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| 1 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 2 | A sting in the tail: the N-terminal domain of the androgen receptor as a drug target显示文摘在前列腺癌症(PCa ) 的开始和前进的雄激素受体(AR ) 的角色很好被建立。AR ligand 有约束力的领域(LBD ) 的竞争抑制是采用在最近的年里与疾病作斗争的 antiandrogen 治疗的主食。然而,他们的功效被抵抗的出现经常限制了,通过点变化,和受体截断调停了。作为结果,为病人与的预后恶意阉割抵抗疾病遗体穷人。AR 的氨基终端的域(NTD ) 被显示了为 AR 功能批评。它的模块化的激活功能(AF-1 ) 在蛋白质蛋白质相互作用为基因规定和参予是重要的。由于领域的内在地混乱的结构,然而,它的潜力在过去被斥为治疗学的干预的一个候选人。小分子 EPI-001 的最近的出现提供了 AR-NTD 能治疗学地被指向的证据,独立于 LBD。AR-NTD 指向有潜力破坏在 AR 和它的 coregulatory 绑定搭挡之间的多重分子间的相互作用,除了在 AR 的领域之间的 intramolecular 串音。直接指向这些蛋白质蛋白质相互作用或 NTD 的治疗学应该也对新兴的 AR 有功效拼接可以在 PCa 起一个作用的变体前进。这评论将在 AR 功能讨论内在的混乱的角色并且说明新兴的治疗怎么可能在 PCa 指向 NTD。 | Amy E Monaghan Iain J McEwan | 2016 | Asian Journal of Andrology2016，18，5： | 3 |
| 3 | Mitral pseudostenosis due to a large left atrial myxoma显示文摘 | Konstantinos C Theodoropoulos Giovanni Masoero Gianpiero Pagnano Nicola Walker Alexandros Papachristidis Mark J Monaghan | 2018 | Journal of Geriatric Cardiology2018，15，3： | 2 |
| 4 | Simulating free surface flows显示文摘 | Monaghan J J | 1994 | Journal of Computational Physics1994，110，： | 1 |
| 5 | Solitary waves on a cretan beach显示文摘 | MONAGHAN J J KOS A | 1999 | Journal of Waterway Port Coastal and Ocean Engineering1999，125，3： | 1 |
| 6 | Modeling two-phase flows using SPH method显示文摘 | VALIZADEH A SHAFIEEFAR M MONAGHAN J | 2008 | Journal of Applied Sciences2008，8，21： | 1 |
| 7 | 2D and 3D finite element a- nal ysis of a three stage forging sequence 显示文摘 | Mac Cormack C Monaghan J | 2002 | Journal of Ma- teri-als Processing Technology2002，，127： | 1 |
| 8 | Smoothed particle hydrodynamics: Theory and applications to non-spherical stars显示文摘 | Gingold R A Monaghan J J | 1997 | Monthly Notices of the Royal Astronomical society1997，181，2： | 1 |
| 9 | SPH and riemann solver显示文摘 | Monaghan J J | 1997 | Journal of computational physics1997，136，： | 1 |
| 10 | SPH without a Tensile Instability 显示文摘 | Monaghan J J | 2002 | J Comput Phys2002，159，： | 1 |
| 11 | Austenite stability in Fe-Mn-Si-based shape memory alloys显示文摘 | Stanford N Dunne D P Monaghan B J | | 0，，： | 1 |
| 12 | ,Simulating free surface flow with SPH 显示文摘 | Monaghan J J | 1994 | Journal of Computational Physic1994，110，2： | 1 |
| 13 | 2D and 3D Finite Element Analysis of a Three Stage Forging Sequence显示文摘 | Cormack C M Monaghan J | 2002 | Journal of Materials Processing Technology2002，127，： | 1 |
| 14 | SPH: Theory and application to non-spherical stars 显示文摘 | Gingold R A Monaghan J J | 1977 | Monthly Notices of the RoyalAstronomical Society1977，181，： | 1 |
| 15 | Mutations in COQ4,an essential component of coenzyme Q biosynthesis,cause lethal neonatal mitochondrial encephalomyopathy显示文摘 | Chung WK Martin K Jalas C Braddock SR Juusola J Monaghan KG | 2015 | J Med Genet2015，52，： | 1 |
| 16 | Smoothed particle hydrodynamics:theory and application to non-spherical stars显示文摘 | Gingold R A Monaghan J J | 1977 | Monthly Notices R Astron Soc1977，181，4： | 1 |
| 17 | On the problem of penetration in particle methods 显示文摘 | Monaghan J J | 1989 | J Comput Phys1989，82，： | 1 |
| 18 | Smoothed particle hydrodynamics显示文摘 | Monaghan J J | 1992 | Annual Review of Astronomy and Astrophysics1992，30，： | 1 |
| 19 | Why Particle Methods Work 显示文摘 | | 1982 | SIAM Journal of Scientific and Statistical Computing1982，3，4： | 1 |
| 20 | A four year retrospective study of 1,062 patients presenting with maxillofacial emergencies at a specialist paediatric hospital显示文摘 | Kotecha S Scannell J Monaghan A | 2008 | Br J oral Maxillofac Surg2008，46，4： | 1 |
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