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| 1 | Influence of vitamin D on liver fibrosis in chronic hepatitis C: A systematic review and meta-analysis of the pooled clinical trials data显示文摘AIM To investigate the relationship between vitamin D and liver fibrosis in hepatitis C-monoinfected or hepatitis C virus(HCV)-human immunodeficiency virus(HIV) coinfected patients. METHODS Pertinent studies were located by a library literature search in PubM ed/Embase/Cochrane/Scopus/LILACS by two individual reviewers. Inclusion criteria:(1) studies with patients with HCV or co-infected HCV/HIV;(2) studies with patients ≥ 18 years old;(3) studies that evaluated liver fibrosis stage, only based on liver biopsy; and(4) studies that reported serum or plasma 25(OH)D levels. Studies that included pediatric patients, other etiologies of liver disease, or did not use liver biopsy for fibrosis evaluation, or studies with inadequate data were excluded. Estimated measures of association reported in the literature, as well as corresponding measures of uncertainty, were recorded and corresponding odds ratios with 95%CI were included in a meta-analysis. RESULTS The pooled data of this systematic review showed that 9 of the 12 studies correlated advanced liver disease defined as a Metavir value of F3/4 with 25(OH) D level insufficiency. The meta-analysis indicated a significant association across studies.CONCLUSION Low vitamin D status is common in chronic Hepatitis C patients and is associated with advanced liver fibrosis. | Alia S Dadabhai Behnam Saberi Katie Lobner Russell T Shinohara Gerard E Mullin | 2017 | World Journal of Hepatology2017，9，5： | 6 |
| 2 | Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data显示文摘AIM To investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and fibrosis stage in patients with non-alcoholic fatty liver disease(NAFLD).METHODS Two individual reviewers identified relevant studies using the Pub Med, EMBASE, Cochrane, and Scopus databases. Inclusion criteria were as follows:(1) Studies that evaluated adults with NAFLD and serum or plasma 25(OH)D levels; and(2) assessed fibrosis stage using liver biopsy. A rigorous analysis yielded six articles as having sufficient data to employ in evaluating the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. To meta-analyze vitamin D levels in F0-F2 vs F3-F4 fibrosis, a random-effects meta-analysis fit using restricted maximum likelihood was applied. To examine trends across each stage of fibrosis with respect to vitamin D levels, a meta-regression was performed. P < 0.05 was considered statistically significant. RESULTS A total of 937 subjects from six studies were included in the final analysis to evaluate the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. First, the investigators performed a meta-analysis to compare serum vitamin D levels in patients with NAFLD with stage F0-F2 compared to F3-F4, which did not show significance [meta-estimate of the pooled mean difference =-0.86, P = 0.08(-4.17, 2.46)]. A metaregression evaluation of serum vitamin 25(OH)D levels across the individual stages(F0-F4) of fibrosis did not show an association for the six included studies.CONCLUSION Low vitamin D status is not associated with higher stages of liver fibrosis in patients with NAFLD. | Behnam Saberi Alia S Dadabhai Julie Nanavati Lin Wang Russell T Shinohara Gerard E Mullin | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 3 | Insights from the fungus Fusarium oxysporum point to high affinity glucose transporters as targets for enhancing ethanol production from lignocellulose显示文摘 | ALI S S NUGENT B MULLINS E | 2013 | PLoS One2013，8，1： | 1 |
| 4 | Consequences on ethylene metabolism of inactivating the ethylene receptor sites in diseased non-climacteric fruit 显示文摘 | MULLINS E D MCCOLLUM T G MCDONALD R E | 2000 | Postharvest Biology and Technology2000，19，2： | 1 |
| 5 | Choice of Surveillance after H epatectomy for Colorectal Metasease显示文摘 | Metcalfe M S Mullin E J mudderm G J | 2004 | Arch Surg2004，139，7： | 1 |
| 6 | A doubleblind multicentre trial comparing sertraline and fluoxetine in outpatient with major depression显示文摘 | BENNIE E MULLIN J M MARTINDALER J J | 1995 | J Clin Psychiatry1995，56，3： | 1 |
| 7 | Troponin I as a marker of cardiac toxicity in acute colchicine overdoes 显示文摘 | Mullins M E Robertson D G Norton R L | 2000 | Am J Emerg Med2000，18，6： | 1 |
| 8 | Chemical aspects of ceramic tribology显示文摘 | T E Fischer W M Mullins | 1992 | J Phy Chem1992，96，： | 1 |
| 9 | Loss of function of the Fusarium oxysporum SNF1 gene reduces virulence on cabbage and Arabidopsis 显示文摘 | OSPINA-GIRALDO M D MULLINS E KANG S | 2003 | Curr Genet2003，44，1： | 1 |
| 10 | Molecular weightmeasurement of UG8 asphaltene using APCI mass spec-troscopy显示文摘 | Cunico R L Sheu E Y Mullins O C | 2004 | Petroleum Science and Technology2004，2278，： | 1 |
| 11 | Weed and crop discrimination using image analysis and artificial intelligence methods显示文摘 | Aitkenhead M J Dalgetty I A Mullins C E | 2003 | Computers and Electronics in Agriculture2003，，39： | 1 |
| 12 | Weed and crop discrimination using image analysis and artificial intelligence methods显示文摘 | Aitkenhead M J Dalgetty I A Mullins C E | 2003 | Computers and Electronics in Agriculture2003，39，3： | 1 |
| 13 | Prevalence of incidental bochdalek's hernia in a large adult population显示文摘 | MULLINS M E STEIN J SAINNI S S | 2001 | AJR2001，177，2： | 1 |
| 14 | The resistance experienced by roots growing in a pressurized cell-a reappraisal 显示文摘 | Bengough A G Mullins C E | 1990 | Plant and Soil1990，123，1： | 1 |
| 15 | Topographic posi- tion affects the water regime in a semideciduous tropical forest in Panama显示文摘 | Daws M I Mullins C E Burslem D F R P | 2002 | Plant Soil2002，238，： | 1 |
| 16 | Agrobacterium tumefaciens-mediated transformation of Fusarium oxysprum:an efficient tool for insertional mutagenic and gene transfer显示文摘 | Mullins E D Chen X Romaine P | | 0，，： | 1 |
| 17 | How much liver resection is too much? 显示文摘 | Mullin E J Metcalfe MS Maddern GJ | 2005 | Am J Surg2005，190，1： | 1 |
| 18 | Agrobacterium-Mediated transformation of Fusarium oxysporum: an efficient tool for insertional mutagenesis and gene transfer 显示文摘 | Mullins E D Chen X Romaine P | 2001 | Phytopathology2001，91，2： | 1 |
| 19 | Arching action in FRP concrete slabs 显示文摘 | Taylor S E Barry Mullin | 2006 | Concrete and Building Materials2006，20，12： | 1 |
| 20 | Nonsurgiical closure of patent ductus arteriosus:Clinical application of the Rashkind PDA Occluder System显示文摘 | Mullins C E Hellembrand W E | 1987 | Circulaation1987，75，3： | 1 |
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