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| 1 | Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review显示文摘AIM:To report our experience with long-term outcomes after multimodal management therapy.METHODS:An observational retrospective study was performed containing seven patients with hepatoblastoma(Hbl)treated in our institution,a tertiary referral center,from 2003 to 2011.Demographic,preoperative,surgical,and outcome variables were collected.A survival analysis and a review of the current literature related to combination neoadjuvant chemotherapy and surgical resection on Hbl were performed.RESULTS:The median age at surgery was 14.4 mo,with a male to female ratio of 4:3.Pretext staging at diagnosis was as follows:stageⅠ,4 cases;stageⅡ,2 patients;and stageⅢ,1 case.Mean pretreatment tumor volume was 735 cm3.Five out of seven patients received neoadjuvant chemotherapy according to SIOPEL-3 or SIOPEL-6 protocols.Tumor volume and alphafetoprotein levels significantly dropped after neoadjuvant therapy.Surgical procedures performed included hemihepatectomies,segmentectomies and atypical resection.All patients received chemotherapy after surgery.Median postoperative hospital stay was 8 d.All patients were alive and disease-free after a median follow-up period of 23 mo.With regards to the literature review,seventeen articles were found that were related to our search.CONCLUSION:Our series shows how multimodal management of Hbl,exhaustive control and a meticulous surgical approach leads to almost 100%complete resection with optimal postoperative results. | Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María José Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado | 2014 | World Journal of Gastroenterology2014，20，29： | 12 |
| 2 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 3 | Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation显示文摘Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult hippocampus.However,this effect has not been observed in long-term sleep deprivation.The precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this process.In this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword clusterization.Our results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate gyrus.We observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep deprivation.In addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(BrdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated group.These findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived conditions.All procedures performed in this study were approved by the Animal Ethics Committee of the University of Guadalajara,Mexico(approval No.CI-16610)on January 2,2016. | Alan Hinojosa-Godínez Luis F. Jave-Suarez Mario Flores-Soto Alma Y. Gálvez-Contreras Sonia Luquín Edith Oregon-Romero Oscar González-Pérez Rocio E. González-Castaneda | 2019 | Neural Regeneration Research2019，14，10： | 2 |
| 4 | Effect of planting date and planting densities on grain number and yield of maize显示文摘 | Cantarero M G Luque S F Rubiolo O J | 2000 | Agricultural Science2000，17，： | 1 |
| 5 | Electric and Thermal Model for Non-uniformly Illuminated Concentration Cells 显示文摘 | Luque A Sala G Arboiro J C | 1998 | Solar Energy Materials & Solar Cells1998，51，： | 1 |
| 6 | Comparison of ultra- and microfihration in the presence and absence of secondary flow with polysaccharides, proteins, and yeast suspensions 显示文摘 | Gehlert G Luque S Belfort G | 1998 | Biotech Prog1998，14，： | 1 |
| 7 | DNA Fragment Assembly Using a Grid-based Genetic Algorithm显示文摘 | NEBRO A J LUQUE G LUNA F | 2008 | Computers & Operations Research2008，35，： | 1 |
| 8 | A Model of Fuzzy Linguistic IRS Based on Multi-granular Linguistic In- formation显示文摘 | Herrera-Viedma E Cordon O Luque M Lopez A G Mufioz A M | 2003 | Internatiooal Journal of Approximate Reasoning2003，34，23： | 1 |
| 9 | Combined cavity ringdown absorption and laser-induced fluorescence imaging measurements of CN(B-X) and CH(B-X) in low-pressure CH4-O2-N2 and CH4-NO-O2-N2 flames显示文摘 | Luque J Jefiries J B Smith G P | 2001 | Combust Flame2001，126，17： | 1 |
| 10 | Quantitative analysis of somatostatin receptor subtypes(1-5)gene expression levels in somatotropinomas and correlation to in vivo hormonal and tumor responses to treatment with octreotide LAR显示文摘 | TABOADA G F LUQUE R M NETO L V | 2008 | Eur J Endocrinol2008，158，3： | 1 |
| 11 | Chemical Vapor Deposition Model of Polysilicon in a Trichloro silane and Hydrogen System显示文摘 | Del Coso G Del C Luque A | 2008 | Electrochem Society2008，155，6： | 1 |
| 12 | Chemical Vapor Deposition Model of Polysilicon in a Trichlorosilane and Hydrogen System显示文摘 | Del Coso G Del C Luque A | 2008 | Electrochem Society2008，155，6： | 1 |
| 13 | Continuous subcritical water extraction of medicinal plant essential oil:comparison with conventional techniques显示文摘 | Gámiz-Gracia L Luque de Castro M D | 2000 | Talanta2000，51，： | 1 |
| 14 | Ultrasound: a powerful tool for leaching显示文摘 | LUQUE G A LUQUE D E CASTRO M D | 2003 | Trends in Analytical Chemistry2003，22，1： | 1 |
| 15 | A comparative study of apical leakage of endomethasone,top Seal,and roeko seal sealer cements 显示文摘 | Martin CL Luque F Rodriguez G | 2002 | J Endod2002，28，6： | 1 |
| 16 | Suspended brain in a degraded bottom: bilateral subdural chronic hematomas with acute rebleeding 显示文摘 | Luque JC Monsalve G | 2010 | J Trauma2010，69，1： | 1 |
| 17 | Management of uecrotizion pancreatitis by repeated operative necrosectomy using zipper technique显示文摘 | Luque de Leon E Sorrelde J A | 1998 | Am J Surs1998，175，2： | 1 |
| 18 | Parallel metaheuristics: recent advances and new trends 显示文摘 | Alba E Luque G Nesmachnow S | 2013 | International Transactions in Operational Research2013，20，1： | 1 |
| 19 | Radiative Energy Loss in a Polysilicon CVD Reactor显示文摘 | Coso G Canizo C Luque A | 2011 | Solar Energy Materials & Solar Cells2011，，95： | 1 |
| 20 | Object-oriented techniques for design and development of standard software solutions in automation and data management in analytical chemistry显示文摘 | Urbano-Cuadrado M Luque de Castro M D Gómez-Nieto M A | 2006 | Trends in Analytical Chemistry2006，25，1： | 1 |
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