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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Recent developments in semiconductor gamma-ray detectors 显示文摘 | Luke P N Amman M TindaU C | 2005 | Journal of Radloanalyrical and Nuclear Chemistry2005，264，1： | 1 |
| 3 | Phaco-trabeculotomy combined with deep sclerectomy,a new technique in combined cataract and glaucoma surgery:complication profile显示文摘 | Luke C Dietlein TS Luke M | 2007 | ActaOphthalmol Scand2007，85，2： | 1 |
| 4 | Primary phacoemulsification and intraocular lens implantation for acute angle-closure glaucoma 显示文摘 | Jacobi PC Dietlein TS Luke C | 2002 | Ophthalmology2002，109，： | 1 |
| 5 | Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults显示文摘 | Karron RA Talaat K Luke C | 2009 | Vaccine2009，27，36： | 1 |
| 6 | Declining rates of physical activity in the United States: What are the contribu- tors? 显示文摘 | BROWNSON R C BOEHMER T K LUKE D A | 2005 | Annu Rev Public Health2005，26，： | 1 |
| 7 | A theoretical model for gas adsorption-induced coal swelling显示文摘 | PAN Z J LUKE D C | 2007 | International Journal of Coal Geology2007，69，4： | 1 |
| 8 | Computational and experimental characterization of physically clustered simple sequence repeats in plants 显示文摘 | Linda C Luke R Dan M | 2000 | Genetics2000，156，2： | 1 |
| 9 | Outcomes of the Bobarth concept on upper limb recovery following stroke 显示文摘 | Luke C Dodd KJ Brock K | 2004 | Clin Rehabil2004，18，： | 1 |
| 10 | Vaccines for pandemic influenza 显示文摘 | LUKE C J SUBBARAO K | 2006 | Emerg Infect Dis2006，12，1： | 1 |
| 11 | A prospective randomised trial of viscocanalostomy with and without implantation of a reticulated hyaluronic acid implant (SKGEL) in open angle glaucoma显示文摘 | Dietlein TS Jacobi PC | 2003 | Br J Ophthalmol2003，87，5： | 1 |
| 12 | Executive Function and Theory of Mind: Stability and Prediction from Ages 2 to 3 显示文摘 | Stephanie M C Dorothy J M Luke W | 2004 | Developmental Psychology2004，40，6： | 1 |
| 13 | Development of specific monoclonal antibodies and a sensitive discriminatory immunoassay for the circulating tumor markers SCCA1 and SCCA2显示文摘 | Catahepe S Schick C Luke CJ | | 0，，1： | 1 |
| 14 | Signal quality of biometry in silicone oil filled eyes using partial coherence laser interferometry显示文摘 | Dietlein TS Roessler G Luke C | 2005 | J Cataract Refract Surg2005，31，5： | 1 |
| 15 | Meat Analysis;convalescent blood products for Spanish influence pheumonis:a future H5N1 treatment显示文摘 | LUKE T C KILBANE E M JACKSON J L | 2006 | Ann Intern Med2006，145，： | 1 |
| 16 | Vaccines for pandemic influen za 显示文摘 | Luke C J Subbarao K | 2006 | Emerg Infect Dis2006，12，1： | 1 |
| 17 | Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration显示文摘 | Otto A Schmidt C Luke G | 2008 | J Cell Sci2008，121，17： | 1 |
| 18 | Primary phacoemulsification and intraocular lens implantation for acute angle-closure glaucoma 显示文摘 | Jacobi PC Dietlein TS Luke C | 2002 | Ophthalmology2002，109，9： | 1 |
| 19 | Risk factors for adverse outcomesin spontaneous versus assisted conception twin pregnancies显示文摘 | Luke B Brown MB Nugent C | 2004 | FertilSteri2004，81，2： | 1 |
| 20 | Single wall carbon nanotube/polyethylene nanocomposites: thermal and electrical conductivity 显示文摘 | HAGGENMUELLER R GUTHY C LUKES J R | 2007 | Macromolecules2007，40，7： | 1 |
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