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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Immunological response in alcoholic liver disease显示文摘The development of alcoholic liver disease (ALD) can be attributed to many factors that cause damage to the liver and alter its functions. Data collected over the last 30 years strongly suggests that an immune component may be involved in the onset of this disease. This is best evidenced by the detection of circulating autoantibodies, infiltration of immune cells in the liver, and the detection of hepatic aldehyde modified proteins in patients with ALD. Experimentally, there are numerous immune responses that occur when proteins are modified with the metabolites of ethanol. These products are formed in response to the high oxidative state of the liver during ethanol metabolism, causing the release of many inflammatory processes and potential of necrosis or apoptosis of liver cells. Should cellular proteins become modified with these reactive alcohol metabolites and be recognized by the immune system, then immune responses may be initiated. Therefore, it was the purpose of this article to shed some insight into how the immune system is involved in the development and/or progression of ALD. | Michael J Duryee Lynell W Klassen Geoffrey M Thiele | 2007 | World Journal of Gastroenterology2007，13，37： | 9 |
| 3 | Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis显示文摘 | Michael JD Lynell WK Courtney SS | | 0，，10： | 1 |
| 4 | Does public reporting measure up-Federalism,accountability and child-care policy in Canada显示文摘 | Lynell Anderson Tammy | 2010 | Canadianpublic administration: Administration publique du Canada2010，53，3： | 1 |
| 5 | Epidemiology of a tuberculosis outbreak in a rural missouri high school 显示文摘 | Lynelle P John C Diane S | 2004 | PEDIATRICS2004，113，6： | 1 |
| 6 | Reproductive Potential: Its Influence on the Susceptibility of a Species to Pesticides显示文摘 | John D. Stark Lynell Tanigoshi Malika Bounfour Arthur Antonelli | 1997 | Ecotoxicology and Environmental Safety1997，，3： | 1 |
| 7 | Short- term exercise training increase Ach- induced relaxation and eNOS protein in porcine pulmonary arteries显示文摘 | Lynelle R Johnson James W E Rhsh James R Turk | | 0，，： | 1 |
| 8 | Short-term exercise training increises Ach-induced relaxation and eNOS protein in porclne pulmomary arteries显示文摘 | Lynelle R Johnson | 2001 | Appl Physiol2001，99，： | 1 |
| 9 | Statin Treatment and Functional Outcome After Ischemic Stroke: Case–Control and Meta-Analysis显示文摘 | Alessandro Biffi William J. Devan Christopher D. Anderson Lynelle Cortellini Karen L. Furie Jonathan Rosand Natalia S. Rost | 2011 | Stroke A Journal of Cerebral Circulation2011，，5： | 1 |
| 10 | Short-term exercise training increase Ach-induced relaxation and eNOS proteinin porcine pulmonary arteries显示文摘 | Lynelle R Johnson James W E Rush James R Turk | 2001 | J Appl Physiol2001，90，： | 1 |
| 11 | Preselection of predatory mites to improve year-round biological control of western flower thrips in greenhouse crops显示文摘 | Yvonne M. Houten Paul C. J. Rijn Lynell K. Tanigoshi Pam Stratum Jan Bruin | 1995 | Entomologia Experimentalis et Applicata1995，，3： | 1 |
| 12 | Short-term exercise training increises Ach-induced relaxation and eNOS protein in porcine pulmomary arteries显示文摘 | LYNELLE R JOHNSON | 2001 | Appl Physiol2001，99，： | 1 |
| 13 | Malondialdehyde–acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis显示文摘 | Michael J. Duryee Lynell W. Klassen Courtney S. Schaffert Dean J. Tuma Carlos D. Hunter Robert P. Garvin Daniel R. Anderson Geoffrey M. Thiele | 2010 | Free Radical Biology and Medicine2010，，10： | 1 |
| 14 | Lynelle:十年磨一剑 | 齐介仑 Lynelle McKay | 2006 | 电子经理世界2006，0，7： | 0 |
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