | 2020 | World Journal of Stem Cells2020，12，11： | 2 |
| 8 | A low steady HBsAg seroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: a systematic review显示文摘 | Sonia Roman Arturo Panduro Yadira Aguilar-Gutierrez Montserrat Maldonado Maclovia Vazquez-VanDyck Erika Martinez-Lopez Bertha Ruiz-Madrigal Zamira Hernandez-Nazara | 2009 | Hepatology International2009，，2： | 2 |
| 9 | 内源性大麻素系统在神经病理性疼痛临床治疗中应用显示文摘1.神经病理性疼痛的治疗现状神经病理性疼痛是严重影响人类生活质量的一种慢性疾病,然而当前针对神经病理性疼痛的治疗效果依然不尽如人意。因此,针对神经病理性疼痛新的治疗策略的研究是当前的重中之重。2.内源性大麻素系统内源性大麻素系统在疼痛调控中起着关键作用。它是由大麻素受体、相应的内源性配体以及与之相关的酶组成。目前已发现2种大麻素受体, | Maldonado R Ba?os JE Caba?ero D 孙武平 | 2016 | 中国疼痛医学杂志2016，22，11： | 2 |
| 10 | Optimized endoscopic treatment of ischemic-type biliary lesions after liver transplantation显示文摘 | Thomas Zoepf Evelyn J. Maldonado de Dechêne Alexander Dechêne Massimo Malágo Susanne Beckebaum Andreas Paul Guido Gerken Philip Hilgard | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 11 | Hot ductility behavior of boron microalloyed steels显示文摘 | E. López-Chipres I. Mejía C. Maldonado A. Bedolla-Jacuinde J.M. Cabrera | 2007 | Materials Science & Engineering A2007，，： | 2 |
| 12 | Total Anomalous Pulmonary Venous Connection: Factors Associated With Mortality and Recurrent Pulmonary Venous Obstruction显示文摘 | S. Adil Husain Elaine Maldonado Debbie Rasch Joel Michalek Richard Taylor Christopher Curzon Steve Neish John H. Calhoon | 2012 | The Annals of Thoracic Surgery2012，，3： | 2 |
| 13 | Rapid and robust slope failure appraisal using aerial photogrammetry and 3D slope stability models显示文摘Slope failures are an inevitable aspect of economic pit slope designs in the mining industry.Large open pit guidelines and industry standards accept up to 30%of benches in open pits to collapse provided that they are controlled and that no personnel are at risk.Rigorous ground control measures including real time monitoring systems at TARP(trigger-action-response-plan)protocols are widely utilized to prevent personnel from being exposed to slope failure risks.Technology and computing capability are rapidly evolving.Aerial photogrammetry techniques using UAV(unmanned aerial vehicle)enable geotechnical engineers and engineering geologists to work faster and more safely by removing themselves from potential line-of-fire near unstable slopes.Slope stability modelling software using limit equilibrium(LE)and finite element(FE)methods in three dimensions(3D)is also becoming more accessible,user-friendly and faster to operate.These key components enable geotechnical engineers to undertake site investigations,develop geotechnical models and assess slope stability faster and in more detail with less exposure to fall of ground hazards in the field.This paper describes the rapid and robust process utilized at BHP Limited for appraising a slope failure at an iron ore mine site in the Pilbara region of Western Australia using a combination of UAV photogrammetry and 3D slope stability models in less than a shift(i.e.less than 12 h). | Neil Bar Michael Kostadinovski Michael Tucker Glen Byng Rully Rachmatullah Arturo Maldonado Markus Pötsch Andreas Gaich Alison McQuillan Thamer Yacoub | 2020 | International Journal of Mining Science and Technology2020，30，5： | 2 |
| 14 | Precipitation of morphine withdrawal syndrome in rats by administration of mu-delta and kappa-selective opioid antagonists显示文摘 | Maldonado R Negus S Koob GF | 1992 | Neuropharmacology1992，31，12： | 1 |
| 15 | Gelatinases A and B are up-regulated in rat lungs by subacute hyperoxia显示文摘 | Pardo A Banias R Maldonado V | 1998 | Am J Pathol1998，153，3： | 1 |
| 16 | Expression of transcription factors in endometrium during natural cycles显示文摘 | Maldonado V Castilla JA Martinez L | 2003 | J Assist Repord Genet2003，20，11： | 1 |
| 17 | Pheochromocytoma of the urinary bladder 显示文摘 | Albores-Saavedra J Maldonado M E Ibarra J Rodriguez H A | 1969 | Cancer1969，23，5： | 1 |
| 18 | Precipitation of morphine withdrawal syndrome in rats by administration of mu-, delta- and kappa-selective opioid antagonists显示文摘 | Maldonado R Negus S Koob GF | 1992 | Neuropharmacology1992，31，12： | 1 |
| 19 | Straining of the intact and fractured proximal humerus under physiologi- cal-like loading 显示文摘 | Maldonado ZM Seebeck J Heller MO | 2003 | J Biomech2003，36，12： | 1 |
| 20 | Plant proteomics update(2007-2008):second-generation proteomic techniques,an appropriate experimental design,and data analysis to fulfill MIAPE standards,increase plant proteome coverage and expand biological knowledge显示文摘 | Jorrín-Novo JV Maldonado AM Echevarría-Zome?o S | 2009 | Journal of Proteomics2009，72，3： | 1 |
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