|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer显示文摘BACKGROUND The connection between inflammatory bowel disease(IBD)and colorectal cancer(CRC)is well-established,as persistent intestinal inflammation plays a substantial role in both disorders.Cytokines may further influence the inflammation and the carcinogenesis process.AIM To compare cytokine patterns of active IBD patients with early and advanced CRC.METHODS Choosing a panel of cytokines crucial for Th17/Treg differentiation and behavior,in colon specimens,as mRNA biomarkers,and their serum protein levels.RESULTS We found a significant difference between higher gene expression of FoxP3,TGFb1,IL-10,and IL-23,and approximately equal level of IL-6 in CRC patients in comparison with IBD patients.After stratification of CRC patients,we found a significant difference in FoxP3,IL-10,IL-23,and IL-17A mRNA in early cases compared to IBD,and IL-23 alone in advanced CRC.The protein levels of the cytokines were significantly higher in CRC patients compared to IBD patients.CONCLUSION Our findings showed that IL-6 upregulation is essential for both IBD and CRC development until the upregulation of other Th17/Treg related genes(TGFb1,IL-10,IL-23,and transcription factor FoxP3)is a crucial primarily for CRC development.The significantly upregulated IL-6 could be a potential drug target for IBD and prevention of CRC development as well. | Tsvetelina Veselinova Velikova Lyuba Miteva Noyko Stanilov Zoya Spassova Spaska Angelova Stanilova | 2020 | World Journal of Gastroenterology2020，26，16： | 10 |
| 2 | Structure-activity relationship in water-gas shift reaction over gold catalysts supported on Y-doped ceria显示文摘The utilization of pure hydrogen as an energy source in fuel cells gave rise to renewed interest in developing active and stable water-gas shift catalysts. Gold catalysts have proven to be very efficient for water-gas shift reaction at low temperature. The aim of the present study was to investigate the effect of:(i) different preparation methods(impregnation and coprecipitation) to obtain a modified ceria support,and(ii) the amount of Y_2 O_3(1.0 wt%, 2.5 wt%, 5.0 wt% and 7.5 wt%) as dopant on the water-gas shift activity of Au/CeO_2 catalysts. An extended characterization by means of S_(BET), XRD, HRTEM/HAADF, FTIR,H_2-TPR and CO-TPR measurements in combination with careful evaluation of the catalyst behavior allowed to shed light on the parameters governing the water-gas shift activity. The catalysts show very high activity(>90% CO conversion) in the temperature range 180-220 ℃,with a slightly better performance of the gold catalysts on supports prepared by impregnation. The decreased activity with increasing Y_2 O_3 concentration is related to the hindering of oxygen mobility due to ordering of surface oxygen vacancies in vicinity of segregated Y^(3+). The effect of catalyst pre-treatments and the stability of the best performing samples were examined as well. | Tatyana Tabakova Lyuba Ilieva Ivan Ivanov Maela Manzoli Rodolfo Zanella Petya Petrova Zbigniew Kaszkur | 2019 | Journal of Rare Earths2019，37，4： | 4 |
| 3 | Screening of Plant Extracts for Antioxidant Activity: a Comparative Study on Three Testing Methods显示文摘 | Irina I.Koleva Teris A.van Beek Jozef P. H.Linssen Aede deGroot Lyuba N.Evstatieva | 2002 | Phytochem Anal2002，，1： | 1 |
| 4 | Characterisation of the nanoporous structure of collagen-glycosaminoglycan hydrogels by freezing-out of bulk and bound water显示文摘 | Lyuba I. Mikhalovska Vlad M. Gun’ko Vlad V. Turov Vlad I. Zarko Stuart L. James Pankaj Vadgama Paul E. Tomlins Sergey Victorovich Mikhalovsky | 2006 | Biomaterials2006，，19： | 1 |
| 5 | Cellular delivery of antisense oligonucleotides 显示文摘 | Irina L Lyuba B Stein CA | 2000 | Eur J Pharm Biopharm2000，50，1： | 1 |
| 6 | The p53 tumor suppressor network is a key responder to micro en- vironmental components of chronic inflammatory stress显示文摘 | Frank Staib Ana I Robles Lyuba Varticovskil | 2006 | Cancer Res2006，118，： | 1 |
| 7 | 无处不在的文化差异显示文摘中西方文化差异其实是广泛存在于不同领域的——比如每天的生活习惯、信仰、道德观、饮食文化等。而我自然会选择我所擅长的领域来谈一谈,就是家庭教育和学术教育上的中西方文化差异。中国人的生活是以家庭为中心、以家庭价值观为主导的。对他们来说,这种关系(甚至是依赖关系)是极其强大的。我经常跟那些为了顺从父母心意而放弃自己个人选择和目标的学生提到这一点。 | Lyuba Atanasova 谢惠君 | 2019 | 国际人才交流2019，0，4： | 1 |
| 8 | Alterations of the content of hydrogen peroxide and malondialdehyde and the activity of some antioxidant enzymes in the roots and leaves of pea and wheat plants exposed to g/yphosate 显示文摘 | Miteva Lyuba Sergive Ivanov Alexieva Vera | 2005 | Science2005，58，： | 1 |
| 9 | Screening of Plant Extracts for Antioxidant Activity: a Comparative Study on Three Testing Methods显示文摘 | Irina I.Koleva Teris A.van Beek Jozef P. H.Linssen Aede deGroot Lyuba N.Evstatieva | 2002 | Phytochem. Anal2002，，1： | 1 |
| 10 | Cellular delivery of antisense oligonucleotides 显示文摘 | Irina L Lyuba B Stein CA | 2000 | Eur J Pharm Biopharm2000，50，1： | 1 |
| 11 | Characterisation of nano- and micron-sized airborne and collected subway particles, a multi-analytical approach显示文摘 | Klara Midander Karine Elihn Anna Wallén Lyuba Belova Anna-Karin Borg Karlsson Inger Odnevall Wallinder | 2012 | Science of the Total Environment2012，，： | 1 |
| 12 | Bombesin stimulates nuclear factor B activation and expression of proangiogenic factors in prostate cancer cells显示文摘 | Lyuba Levine Joseph A Lucci Ⅲ Barbara Pazdrak | 2003 | Cancer Research2003，63，1： | 1 |
| 13 | In vitro host response assessment of biomaterials for cardiovascular stent manufacture显示文摘 | Matteo Santin Lyuba Mikhalovska Andrew W. Lloyd Sergey Mikhalovsky Louise Sigfrid Stephen P. Denyer Susanna Field Dennis Teer | 2004 | Journal of Materials Science: Materials in Medicine2004，，4： | 1 |
| 14 | Emerging robot swarm traffic显示文摘Purpose-This paper aims to discuss traffic patterns generated by swarms of robots while commuting to and from a base station.Design/methodology/approach-The paper adopts a mathematical evaluation and robot swarm simulation.The swarm approach is bottom-up:designing individual agents the authors are looking for emerging group behaviour patterns.Examples of group behaviour patterns are human-driven motorized traffic which is rigidly structured in two lanes,while army ants develop a three-lane pattern in their traffic.The authors copy army ant characteristics onto their robots and investigate whether the three lane traffic pattern may emerge.They follow a three-step approach.The authors first investigate the mathematics and geometry of cases occurring when applying the artificial potential field method to three“perfect”robots.Any traffic pattern(two,three or more lanes)appears to be possible.Next,they use the mathematical cases to study the impact of limited visibility by defining models of sensor designs.In the final step the authors implement ant inspired sensor models and a trail following mechanism on the robots in the swarm and explore which traffic patterns do emerge in open space as well as in bounded roads.Findings-The study finds that traffic lanes emerge in the swarm traffic;however the number of lanes is dependent on the initial situation and environmental conditions.Intrinsically the applied robot models do not determine a specific number of traffic lanes.Originality/value-The paper presents a method for studying and simulating robot swarms. | Jacques Penders Lyuba Alboul | 2012 | International Journal of Intelligent Computing and Cybernetics2012，5，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员