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| 1 | Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning显示文摘AIM:To assess the relationship between preoperative computed tomography(CT)and postoperative pathological measurements of esophageal tumor length and the prognostic significance of CT tumor length data.METHODS:A retrospective study was carried out in 56 patients who underwent curative esophagogastrectomy.Tumor lengths were measured on the immediate preoperative CT and on the post-operative resection specimens.Inter-and intra-observer variations in CT measurements were assessed.Survival data were collected.RESULTS:There was a weak correlation between CT and pathological tumor length(r=0.30,P=0.025).CT lengths were longer than pathological lengths in 68%(38/56)of patients with a mean difference of 1.67 cm(95%CI:1.18-2.97).The mean difference in measurements by two radiologists was 0.39 cm(95% CI:-0.59-1.44).The mean difference between repeat CT measured tumor length(intra-observer variation) were 0.04 cm(95%CI:-0.59-0.66)and 0.47 cm (95%CI:-0.53-1.47).When stratified,patients not receiving neoadjuvant chemotherapy showed a strong correlation between CT and pathological tumor length(r =0.69,P=0.0014,n=37)than patients that did(r= 0.13,P=0.43,n=19).Median survival with CT tumor length>5.6 cm was poorer than with smaller tumors,but the difference was not statistically significant.CONCLUSION:Esophageal tumor length assessed using CT does not reflect pathological tumor extent and should not be the only modality used for management decisions,particularly for planning radiotherapy. | Karim Sillah Luke R Williams Hans-Ulrich Laasch Azeem Saleem Gillian Watkins Susan A Pritchard Patricia M Price Catharine M West Ian M Welch | 2010 | World Journal of Gastrointestinal Oncology2010，2，4： | 10 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair显示文摘Varicoceles adversely impact semen quality and sperm DNA fragmentation,which typically improve with surgical repair.Some men with varicoceles have ipsilateral testicular atrophy due to damage from the varicocele.This study assessed semen quality and the sperm DNA fragmentation index(DFI)response to varicocele repair in men with ipsilateral testicular atrophy(TA)versus men with no testicular atrophy(NTA).Semen parameter values and DFI in both groups were compared preoperatively and postoperatively.The Mann-Whitney U test and the Wilcoxon signed-rank test were used where appropriate.There were 20 men in the TA group and 121 men in the NTA group with no difference in age,varicocele grade,or preoperative semen parameter values between the two groups.The NTA group had a higher preoperative DFI than the TA group.Both groups showed improvement in semen quality postoperatively,only the TA group showed a significant improvement in DFI,whereas the NTA group showed significant improvements in several parameter values and DFI.The change from preoperative to postoperative parameter values when comparing the two groups revealed a difference in total sperm motile count and DFI,with a larger mean improvement in the NTA group than in the TA group.Both TA and NTA groups showed improved semen quality and DFI after varicocele repair,but the NTA group had more improvement than the TA group.However,only total motile count(TMC)and DFI had a significantly greater mean change in preoperative to postoperative response in the NTA group than in the TA group. | Parviz K Kavoussi Natasha Abdullah Melissa S Gilkey Caitlin Hunn G Luke Machen Shu-Hung Chen Keikhosrow M Kavoussi Amy Esqueda J David Wininger Shahryar K Kavoussi | 2021 | Asian Journal of Andrology2021，23，2： | 2 |
| 4 | Recent developments in semiconductor gamma-ray detectors 显示文摘 | Luke P N Amman M TindaU C | 2005 | Journal of Radloanalyrical and Nuclear Chemistry2005，264，1： | 1 |
| 5 | Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor显示文摘 | Sven P Luke M | 2000 | Clin Cancer Res2000，，6： | 1 |
| 6 | H5N1 vaccines in humans显示文摘 | Baz M Luke CJ Cheng X | | 0，，： | 1 |
| 7 | Phaco-trabeculotomy combined with deep sclerectomy,a new technique in combined cataract and glaucoma surgery:complication profile显示文摘 | Luke C Dietlein TS Luke M | 2007 | ActaOphthalmol Scand2007，85，2： | 1 |
| 8 | Botulinum toxin treatment for lower limb extensor spasticity in chronic hemiparetic patients显示文摘 | Hesse S Luke D Malezic M | 1994 | J Neurol Neurosurg Psysiatry1994，57，： | 1 |
| 9 | Oral treatment of chickens with Lactobacillus reuteri LM1 reduces Brachyspira pilosicoli-induced pathology显示文摘 | Luke J M Monika A T Alejandro N | 2013 | Journal of Medical Microbiolo- gy2013，62，2： | 1 |
| 10 | Endotoxin-induced acute renal failure in the rat: effects of urodilatin and diltiazem on renal function 显示文摘 | Schramm L Heidbreder E Lukes M | 1996 | Clin Nephrol1996，46，2： | 1 |
| 11 | Very High Pressure Gradient LC/ MS/ MS显示文摘 | James W jorgenson M arthur Mosel Ey | 2001 | Analytical Chemistry2001，73，： | 1 |
| 12 | Economic analysis in the MRO in- dustry: an options approach 显示文摘 | LUKE T M CHAN S P | 2004 | The Engineering Econo- mist2004，49，5： | 1 |
| 13 | Computational and experimental characterization of physically clustered simple sequence repeats in plants 显示文摘 | Linda C Luke R Dan M | 2000 | Genetics2000，156，2： | 1 |
| 14 | Executive Function and Theory of Mind: Stability and Prediction from Ages 2 to 3 显示文摘 | Stephanie M C Dorothy J M Luke W | 2004 | Developmental Psychology2004，40，6： | 1 |
| 15 | Sesquiterpenes from clove (Eugenia caryophyllata) as potential antlcarcinogenie agents显示文摘 | Zheng G Q Patrick M K Luke K T L | 1992 | J Natur Pro1992，55，7： | 1 |
| 16 | Nuclear magnetic resonance imaging in multiple sclerosis 显示文摘 | Lukes S A Crookes L E Aminoff M J | 1983 | Ann Neurol1983，13，： | 1 |
| 17 | Meat Analysis;convalescent blood products for Spanish influence pheumonis:a future H5N1 treatment显示文摘 | LUKE T C KILBANE E M JACKSON J L | 2006 | Ann Intern Med2006，145，： | 1 |
| 18 | Perfect ter- nary arrays 显示文摘 | ANTWEILER M M BOMER L LUKE H D | 1990 | IEEE Trans Information Theory1990，36，3： | 1 |
| 19 | 显示文摘 | Lukes R Pergal M | 1959 | Coll Czech Chem Commun1959，24，1： | 1 |
| 20 | The Associ- ation of Surgical Margins and Local Recurrence in Women with Early-Stage Invasive Breast Cancer Treated with Breast-Conserving Therapy: A Meta-Analysis显示文摘 | Houssami N Macaskill P Luke Marinovich M | 2014 | Ann Surg Oncol2014，21，3： | 1 |
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