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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | The effect of pravastation on coronary avents after myocardial infarction in patients with average cholesterol levels 显示文摘 | Sacks FM Pfeffer MA Moye L | 1996 | NEJM1996，335，： | 1 |
| 3 | The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels 显示文摘 | Sacks FM Pfeffer MA Moye LA | 1996 | N Engl J Med1996，335，14： | 1 |
| 4 | Medication taking in coronary artery disease : a systematic review and qualitative synthesis显示文摘 | Rashid MA Edwards D Walter FM ct al | 2014 | Ann Fam Med2014，12，3： | 1 |
| 5 | A Newton-type algorithm for generalized linear complementarity problem over a polyhedral cone显示文摘 | Zhang X Z Ma FM Wang YJ | | Appl Math0，，： | 1 |
| 6 | The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels显示文摘 | Sacks FM Pfeffer MA Moye LA | 1996 | N Engl J Med1996，335，14： | 1 |
| 7 | A radiographic evaluation of the availability of bone for placement of miniscrews显示文摘 | Schnelle MA Beck FM Jaynes RM | | 0，，06： | 1 |
| 8 | The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels显示文摘 | Sacks FM Pfeiffer MA Moye LA | 1996 | N Engl J med1996，335，： | 1 |
| 9 | Clustering of invasive Aspergillus ustuseye infections in a tertiary care hospital : amolecular epidemiologic study of an uncommonspecies显示文摘 | Saracli MA’Mutlu FM Yildiran ST | 2007 | Med Mycol2007，45，4： | 1 |
| 10 | Particle Size Effect on Heat Transfer Performance in an Oscillating Heat Pipe 显示文摘 | JI YL MA HB SU FM | 2011 | Ex- perimental Thermal and Fluid Science2011，35，72： | 1 |
| 11 | Apolipoprotein (a) size and lipo- protein (a) concerntration and future risk angine pectoris with evi- dence of severe coronary atheroselerosis in men: the physicians, health study 显示文摘 | Rifai N Ma J Sacks FM | 2004 | Clin Chem2004，50，： | 1 |
| 12 | Palmitoylcarnitine, a surface- active metabolite显示文摘 | Goni FM Requero MA Alonso A | 1996 | FEBS Lett1996，390，1： | 1 |
| 13 | Efficient repair of bulky anti-BPDE DNA adducts from non- transcribed DNA strand requires functional p53 but not p21 (wafl/cipl) and pRb显示文摘 | Wani MA E1-Mahdy MA Hamada FM | 2002 | Mutat Res2002，505，12： | 1 |
| 14 | Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans显示文摘 | Hutter CM Austin MA Farin FM | 2006 | Atherosclerosis2006，185，1： | 1 |
| 15 | Inhibition of endothelium-dependent vascular relaxation by tetrandrine显示文摘 | KWAN CY MA FM HUI SC | 1999 | Life Sci1999，64，25： | 1 |
| 16 | The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels 显示文摘 | Sacks FM Pfeffer MA Moye LA | 1996 | N Engl J Med1996，335，： | 1 |
| 17 | The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels 显示文摘 | Sacks FM Pfeffer MA Moye LA | 1996 | N Engl J Med1996，335，： | 1 |
| 18 | The effect of pravastatin on coronary events after myocardial in patients with average cholesterol levels显示文摘 | SackS FM Pfeffer MA Moye LA | 1996 | N Engl J Med1996，335，： | 1 |
| 19 | Continuous 14 days infusion of IGF-Ⅱ increases the growth of normal female rats,but exhibits a lower potency than IGF-Ⅰ显示文摘 | Conlon MA Francis GL Tomas FM | 1995 | J Endocr1995，144，1： | 1 |
| 20 | Quality of life in pa- tients with psoriasis: a systematic literature review 显示文摘 | de Korte J Sprangers MA Mombers FM | 2004 | J Investig Dermatol Symp Proc2004，9，： | 1 |
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