|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson’s disease显示文摘Parkinson’s disease is the second most common neurodegenerative disorder;it affects 1%of the population over the age of 65.The number of people with Parkinson’s disease is set to rapidly increase due to changing demographics and there is an unmet clinical need for disease-modifying therapies.The pathological hallmarks of Parkinson’s disease are the progressive degeneration of dopaminergic neurons in the substantia nigra and their axons which project to the striatum,and the aggregation ofα-synuclein;these result in a range of debilitating motor and non-motor symptoms.The application of neurotrophic factors to protect and potentially regenerate the remaining dopaminergic neurons is a major area of research interest.However,this strategy has had limited success to date.Clinical trials of two well-known neurotrophic factors,glial cell line-derived neurotrophic factor and neurturin,have reported limited efficacy in Parkinson’s disease patients,despite these factors showing potent neurotrophic actions in animal studies.There is therefore a need to identify other neurotrophic factors that can protect againstα-synuclein-induced degeneration of dopaminergic neurons.The bone morphogenetic protein(BMP)family is the largest subgroup of the transforming growth factor-βsuperfamily of proteins.BMPs are naturally secreted proteins that play crucial roles throughout the developing nervous system.Importantly,many BMPs have been shown to be potent neurotrophic factors for dopaminergic neurons.Here we discuss recent work showing that transcripts for the BMP receptors and BMP2 are co-expressed with several key markers of dopaminergic neurons in the human substantia nigra,and evidence for downregulation of BMP2 expression at distinct stages of Parkinson’s disease.We also discuss studies that explored the effects of BMP2 treatment,in in vitro and in vivo models of Parkinson’s disease.These studies found potent effects of BMP2 on dopaminergic neurites,which is important given that axon degeneration is increasingly recognized as a key early event in Parkinson’s disease.Thus,the aim of this mini-review is to give an overview of the BMP family and the BMP-Smad signalling pathway,in addition to reviewing the available evidence demonstrating the potential of BMP2 for Parkinson’s disease therapy. | Susan R.Goulding Aideen M.Sullivan Gerard W.O’Keeffe Louise M.Collins | 2020 | Neural Regeneration Research2020，15，8： | 7 |
| 2 | Global, 30-m resolution continuous fields of tree cover: Landsat-based rescaling of MODIS vegetation continuous fields with lidar-based estimates of error显示文摘We developed a global,30-m resolution dataset of percent tree cover by rescaling the 250-m MOderate-resolution Imaging Spectroradiometer(MODIS)Vegetation Continuous Fields(VCF)Tree Cover layer using circa-2000 and 2005 Landsat images,incorporating the MODIS Cropland Layer to improve accuracy in agricultural areas.Resulting Landsat-based estimates maintained consistency with the MODIS VCF in both epochs(RMSE=8.6%in 2000 and 11.9%in 2005),but showed improved accuracy in agricultural areas and increased discrimination of small forest patches.Against lidar measurements,the Landsat-based estimates exhibited accuracy slightly less than that of the MODIS VCF(RMSE=16.8%for MODIS-based vs.17.4%for Landsat-based estimates),but RMSE of Landsat estimates was 3.3 percentage points lower than that of the MODIS data in an agricultural region.The Landsat data retained the saturation artifact of the MODIS VCF at greater than or equal to 80%tree cover but showed greater potential for removal of errors through calibration to lidar,with post-calibration RMSE of 9.4%compared to 13.5%in MODIS estimates.Provided for free download at the Global Land Cover Facility(GLCF)website(www.landcover.org),the 30-m resolution GLCF tree cover dataset is the highest-resolution multi=temporal depiction of Earth’s tree cover available to the Earth science community. | Joseph O.Sexton Xiao-Peng Song Min Feng Praveen Noojipady Anupam Anand Chengquan Huang Do-Hyung Kim Kathrine M.Collins Saurabh Channan Charlene DiMiceli John R.Townshend | 2013 | International Journal of Digital Earth2013，6，5： | 5 |
| 3 | Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds显示文摘Carbon nitrides integrating macroheterocycles offer unique potential as hosts for stabilizing metal atoms due to their rich electronic structure. To date, only graphitic heptazine-based polymers have been studied.Here, we demonstrate that palladium atoms can be effectively isolated on other carbon nitride scaffolds including linear melem oligomers and poly(triazine/heptazine imides). Increased metal uptake was linked to the larger cavity size and the presence of chloride ions in the polyimide structures. Changing the host structure leads to significant variation in the average oxidation state of the metal, which can be tuned by exchange of the ionic species as evidenced by X-ray photoelectron spectroscopy and supported by density functional theory. Evaluation in the semi-hydrogenation of 2-methyl-3-butyn-2-ol reveals an inverse correlation between the activity and the degree of oxidation of palladium, with oligomers exhibiting the highest activity. These findings provide new mechanistic insights into the influence of the carbon nitride structure on metal stabilization. | Zupeng Chen Evgeniya Vorobyeva Sharon Mitchell Edvin Fako Núria López Sean M.Collins Rowan K.Leary Paul A.Midgley Roland Hauert Javier Pérez-Ramírez | 2018 | National Science Review2018，5，5： | 4 |
| 4 | 探究教学的认知理论显示文摘本文选用多学科教学实例来说明教师如何运用探究教学的十种策略促使学生解决各种问题。在这一过程中,学生既学习知识领域的具体理论,又学习各种推理技能,包括构建假设、验证假设、提出预测、选择验证理论的合适的案例、提出反例和假设案例、区别必要条件和充分条件、考虑不同的假设、熟悉规则或理论可能的形式、知道提问的策略等。在某种意义上,探究法为学生展示了一个造就科学家的模拟过程。这种教学模式对学生的学习有特别的激励作用。 | Allan M.Collins 褚献华 | 2006 | 远程教育杂志2006，24，2： | 2 |
| 5 | Distribution,structure and biosynthetic gene families of(1,3;1,4)-β-glucan in Sorghum bicolor显示文摘In cereals, the presence of soluble polysaccharides including(1,3;1,4)-b-glucan has downstream implications for human health, animal feed and biofuel applications. Sorghum bicolor(L.) Moench is a versatile crop, but there are limited reports regarding the content of such soluble polysaccharides.Here, the amount of(1,3;1,4)-b-glucan present in sorghum tissues was measured using a Megazyme assay. Very low amounts were present in the grain, ranging from 0.16%–0.27%(w/w), while there was a greater quantity in vegetative tissues at 0.12–1.71%(w/w). The fine structure of(1,3;1,4)-b-glucan, as denoted by the ratio of cellotriosyl and cellotetraosyl residues,was assessed by high performance liquid chromatography(HPLC) and ranged from 2.6–3:1 in the grain, while ratios in vegetative tissues were lower at 2.1–2.6:1. The distribution of(1,3;1,4)-b-glucan was examined using a specific antibody and observed with fl uorescence and transmission electron microscopy. Micrographs showed a variable distribution of(1,3;1,4)-b-glucan in fl uenced by temporal and spatial factors. The sorghum orthologs of genes implicated in the synthesis of(1,3;1,4)-b-glucan in other cereals, such as the Cellulose synthase-like(Csl) F and H gene families were de fined.Transcript pro filing of these genes across sorghum tissues was carried out using real-time quantitative polymerase chain reaction, indicating that, as in other cereals, Csl F6 transcripts dominated. | Riksfardini A.Ermawar Helen M.Collins Caitlin S.Byrt Natalie S.Betts Marilyn Henderson Neil J.Shirley Julian Schwerdt Jelle Lahnstein Geoffrey B.Fincher Rachel A.Burton | 2015 | Journal of Integrative Plant Biology2015，57，4： | 2 |
| 6 | Polymorphisms in tumour necrosis factor‐α, transforming growth factor‐β, interleukin‐10, interleukin‐6, interferon‐γ, and outcome of hepatitis C virus infection显示文摘 | S.Barrett M.Collins C.Kenny E.Ryan C.O.Keane J.Crowe | 2003 | J. Med. Virol2003，，2： | 1 |
| 7 | Matrix metalloproteinases显示文摘 | S. L.Parsons S. A.Watson P. D.Brown H. M.Collins R. J. C.Steele | 2005 | Br J Surg2005，，2： | 1 |
| 8 | Matrix metalloproteinases显示文摘 | S. L.Parsons S. A.Watson P. D.Brown H. M.Collins R. J. C.Steele | 2005 | Br J Surg2005，，2： | 1 |
| 9 | Matrix metalloproteinases显示文摘 | S. L.Parsons S. A.Watson P. D.Brown H. M.Collins R. J. C.Steele | 2005 | Br J Surg2005，，： | 1 |
| 10 | Growth differentiation factor 5:a neurotrophic factor with neuroprotective potential in Parkinson’s disease显示文摘Parkinson’s disease is the most common movement disorder worldwide,affecting over 6 million people.It is an age-related disease,occurring in 1%of people over the age of 60,and 3%of the population over 80 years.The disease is characterized by the progressive loss of midbrain dopaminergic neurons from the substantia nigra,and their axons,which innervate the striatum,resulting in the characteristic motor and non-motor symptoms of Parkinson’s disease.This is paralleled by the intracellular accumulation ofα-synuclein in several regions of the nervous system.Current therapies are solely symptomatic and do not stop or slow disease progression.One promising disease-modifying strategy to arrest the loss of dopaminergic neurons is the targeted delivery of neurotrophic factors to the substantia nigra or striatum,to protect the remaining dopaminergic neurons of the nigrostriatal pathway.However,clinical trials of two well-established neurotrophic factors,glial cell line-derived neurotrophic factor and neurturin,have failed to meet their primary end-points.This failure is thought to be at least partly due to the downregulation byα-synuclein of Ret,the common co-receptor of glial cell line-derived neurorophic factor and neurturin.Growth/differentiation factor 5 is a member of the bone morphogenetic protein family of neurotrophic factors,that signals through the Ret-independent canonical Smad signaling pathway.Here,we review the evidence for the neurotrophic potential of growth/differentiation factor 5 in in vitro and in vivo models of Parkinson’s disease.We discuss new work on growth/differentiation factor 5’s mechanisms of action,as well as data showing that viral delivery of growth/differentiation factor 5 to the substantia nigra is neuroprotective in theα-synuclein rat model of Parkinson’s disease.These data highlight the potential for growth/differentiation factor 5 as a disease-modifying therapy for Parkinson’s disease. | Susan R.Goulding Jayanth Anantha Louise M.Collins Aideen M.Sullivan Gerard W.O’Keeffe | 2022 | Neural Regeneration Research2022，17，1： | 0 |
| 11 | Macroscopic analysis of time dependent plasticity in Ti alloys显示文摘Cold dwell fatigue is the critical technological issue in Ti alloys used in the cooler front sections of aerospace jet engines.When subjected to a sustained load(stress dwell),the lifetime of these Ti components can be drastically reduced by as much as an order of magnitude[1–4].Without a clear understanding of the effect,safety concerns are raised. | Yi Xiong Phani S.Karamched Chi-Toan Nguyen David M.Collins Christopher M.Magazzeni Edmund Tarleton Angus J.Wilkinson | 2022 | Journal of Materials Science & Technology2022，，29： | 0 |
| 12 | A database of experimentally measured lithium solid electrolyte conductivities evaluated with machine learning显示文摘The application of machine learning models to predict material properties is determined by the availability of high-quality data.We present an expert-curated dataset of lithium ion conductors and associated lithium ion conductivities measured by a.c.impedance spectroscopy.This dataset has 820 entries collected from 214 sources;entries contain a chemical composition,an expert-assigned structural label,and ionic conductivity at a specific temperature(from 5 to 873°C).There are 403 unique chemical compositions with an associated ionic conductivity near room temperature(15–35°C).The materials contained in this dataset are placed in the context of compounds reported in the Inorganic Crystal Structure Database with unsupervised machine learning and the Element Movers Distance.This dataset is used to train a CrabNet-based classifier to estimate whether a chemical composition has high or low ionic conductivity.This classifier is a practical tool to aid experimentalists in prioritizing candidates for further investigation as lithium ion conductors. | Cameron J.Hargreaves Michael W.Gaultois Luke M.Daniels Emma J.Watts Vitaliy A.Kurlin Michael Moran Yun Dang Rhun Morris Alexandra Morscher Kate Thompson Matthew A.Wright Beluvalli-Eshwarappa Prasad Frédéric Blanc Chris M.Collins Catriona A.Crawford Benjamin B.Duff Jae Evans Jacinthe Gamon Guopeng Han Bernhard T.Leube Hongjun Niu Arnaud J.Perez Aris Robinson Oliver Rogan Paul M.Sharp Elvis Shoko Manel Sonni William J.Thomas Andrij Vasylenko Lu Wang Matthew J.Rosseinsky Matthew S.Dyer | 2023 | npj Computational Materials2023，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员