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| 1 | Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease显示文摘Background:Evidence suggests that glucocorticoids are important in the treatment of sudden hearing loss(SHL)and Meniere’s disease(MD).However,different glucocorticoid administration methods may have a significant impact on treatment outcomes.Objective:This study aimed to investigate effects of different glucocorticoid administration methods on sudden hearing loss and Meniere’s disease.Methods:In this study,glucocorticoids were administered orally in 18 patients,by retroauricular injection in 15 patients and by intratympanic injection in 15 patients.White blood cell(WBC)count,serum Kt,fasting plasma glucose(FPG),body temperature,heart rate and blood pressure were used to evaluate effects of glucocorticoids on patients with hearing loss.Visual analog scale(VAS)of pain and sleep disorders were also surveyed,and pure tone audiometry(PTA)results were compared among groups to evaluate efficacy of different glucocorticoids administration methods.Result:WBC count,heart rate and blood pressure were higher in patients taking oral glucocorticoids,while body temperature,serum Kt and FPG levels did not change in all three groups.However,patients who received intratympanic injection of glucocorticoids experienced more pain,while those taking oral glucocorticoids reported more sleep impairment.Treatment efficacy on hearing loss was not significantly different among the three groups.Conclusion:These findings suggest that systemic glucocorticoid administration can result in greater whole body responses than local administration,but with similar hearing treatment efficacy. | Dan Chen Zhipeng Li Qilin Zhou Yubin Chen Luoying Yang Jingqian Tan Xiangli Zeng Peng Li | 2020 | Journal of Otology2020，15，4： | 4 |
| 2 | Nuclear Envelope Protein MAN1 Regulates the Drosophila Circadian Clock via Period显示文摘Almost all organisms exhibit ~24-h rhythms, or circadian rhythms, in a plentitude of biological processes.These rhythms are driven by endogenous molecular clocks consisting of a series of transcriptional and translational feedback loops. Previously, we have shown that the inner nuclear membrane protein MAN1 regulates this clock and thus the locomotor rhythm in flies, but the mechanism remains unclear. Here, we further confirmed the previous findings and found that knocking down MAN1 in the pacemaker neurons of adult flies is sufficient to lengthen the period of the locomotor rhythm. Molecular analysis revealed that knocking down MAN1 led to reduced m RNA and protein levels of the core clock gene period(per),likely by reducing its transcription. Over-expressing per rescued the long period phenotype caused by MAN1 deficiency whereas per mutation had an epistatic effect on MAN1, indicating that MAN1 sets the pace of the clock by targeting per. | Bei Bu Weiwei He Li Song Luoying Zhang | 2019 | Neuroscience Bulletin2019，35，6： | 2 |
| 3 | Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1显示文摘Bone regeneration remains a great clinical challenge. Low intensity near-infrared(NIR) light showed strong potential to promote tissue regeneration, offering a promising strategy for bone defect regeneration. However, the effect and underlying mechanism of NIR on bone regeneration remain unclear. We demonstrated that bone regeneration in the rat skull defect model was significantly accelerated with low-intensity NIR stimulation. In vitro studies showed that NIR stimulation could promote the osteoblast differentiation in bone mesenchymal stem cells(BMSCs) and MC3T3-E1 cells, which was associated with increased ubiquitination of the core circadian clock protein Cryptochrome 1(CRY1) in the nucleus. We found that the reduction of CRY1 induced by NIR light activated the bone morphogenetic protein(BMP) signaling pathways, promoting SMAD1/5/9 phosphorylation and increasing the expression levels of Runx2 and Osterix. NIR light treatment may act through sodium voltage-gated channel Scn4a, which may be a potential responder of NIR light to accelerate bone regeneration. Together, these findings suggest that low-intensity NIR light may promote in situ bone regeneration in a CRY1-dependent manner, providing a novel, efficient and non-invasive strategy to promote bone regeneration for clinical bone defects. | Jinfeng Peng Jiajia Zhao Qingming Tang Jinyu Wang Wencheng Song Xiaofeng Lu Xiaofei Huang Guangjin Chen Wenhao Zheng Luoying Zhang Yunyun Han Chunze Yan Qian Wan Lili Chen | 2022 | International Journal of Oral Science2022，14，4： | 2 |
| 4 | Coopetition Perspective of Global Competition 显示文摘 | Luoy A | 2007 | Joumal of World Business2007，42，1： | 1 |
| 5 | 查看详情显示文摘 | Zhu A W LuoY P Tian Y | | 0，，17： | 1 |
| 6 | MicedeficientinBACE1,theAlzheimer′sbeta-secretase,havenormalphenotypeandabolishedbeta-amyloidgeneration显示文摘 | LuoY BolonB KahnS etal | 2001 | NatNeurosci2001，4，3： | 1 |
| 7 | Event - specific qualitative and quantitative PCR detection of roundup ready event GT73 based on the 3'- integration junction 显示文摘 | Yang R Xu W LuoY | 2007 | Plant Cell Rep2007，26，： | 1 |
| 8 | Phase-change nanoparticles using highly volatile perfluorocarbons: to- ward a platform for extravascular ultrasound imaging 显示文摘 | Matsunaga TO Sheeran PS Luois S | 2012 | Theranostics2012，2，12： | 1 |
| 9 | Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons显示文摘 | Paul S. Sheeran Samantha H. Luois Lee B. Mullin Terry O. Matsunaga Paul A. Dayton | 2012 | Biomaterials2012，，11： | 1 |
| 10 | Design of ultra- sonically-activatable nanoparticles using low boiling point perfluorocarbons 显示文摘 | Sheeran PS Luois SH Mullin LB | 2012 | Biomaterials2012，33，11： | 1 |
| 11 | Current concept about postoperative cholan- gitis in biliary atresia显示文摘 | LuoY ZhengS | 2008 | World J Pediatr2008，4，1： | 1 |
| 12 | A comparativebiomechanicalstudyofproximalfemoralnail(InterTAN) andproximalfemoralnailantirotationforintertrochantericfractures显示文摘 | HuangY ZhangC LuoY | 2013 | IntOrthop2013，37，12： | 1 |
| 13 | Four new dibenzocyclooctadiene lignansfrom Schisandra rubriflora显示文摘 | LI H M LUOY M PU J X | 2008 | Helvetica Chimica Acta2008，91，： | 1 |
| 14 | The combinatorial effect of complexing anent and inhibitor on chemical mechanical planarization of copper 显示文摘 | Du T B LuoY Desai V | 2004 | Micro electronic Engineering2004，71，1： | 1 |
| 15 | Synthesis of PMMA-b-PBA block copolymer in homogeneous and mini- emulsion systems by DPE controlled radical polymerization显示文摘 | LuoY D Chou I C Chiu W Y etal | 2009 | J Polym Sci Part A: Polym Chem2009，47，： | 1 |
| 16 | A consolidated evaluation of the FAO-56 dual crop coefficient approach using the lysimeter data in the North China Plain显示文摘 | Liu Y J LuoY | 2010 | Agrieultural Water Management2010，97，1： | 1 |
| 17 | AstragalosideIVamelioratesdia-beticnephropathyinvolvingprotectionofpodocytesinstreptozoto-cininduceddiabeticrats显示文摘 | ChenJ ChenY LuoY etal | 2014 | EurJPharmacol2014，736，： | 1 |
| 18 | Homocysteine induces tau hyperphosphorylation in rats 显示文摘 | LuoY ZhouX Yang X | 2007 | Neuroreport2007，18，： | 1 |
| 19 | Knockdown of P-Catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1α显示文摘 | Zhao J H LuoY Jiang Y G | 2011 | Cancer Invest2011，29，6： | 1 |
| 20 | Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition显示文摘 | LuoY Smith RA Guan R | 2004 | Biochemistry2004，43，5： | 1 |
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