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| 1 | Photoprotective Effects of Hydroxychloroqine and TCMs on Human Keratinocytes Damaged from Ultraviolet Irradiation显示文摘Objective: To investigate damage effects of ultraviolet irradiation on eternal keratinocyte-HaCaT cells and to evaluate photo-protective efficiency of hydroxychloroqine and Traditional Chinese Medicines ( epigallocatechingallate[EGCG], baikal skullcap root and szechwan lovge rhizome) on HaCaT ceils damaged by middle wave ultraviolet(UVB) irradiation. Methods: Subconfluent HaCaT cells were sham or UVB irradiated and treated with above TCM agents. The damage degree of HaCaT cells was observed by a light microscop. Cell growth was recorded by cellcount and cellular activity was detected by MTT method. The secretion amount of IL-6 and TNF-α was measured by ELISA. Results: The irradiation damage of HaCaT cells was depended on the irradiated dosages and cellular activity was reduced by 36%-80%, with a maximum decrease over 90% after 72 h. The intervention of the above drugs may increase the cellular activity by 10%-72%. The photo-protective efficiency was more apparent in F_A^G (from 1.19+0.07 to 1.28 + 0.06, P < 0.01 ) than that in hydroxychloroqine ( from 0.43 + 0.04 to 0.96 + 0.04, P < 0.05). The other two tested drugs also showed photo-protective effect( from 0.44 + 0.07 to 1.21 -+ 0.02, P < 0.05). As to cytokine secretion, EGCG could decline the secretion amount of IL-6 and TNF.a apparently. Hydroxychloroqine and baikal skullcap root baikal skullcap root could only reduce the secretion of ID6. The secretion of IL-6 and TNF-α could not be inhibitedby szechwan lovge rhizome. Conclusion : The injury effect of UVB irradiation on cultured keratinocytes is dose-dependent and the tested drugs have photo-protective potency. Inhibition of cytokine secretion may be one of the mechanisms related to reducing the damage effect of UVB irradiation. | LUODan MINWei LINXiang-fei WUDi MIAOXu | 2004 | Journal of Nanjing Medical University2004，18，4： | 10 |
| 2 | Protective effect of Yiguanjian decoction against DNA damage on concanavalin A-induced liver injury mice model显示文摘OBJECTIVE:To investigate the inhibitory effect of Yiguanjian decoction(YD) on DNA damage in Concanavalin A(Con A)-induced liver injury mice model and to explain the possible mechanism.METHODS:Totally 120 male BALB/c mice were randomly divided into 6 groups,20 mice each:normal group,model group,Bifendate group,YD low dose group,YD middle dose group and YD high dose group.Except normal group,liver injury model induced by Con A was established.While modeling,each mouse in YD group was given YD(0.4 m L/20 g per day) by intragastric administration(0.13 g YD for YD low dose group;0.26 g for YD middle dose group;0.52 g for YD high dose group).Bifendate group was given Bifendate(0.2 gnd model·kg-1 grou·d-1) by gavage.Normal group ap were fed with same volume of physiological saline daily.After 8 weeks,the serum alanine transaminase(ALT)and aspartate transaminase(AST) were tested.The hematoxylin-eosin staining was used to evaluate the grade of liver inflammation and liver fibrosis stage.Hepatocellular DNA damage was detected by single cell gel electrophoresis technology.The protein expression of tumor necrosis factor-α(TNF-α),Bax and Mut T Homolog 1(MTH1) was detected by western blotting and enzyme linked immunosorbent assay.Bax m RNA and MTH1 m RNA were detected by Real-time Polymerase Chain Reaction(PCR).RESULTS:YD can improve the degree of liver inflammation and fibrosis in the liver of chronic hepatitis mice,the dose effect relationship is remarkable(P < 0.05).YD can reduce liver cell DNA damage.The difference between YD middle dose group and model group was statistically significant(P < 0.05).YD middle dose group had decreased the protein expression of TNF-α in the mice liver of immunological liver injury(P < 0.05).YD can increase the protein expression of Bax(P < 0.05).Compared with normal group,the protein expression of MTH1 was decreased(P < 0.05),but there was no statistical significance between YD group and model group(P >0.05).YD can increase the m RNA expression of Bax and MTH1(both P < 0.05).CONCLUSION:YD can effectively inhibit the DNA damage in immunological liver injury mice,the mechanism may be that it can decrease the TNF-αand increase the Bax and MTH1 expression. | Tian Mengxi Liu Wenlan You Hongjie Zhao Qingzhou Ouyang Luodan Gao Biane Zhang Xin Che Niancong | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 7 |
| 3 | Construction of ecological security patterns and ecological restoration zones in the city of Ningbo,China显示文摘Studying an ecological restoration zoning process under the background of ecological security patterns is of great significance to the rapid adjustment and optimization of a landscape pattern.In this study,a remote sensing ecological index and a morphological spatial pattern analysis method were used to assess the quality of habitats and identify ecological sources in the city of Ningbo;ecological corridors,ecological pinch points,and ecological barrier points were extracted by using a circuit theory to construct ecological security patterns and ecological restoration zones.The results indicate:(1)There were 47 ecological sources,and 83 key ecological corridors in Ningbo,and the ecological land area was about 1898.39 km^(2),accounting for 19.89%of the total study area.(2)The ecological source areas were distributed in“one patch and three belts”,and the low-resistance ecological corridors were concentrated in southern Yuyao city,western Haishu district,and central and western Fenghua district;the ecological network in the western and southern regions was dense.(3)There were four types of ecological restoration zones that need to be established,which were prioritized restoration zones,prioritized protection zones,key conservation zones,and general conservation zones distributed hierarchically from inner part towards outside.(4)Ninghai county,Yuyao city,and Fenghua district had large ecological land areas,however,prioritized restoration and protection zones in Ninghai and Fenghua were also large.The analysis results are expected to provide a reference for optimizing a territorial ecological space in a city. | ZHANG Haitao LI Jialin TIAN Peng PU Ruiliang CAO Luodan | 2022 | Journal of Geographical Sciences2022，32，4： | 7 |
| 4 | H2O2-responsive theranostic nanomedicine显示文摘The fast progress of stimuli-responsive theranostic nanomedicine can achieve the specific and highperformance diagnosis and therapy of various diseases.Especially,H_2O_2-responsive theranostic nanomedicine is recently emerging as a new stimuli-responsive modality showing the great potential for the theranostic of diseases with overexpressed H_2O_2 because H_2O_2 is associated with several kinds of human diseases as the most stable and abundant reactive oxygen species.This review summarizes and discusses the very-recent developments of H_2O_2-responsive theranostic nanoplatforms for versatile biomedical applications,including diagnostic imaging,attenuating tumor hypoxia,enhancing the therapeutic efficiency of photodynamic therapy/radiation therapy/chemotherapy and theranostic of inflammation/diabetic.The facing challenges and future developments of H_2O_2-responisve theranostics are also briefly discussed to further promote the clinical translation of this new responsive theranostic modality.It is highly believed that H_2O_2-responsive theranostic nanomedicine will be extensively developed a new specific and efficient theranostic modality to benefit the personalized biomedicine in the near future. | Luodan Yu Yu Chen Hangrong Chen | 2017 | Chinese Chemical Letters2017，28，9： | 5 |
| 5 | Theranostic nanomedicine by surface nanopore engineering显示文摘Theranostic nanomedicine that integrates diagnostic and therapeutic agents into one nanosystem has gained considerable momentum in the field of cancer treatment. Among diverse strategies for achieving theranostic capabilities, surface-nanopore engineering based on mesoporous silica coating has attracted great interest because of their negligible cytotoxicity and chemically active surface that can be easily modified to introduce various functional groups(e.g.,-COOH,-NH_2,-SH, etc.) via silanization, which can satisfy various requirements of conjugating biological molecules or functional nanoparticles. In addition,the nanopore-engineered biomaterials possess large surface area and high pore volume, ensuring desirable loading of therapeutic guest molecules. In this review, we comprehensively summarize the synthetic procedure/paradigm of nanopore engineering and further broad theranostic applications. Such nanopore-engineering strategy endows the biocompatible nanocomposites(e.g., Au,Ag, graphene, upconversion nanoparticles, Fe_3O_4, MXene, etc.) with versatile functional moieties, which enables the development of multifunctional nanoplatforms for multimodal diagnostic bio-imaging, photothermal therapy, photodynamic therapy,targeted drug delivery, synergetic therapy and imaging-guided therapies. Therefore, mesoporous silica-based surface-nanopore engineering integrates intriguing unique features for broadening the biomedical applications of the single mono-functional nanosystem, facilitating the development and further clinical translation of theranostic nanomedicine. | Zhenli Li Luodan Yu Tian Yang Yu Chen | 2018 | Science China Chemistry2018，61，10： | 3 |
| 6 | Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation显示文摘Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress,which are important factors contributing to the development of brain disease.Ample evidence suggests mitochondria are a promising target for neuroprotection.Recently,methods targeting mitochondria have been considered as potential approaches for treatment of brain disease through the inhibition of inflammation and oxidative injury.This review will discuss two widely studied approaches for the improvement of brain mitochondrial respiration,methylene blue(MB)and photobiomodulation(PBM).MB is a widely studied drug with potential beneficial effects in animal models of brain disease,as well as limited human studies.Similarly,PBM is a non-invasive treatment that promotes energy production and reduces both oxidative stress and inflammation,and has garnered increasing attention in recent years.MB and PBM have similar beneficial effects on mitochondrial function,oxidative damage,inflammation,and subsequent behavioral symptoms.However,the mechanisms underlying the energy enhancing,antioxidant,and anti-inflammatory effects of MB and PBM differ.This review will focus on mitochondrial dysfunction in several different brain diseases and the pathological improvements following MB and PBM treatment. | Luodan Yang Hannah Youngblood Chongyun Wu Quanguang Zhang | 2020 | Translational Neurodegeneration2020，9，2： | 2 |
| 7 | Ecosystem service valuation of bays in East China Sea and its response to sea reclamation activities显示文摘Ecosystem service values(ESVs)of bays and their response to sea reclamation are of great practical importance for forming bay eco-compensation policy and extension of blue economic space.Based on land use information of bays collected during the period of 1990–2015,the spatiotemporal evolution of ESVs of 12 main bays in East China Sea and their response to sea reclamation activities over the past 25 years were quantitatively analyzed.The analysis results indicate that ESVs of bays in East China Sea showed a continuous downward trend and the whole ecosystem was continuously degraded,in which the degradation degree of ESV in the southern bays was higher than that in the northern bays.Spatial zoning of ESVs of bays in East China Sea was remarkable,showing a continuous downward trend from low-value to high-value zone.Spatial variation of ESVs of each bay was also significant,expanding from a city and from inland to the coast,which suggests that human activities,mainly reclamation,have become main agents for ESV evolution of bays in East China Sea.ESVs of bays have a significant response to sea reclamation,manifested as a significant negative correlation between ESV and reclamation intensity.The correlation in the southern bays was stronger than that in the northern bays,which was caused by different effects of sea reclamation modes on ESV evolution of muddy and bedrock bays.A negative effect of sea reclamation activities on bay ecosystem was hysteretic.Therefore,an attention should be paid to dynamic monitoring and early warning of development status in offshore areas,ecosystem-level reclamation control policy,and coastal wetland reserves planning.Moreover,the spatial coupling mechanism study between bay ecosystem service demand and its service supply capacity should be strengthened to realize systematic regulation of bay ecological security pattern. | LIU Ruiqing XU Hao LI Jialin PU Ruiliang SUN Chao CAO Luodan JIANG Yimei TIAN Peng WANG Lijia GONG Hongbo | 2020 | Journal of Geographical Sciences2020，30，7： | 2 |
| 8 | Generic synthesis and versatile applications of molecularly organic-inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures显示文摘 | Guiju Tao Zhengyuan Bai Yu Chen Heliang Yao Meiying Wu Ping Huang Luodan Yu Jiamin Zhang Chen Dai Long Zhang | 2017 | Nano Research2017，10，11： | 2 |
| 9 | Effect of Earlier Vaccination and a Two-Dose Varicella Vaccine Schedule on Varicella Incidence—Beijing Municipality,2007-2018显示文摘Summary What is already known about this topic?The World Health Organization(WHO)varicella vaccines position paper states that countries where varicella is an important public health burden could consider introducing varicella vaccine(VarV)in the routine childhood immunization program(1).VarV has been available for many years in China but is not included in most routine immunization programs in China. | Dan Zhao Luodan Suo Li Lu Jingbin Pan Xinghuo Pang Wei Yao | 2021 | China CDC weekly2021，3，15： | 2 |
| 10 | Microglial SIRPα Deletion Facilitates Synapse Loss in Preclinical Models of Neurodegeneration显示文摘Microglia,the principal immune cells in the brain,play a vital role in the development and homeostasis of the central nervous system[1,2].During early brain development,microglia-mediated synapse pruning contributes to eliminating excess synapses that are unnecessary in adulthood[3].Excessive microglia-mediated pruning in the adult brain is implicated in neurodegeneration-associated behav・ioral deficits[4,5]. | Chongyun Wu Luodan Yang Hannah Youngblood Timon Cheng-Yi Liu Rui Duan | 2022 | Neuroscience Bulletin2022，38，2： | 2 |
| 11 | Perception of the COVID-19 Epidemic and Acceptance of Vaccination Among Healthcare Workers Prior to Vaccine Licensure——Beijing Municipality,China,May-July 2020显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)vaccine development has been progressing,but acceptance of the new vaccines by healthcare workers(HCWs)was not well known prior to approval of COVID-19 vaccines in China.What is added by this report? | Luodan Suo Rui Ma Zhongzhan Wang Tian Tang Haihong Wang Fang Liu Jinfeng Tang Xinghui Peng Xue Guo Li Lu Xinghuo Pang | 2021 | China CDC weekly2021，3，27： | 1 |
| 12 | Willingness of the General Public to Receive the COVID-19 Vaccine During a Second-Level Alert——Beijing Municipality,China,May 2020显示文摘Summary What is already known on this topic?Preclinical trials showed the effectiveness of domestic inactivated vaccine candidates for coronavirus disease 2019(COVID-19).However,it is necessary to evaluate the willingness of the public to receive future domestic vaccines and to understand factors associated with willingness at the early stages of vaccine development. | Rui Ma Luodan Suo Li Lu Xinghuo Pang | 2021 | China CDC weekly2021，3，25： | 1 |
| 13 | A varicella outbreak in a school with high one-dose vaccination coverage, Beijing, China 显示文摘 | Lu Li Suo Luodan Li Juan | 2012 | Vaccine2012，30，34： | 1 |
| 14 | Deregulation of Bmi-1 is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma显示文摘 | Boyang Chang Su Li Qianting He Zhonghua Liu Luodan Zhao Tingting Zhao Anxun Wang | 2014 | BBA - General Subjects2014，，12： | 1 |
| 15 | The Lung Microbiome:A Potential Target in Regulating Autoimmune Inflammation of the Brain显示文摘Under normal conditions,the immune system protects the brain from outside invaders,including viruses,bacteria,toxins,and fungi.However,an abnormal immune response within the brain affects its function and contributes to the progression of neurological diseases. | Luoman Yang Shu Feng Chongyun Wu Luodan Yang | 2022 | Neuroscience Bulletin2022，38，11： | 0 |
| 16 | Photobiomodulation:A Potential Non-invasive Method to Alleviate Neurological Events Following COVID-19 Infection显示文摘In the past several months,confirmed cases have surged as many countries have loosened their bans on Coronavirus disease 2019(COVID-19)epidemic prevention and control.As a respiratory infectious disease caused by a novel coronavirus called SARS-CoV-2,COVID-19 emerged in late December 2019 and lasted for more than three years worldwide[1]. | Chongyun Wu Timon Cheng-Yi Liu Rui Duan Luodan Yang | 2023 | Neuroscience Bulletin2023，39，10： | 0 |
| 17 | Microglia-Mediated Aβ Propagation in Alzheimer’s Disease显示文摘The accumulation of extracellular amyloid-βpeptide(Aβ)in thebrain is oneof theprimary pathological hallmarks of Alzheimer's disease(AD)[1].Several factors contribute to theformation and spread of Aβ,includingmicroglia[1,2].Microglia,the primary resident macrophages in the central nervous system,play a vital role in brain development,homeostasis,and neurodegeneration[3,4]. | Luoman Yang Shu Feng Chongyun Wu Luodan Yang | 2022 | Neuroscience Bulletin2022，38，10： | 0 |
| 18 | Astrocyte-Mediated Myelin Phagocytosis in Ischemia显示文摘The myelin sheath-supporting cells,oligodendrocytes and Schwann cells,are susceptible toischemia.Therefore,ischemic stroke is usually characterized by evident demyelination^([l]).Although oligodendrocytes are the major player in myelination,glial cells,including microglia and astrocytes,also contribute to myelination and demyelination^([2]).In the early stages of ischemic stroke,microgliamediated myelin debris removal through phagocytosis has been widely studied^([3]). | Luodan Yang Dongyu Zhang Quanguang Zhang | 2023 | Neuroscience Bulletin2023，39，1： | 0 |
| 19 | Oxygen-evolving photosynthetic cyanobacteria for 2D bismuthene radiosensitizer-enhanced cancer radiotherapy显示文摘The local hypoxic tumor environment substantially hampers the therapeutic efficiency of radiotherapy, which typically requires the large X-ray doses for tumor treatment but induces the serious side effects. Herein, a bio-mimetic radiosensitized platform based on a natural in-situ oxygen-evolving photosynthetic cyanobacteria combined with two-dimensional (2D) bismuthene with high atomic-number (Z) components, is designed and engineered to effectively modulate the radiotherapy-resistant hypoxic tumor environment and achieve sufficient radiation energy deposition into tumor. Upon the exogenous sequential irradiation of 660 nm laser and X-ray beam, continuous photosynthetic oxygen evolution by the cyanobacteria and considerable generation of reactive oxygen species by the 2D bismuthene radiosensitizer substantially augmented the therapeutic efficacy of radiotherapy and suppressed the in vivo tumor growth, as demonstrated on both LLC-lung tumor xenograft-bearing C57/B6 mice model and 4T1-breast tumor xenograft-bearing Balb/c mice model, further demon-strating the photosynthetic hypoxia-alleviation capability and radiosensitization performance of the engineered biomimetic radiosensitized platform. This work exemplifies a distinct paradigm on the construction of microorganism-enabled tumor-microenvironment modulation and nanoradiosensitizer-augmented radiotherapy for efficient tumor treatment. | Rong Chai Luodan Yu Caihong Dong Yipengchen Yin Sheng Wang Yu Chen Qin Zhang | 2022 | Bioactive Materials2022，7，11： | 0 |
| 20 | Infusion of Cerebrospinal Fluid from Young Mice Reverses Memory Loss in Aged Mice显示文摘Aging causes changes in synaptic plasticity,myelination,vasculature,and cognitive function[l].Accumulating evidence highlights that improvement of the systemic environment benefits brain function and alleviates brain aging.Such improvements include heterochronic parabiosis,transplantation of bone marrow,young blood,or fecal microbiota,and plasma transfer experiments[2-5]. | Luodan Yang Quanguang Zhang | 2023 | Neuroscience Bulletin2023，39，2： | 0 |
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