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| 1 | Boceprevir,GC-376,and calpain inhibitors Ⅱ,Ⅻ inhibit SARS-CoV-2 viral replication by targeting the viral main protease显示文摘A new coronavirus SARS-CoV-2,also called novel coronavirus 2019(2019-nCoV),started to circulate among humans around December 2019,and it is now widespread as a global pandemic.The disease caused by SARS-CoV-2 virus is called COVID-19,which is highly contagious and has an overall mortality rate of 6.35%as of May 26,2020.There is no vaccine or antiviral available for SARS-CoV-2.In this study,we report our discovery of inhibitors targeting the SARS-CoV-2 main protease(Mpro).Using the FRET-based enzymatic assay,several inhibitors including boceprevir,GC-376,and calpain inhibitorsⅡ,andⅫwere identified to have potent activity with single-digit to submicromolar ICs0 values in the enzymatic assay.The mechanism of action of the hits was further characterized using enzyme kinetic studies,thermal shift binding assays,and native mass spectrometry.Significantly,four compounds(boceprevir,GC-376,calpain inhibitorsⅡandⅫ)inhibit SARS-CoV-2 viral replication in cell culture with EC50 values ranging from 0.49 to 3.37μM.Notably,boceprevir,calpain inhibitorsⅡandⅫrepresent novel chemotypes that are distinct from known substrate-based peptidomimetic Mpro inhibitors.A complex crystal structure of SARS-CoV-2 Mpro with GC-376,determined at 2.15(A)resolution with three protomers per asymmetric unit,revealed two unique binding configurations,shedding light on the molecular interactions and protein conformational flexibility underlying substrate and inhibitor binding by Mpro.Overall,the compounds identified herein provide promising starting points for the further development of SARS-CoV-2 therapeutics. | Chunlong Ma Michael Dominic Sacco Brett Hurst Julia Alma Townsend Yanmei Hu Tommy Szeto Xiujun Zhang Bart Tarbet Michael Thomas Marty Yu Chen Jun Wang | 2020 | Cell Research2020，30，8： | 13 |
| 2 | Fracture evolution characteristics of sandstone containing double fissures and a single circular hole under uniaxial compression显示文摘The uniaxial compression experiments on the sandstone samples containing double fissures and a single circular hole were carried out by using electro-hydraulic servo universal testing machine to investigate the effect of rock bridge angle β and fissure angle α on mechanical properties and evolution characteristics of cracks.The results show that the peak strength,peak strain and elastic modulus of defected specimens decrease comparing with those for intact sample,and show a decreased trend firstly and then increase with β changing from 0° to 90°.The peak strength and elastic modulus achieve the minimum value as the rock bridge angle is 60°,while the peak strain reaches the minimum value with the rock bridge angle of 45°.The crack initiation of tested rock samples occurs firstly in stress concentration areas at tips of prefabricated fissures under uniaxial compression,and then propagates constantly and coalescences with the prefabricated hole.Some secondary cracks initiate and propagate as well until buckling failure happens.The rock bridge angle has a great influence on crack initiation,coalescence,final failure mode,crack initiation stress and transfixion stress.The peak strength varies significantly,while the elastic modulus and peak strain change slightly,and the failure modes are also different due to the influence of fissure angle. | Chen Minliang Jing Hongwen Ma Xiujun Su Haijian Du Mingrui Zhu Tantan | 2017 | International Journal of Mining Science and Technology2017，27，3： | 11 |
| 3 | Mining geographic episode association patterns of abnormal events in global earth science data显示文摘Abnormal events in earth science have great influence on both the natural envi-ronment and the human society. Finding association patterns among these events has great significance. Because data in earth science has characteristics of mass,high dimension,spatial autocorrelation and time delay,existing mining technolo-gies cannot be directly used on it. We propose a RSNN (range-based searching nearest neighbors) spatial clustering algorithm to reduce the data size and auto-correlation. Based on the clustered data,we propose a GEAM (geographic episode association pattern mining) algorithm which can deal with events time lags and find interesting patterns with specific constraints,to mine the association patterns. We carried out experiments on global climate datasets and found many interesting association patterns. Some of the patterns are coincident with known knowledge in climate science,which indicates the correctness and feasibilities of our methods,and the others are unknown to us before,which will give new information to this research field. | WU TianShu,SONG GuoJie,MA XiuJun,XIE KunQing,GAO XiaoPing & JIN XingXing Key Laboratory of Machine Perception,Ministry of Education,and Department of Machine Intelligence,Peking University,Beijing 100871,China | 2008 | Science China(Technological Sciences)2008，51，S1： | 5 |
| 4 | Decorin accelerates the liver regeneration after partial hepatectomy in fibrotic mice显示文摘 | Ma Rui Chen Jiang Li Zheyong Tang Jiacheng Wang Yifan Cai Xiujun | 2014 | Chinese Medical Journal2014，，14： | 4 |
| 5 | Perioperative outcomes of laparoscopic versus open splenectomy for nontraumatic diseases: a meta-analysis显示文摘 | Chen Jiang Ma Rui Yang Shouzhang Lin Shuang He Shilin Cai Xiujun | 2014 | Chinese Medical Journal2014，，13： | 4 |
| 6 | Surface Roughness and Roundness of Bearing Raceway Machined by Floating Abrasive Polishing and Their Effects on Bearing's Running Noise显示文摘As the two most important indexes of bearing raceway,surface roughness and roundness have significant influence on bearing noise.Some researchers have carried out studies in this field,however,reason and extent of the influence of raceway surface geometric characteristics on bearing running noise are not perfectly clear up to now.In this paper,the raceway of 6309 type bearing’s inner and outer ring is machined by floating abrasive polishing adopting soft abrasive pad.Surface roughness parameters,arithmetical mean deviation of the profile Ra,the point height of irregularities Rz,maximum height of the profile Rmax and roundness f of raceways,are measured before and after machining,and the change rules of the measured results are studied.The study results show that the floating abrasive polishing can reduce the surface geometric errors of bearing raceway evidently.The roundness error is reduced by 25%,Rmax value is reduced by 35.5%,Rz value is reduced by 22%and Ra value is reduced by 5%.By analyzing the change of the geometrical parameters and the shape difference of the raceway before and after machining,it is found that the floating abrasive polishing method can affect the roundness error mainly by modifying the local deviation of the raceway’s surface profile.Bearings with different raceway surface geometrical parameter value are assembled and the running noise is tested.The test results show that Ra has a little,Rmax and Rz have a measurable,and the roundness error has a significant influence on the running noise.From the viewpoint of controlling bearings’running noise,raceway roundness error should be strictly controlled,and for the surface roughness parameters,Rmax and Rz should be mainly controlled.This paper proposes an effective method to obtain the low noise bearing by machining the raceway with floating abrasive polishing after super finishing. | PANG Guibing QI Xuezhi MA Qinyi ZHAO Xiujun WEN Chunsheng XU Wenji PENG Yanping | 2014 | Chinese Journal of Mechanical Engineering2014，27，3： | 3 |
| 7 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 8 | Towards Estimating Urban Population Distributions from Mobile Call Data显示文摘 | KANG Chaogui LIU Yu MA Xiujun | 2012 | Journal of Urban Technology2012，，4： | 1 |
| 9 | An improved DBSCAN algorithm which is insensitive to input parameters显示文摘 | CAI Yingkun XIE Kunqing MA Xiujun | 2004 | Acta Scientiarum Naturalium Universitatics Pekinensis2004，40，3： | 1 |
| 10 | Selective coordination of polyazin sapanisertib with halide vacancy for printable mesoscopicperovskite solar cells显示文摘The mitigation of under-coordinated Pb^(2+)(halide vacancy)defect remains an imperative challenge in the perovskite solar cells,especially printable mesoscopic perovskite solar cells(FP-PsCs).Here we re port a commercial-available polyazin anticancer drug Sapanisertib as coordination passivator of halide vacancies in FP-PSCs,thereby achieving the photoelectric conversion efficiency(PCE)to 18.46%,along with a record certified PCE of 18.27%.In polazin Sapanisertib(Sap),there exists two kinds of nitrogen atoms:in-aromatic ring(in purine and oxazole rings,IAR-Ns)and out-aromatic ring(substituted amino groups,OAR-Ns).Through multiple characterizations,and DFT calculations show that substituted amino groups OAR-Ns hardly get interaction with the halide vacancy due to the distribution of charge density in Sapanisertib.Our work suggests that the selective coordination is of great significance for the design of high-performance passivators for printable mesoscopic perovskite solar cells. | Dun Ma Xiujun He Jingshan He Huanxin Guo Yongzhen Wu Wenjun Wu Weihong Zhu | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 11 | Development of synthetic lethality in cancer:molecular and cellular classification显示文摘Recently,genetically targeted cancer therapies have been a topic of great interest.Synthetic lethality provides a new approach for the treatment of mutated genes that were previously considered unable to be targeted in traditional genotype-targeted treatments.The increasing researches and applications in the clinical setting made synthetic lethality a promising anticancer treatment option.However,the current understandings on different conditions of synthetic lethality have not been systematically assessed and the application of synthetic lethality in clinical practice still faces many challenges.Here,we propose a novel and systematic classification of synthetic lethality divided into gene level,pathway level,organelle level,and conditional synthetic lethality,according to the degree of specificity into its biological mechanism.Multiple preclinical findings of synthetic lethality in recent years will be reviewed and classified under these different categories.Moreover,synthetic lethality targeted drugs in clinical practice will be briefly discussed.Finally,we will explore the essential implications of this classification as well as its prospects in eliminating existing challenges and the future directions of synthetic lethality. | Shijie Li Win Topatana Sarun Juengpanich Jiasheng Cao Jiahao Hu Bin Zhang Diana Ma Xiujun Cai Mingyu Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 12 | Residual Regularity in Tissues of Layer after Combined Exposure to Lead(Pb)and Cadmium(Cd)显示文摘[Objective]The study was to investigate residual regularity in tissues of layer after combined exposure to lead (Pb)and/or cadmium (Cd).[Method]Lead acetate (100 mg/L)and/or cadmium chloride (50 mg/L)were administered in drinking water to 120 individuals of 40-week-old hyline layers for 8 weeks.[Result]Compared with the Cd group,the Cd content in various tissues,except kidney and femur,in Cd+Pb group all increased,but the difference was not significant (P>0.05).The Cd contents in kidney and femur in Cd group were significantly higher than that in Cd+Pb group.Compared with the group Pb,the Pb contents in breast muscle and kidney in Cd+Pb group decreased significantly (P<0.05);the Pb contents in femur decreased extremely (P<0.01);while the Pb contents in leg muscle,heart and spleen increased significantly (P<0.05);the Pb contents in liver and glandular stomach were almost the same.Compared with the control group,the Cd content in various tissues in Pb group increased significantly (P<0.05);no significant changes were observed for Pb content in Cd group.[Conclusion]Deposit of Pb and Cd in poultry body had complex interaction. | Chen Dawei Liu Yinyin Wang Qianqian Pu Junhua Ma Lina Ge Qinglian Tang Xiujun Gao Yushi | 2016 | Animal Husbandry and Feed Science2016，8，5： | 0 |
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