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| 1 | Three-dimensional numerical modeling of single geocellreinforced sand显示文摘This paper summarizes the development of a three-dimensional numerical model for analyzing single geocell-reinforced soil.In this model,the infill soil was modeled using the Duncan-Chang model,which can simulate non-linearity and stress-dependency of soil.Geocell was modeled using linearly elastic plate elements,which can carry both bending and membrane stresses.A linear interface stress-strain relationship with a MohrCoulomb yield criterion was adopted to model the interface friction between the geocell wall and the soil.By modeling the geocell and the soil separately,the interaction between the soil and the geocell can be accurately simulated.To verify this model,a plate load test was conducted in the laboratory,in which a 12-cmthick sand layer reinforced by a single geocell was subjected to a vertical load from a circular steel plate.The load-displacement curves and the horizontal tensile strain of the geocell were recorded during the test.A numerical model was created according to the setup of the load test.The numerical results compared reasonably well with the test data. | Xiaoming YANG Jie HAN Robert L.PARSONS Dov LESHCHINSKY | 2010 | Frontiers of Structural and Civil Engineering2010，4，2： | 1 |
| 2 | Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment显示文摘Incidences of head and neck squamous cell carcinoma(HNSCC)have been on the rise in the last few decades,with a significant risk factor being human papillomavirus(HPV)type-16/18 infection,particularly in the development of oropharyngeal cancers.Radiotherapy(RT)is an important treatment modality for HNSCC,where it promotes extensive cellular DNA damage leading to the therapeutic effect.It has been well-established that HPV-positive HNSCC display better response rates and improved survival following RT compared to HPV-negative HNSCC.The differential radiosensitivity has been largely associated with altered cellular DNA damage response mechanisms in HPV-positive HNSCC,and particularly with the signaling and repair of DNA double strand breaks.However,other factors,particularly hypoxia present within the solid cancer,have a major impact on relative radioresistance.Consequently,recent approaches aimed at enhancing the radiosensitivity of HNSCC have largely centered on targeting key proteins involved in DNA repair,DNA damage checkpoint activation,and hypoxia signaling.These studies have utilised in vitro and in vivo models of HPV-positive and HPV-negative HNSCC and examined the impact of specific inhibitors against the targets in combination with radiation in suppressing HNSCC cell growth and survival.Here,accumulating evidence has shown that targeting enzymes including poly(ADP-ribose)polymerase,ataxia telangiectasia and Rad-3 related,DNA-dependent protein kinase catalytic subunit,and checkpoint kinase 1 can radiosensitise HNSCC cells which should be taken forward in further preclinical studies,with the goal of optimizing the future effective RT treatment of HNSCC. | Maria Rita Fabbrizi Jason L.Parsons | 2020 | Cancer Drug Resistance2020，3，4： | 1 |
| 3 | Levels of 4‐aminobiphenyl‐induced somatic H‐ras mutation in mouse liver DNA correlate with potential for liver tumor development显示文摘 | Barbara L.Parsons Frederick A.Beland Linda S.Von Tungeln Robert R.Delongchamp Peter P.Fu Robert H.Heflich | 2005 | Mol. Carcinog2005，，4： | 1 |
| 4 | Matrix metalloproteinases显示文摘 | S. L.Parsons S. A.Watson P. D.Brown H. M.Collins R. J. C.Steele | 2005 | Br J Surg2005，，2： | 1 |
| 5 | Matrix metalloproteinases显示文摘 | S. L.Parsons S. A.Watson P. D.Brown H. M.Collins R. J. C.Steele | 2005 | Br J Surg2005，，2： | 1 |
| 6 | 用于飞机货舱防火的热监视系统显示文摘现在飞机货舱配置的火灾探测系统并不符合目前联邦航空管理局的要求,其中有一条技术规定,即在火灾发生后一分钟内将其探测出来。联邦航空管理局关于适航性的新规定要求改进由波音公司和麦克道耐尔道格拉斯公司生产的所有客货飞机上的火灾探测系统。人们研制了一种符合联邦航空管理局新规定的热监视/火灾探测系统。它基于同菲涅耳扫描光学系统耦合起来的红外探测技术,并且使用双重的计算机控制装置,这使得该系统能够对货舱进行全面的热监视。系统对过热和火灾状态敏感,它具有三种火警信号电平,包含完整的光学视界和电路,能够提供有关火焰位置的信息。它可靠性高,不会产生误警。每个传感器都被设计得能够复盖高度为12英尺的一部分货舱。本文介绍该系统对火灾和过热状态的敏感特性,并且讨论它对误警的免疫能力。 | Michael L.Parsons 顾聚兴 | 1994 | 红外1994，，3： | 1 |
| 7 | Matrix metalloproteinases显示文摘 | S. L.Parsons S. A.Watson P. D.Brown H. M.Collins R. J. C.Steele | 2005 | Br J Surg2005，，： | 1 |
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