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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | An innovative flake graphite upgrading process based on HPGR,stirred grinding mill, and nanobubble column flotation显示文摘Physical upgrading of graphite is typically achieved with many stages of grinding and flotation to produce a concentrate with approximately 95% carbon grade.An innovative grinding and column flotation process has been developed for efficient graphite upgrading to substantially simplify the process flowsheet and reduce operating costs.In this process,a high-pressure grinding roller(HPGR) and a stirred mill were employed as primary comminution techniques and a nanobubble flotation column as a key separation process.The results obtained with a crystalline flake graphite sample with a carbon grade of 11.15% show that the novel process can produce a concentrate with 94.82% carbon grade and 97.89% recovery from an open circuit of one rougher and two cleaner flotation stages.Scanning electron microscope(SEM)microphotographs indicate that HPGR offers the advantage of more effective protection of graphite flakes during crushing.Grinding test results show that stirred mill could not only protect graphite flakes but also promote the efficient liberation of graphite.Compared with the traditional flotation process,nanobubble flotation can effectively recover ultrafine graphite.The new process possesses a number of important advantages over the traditional method,including substantially higher graphite recovery,greatly simplified process flowsheet,better protection of flake size,reduced reagent consumption and process costs,etc. | Fangyuan Ma Dongping Tao Youjun Tao Shuyong Liu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 9 |
| 3 | A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China显示文摘The coronavirus disease 2019(COVID-19)pandemic is a global crisis,and medical systems in many countries are overwhelmed with supply shortages and increasing demands to treat patients due to the surge in cases and severe illnesses.This study aimed to assess COVID-19-related essential clinical resource demands in China,based on different scenarios involving COVID-19 spreads and interventions.We used a susceptible–exposed–infectious–hospitalized/isolated–removed(SEIHR)transmission dynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essential healthcare resources needed.We found that,under strict non-pharmaceutical interventions(NPIs)or mass vaccination of the population,China would be able to contain community transmission and local outbreaks rapidly.However,under scenarios involving a low intensity of implemented NPIs and a small proportion of the population vaccinated,the use of a peacetime–wartime transition model would be needed for medical source stockpiles and preparations to ensure a normal functioning healthcare system.The implementation of COVID-19 vaccines and NPIs in different periods can influence the transmission of COVID-19 and subsequently affect the demand for clinical diagnosis and treatment.An increased proportion of asymptomatic infections in simulations will not reduce the demand for medical resources;however,attention must be paid to the increasing difficulty in containing COVID-19 transmission due to asymptomatic cases.This study provides evidence for emergency preparations and the adjustment of prevention and control strategies during the COVID-19 pandemic.It also provides guidance for essential healthcare investment and resource allocation. | Ting Zhang Qing Wang Zhiwei Leng Yuan Yang Jin Yang Fangyuan Chen Mengmeng Jia Xingxing Zhang Weiran Qi Yunshao Xu Siya Chen Peixi Dai Libing Ma Luzhao Feng Weizhong Yang | 2021 | Engineering2021，7，7： | 7 |
| 4 | Recent advances in carbon nanostructures prepared from carbon dioxide for high-performance supercapacitors显示文摘The burgeoning global economy during the past decades gives rise to the continuous increase in fossil fuels consumption and rapid growth of CO_(2) emission,which demands an urgent exploration into green and sustainable devices for energy storage and power management.Supercapacitors based on activated carbon electrodes are promising systems for highly efficient energy harvesting and power supply,but their promotion is hindered by the moderate energy density compared with batteries.Therefore,scalable conversion of CO_(2) into novel carbon nanostructures offers a powerful alternative to tackle both issues:mitigating the greenhouse effect caused by redundant atmospheric CO_(2) and providing carbon materials with enhanced electrochemical performances.In this tutorial review,the techniques,opportunities and barriers in the design and fabrication of advanced carbon materials using CO_(2) as feedstock as well as their impact on the energy-storage performances of supercapacitors are critically examined.In particular,the chemical aspects of various Cv2 conversion reactions are highlighted to establish a detailed understanding for the science and technology involved in the microstructural evolution,surface engineering and porosity control of CO_(2)-converted carbon nanostructures.Finally,the prospects and challenges associated with the industrialization of CO_(2) conversion and their practical application in supercapacitors are also discussed. | Chen Li Xiong Zhang Kai Wang Fangyuan Su Cheng-Meng Chen Fangyan Liu Zhong-Shuai Wu Yanwei Ma | 2021 | Journal of Energy Chemistry2021，30，3： | 4 |
| 5 | Surface nanobubble characterization and its enhancement mechanisms for fine-particle flotation:A review显示文摘Froth flotation is often used for fine-particle separation,but its process efficiency rapidly decreases with decreasing particle size.The efficient separation of ultrafine particles(UFPs)has been a major challenge in the mineral processing field for many years.In recent years,the use of surface nanobubbles in the flotation process has been recognized as an effective approach for enhancing the recovery of UFPs.Compared with traditional macrobubbles,nanobubbles possess unique surface and bulk characteristics,and their effects on the UFP flotation behavior have been a topic of intensive research.This review article is focused on the studies on various unique characteristics of nanobubbles and their mechanisms of enhancing the UFP flotation.The purpose of this article is to summarize the major achievements on the two topics and pinpoint future research needs for a better understanding of the fundamentals of surface nanobubble flotation and developing more feasible and efficient processes for fine and UFPs. | Fangyuan Ma Patrick Zhang Dongping Tao | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，4： | 2 |
| 6 | Aerobic denitrification characteristics research of pseudomonas strains HFX0$ 显示文摘 | Ma Xiulan Shan Yuxun Zhang Fangyuan | 2013 | Applied Mechanics and Materials2013，，： | 1 |
| 7 | Anthraquinone Covalently Modified Carbon Nanotubes for Efficient and Steady Electrocatalytic H2O2 Generation显示文摘Anthraquinone(AQ)modified carbon materials could be endowed with significantly improved oxygen re-duction reaction(ORR)activity.However,the application of these materials in the generation of hydrogen peroxide(H2O2)has been rarely investigated.For this motivation,AQ covalently modified carbon nanotube(AQ-CNT)was pur-posely synthesized for H2O2 generation.It was found that the cumulative H2O2 concentration reached up to 187.18 mg(Lh)over AQ(40)-CNT catalyst,nearly 2.0 times higher than that over CNT,and being superior to those over most carbon materials reported.The enhanced activity stemmed from the improved mass transfer fficiency of oxygen and the enhanced electrocatalytic activity.Noteworthily,the AQ(40)-CNT material exhibited satisfactory stability for H2O2 generation,which was ascribed to the strong interaction force of C-N covalent bond.The present work could provide a vital idea for designing electrode material with simultancously improved activity and stability for H2O2 gencration. | YU Fangyuan WANG Kai WANG Chuan HE Xinxia LIAO Yang ZHAO Shilin MAO Hui LI Xiaoting MA Jun | 2020 | Chemical Research in Chinese Universities2020，36，6： | 1 |
| 8 | Submicrometer optical frequency combs based on SPPs metallic multi-ring resonators显示文摘Optical frequency combs(OFCs)have great potential in communications,especially in dense wavelength-division multiplexing.However,the size of traditional OFCs based on conventional optical microcavities or dispersion fibers is at least tens of micrometers,far larger than that of nanoscale electronic chips.Therefore,reducing the size of OFCs to match electronic chips is of necessity.Here,for the first time to our knowledge,we introduce surface plasmon polaritons(SPPs)to the construction of OFCs to realize a miniature device.The thickness of our device is reduced below 1μm.Though the presence of SPPs may induce ohmic and scattering loss,the threshold of the device is obtained as 9μW,comparable to the conventional device.Interestingly,the response time is 13.2 ps,much faster than the optical counterparts.This work provides a feasible strategy for the miniaturization of OFCs. | ZHITAO HUANG FANGYUAN MA KEQIAN DONG SHIZHONG YUE CHAO LI YULIN WU JUNHUI HUANG XU HAN JIAQIAN SUN ZHAOFENG LI KONG LIU ZHIJIE WANG YONG LEI SHENGCHUN QU ZHANGUO WANG | 2023 | Photonics Research2023，11，12： | 0 |
| 9 | Strongly nonlinear topological phases of cascaded topoelectrical circuits显示文摘Circuits provide ideal platforms of topological phases and matter,yet the study of topological circuits in the strongly nonlinear regime,has been lacking.We propose and experimentally demonstrate strongly nonlinear topological phases and transitions in one-dimensional electrical circuits composed of nonlinear capacitors.Nonlinear topological interface modes arise on domain walls of the circuit lattices,whose topological phases are controlled by the amplitudes of nonlinear voltage waves.Experimentally measured topological transition amplitudes are in good agreement with those derived from nonlinear topological band theory.Our prototype paves the way towards flexible metamaterials with amplitude-controlled rich topological phases and is readily extendable to two and three-dimensional systems that allow novel applications. | Jijie Tang Fangyuan Ma Feng Li Honglian Guo Di Zhou | 2023 | Frontiers of physics2023，18，3： | 0 |
| 10 | 3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome显示文摘Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity. An increasing body of evidence suggests that aberrant synaptic plasticity is associated with the activation of the NOD-like receptor family pyrin domain containing-3(NLRP3) inflammasome. 3′-Deoxyadenosin, an active component of the Chinese fungus Cordyceps militaris, has strong anti-inflammatory effects. However, whether 3′-deoxyadenosin attenuates methamphetamine-induced aberrant synaptic plasticity via an NLRP3-mediated inflammatory mechanism remains unclear. We first observed that 3′-deoxyadenosin attenuated conditioned place preference scores in methamphetamine-treated mice and decreased the expression of c-fos in hippocampal neurons. Furthermore, we found that 3′-deoxyadenosin reduced the aberrant potentiation of glutamatergic transmission and restored the methamphetamine-induced impairment of synaptic plasticity. We also found that 3′-deoxyadenosin decreased the expression of NLRP3 and neuronal injury. Importantly, a direct NLRP3 deficiency reduced methamphetamine-induced seeking behavior, attenuated the impaired synaptic plasticity, and prevented neuronal damage. Finally, NLRP3 activation reversed the effect of 3′-deoxyadenosin on behavior and synaptic plasticity, suggesting that the anti-neuroinflammatory mechanism of 3′-deoxyadenosin on aberrant synaptic plasticity reduces methamphetamine-induced seeking behavior. Taken together, 3′-deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome. | Yize Qi Yao Zhou Jiyang Li Fangyuan Zhu Gengni Guo Can Wang Man Yu Yijie Wang Tengfei Ma Shanwu Feng Li Zhou | 2024 | Neural Regeneration Research2024，19，10： | 0 |
| 11 | Early identification of process deviation based on convolutional neural network显示文摘A novel process monitoring method based on convolutional neural network(CNN)is proposed and applied to detect faults in industrial process.By utilizing the CNN algorithm,cross-correlation and autocorrelation among variables are captured to establish a prediction model for each process variable to approximate the first-principle of physical/chemical relationships among different variables under normal operating conditions.When the process is operated under pre-set operating conditions,prediction residuals can be assumed as noise if a proper model is employed.Once process faults occur,the residuals will increase due to the changes of correlation among variables.A principal component analysis(PCA)model based on the residuals is established to realize process monitoring.By monitoring the changes in main feature of prediction residuals,the faults can be promptly detected.Case studies on a numerical nonlinear example and data from two industrial processes are presented to validate the performance of process monitoring based on CNN. | Fangyuan Ma Cheng Ji Jingde Wang Wei Sun | 2023 | Chinese Journal of Chemical Engineering2023，56，4： | 0 |
| 12 | Design, Synthesis, Inhibiting HDACs Ability and Antitumor Activity of Pyrimidin-4(3H)-one Hydroxamate Derivatives显示文摘 | LU Haibin JIN Xiangqun JIN Yang HUANG Bangrui WANG Cheng WANG Chunhe MA Fangyuan CHEN Yuting LI Jiarui CONG Yu WANG Wenlong SONG Yuming MU Xupeng | 2016 | Chemical Research in Chinese Universities2016，32，4： | 0 |
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