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| 1 | Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review显示文摘AIM:To report our experience with long-term outcomes after multimodal management therapy.METHODS:An observational retrospective study was performed containing seven patients with hepatoblastoma(Hbl)treated in our institution,a tertiary referral center,from 2003 to 2011.Demographic,preoperative,surgical,and outcome variables were collected.A survival analysis and a review of the current literature related to combination neoadjuvant chemotherapy and surgical resection on Hbl were performed.RESULTS:The median age at surgery was 14.4 mo,with a male to female ratio of 4:3.Pretext staging at diagnosis was as follows:stageⅠ,4 cases;stageⅡ,2 patients;and stageⅢ,1 case.Mean pretreatment tumor volume was 735 cm3.Five out of seven patients received neoadjuvant chemotherapy according to SIOPEL-3 or SIOPEL-6 protocols.Tumor volume and alphafetoprotein levels significantly dropped after neoadjuvant therapy.Surgical procedures performed included hemihepatectomies,segmentectomies and atypical resection.All patients received chemotherapy after surgery.Median postoperative hospital stay was 8 d.All patients were alive and disease-free after a median follow-up period of 23 mo.With regards to the literature review,seventeen articles were found that were related to our search.CONCLUSION:Our series shows how multimodal management of Hbl,exhaustive control and a meticulous surgical approach leads to almost 100%complete resection with optimal postoperative results. | Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María José Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado | 2014 | World Journal of Gastroenterology2014，20，29： | 12 |
| 2 | Denervated muscle extract promotes recovery of muscle atrophy through activation of satellite cells. An experimental study显示文摘Purpose: The objective of the present study was to determine whether a denervated muscle extract(DmEx) could stimulate satellite cell response in denervated muscle.Methods: Wistar rats were divided into 4 groups: normal rats, normal rats treated with DmEx, denervated rats, and denervated rats treated with DmEx. The soleus muscles were examined using immunohistochemical techniques for proliferating cell nuclear antigen, desmin, and myogenic differentiation antigen(MyoD), and electron microscopy was used for analysis of the satellite cells.Results: The results indicate that while denervation causes activation of satellite cells, DmEx also induces myogenic differentiation of cells localized in the interstitial space and the formation of new muscle fibers. Although DmEx had a similar effect in nature on innervated and denervated muscles, this response was of greater magnitude in denervated vs. intact muscles.Conclusion: Our study shows that treatment of denervated rats with DmEx potentiates the myogenic response in atrophic denervated muscles. | Eduardo Aguera Salvador Castilla Evelio Luque Ignacio Jimena Ignacio Ruz-Caracuel Fernando Leiva-Cepas Jos Pea | 2019 | Journal of Sport and Health Science2019，8，1： | 4 |
| 3 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 4 | ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165显示文摘 | Carpizo DR Iruela-Arispe ML | 2003 | J Biol Chem2003，278，23： | 1 |
| 5 | Thrombospondin modules and angiogenesis显示文摘 | Iruela-Arispe ML Luque A Lee N | 2004 | Int J Biochem Cell Biol2004，36，6： | 1 |
| 6 | CD105 positive neovessels are prevalent in early stage carotid lesions,and correlate with the grade in more advanced carotid and coronary plaques显示文摘 | Luque A Slevin M Turu MM | | Journal of Angiogenesis Research0，，： | 1 |
| 7 | Electric and Thermal Model for Non-uniformly Illuminated Concentration Cells 显示文摘 | Luque A Sala G Arboiro J C | 1998 | Solar Energy Materials & Solar Cells1998，51，： | 1 |
| 8 | Study of spectral analytical data using fin- gerprints and scaledsimilarity measurements显示文摘 | M Urbano Cuadrado M D Luque de Castro M A Go mez-Nieto | 2005 | Anal Bioanal Chem2005，381，： | 1 |
| 9 | Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells 显示文摘 | Chen TT Luque A Lee S | 2010 | J Cell Biol2010，188，4： | 1 |
| 10 | Peptide toxins from Conus geographus venom 显示文摘 | Gray W R Luque A Olivera B M | 1981 | J Biol Chem1981，256，： | 1 |
| 11 | Use of near infrared spectroscopy in a study of binding media used in paintings 显示文摘 | JURADO-LOPEZ A LUQUE DE CASTRO M D | 2004 | Anal Bioanal Chem2004，380，： | 1 |
| 12 | Photochemical-spectrofluorimetric determination of phenothiazine compounds by unsegmented-flow methods显示文摘 | CHEN D RIOS A LUQUE De CASTRO M D | 1991 | Analyst1991，116，： | 1 |
| 13 | S ibulramine: a serotonin-norepinephrine reuptakeinhibitorfor the treatment of obesity显示文摘 | LUQUE C A REY J A | 1999 | Ann Pharmacother1999，33，9： | 1 |
| 14 | Influence of salinity on germination and seeds viability of two primary colonizers of Mediterranean salt pans显示文摘 | Rubio-Casal A E Castillo J M Luque C J | 2003 | J Arid Environ2003，53，2： | 1 |
| 15 | Fast ultrasound-assisted method for the determination of the oxidative stability of virgin olive oil显示文摘 | CANIZARES-MACIAS M P GARCIA-MESA J A LUQUE M D | 2004 | Analytica Chimica Acta2004，502，： | 1 |
| 16 | Simultaneous flow-injection determination of chlorpromazine and promethazine by photochemical reaction显示文摘 | CHEN D RIOS A LUQUE De CASTRO M D | 1991 | Talanta1991，38，： | 1 |
| 17 | Influence of salinity on germination and seeds viability of two primary colonizers of Mediterranean salt pans显示文摘 | Rubio-Casal A E Castillo J M Luque C J | 2003 | Journal of Arid Environments2003，53，： | 1 |
| 18 | Prognostic factors in stage T1 grade 3 bladder cancer survival:the role of G1-S modulators (p53,p21Waf1,p27kip1, Cyclin Dl,and Cyclin D3)and proliferation index (ki67-MIB1)显示文摘 | Lopez-Beltran A Luque R J Alvarez-Kindelan J et aI | 2004 | Eur Urol2004，45，5： | 1 |
| 19 | Glucagon-like pep- tide-1 (GLP-1) and glucose metabolism in human myocytes显示文摘 | Luque M A Gonzalez N Marquez L | 2002 | Journal of Endocrinology2002，173，3： | 1 |
| 20 | Synthesis,Crystal Structrue and Magnetic Properties of a one-dimensional Polymeric Copper(II)Complex Containing an Unusual 1,1'-Bieoordinatrd OxalatoBridge显示文摘 | Castillo O Luque A Sertucha S | | 0，，06： | 1 |
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