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| 1 | 血管周围脂肪组织中的Bmal1通过血管紧张素原转录调控管理静息期血压显示文摘血管周围脂肪组织(perivascular adipose tissue,PVAT)围绕血管,构成了在生理条件下保持血管张力所需的脉管系统的独特的功能整体层。然而,关于PVAT与血压调节之间的关系的资料很少,包括其对昼夜血压变化的潜在作用。 | Chang L Xiong W Zhao X Fan Y Guo Y Garcia-Barrio M Zhang J Jiang Z Lin JD Chen YE 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 23 |
| 2 | Out of southern East Asia: the natural history of domestic dogs across the world显示文摘 | Guo-Dong Wang Weiwei Zhai He-Chuan Yang Lu Wang LioZhong Yan-Hu Liu Ruo-Xi Fan Ting-Ting Yin Chun-Ling Zhu Andrei D Poyarkov David M Irwin Marjo K Hytonen Hannes Lohi Chung-I Wu Peter Savolainen Ya-Ping Zhang | 2016 | Cell Research2016，26，1： | 16 |
| 3 | Methionine adenosyltransferases in liver cancer显示文摘Methionine adenosyltransferases(MATs)are essential enzymes for life as they produce S-adenosylmethionine(SAMe),the biological methyl donor required for a plethora of reactions within the cell.Mammalian systems express two genes,MAT1A and MAT2A,which encode for MATα1 and MATα2,the catalytic subunits of the MAT isoenzymes,respectively.A third gene MAT2B,encodes a regulatory subunit known as MATβwhich controls the activity of MATα2.MAT1A,which is mainly expressed in hepatocytes,maintains the differentiated state of these cells,whilst MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal cells of the liver(e.g.,hepatic stellate and Kupffer cells).The biosynthesis of SAMe is impaired in patients with chronic liver disease and liver cancer due to decreased expression and inactivation of MATα1.A switch from MAT1A to MAT2A/MAT2B occurs in multiple liver diseases and during liver growth and dedifferentiation,but this change in the expression pattern of MATs results in reduced hepatic SAMe level.Decades of study have utilized the Mat1a-knockout(KO)mouse that spontaneously develops non-alcoholic steatohepatitis(NASH)and hepatocellular carcinoma(HCC)to elucidate a variety of mechanisms by which MAT proteins dysregulation contributes to liver carcinogenesis.An increasing volume of work indicates that MATs have SAMe-independent functions,distinct interactomes and multiple subcellular localizations.Here we aim to provide an overview of MAT biology including genes,isoenzymes and their regulation to provide the context for understanding consequences of their dysregulation.We will highlight recent breakthroughs in the field and underscore the importance of MAT’s in liver tumorigenesis as well as their potential as targets for cancer therapy. | Ben Murray Lucia Barbier-Torres Wei Fan JoséM Mato Shelly C Lu | 2019 | World Journal of Gastroenterology2019，25，31： | 10 |
| 4 | Convergent genomic signatures of high-altitude adaptation among domestic mammals显示文摘Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence.Here,we used 327 genomes from horses,sheep,goats,cattle,pigs and dogs living at both high and low altitudes,including 73 genomes generated for this study,to disentangle the genetic mechanisms underlying local adaptation of domestic mammals.Although molecular convergence is comparatively rare at the DNA sequence level,we found convergent signature of positive selection at the gene level,particularly the EPAS1 gene in these Tibetan domestic mammals.We also reported a potential function in response to hypoxia for the gene C10 orf67,which underwent positive selection in three of the domestic mammals.Our data provide an insight into adaptive evolution of high-altitude domestic mammals,and should facilitate the search for additional novel genes involved in the hypoxia response pathway. | Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang | 2020 | National Science Review2020，7，6： | 7 |
| 5 | 硬膜外腔注射吗啡新斯的明复合液用于下肢骨科手术后镇痛显示文摘 | 姚明 M Fan | 2000 | 临床麻醉学杂志2000，16，5： | 7 |
| 6 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 7 | Shift current bulk photovoltaic effect in polar materials—hybrid and oxide perovskites and beyond显示文摘The bulk photovoltaic effect(BPVE)refers to the generation of a steady photocurrent and above-bandgap photovoltage in a single-phase homogeneous material lacking inversion symmetry.The mechanism of BPVE is decidedly different from the typical p-n junction-based photovoltaic mechanism in heterogeneous materials.Recently,there has been renewed interest in ferroelectric materials for solar energy conversion,inspired by the discovery of above-bandgap photovoltages in ferroelectrics,the invention of low bandgap ferroelectric materials and the rapidly improving power conversion efficiency of metal halide perovskites.However,as long as the nature of the BPVE and its dependence on composition and structure remain poorly understood,materials engineering and the realisation of its true potential will be hampered.In this review article,we survey the history,development and recent progress in understanding the mechanisms of BPVE,with a focus on the shift current mechanism,an intrinsic BPVE that is universal to all materials lacking inversion symmetry.In addition to explaining the theory of shift current,materials design opportunities and challenges will be discussed for future applications of the BPVE. | Liang Z Tan Fan Zheng Steve M Young Fenggong Wang Shi Liu Andrew M Rappe | 2016 | npj Computational Materials2016，，1： | 4 |
| 8 | Breast cancer in China显示文摘 | Lei Fan Kathrin Strasser-Weippl Jun-Jie Li Jessica St Louis Dianne M Finkelstein Ke-Da Yu Wan-Qing Chen Zhi-Ming Shao Paul E Goss | 2014 | Lancet Oncology2014，，7： | 4 |
| 9 | A Theoretical Study on Pyrolysis and Sensitivity of Energetic Compounds(Ⅴ)──Nitro Derivatives of Methylbenzene显示文摘UHF-SCF-AM1 MO calculations were performed for two kinds of pyrolysis reactions of seven nitro derivatives of methylbenzene(homolysis reactions by the rupture of bond C-NO2 into radicals and isomerization reactions in the way of methyl H transferring to the ortho nitro O atom). The molecular geometries of the reactants, the transition states and the products of the fourteen reactions were fully optimized. The activation energies for these two kinds of reactions have been obtained. The results indicate that this category of compounds is more easily pyrolyzed by being initiated via isomerization reactions. A parallel relationship exists between the activation energy of the isomerization reactions and the impact sensitivity of the seven titled compounds. | GU Zhi-ming FAN Jian-fen XIAO He-ming and DONG Hai-shan (Department of Chemistry, Nanjing University of Science and Technology, Nanjing 210094, P. R. China Department of Chemistry, Suzhou University, Suzhou 215006, P. R. China Institute of Chemical M | 2000 | Chemical Research in Chinese Universities2000，16，1： | 4 |
| 10 | Isolation and Expression Analysis of Two Genes Encoding Cinnamate 4-Hydroxylase from Cotton(Gossypium hirsutum)显示文摘Two genes(GhC4H1 and GhC4H2) that encode putative cotton cinnamate 4-hydroxylases that catalyze the second step in the phenylpropanoid pathway were isolated from developing cotton fibers. GhC4H1 and GhC4H2 each contain open reading frames of 1 518 base pairs(bp) in length and both encode proteins consisting of 505 amino acid residues. They are 90.89% identical to each other at the amino acid sequence level and belong to class I of plant C4 Hs. GhC4H1 and GhC4H2 genomic DNA are 2 247 and 2 161 bp long, respectively, and contain two introns located at conserved positions relative to the coding sequence. GhC4H1 and GhC4H2 promoters were isolated and found to contain many cis-elements(boxes P, L and AC-I element) previously identified in the promoters of other phenylpropanoid pathway genes. Histochemical staining showed GUS expression driven by the GhC4H1 and GhC4H2 promoters in ovules and fibers tissues. GhC4H1 and GhC4H2 were also widely expressed in other cotton tissues. GhC4H2 expression reached its highest level during the elongation stage of fiber development, whereas GhC4H1 expression increased during the secondary wall development period in cotton fibers. Our results contribute to a better understanding of the biochemical role of GhC4H1 and GhC4H2 in cotton fiber development. | NI Zhi-yong LI Bo Neumann M Peter Lü Meng FAN Ling | 2014 | Journal of Integrative Agriculture2014，13，10： | 3 |
| 11 | Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice显示文摘 | Rui Kang Qiuhong Zhang Wen Hou Zhenwen Yan Ruochan Chen Jillian Bonaroti Preeti Bansal Timothy R. Billiar Allan Tsung Qingde Wang David L. Bartlett David C. Whitcomb Eugene B. Chang Xiaorong Zhu Haichao Wang Ben Lu Kevin J. Tracey Lizhi Cao Xue-Gong Fan M | 2013 | Gastroenterology2013，，： | 2 |
| 12 | Hydrogen storage in single- walled carbon nanotubes at room temperature显示文摘 | Liu C Fan Y Y Liu M | 1999 | Science1999，286，5442： | 2 |
| 13 | MProbe: computer aimed probe design for oligonucleotide microarray 显示文摘 | Li W J Huang J Fan M | 2002 | Bioinformatics2002，1，3： | 2 |
| 14 | 世界农业中硫肥研究和应用显示文摘近20年来,作物生产中硫肥的研究和经营管理已在世界各地开展起来.由于SO2排放量的降低,高效复合肥作为主要肥料的施用,以及农业生产更加集约化,缺硫已日益成为大多数农业体系中持续发展的重要议题.在北美,缺硫常出现在温带地区,因为那里降水和灌水能提供的硫很少,况且黄土和岩浆岩母质发育的土壤本底含硫量就很低.有25%的缺N土壤,也缺S.这些土壤除非配施了S肥,否则,仅施N肥的效果很低.北美在作物施硫效应、土壤测定方法的发展,以及S肥施用的推广等方面,都取得了相当多的成果.在加拿大和美国施用硫11~56 kg/ha已在实际生产中广泛采用.在欧洲,由于SO2排放量的降低以及农业集约化经营,包括高效无硫复合肥的施用,使欧洲农业生产走向恶化.欧洲北部农作区的缺硫已成为耕地作物的障碍因子.根据一项采用土壤、大气沉降和气象资料所设计的质量评估模式显示,在英国(UK)有11%的土地处于严重缺硫区,22%属中等缺硫区.如果在该国SO2排放量到2003年降低到1986年排放量的60%,那么,将有23%的农田成为严重缺硫区,27%成为中等缺硫区,这实际上相当于该国的全部可耕地.亚洲农业对硫肥需求量的增加将是最高的.近20年来通过不断增加N肥的用量来加强农业生产的集约化,导致了营养的不平衡,使作物广泛缺硫.大量试验结果表明,在中国主要农作区大约有30%的土壤(大约相当于3000万公顷的面积)是缺硫的.印度在研究土壤S状况和农业中硫肥施用技术方面取得了很大进展.目前,印度有30%的土壤缺硫.40多种大田作物施用硫肥有积极效果;15个州130个地区的5100万公顷(相当于印度16900万公顷耕地的30%)基本上肯定在不同程度上缺硫.对一些州的主要作物,硫肥的特别推荐用量是20~50 kg/ha.施用硫肥可增加产量,改善品质,其经济效益一般都超过了硫肥成本.这种产投比的提高,最终增加了生产效率和农民的经济收入.1995年全世界通过施肥而进入土壤中的硫仅为910万吨,其中73%是以硫铵和普钙中的S施入的.目前,对每年世界硫亏缺量的估计表明作物生产中硫的需求量增加了730万吨.如果粮食生产继续按现有速度增长,那么,在生产增长和继续需硫的情况下,估计世界硫肥市场的年平均增长率将会是3.7%,到2007年达到1050万吨. | D L Messick M X Fan | 2000 | 安徽农业大学学报2000，27，z1： | 2 |
| 15 | Optimal harvesting policy for single population with periodic coefficients显示文摘 | Fan M Wang K | 1998 | Math Biosci1998，152，1： | 2 |
| 16 | 中国农业持续发展中的硫肥及其重要性显示文摘在现在农业生产中,增施肥料不失为一个作物增产的战略措施.硫和N、P、K一样,是植物不可缺乏的营养元素.近年来在中国卓有成效的研究,已经取得了显著的成果.现已了解到缺硫正越来越成为农业持续增产中的限制因子之一.1994年以来,已经在17个省进行了110个田间硫肥试验.为了查清土壤硫肥力状况,已对10000多个农田土壤样品进行分析.结果表明,在中国,大约有30%土壤缺硫.特别是安徽、黑龙江、河南、江西、吉林、辽宁、陕西和云南等省,土壤缺硫面积较大.农业土壤的缺硫不仅仅由于土壤本身性质(如质地和有机质含量)所决定,而且与施肥和种植制度也密切相关.在中国,施用硫肥已明显地提高了稻、麦、玉米、马铃薯、大豆、花生、油菜、棉花、蕃茄、茶叶、甘蔗和甜菜等主要作物的产量.从总的情况来看,旱地作物,如花生、大豆、玉米、烟草、油料和糖料作物施硫效果更好.硫肥的施用也改进了作物品质,增加了它们的市场价值.这一点对油菜、甘蔗和茶叶来说,意义尤为重要.对中国S平衡的分析表明,1995年S亏缺量为90万吨,占总需求量的27%.到2010年,S亏缺量增加到230万吨.这些分析指出,随着农业生产的不断提高和无硫高效肥料的继续施用,中国农业中严重缺硫问题将不可避免地发生.因此,只有从有效地提供S肥的战略高度出发,才能保持农业的持续发展.据推测,在未来的10年中,中国的硫肥使用将会显著增加,包括S在内的平衡施肥,将对中国农业作出更大贡献. | M X Fan D L Messick | 2000 | 安徽农业大学学报2000，27，z1： | 2 |
| 17 | Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression显示文摘 | Endres M Fan G Hirt L | 2000 | J Cereb Blood Flow Metab2000，20，1： | 2 |
| 18 | Headspace solid phase microextraction and gas chromatography-olfactometry dilution analysis of young and aged Chinese'Yanghe Daqu'liquors显示文摘 | Fan W L Qian M C | 2005 | Journal of Agricultural and Food Chemistry2005，53，20： | 2 |
| 19 | Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro 显示文摘 | Fan J M Ng Y Y Hill P A | 1999 | Kidney Int1999，56，4： | 2 |
| 20 | Insights into human CD34(+) hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome显示文摘 | Liu F Lu J Fan HH Wang ZQ Cui SJ Zhang GA Chi M Zhang X Yang PY Chen Z Han ZG | 2006 | 中国生物学文摘2006，20，5： | 2 |
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