| 1 | H2O2-responsive theranostic nanomedicine显示文摘The fast progress of stimuli-responsive theranostic nanomedicine can achieve the specific and highperformance diagnosis and therapy of various diseases.Especially,H_2O_2-responsive theranostic nanomedicine is recently emerging as a new stimuli-responsive modality showing the great potential for the theranostic of diseases with overexpressed H_2O_2 because H_2O_2 is associated with several kinds of human diseases as the most stable and abundant reactive oxygen species.This review summarizes and discusses the very-recent developments of H_2O_2-responsive theranostic nanoplatforms for versatile biomedical applications,including diagnostic imaging,attenuating tumor hypoxia,enhancing the therapeutic efficiency of photodynamic therapy/radiation therapy/chemotherapy and theranostic of inflammation/diabetic.The facing challenges and future developments of H_2O_2-responisve theranostics are also briefly discussed to further promote the clinical translation of this new responsive theranostic modality.It is highly believed that H_2O_2-responsive theranostic nanomedicine will be extensively developed a new specific and efficient theranostic modality to benefit the personalized biomedicine in the near future. | Luodan Yu Yu Chen Hangrong Chen | 2017 | Chinese Chemical Letters2017，28，9： | 5 |
| 2 | Theranostic nanomedicine by surface nanopore engineering显示文摘Theranostic nanomedicine that integrates diagnostic and therapeutic agents into one nanosystem has gained considerable momentum in the field of cancer treatment. Among diverse strategies for achieving theranostic capabilities, surface-nanopore engineering based on mesoporous silica coating has attracted great interest because of their negligible cytotoxicity and chemically active surface that can be easily modified to introduce various functional groups(e.g.,-COOH,-NH_2,-SH, etc.) via silanization, which can satisfy various requirements of conjugating biological molecules or functional nanoparticles. In addition,the nanopore-engineered biomaterials possess large surface area and high pore volume, ensuring desirable loading of therapeutic guest molecules. In this review, we comprehensively summarize the synthetic procedure/paradigm of nanopore engineering and further broad theranostic applications. Such nanopore-engineering strategy endows the biocompatible nanocomposites(e.g., Au,Ag, graphene, upconversion nanoparticles, Fe_3O_4, MXene, etc.) with versatile functional moieties, which enables the development of multifunctional nanoplatforms for multimodal diagnostic bio-imaging, photothermal therapy, photodynamic therapy,targeted drug delivery, synergetic therapy and imaging-guided therapies. Therefore, mesoporous silica-based surface-nanopore engineering integrates intriguing unique features for broadening the biomedical applications of the single mono-functional nanosystem, facilitating the development and further clinical translation of theranostic nanomedicine. | Zhenli Li Luodan Yu Tian Yang Yu Chen | 2018 | Science China Chemistry2018，61，10： | 3 |
| 4 | Oxygen-evolving photosynthetic cyanobacteria for 2D bismuthene radiosensitizer-enhanced cancer radiotherapy显示文摘The local hypoxic tumor environment substantially hampers the therapeutic efficiency of radiotherapy, which typically requires the large X-ray doses for tumor treatment but induces the serious side effects. Herein, a bio-mimetic radiosensitized platform based on a natural in-situ oxygen-evolving photosynthetic cyanobacteria combined with two-dimensional (2D) bismuthene with high atomic-number (Z) components, is designed and engineered to effectively modulate the radiotherapy-resistant hypoxic tumor environment and achieve sufficient radiation energy deposition into tumor. Upon the exogenous sequential irradiation of 660 nm laser and X-ray beam, continuous photosynthetic oxygen evolution by the cyanobacteria and considerable generation of reactive oxygen species by the 2D bismuthene radiosensitizer substantially augmented the therapeutic efficacy of radiotherapy and suppressed the in vivo tumor growth, as demonstrated on both LLC-lung tumor xenograft-bearing C57/B6 mice model and 4T1-breast tumor xenograft-bearing Balb/c mice model, further demon-strating the photosynthetic hypoxia-alleviation capability and radiosensitization performance of the engineered biomimetic radiosensitized platform. This work exemplifies a distinct paradigm on the construction of microorganism-enabled tumor-microenvironment modulation and nanoradiosensitizer-augmented radiotherapy for efficient tumor treatment. | Rong Chai Luodan Yu Caihong Dong Yipengchen Yin Sheng Wang Yu Chen Qin Zhang | 2022 | Bioactive Materials2022，7，11： | 0 |
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