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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Immunological response in alcoholic liver disease显示文摘The development of alcoholic liver disease (ALD) can be attributed to many factors that cause damage to the liver and alter its functions. Data collected over the last 30 years strongly suggests that an immune component may be involved in the onset of this disease. This is best evidenced by the detection of circulating autoantibodies, infiltration of immune cells in the liver, and the detection of hepatic aldehyde modified proteins in patients with ALD. Experimentally, there are numerous immune responses that occur when proteins are modified with the metabolites of ethanol. These products are formed in response to the high oxidative state of the liver during ethanol metabolism, causing the release of many inflammatory processes and potential of necrosis or apoptosis of liver cells. Should cellular proteins become modified with these reactive alcohol metabolites and be recognized by the immune system, then immune responses may be initiated. Therefore, it was the purpose of this article to shed some insight into how the immune system is involved in the development and/or progression of ALD. | Michael J Duryee Lynell W Klassen Geoffrey M Thiele | 2007 | World Journal of Gastroenterology2007，13，37： | 9 |
| 3 | Scavenger receptorson sinusoidal liver endothelial cells are involved in the uptake ofaldehyde - modified proteins 显示文摘 | Duryee MJ Freeman TL Willis MS | 2005 | Mol Pharmacol2005，68，5： | 1 |
| 4 | Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells 显示文摘 | Duryee M J Klassen LW Freeman TL | 2003 | Biochem Pharmacol2003，66，6： | 1 |
| 5 | Albumin-based microbubbles bind up-regulated scavenger receptors following vascular injury显示文摘 | Anderson DR Duryee MJ Anellan RK | 2010 | J Biol Chem2010，285，40： | 1 |
| 6 | Rat sinusoidal liver endothelial cells produce pro-fibrotic factors in response to adduets formed from the metabolites nf ethanol 显示文摘 | Thiele GM Duryee M J Freeman TL | 2005 | Biochem Pharmacol2005，70，11： | 1 |
| 7 | Lipopolysaccharide is a cofactor for ???? malondia/dehyde- acetaldehyde adduct- mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells显示文摘 | Duryee M J Klassen L W Freeman T L | 2004 | Alcohol Clin Exp Res2004，28，： | 1 |
| 8 | Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis显示文摘 | Duryee MJ Klassen LW Schaffert CS | 2010 | Free Radic Biol Med2010，49，10： | 1 |
| 9 | Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis显示文摘 | Duryee MJ Klassen LW Schaffert CS | 2010 | Free Radic Biol Med2010，49，10： | 1 |
| 10 | Rat sinusoidal liver endothelial cells (SECs) produce profibrotic factors in response to adducts formed from the metabolites of ethanol显示文摘 | Thiele G M Duryee M J Freeman T L | 2005 | Biochem Pharmacol2005，70，： | 1 |
| 11 | Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis显示文摘 | Schaffert C S Duryee M J Bennett R G | 2010 | Am J Physiol:Gastrointestinal Liver Physiol2010，299，3： | 1 |
| 12 | Autoimmune hepatitis in- duced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites 显示文摘 | Thiele GM Duryee MJ Willis MS | 2010 | Alcohol Clin Exp Res2010，34，12： | 1 |
| 13 | Carbohydrate metabolism in Micrococcus radiodurans 显示文摘 | Duryee F L Elliker P R Anderson A W Raj H D Wang C H | 1961 | Canadian Journal of Microbiology1961，7，5： | 1 |
| 14 | Malondialdehyde- acetaldehyde adduct is the dominant epitope after MDA modifica- tion of proteins in atherosclerosis显示文摘 | Duryee M J Klassen L W Schaffert C S | 2010 | Free Radic Biol Med2010，49，10： | 1 |
| 15 | Exposure ofprecision-cut rat liver slices to ethanol accelerates fibrogenesis显示文摘 | Schaffert C S Duryee M J Bennett R G | 2010 | Am J Physiol Gastrointest Liver Physiol2010，299，3： | 1 |
| 16 | Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde 显示文摘 | Duryee MJ Klassen LW Jones BL | 2008 | Int Immunopharmacol2008，8，8： | 1 |
| 17 | An in vitro method of alcoholic liver injury using precision-cut liver slices from rats 显示文摘 | KLASSEN LW THIELE GM DURYEE M J | 2008 | Biochem Pharmacol2008，76，3： | 1 |
| 18 | Differences in geriatric psychiatry outpatients with early vs late-onset depression显示文摘 | Holroyd S Duryee JJ | 2004 | Int J Geriatr Psychiatry2004，36，： | 1 |
| 19 | Chronic ethanol consmnption impairs receptor - mediated endocytosis of MAA - modified albumin by liver endothelial cells显示文摘 | Duryee MJ Klassen LW Freeman TL | 2003 | Biochem Pharmacol2003，66，6： | 1 |
| 20 | Rat sinusoidal liver endothelial cells produce pro - fibrotic factors in response to adducls formed from the metabolites of ethanol显示文摘 | Thiele GM Duryee MJ Freeman TL | 2005 | Biochemical Pharmacology2005，70，11： | 1 |
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