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| 1 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 2 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 3 | Dietary approach in the treatment of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) has been identified as one of the most prevalent chronic liver disease in adults and children populations. NAFLD is usually associated with the metabolic syndrome(MS), which is chiefly related to insulin resistance and its consequences. Insulin resistance has a crucial role in the pathogenesis of hepatic steatosis and potentially nonalcoholic steatohepatitis(NASH). Because of the contemporary epidemics of MS and obesity, the burden of NAFLD is also expected to rise. Unhealthy diets, such as the so-called western diet, are enriched in fructose, trans-fatty acids and saturated fat and seem to be associated with the development of NAFLD. In human studies, certain dietary sugars, particularly fructose, are used as a substrate for lipogenesis leading to hepatic fatty infiltration, inflammation, and possibly fibrosis. Other investigations have shown that fat consumption especially cholesterol and trans/saturated fatty acids are also steatogenic and seem to increase visceral adiposity. The identification of specific dietary components that favor the development of NASH could be important for the management of this disorder. This review focuses on the effects of different dietary approaches to prevent and treat NAFLD emphasizing the macronutrients and energy composition. | Silvia Marinho Ferolla Luciana Costa Silva Maria de Lourdes Abreu Ferrari Aloísio Sales da Cunha Flaviano dos Santos Martins Cláudia Alves Couto Teresa Cristina Abreu Ferrari | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 4 | Parathyroid ultrasonography and bone metabolic profile of patients on dialysis with hyperparathyroidism显示文摘AIM To evaluate the parathyroid ultrasonography and define parameters that can predict poor response to treatment in patients with secondary hyperparathyroidism due to renal failure.METHODS This cohort study evaluated 85 patients with chronic kidney disease stage V with parathyroid hormone levels above 800 pg/mL. All patients underwent ultrasonography of the parathyroids and the following parameters were analyzed: Demographic characteristics(etiology of chronic kidney disease, gender, age, dialysis vintage, vascular access, use of vitamin D), laboratory(calcium, phosphorus, parathyroid hormone, alkaline phosphatase, bone alkaline phosphatase), and the occurrence of bone changes, cardiovascular events and death. The χ~2 test were used to compare proportions or the Fisher exact test for small sample frequencies. Student t-test was used to detect differences between the two groups regarding continuous variables.RESULTS Fifty-three patients(66.4%) had parathyroid nodules with higher levels of parathyroid hormone, calcium and phosphorus. Sixteen patients underwent parathyroidectomy and had higher levels of phosphorus and calcium × phosphorus product(P = 0.03 and P = 0.006, respectively). They also had lower mortality(32% vs 68%, P = 0.01) and lower incidence of cardiovascular or cerebrovascular events(27% vs 73%, P = 0.02). Calcium × phosphorus product above 55 mg^2/dL^2 [RR 1.48(1.06, 2.08), P = 0.03], presence of vascular calcification [1.33(1.01, 1.76), P = 0.015] and previous occurrence of vascular events [RR 2.25(1.27, 3.98), P < 0.001] were risk factors for mortality in this population. There was no association between the occurrence of nodules and mortality.CONCLUSION The identification of nodules at ultrasonography strengthens the indication for parathyroidectomy in patients with secondary hyperparathyroidism due to renal failure. | Cláudia Ribeiro Maria Goretti Moreira Guimaraes Penido Milena Maria Moreira Guimaraes Marcelo de Sousa Tavares Bruno das Neves Souza Anderson Ferreira Leite Leonardo Martins Caldeira de Deus Lucas Joséde Campos Machado | 2016 | World Journal of Nephrology2016，5，5： | 2 |
| 5 | Local delivery of EGF -liposome mediated bone modeling in orthodontic tooth movement by increasing RANKL expression显示文摘 | Alves JB Ferreira CL Martins AF | 2009 | Life Sci2009，85，920： | 1 |
| 6 | HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection显示文摘 | Khakoo SI Thio CL Martin MP | 2004 | Science2004，305，： | 1 |
| 7 | Vibration perception threshold as a measure of distal symmetrical peripheral neuropathy in type 1 diabetes results from the DCCT/EDIC study 显示文摘 | Martin CL Waberski BH Pop-Busui R | 2010 | Diabetes Care2010，33，12： | 1 |
| 8 | Vibration perception threshold as a measure of distal symmetrical peripheral neuropathy in diabetes : results from the DCCT/EDIC study显示文摘 | Martin CL Waberski BH Pop-Busui R | 2010 | Diabetes Care2010，33，12： | 1 |
| 9 | Serum micronutrient concentrations and risk of uterine fibroids 显示文摘 | Martin CL Huber LR Thompson ME | 2011 | J Women''s Health2011，20，6： | 1 |
| 10 | A donor-site preference utility study for three gaps used in lower extremity microvascular recon- struction 显示文摘 | Yeung LC Ellstrom CL Martin MC | 2011 | Ann Plast Surg2011，66，1： | 1 |
| 11 | Genetic variation in IL28B and spontaneous clearance of hepatitis C virus显示文摘 | Thomas DL Thio CL Martin MP | 2009 | Nature2009，461，7265： | 1 |
| 12 | The genotype of Toxoplasma gondii strains causing ocular toxoplasmosis in humans in Brazil显示文摘 | Adriana Lima Vallochi Cristina Muccioli Maria Cristina Martins Cláudio Silveira Rubens Belfort Luiz Vicente Rizzo | 2005 | American Journal of Ophthalmology2005，，2： | 1 |
| 13 | Tumor stroma marker cndosialin( Tern 1) is a binding partner of metasltasis-related prorcin Mac-2 BP/90K 显示文摘 | Renate B Martin CL | 2008 | The FASEB Joumal2008，22，： | 1 |
| 14 | Genetic variation in IL28B and spontaneous clearance of hepatitis C virus 显示文摘 | Thomas DL Thio CL Martin MP | 2009 | Nature2009，461，7265： | 1 |
| 15 | A pilot exploratory study of oral electrical stimulation on swallow function following stroke:an innovative technique显示文摘 | O'Neill PA Martin DF | 1997 | Dysphagia1997，12，： | 1 |
| 16 | Mcoplasma genitalium-Encoded MG309 Acti- vates NF-B via Toll-LikeReceptors 2 and 6 To Elicit Proinflammatory Cytokine Secretion from Human Genital Epithelial ells显示文摘 | MeGowin CL Ma L Martin DH | 2009 | Infection and Immunity2009，77，3： | 1 |
| 17 | Neuropathy among the Diabetes Control and Complications Trial cohort 8 years after trial completion 显示文摘 | Martin CL Albers J Herman WH | 2006 | Diabetes Care2006，29，： | 1 |
| 18 | Glutamate and GABA content of calbindin-immunoreactive nerve terminals in the rat intermediolateal cell column 显示文摘 | Lewellyn-Smith I J Martin CL Minson JB | 2002 | Autonomic Neuroscience:Basic and Clinical2002，98，： | 1 |
| 19 | Genomic insights into thecauses and classification ofthe cerebral palsies 显示文摘 | Moreno-De-Luca A Ledbetter DH Martin CL | 2012 | Lancet Neurol2012，11，3： | 1 |
| 20 | Preconditioning:an endogenous defense against the insult of myocardial ischemia显示文摘 | Martin HB Walter CL | 1996 | Anesth Analg1996，83，： | 1 |
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