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| 1 | Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation显示文摘用 Yamanaka 因素产生的导致的 pluripotent 茎(iPS ) 细胞在自体同源的细胞治疗为使用有大潜力。然而, genomic 畸形充分在人的 iPS 房间,和房间不是的大多数老鼠 iPS 存在 pluripotent 由 tetraploid 互补试金评估了 TCA ) ;这很可能与 DNA 损坏反应(DDR ) 被联系在 Yamanaka 因素导致的早 reprogramming 发生了。相反,原子转移忠实地装改编体的房间进胚胎的茎(ES ) 满足 TCA 的房间。我们因此假设了涉及导致卵母细胞的 reprogramming 的因素可以在 reprogramming 期间稳定体的染色体,并且改进结果的 iPS 房间的质量。测试这个假设,我们在 iPS 期间为能减少的因素屏蔽了 DDR 信号房间正式就职。我们决定了那 Zscan4,在有 Yamanaka 因素的联合,不是仅仅显著地减少了 DDR 而且显著地支持了 iPS 房间产生的效率。Zscan4 的包括稳定了 genomic DNA,导致 p53 downregulation。而且, Zscan4 也提高了象通过 telomere 感染以后的 3 天一样早变长的 telomere 基于再结合的机制。作为结果,与 Zscan4 的增加产生的 iPS 房间比古典 iPS 房间展出了更长的 telomeres。惊人地,超过 50% iPS 房间线(11/19 ) 经由这生产了 “ Zscan4 protocol”产生了由 TCA 决定了的实时熊的 all-iPS 房间老鼠,与为用古典 Yamanaka 因素生产的线的 1/12 相比。我们的调查结果提供在 reprogramming 期间维持 genomic 稳定性支持的第一示范高质量的 iPS 房间的产生。 | Jing Jiang Wenjian Lv Xiaoying Ye Lingbo Wang Man Zhang Hui Yang Maja Okuka Chikai Zhou Xuan Zhang Lin Liu Jinsong Li | 2013 | Cell Research2013，23，1： | 14 |
| 2 | Nonalcoholic fatty liver disease and liver transplantation-Where do we stand?显示文摘Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis(NAFLD/NASH) is a challenging and multisystem disease that has a high socioeconomic impact. NAFLD/NASH is a main cause of macrovesicular steatosis and has multiple impacts on liver transplantation(LT), on patients on the waiting list for transplant, on posttransplant setting as well as on organ donors. Current data indicate new trends in the area of chronic liver disease. Due to the increased incidence of metabolic syndrome(Met S) and its components, NASH cirrhosis and hepatocellular carcinoma caused by NASH will soon become a major indication for LT. Furthermore, due to an increasing incidence of Met S and, consequently, NAFLD, there will be more steatotic donor livers and less high quality organs available for LT, in addition to a lack of available liver allografts. Patients who have NASH and are candidates for LT have multiple comorbidities and are unique LT candidates. Finally, we discuss long-term grafts and patient survival after LT, the recurrence of NASH and NASH appearing de novo after transplantation. In addition, we suggest topics and areas that require more research for improving the health care of this increasing patient population. | Ivana Mikolasevic Tajana Filipec-Kanizaj Maja Mijic Ivan Jakopcic Sandra Milic Irena Hrstic Nikola Sobocan Davor Stimac Patrizia Burra | 2018 | World Journal of Gastroenterology2018，24，14： | 14 |
| 3 | Language of plants: Where is the word?显示文摘Plants emit biogenic volatile organic compounds(BVOCs) causing transcriptomic, metabolomic and behavioral responses in receiver organisms. Volatiles involved in such responses are often called 'plant language'. Arthropods having sensitive chemoreceptors can recognize language released by plants. Insect herbivores, pollinators and natural enemies respond to composition of volatiles from plants with specialized receptors responding to different types of compounds. In contrast, the mechanism of how plants'hear' volatiles has remained obscured. In a plant-plant communication, several individually emitted compounds are known to prime defense response in receiver plants with a specific manner according to the chemical structure of each volatile compound. Further, composition and ratio of volatile compounds in the plant-released plume is important in plantinsect and plant-plant interactions mediated by plant volatiles. Studies on volatile-mediated plant-plant signaling indicate that the signaling distances are rather short, usually not longer than one meter. Volatile communication from plants to insects such as pollinators could be across distances of hundreds of meters. As many of the herbivore induced VOCs have rather short atmospheric life times, we suggest that in long-distant communications with plant volatiles,reaction products in the original emitted compounds may have additional information value of the distance to emission source together with the original plant-emitted compounds. | Maja impraga Junji Takabayashi Jarmo K.Holopainen | 2016 | Journal of Integrative Plant Biology2016，58，4： | 14 |
| 4 | 环十二烷法提取修复石铠甲显示文摘为了探索脆弱考古出土物的提取和修复方法,利用环十二烷法对一副秦陵石铠甲进行了提取和修复。环十二烷常温下是一种半透明蜡状固体,当加热至60℃以上后可以涂刷或喷涂于器物上进行加固,由于该试剂在室温下能够逐渐地挥发掉,所以可作为脆弱文物的临时性加固剂。结果表明,该方法修复后的石铠甲效果良好,与传统方法相比保留了大量原始铜丝。并可望在其它脆弱文物的保护和修复中得到应用。 | 夏寅 WEICHERT Maja 张志军 周铁 马生涛 | 2005 | 文物保护与考古科学2005，17，2： | 12 |
| 5 | Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome显示文摘AIM: To determine clinical characteristics and treatment outcome of gastric lymphoma after chemotherapy and immuno-chemotherapy. METHODS: Thirty four patients with primary gastric mucosa associated lymphoid tissue (MALT) lymphoma (Ann Arbor stages Ⅰ to Ⅳ) were enrolled. All had upper gastric endoscopy, abdominal ultrasonography, CT and H pylori status assessment (histology and serology). After anti-H pylori treatment and initial chemotherapy, patients were re-examined every 4 mo. RESULTS: Histological regression of the lymphoma was complete in 22/34 (64.7%) and partial in 9 (26.5%) patients. Median follow up time for these 31 responders was 60 mo (range 48-120). No regression was noted in 3 patients. Among the 25 (73.5%) H pylori positive patients, the eradication rate was 100%.CONCLUSION: Using univariate analysis, predictive factors for overall survival were international prognostic index (IPI) score, hemoglobin level, erythrocyte sedimentation rate (ESR), and platelet numbers (P < 0.005). In addition to this, Cox proportion hazard model differentiate IPI score, ESR, and platelets as predictors of survival. | Milena Todorovic Bela Balint Miodrag Jevtic Nada Suvajdzic Amela Ceric Dragana Stamatovic Olivera Markovic Maja Perunicic Slobodan Marjanovic Miodrag Krstic | 2008 | World Journal of Gastroenterology2008，14，15： | 10 |
| 6 | Post-transplant diabetes mellitus and preexisting liver disease-a bidirectional relationship affecting treatment and management显示文摘Liver cirrhosis and diabetes mellitus(DM)are both common conditions with significant socioeconomic burden and impact on morbidity and mortality.A bidirectional relationship exists between DM and liver cirrhosis regarding both etiology and disease-related complications.Type 2 DM(T2DM)is a wellrecognized risk factor for chronic liver disease and vice-versa,DM may develop as a complication of cirrhosis,irrespective of its etiology.Liver transplantation(LT)represents an important treatment option for patients with end-stage liver disease due to non-alcoholic fatty liver disease(NAFLD),which represents a hepatic manifestation of metabolic syndrome and a common complication of T2DM.The metabolic risk factors including immunosuppressive drugs,can contribute to persistent or de novo development of DM and NAFLD after LT.T2DM,obesity,cardiovascular morbidities and renal impairment,frequently associated with metabolic syndrome and NAFLD,may have negative impact on short and long-term outcomes following LT.The treatment of DM in the context of chronic liver disease and post-transplant is challenging,but new emerging therapies such as glucagon-like peptide-1 receptor agonists(GLP-1RAs)and sodium–glucose cotransporter 2 inhibitors(SGLT2i)targeting multiple mechanisms in the shared pathophysiology of disorders such as oxidative stress and chronic inflammation are a promising tool in future patient management. | Maja Cigrovski Berkovic Lucija Virovic-Jukic Ines Bilic-Curcic Anna Mrzljak | 2020 | World Journal of Gastroenterology2020，26，21： | 10 |
| 7 | Pancreatic exocrine insufficiency, diabetes mellitus and serum nutritional markers after acute pancreatitis显示文摘AIM:To investigate impairment and clinical significance of exocrine and endocrine pancreatic function in patients after acute pancreatitis(AP).METHODS:Patients with AP were invited to participate in the study.Severity of AP was determined by the Atlanta classification and definitions revised in2012.Pancreatic exocrine insufficiency(PEI)was diagnosed by the concentration of fecal elastase-1.An additional work-up,including laboratory testing of serum nutritional markers for determination ofmalnutrition,was offered to all patients with low levels of fecal elastase-1 FE.Hemoglobin A1c or oral glucose tolerance tests were also performed in patients without prior diabetes mellitus,and type 3c diabetes mellitus(T3c DM)was diagnosed according to American Diabetes Association criteria.RESULTS:One hundred patients were included in the study:75%(75/100)of patients had one attack of AP and 25%(25/100)had two or more attacks.The most common etiology was alcohol.Mild,moderately severe and severe AP were present in 67,15 and 18%of patients,respectively.The mean time from attack of AP to inclusion in the study was 2.7 years.PEI was diagnosed in 21%(21/100)of patients and T3c DM in14%(14/100)of patients.In all patients with PEI,at least one serologic nutritional marker was below the lower limit of normal.T3c DM was more frequently present in patients with severe AP(P=0.031),but was also present in some patients with mild and moderately severe AP.PEI was present in all degrees of severity of AP.There were no statistically significantly differences according to gender,etiology and number of AP attacks.CONCLUSION:As exocrine and endocrine pancreatic insufficiency can develop after AP,routine follow-up of patients is necessary,for which serum nutritional panel measurements can be useful. | Miroslav Vujasinovic Bojan Tepes Jana Makuc Sasa Rudolf Jelka Zaletel Tjasa Vidmar Maja Seruga Bostjan Birsa | 2014 | World Journal of Gastroenterology2014，20，48： | 10 |
| 8 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 9 | A Comparative Study on the Role of Cytokinins in Caryopsis Development in the Maize miniature1 Seed Mutant and Its Wild Type显示文摘We report here on a comparative developmental profile of plant hormone cytokinins in relation to cell size,cell number and endoreduplication in developing maize caryopsis of a cell wall invertase-deficient miniature1(mn1) seed mutant and its wild type,Mn1,genotype.Both genotypes showed extremely high levels of total cytokinins during the very early stages of development,followed by a marked and genotype specific reduction.While the decrease of cytokinins in Mn1 was associated with their deactivation by 9-glucosylation,the absolute and the relative part of active cytokinin forms was higher in the mutant.During the exponential growth phase of endosperm between 6 d after pollination and 9 d after pollination,the mean cell doubling time,the absolute growth rate and the level of endoreduplication were similar in the two genotypes.However,the entire duration of growth was longer in Mn1 compared with mn1,resulting in a significantly higher cell number in the Mn1 endosperm.These data correlate with the previously reported peak levels of the Mn1-encoded cell wall invertase-2(INCW2) at 12 d after pollination in the Mn1 endosperm.A model showing possible crosstalk among cytokinins,cell cycle and cell wall invertase as causal to increased cell number and sink strength of the Mn1 developing endosperm is discussed. | Tomaz Rijavec Maja Kova Ale Kladnik Prem S.Chourey Marina Dermastia | 2009 | Journal of Integrative Plant Biology2009，51，9： | 7 |
| 10 | New strategy for reducing the EHL friction in steel contacts using additive-formed oleophobic boundary films显示文摘In this study we present a mechanism for the elastohydrodynamic(EHD)friction reduction in steel/steel contacts,which occurs due to the formation of oleophobic surface boundary layers from common boundary-lubrication additives.Several simple organic additives(amine,alcohol,amide,and fatty acid)with different molecular structures were employed as the model additives.It was found that the stronger chemisorption at 100℃,rather than the physisorption at 25℃,is more effective in friction reduction,which reaches 22%.What is more,EHD friction reduction was obtained in steel/steel contacts without use of the diamond-like carbon(DLC)coatings with their wetting or thermal effect,which was previously suggested as possible EHD friction reduction mechanism;yet about the same friction reduction of about 20%was obtained here—but with much simpler and less expensive technology,namely with the adsorbed oleophobic surface layers.A small variation in the additive’s molecular structure results in significant changes to the friction,indicating good potential in future EHD lubrication technology,where these additives could be designed and well optimised for notable reduction of the friction losses in the EHD regime. | Mitjan KALIN Maja KUS | 2021 | Friction2021，9，6： | 6 |
| 11 | Update on biomarkers of glycemic control显示文摘Attaining and maintaining good glycemic control is a cornerstone of diabetes care. The monitoring of glycemic control is currently based on the self-monitoring of blood glucose(SMBG) and laboratory testing for hemoglobin A1 c(HbA1 c),which is a surrogate biochemical marker of the average glycemia level over the previous 2-3 mo period. Although hyperglycemia is a key biochemical feature of diabetes, both the level of and exposure to high glucose, as well as glycemic variability, contribute to the pathogenesis of diabetic complications and follow different patterns in type 1 and type 2 diabetes. HbA1 c provides a valuable,standardized and evidence-based parameter that is relevant for clinical decision making, but several biological and analytical confounders limit its accuracy in reflecting true glycemia. It has become apparent in recent years that other glycated proteins such as fructosamine, glycated albumin, and the nutritional monosaccharide 1,5-anhydroglucitol, as well as integrated measures from direct glucose testing by an SMBG/continuous glucose monitoring system, may provide valuable complementary data, particularly in circumstances when HbA1 c results may be unreliable or are insufficient to assess the risk of adverse outcomes. Long-term associations of these alternative biomarkers of glycemia with the risk of complications need to be investigated in order to provide clinically relevant cut-off values and to validate their utility in diverse populations of diabetes patients. | Maja Krhac Marijana Vucic Lovrencic | 2019 | World Journal of Diabetes2019，10，1： | 5 |
| 12 | Sodium-glucose cotransporter 2 inhibitors’ mechanisms of action in heart failure显示文摘Three major cardiovascular outcome trials(CVOTs)with a new class of antidiabetic drugs-sodium-glucose cotransporter 2(SGLT2)inhibitors(EMPAREG OUTCOME trial with empagliflozin,CANVAS Program with canagliflozin,DECLARE-TIMI 58 with dapagliflozin)unexpectedly showed that cardiovascular outcomes could be improved possibly due to a reduction in heart failure risk,which seems to be the most sensitive outcome of SGLT2 inhibition.No other CVOT to date has shown any significant benefit on heart failure events.Even more impressive findings came recently from the DAPA-HF trial in patients with confirmed and well-treated heart failure:Dapagliflozin was shown to reduce heart failure risk for patients with heart failure with reduced ejection fraction regardless of diabetes status.Nevertheless,despite their possible wide clinical implications,there is much doubt about the mechanisms of action and a lot of questions to unravel,especially now when their benefits translated to nondiabetic patients,rising doubts about the validity of some current mechanistic assumptions.The time frame of their cardiovascular benefits excludes glucoselowering and antiatherosclerotic-mediated effects and multiple other mechanisms,direct cardiac as well as systemic,are suggested to explain their early cardiorenal benefits.These are:Anti-inflammatory,antifibrotic,antioxidative,antiapoptotic properties,then renoprotective and hemodynamic effects,attenuation of glucotoxicity,reduction of uric acid levels and epicardial adipose tissue,modification of neurohumoral system and cardiac fuel energetics,sodiumhydrogen exchange inhibition.The most logic explanation seems that SGLT2 inhibitors timely target various mechanisms underpinning heart failure pathogenesis.All the proposed mechanisms of their action could interfere with evolution of heart failure and are discussed separately within the main text. | Petra Grubić Rotkvić Maja Cigrovski Berković Nikola Bulj Luka Rotkvić Ivana Ćelap | 2020 | World Journal of Diabetes2020，11，7： | 5 |
| 13 | Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors显示文摘 | Giulia Mesiano Maja Todorovic Loretta Gammaitoni Valeria Leuci Lidia Giraudo Diego Fabrizio Carnevale-Schianca Franca Fagioli Wanda Piacibello Massimo Aglietta Dario Sangiolo | 2012 | Expert Opinion on Biological Therapy2012，，6： | 5 |
| 14 | Cytomegalovirus immune evasion by perturbation ot endosomal trafficking显示文摘 | Pero Lucin Hana Mahmutefendic Gordana Blagojevic Zagorac Maja Ilic Tomas | 2015 | Cellular & Molecular Immunology2015，12，2： | 5 |
| 15 | Ce对Al-Si-Cu合金中a(Al)-Al_(2)Cu共晶形貌的影响(英文)显示文摘采用热分析、光学显微镜技术、扫描电镜技术、聚焦离子束和能量色散谱分析方法研究Ce对Al-Si-Cu合金中α(Al)-Al2Cu共晶形貌的影响。结果表明,在枝晶、硅和AlSiFeMn之间较小空间内形成了α(Al)-Al2Cu共晶。Al2Cu为非层状的不规则共晶组织。Al2Cu在经Ce改性的合金中更加致密。部分Ce溶解于Al2Cu中,这是粗晶Al2Cu形成的原因。与基体Al-Si-Cu合金相比,Ce的加入能使α(Al)-Al2Cu共晶合金的显微硬度提高约10%。 | Maja VONCINA Jozef MEDVED Tonica BONCINA Franc ZUPANIC | 2014 | Transactions of Nonferrous Metals Society of China2014，24，1： | 4 |
| 16 | 无脑电图仪监测下渐进式大鼠脑死亡模型的建立显示文摘目的为研究供体脑死亡对供体外周器官的影响,建立一种无脑电图仪监测下渐进式大鼠脑死亡模型。探讨大鼠脑死亡模型制作要点、成功率以及血流动力学参数。方法57只Fisher大鼠行动脉插管、气管插管、诱导建立脑死亡模型,取肾前维持机械呼吸6h。将平均动脉压(MAP)>80mmHg的脑死亡大鼠,取其肾脏原位移植给Lewis大鼠。另外10只Fisher大鼠作为正常对照组供体。结果57只Fisher大鼠中45只(78.9%)在6h的机械性人工呼吸观察中,MAP始终在正常水平,可作为脑死亡供体。10只正常对照组大鼠,MAP虽呈下降趋势,但仍在正常水平。来自脑死亡大鼠的肾脏移植后再灌注时间(22±7)min与来自对照组的(5±3)min相比差异具有显著性(P<0.001)。其余12只大鼠被剔除出研究。结论无脑电图仪监测下,渐进式建立大鼠脑死亡模型,可达到与标准方法建立的脑死亡模型相似的保持正常血压的效果,可用于改善脑死亡供体器官质量和移植物功能。 | 陈洁 苏泽轩 Francuski Maja Pratschke Johann | 2005 | 广东医学2005，26，6： | 4 |
| 17 | Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats显示文摘Objective The aim of this study is to investigate the effects of oral cadmium(Cd) ingestion on the pulmonary immune response. Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration(5 and 50 mg/L). Antioxidant enzyme defense(superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor(TNF) and interferon(IFN)-γ, as well as the activity of myeloperoxidase(MPO), nitric oxide(NO), and various cytokines [interleukin(IL)-1β, IL-6, IL-10, and IL-17] were investigated. Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal. | KULAS Jelena NINKOV Marina TUCOVIC Dina POPOV Aleksandrov Aleksandra UKROPINA Mirela CAKIC MILOSEVIC Maja MUTIC Jelena KATARANOVSKI Milena MIKROV Ivana | 2019 | Biomedical and Environmental Sciences2019，32，7： | 4 |
| 18 | Integrated Assessment of Natural Hazards, Including Climate Change’s Influences, for Cultural Heritage Sites: The Case of the Historic Centre of Rethymno in Greece显示文摘Within the framework of disaster risk management, this article proposes an interdisciplinary method for the analysis of multiple natural hazards, including climate change’s influences, in the context of cultural heritage. A taxonomy of natural hazards applicable to cultural heritage was developed based on the existing theoretical and conceptual frameworks. Sudden-onset hazards, such as earthquakes and floods, and slow-onset hazards, such as wetting–drying cycles and biological contamination, were incorporated into the hazard assessment procedure. Future alteration of conditions due to climate change, such as change in heat waves’ duration, was also taken into account. The proposed hazard assessment framework was applied to the case of the Historic Centre of Rethymno, a city on the northern coast of the island of Crete in Greece,to identify, analyze, and prioritize the hazards that have the potential to cause damage to the center’s historic structures. The assessment procedure includes climate model projections, GIS spatial modeling and mapping, and finally a hazard analysis matrix to enable the sharing of a better understanding of multiple hazards with the stakeholders.The results can facilitate decision making by providing the vulnerability and risk analysis with the nature and spatial distribution of the significant hazards within the study area and its setting. | Mohammad Ravankhah Rosmarie de Wit Athanasios V.Argyriou Angelos Chliaoutakis Maria Joao Revez Joern Birkmann Maja Zuvela-Aloise Apostolos Sarris Anastasia Tzigounaki Kostas Giapitsoglou | 2019 | International Journal of Disaster Risk Science2019，10，3： | 3 |
| 19 | Oxy-fuel combustion of solid fuels显示文摘 | Maja B. Toftegaard Jacob Brix Peter A. Jensen Peter Glarborg Anker D. Jensen | 2010 | Progress in Energy and Combustion Science2010，，5： | 3 |
| 20 | Exploring new treatment options for polycystic ovary syndrome: Review of a novel antidiabetic agent SGLT2 inhibitor显示文摘Polycystic ovary syndrome(PCOS)is the most common endocrinopathy in women of reproductive age associated with long-term metabolic and cardiovascular consequences.A plethora of symptoms and their severity differentiate on an individual level,giving the syndrome numerous phenotypes.Due to menstrual cycle abnormalities,women suffer from irregular menstrual bleeding,difficulty in conception,and infertility.Furthermore,the risk of pregnancy complications such as gestational diabetes mellitus,hypertensive disorders of pregnancy,and preterm birth are higher in women with PCOS than in the general population.Often,women with PCOS have comorbidities such as dyslipidemia,obesity,glucose intolerance or diabetes type 2,non-alcoholic fatty liver disease,and metabolic syndrome,which all influence the treatment plan.Historic insulinsensitizing agents,although good for some of the metabolic derangements,do not offer long-term cardiovascular benefits;therefore,new treatment options are of paramount importance.Sodium-glucose co-transporter-2(SGLT-2)inhibitors,a new class of antidiabetic agents with beneficial cardiovascular,bodyweight,and antihyperglycemic effects,although not approved for the treatment of PCOS,might be an attractive therapeutic addition in the PCOS armamentarium.Namely,recent studies with SGLT-2 inhibitors showed promising improvements in anthropometric parameters and body composition in patients with PCOS.It is important to further explore the SGLT-2 inhibitors potential as an early therapeutic option because of the PCOS-related risk of metabolic,reproductive,and psychological consequences. | Jelena Marinkovic-Radosevic Maja Cigrovski Berkovic Egon Kruezi Ines Bilic-Curcic Anna Mrzljak | 2021 | World Journal of Diabetes2021，12，7： | 3 |
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