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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Sieving characteristics of cytokine-and peroxide-induced epithelial barrier leak:Inhibition by berberine显示文摘AIM:To study whether the inflammatory bowel disease(IBD)colon which exhibits varying severity and cytokine levels across its mucosa create varying types of transepithelial leak.METHODS:We examined the effects of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-1-β(IL1β)and hydrogen peroxide(H_2O_2)-singly and in combinations-on barrier function of CACO-2 cell layers.Our focus was on the type(not simply the magnitude)of transepithelial leak generated by these agents as measured by transepithelial electrical resistance(TER)and transepithelial flux of ^(14)C-D-mannitol,3H-Lactulose and ^(14)C-Polyethylene glycol as radiolabeled probe molecules.The isoquinoline alkaloid,berberine,was then examined for its ability to reduce specific types of transepithelial leak.RESULTS:Exposure to TNF-α alone(200 ng/mL;48 h)induced a 50% decrease in TER,i.e.,increased leak of Na^+ and Cl--with only a marginal but statistically significant increase in transepithelial leak of ^(14)C-mannitol(Jm).Exposure to TNF-α + IFN-γ(200 ng/mL;48 h)+ IL1β(50 ng/mL;48 h)did not increase the TER change(from TNF-α alone),but there was now a 100% increase in J_m.There however was no increase in transepithelial leak of two larger probe molecules,~3H-lactulose and ^(14)C-polyethylene glycol(PEG).However,exposure to TNF-α + IFN-γ + IL1β followed by a 5 h exposure to2 mmol/L H_2O_2 resulted in a 500% increase in ^(14)C-PEG leak as well as leak to the luminal mitogen,epidermal growth factor.CONCLUSION:This model of graded transepithelial leak is useful in evaluating therapeutic agents reducing IBD morbidity by reducing barrier leak to various luminal substances. | Katherine M DiGuilio Christina M Mercogliano Jillian Born Brendan Ferraro Julie To Brittany Mixson Allison Smith Mary Carmen Valenzano James M Mullin | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 6 |
| 3 | Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors显示文摘AIM: To determine if the observed paracellular sucrose leak in Barrett's esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett's patients and to non-Barrett's patients on continuous PPI therapy. Degree of leak was tested for correlation with presence of Barrett's, use of PPIs, and length of Barrett's segment and duration of PPI use. RESULTS: Barrett's patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was observed in Barrett's patients who ceased PPI use for 7 d.Although initial introduction of PPI use (in a PPI-na ve population) results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spontaneous decline in leak. The sucrose leak observed in Barrett's patients showed no correlation to the amount of Barrett's tissue present in the esophagus. CONCLUSION: Although future research is needed to determine the degree of paracellular leak in actual Barrett's mucosa, the relatively high degree of leak observed with in vivo sucrose permeability measurement of Barrett's patients reflects their PPI use and not their Barrett's tissue per se . | Christopher Farrell Melissa Morgan Owen Tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo Mercogliano James J Thornton Mary Carmen Valenzano James M Mullin | 2012 | World Journal of Gastroenterology2012，18，22： | 2 |
| 4 | An interlaboratory test of a procedure to assess soybean quality for soymilk and tofu production显示文摘 | Fregeaul-Reid J A Butler M | 2001 | Food Research International2001，34，： | 1 |
| 5 | Changes in anthocyanin and phenolics content of grapevine leaf and fruit tissues treated with sucrose, nitrate abscisic acid显示文摘 | Pifie A Mullins M G | 1976 | Plant Physiol1976，58，4： | 1 |
| 6 | Preparation and comparison of supported gold nanocatalysts on anatase, brookite, rutile, and P25 polymorphs of TiO2 for catalytic oxidation of CO 显示文摘 | Yan Wenfu Chen Bei Mahurin S M Schwartz V Mullins D R Lupini R Andrew Pennycook S J Dai Sheng Overbury S H | 2005 | Journal of Physical Chemistry B2005，109，10： | 1 |
| 7 | High levels of miticides and agrochemicals in North American apiaries: implications for honey bee health显示文摘 | MULLIN C A FRAZIER M FRAZIER J L | 2010 | PLOS2010，5，3： | 1 |
| 8 | Choice of Surveillance after H epatectomy for Colorectal Metasease显示文摘 | Metcalfe M S Mullin E J mudderm G J | 2004 | Arch Surg2004，139，7： | 1 |
| 9 | Induction of adventitious rooting in vitro in difficult-to-propagate eultivars of apple显示文摘 | Sriskandarajah S Mullins M G Nair Y | 1982 | Plant Science Letters1982，24，1： | 1 |
| 10 | A doubleblind multicentre trial comparing sertraline and fluoxetine in outpatient with major depression显示文摘 | BENNIE E MULLIN J M MARTINDALER J J | 1995 | J Clin Psychiatry1995，56，3： | 1 |
| 11 | Troponin I as a marker of cardiac toxicity in acute colchicine overdoes 显示文摘 | Mullins M E Robertson D G Norton R L | 2000 | Am J Emerg Med2000，18，6： | 1 |
| 12 | Chemical aspects of ceramic tribology显示文摘 | T E Fischer W M Mullins | 1992 | J Phy Chem1992，96，： | 1 |
| 13 | Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity 显示文摘 | BERKOWITZ B A LUKASZEW R A MULLINS C M | 1998 | Invest Ophthalmol Vis Sci1998，39，2： | 1 |
| 14 | Loss of function of the Fusarium oxysporum SNF1 gene reduces virulence on cabbage and Arabidopsis 显示文摘 | OSPINA-GIRALDO M D MULLINS E KANG S | 2003 | Curr Genet2003，44，1： | 1 |
| 15 | Vip3A, a novel Bacillus thuringiensis vegetative insecticidal protein with a wide spectrum of activities against lepidopteran insects显示文摘 | Estruch J J Warren G W Mullins M A | 1996 | Proceedings of the National Academy of Sciences of the United States of America1996，93，11： | 1 |
| 16 | Weed and crop discrimination using image analysis and artificial intelligence methods显示文摘 | Aitkenhead M J Dalgetty I A Mullins C E | 2003 | Computers and Electronics in Agriculture2003，，39： | 1 |
| 17 | Vip3A,a novel Bacillus thuringiensis vegetative insecticidal protein with a wide spectrum of activities against lepidopteran insects显示文摘 | Estruch J J Warren G W Mullins M A | 1996 | Proc Natl Acad Sci USA1996，93，11： | 1 |
| 18 | Weed and crop discrimination using image analysis and artificial intelligence methods显示文摘 | Aitkenhead M J Dalgetty I A Mullins C E | 2003 | Computers and Electronics in Agriculture2003，39，3： | 1 |
| 19 | Changes in anthocyanin and phenolics content of grapevine leaf and fruit tissues treated with sucrose,nitrate, and abscisic acid显示文摘 | PIRIE A MULLINS M G | 1976 | Plant Physiology1976，69，2： | 1 |
| 20 | Agrobacterium-mediated genetic transformation of grapevines: transgenic plants of Vitis rupestris Scheele and buds of Vitis vinifera L显示文摘 | Mullins M G Tang F C A Faceiotti B | 1990 | Bio-Technol1990，8，： | 1 |
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