|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biliary tract schwannoma:A rare cause of obstructive jaundice in a young patient显示文摘Schwannoma is a tumor derived from Schwann cells which usually arises in the upper extremities, trunk, head and neck, retroperitoneum, mediastinum, pelvis, and peritoneum. However, it can arise in the gastro-intestinal tract, including biliary tract. We present a 24-year-old male patient with obstructive jaundice, whose investigation with computed tomography abdomen showed focal wall thickening in the common hepatic duct, difficult to differentiate with hilar adenocarcinoma. He was diagnosed intraoperatively schwannoma of common bile duct and treated with local resection. The patient recovered well without signs of recurrence of the lesion after 12 mo. We also reviewed the common bile duct schwannoma related in the literature and evaluated the difficulty in pre and intraoperative differential diagnosis with adenocarcinoma hilar. Resection is the treatment of choice for such cases and the tumordid not recur in any of the resected cases. | Gilton Marques Fonseca André Luis Montagnini Manoel de Souza Rocha Rosely Antunes Patzina Mário Vinícius Angelete Alvarez Bernardes Ivan Cecconello José Jukemura | 2012 | World Journal of Gastroenterology2012，18，37： | 10 |
| 2 | AMP-activated kinase in human spermatozoa: identification, intracellular localization, and key function in the reRulation of sperm motility显示文摘 | Violeta Calle-Guisado Ana Hurtado de Llera David Martin-Hidalgo Jose Mijares Maria C Gil Ignacio S Alvarez Maria J Bragado Luis J Garcia-Marin | 2017 | Asian Journal of Andrology2017，19，6： | 5 |
| 3 | Unraveling the Biochemical and Molecular Networks Involved in Maize Cell Habituation to the Cellulose Biosynthesis Inhibitor Dichlobenil显示文摘面对纤维素生合成禁止者 dichlobenil (DCB ) 涉及玉米细胞的使习惯到生长的生物化学、分子的过程被调查。DCB 在活跃、静止的生长阶段两个都影响纤维素的合成并且改变几 CesA 基因的表示。这些, ZmCesA5 和 ZmCesA7 似乎在使熟习起一个主要作用房间到生长面对 DCB。作为在纤维素的减小的后果,涉及 hydroxycinnamates 的合成的几基因的表示被增加,导致有 ferulic 和 p-coumaric 酸的高水平的房间墙。proteomic 分析表明到 DCB 的使习惯在几条新陈代谢的小径被连接到修正。最后,使熟习房间在除去的谷胱甘肽 S-transferase 介绍减小活动和抗氧化剂活动。到纤维素生合成要求的如此的关键进程的骚乱的植物房间改编在几个新陈代谢的网络变化,以便修改房间墙建筑学和新陈代谢,并且面对禁止者幸存。一些这些修正在这份报纸被描述。 | Hugo Melida Antonio Encina Jesus Alvarez Jose Luis Acebes David Caparros-Ruiz | 2010 | Molecular Plant2010，3，5： | 5 |
| 4 | Changes in Cinnamic Acid Derivatives Associated with the Habituation of Maize Cells to Dichlobenil显示文摘到象 dichlobenil (DCB ) 那样的纤维素生合成禁止者的房间文化的使习惯表示改进我们机制的知识的一个珍贵工具在植物房间墙中包含了结构的粘性。玉米房间线使熟习到 DCB 的致命的集中能通过在哪个纤维素被 arabinoxylans 的一个更广泛的网络部分代替的一面修改房间墙的获得成长。这个工作的目的是调查非使熟习、使熟习 DCB 的玉米房间文化的酉分的新陈代谢。玉米房间文化被喂[14C ] cinnamate 和在在整个文化周期的不同 intra 原形质、墙局部性的部分的放射性的命运被 autoradiography 并且焕发数分析。非使熟习、使熟习的文化显著地没处于他们举起的能力不同外长[14C ] 苯乙烯的酸。然而,有趣的差别在 radiolabeling 被发现低 -- 先生和高度 -- 先生代谢物。使熟习的文化显示了 radiolabeled 的一个更高的数字和数量低 -- 先生加重,它能充当以后为多糖 feruloylation 使用的储备。使熟习 DCB 的文化高度在 esterified 被充实[14C ] dehydrodiferulates 和更大的联合产品。在结论, hydroxycinnamates 的广泛、早的 cross-linking 在使熟习 DCB 的文化被观察,可能加强他们的纤维素缺乏的墙。 | Hugo Melida Jesus Alvarez Jose Luis Acebes Antonio Encina Stephen C. Fry | 2011 | Molecular Plant2011，4，5： | 4 |
| 5 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 6 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 7 | Mitochondrial Sulfide Detoxification Requires a Functional Isoform O-Acetylserine(thiol)lyase C in Arabidopsis thaliana显示文摘在 non-cyanogenic 种类,氰化物的主要来源源于乙烯和 camalexin biosyntheses。在线粒体,氰化物是细胞色素 c oxidase 的一个有势力禁止者并且被 -cyanoalanine synthase CYS-C1 使产生代射变化,催化到氢硫化物和 -cyanoalanine 的半胱氨酸和氰化物的变换。释放的氢硫化物也禁止细胞色素 c oxidase 并且需要被 O-acetylserine (thiol ) lyase mitochondrial isoform 除去, OAS-C,催化硫化物的加入到 O-acetylserine 生产半胱氨酸,因此在线粒体产生一条周期的小径。功能的 OAS-C isoforms 的损失引起 phenotypic 很类似于 CYS-C1 酶的损失的特征,显示出在根头发形成的缺点。有 OAS-C 基因的基因互补救根头发延伸的缺陷,恢复野类型的显型。线粒体妥协他们适当地除去的能力氰化物和产生硫化物因为后者不能在 oas-c 0 异种重新吸收进半胱氨酸。因而,我们观察硫化物和氰化物并且其他的 oxidase 的累积,它是不能的由于两个有毒的分子的累积可能阻止反应的氧种类的生产。我们的结果允许我们建议 OAS-C 的意义在线粒体与它在合适的硫化物和氰化物 detoxification 的角色有关。 | Consolacien Alvarez Irene Garcia Luis C Romero Cecilia Gotor | 2012 | Molecular Plant2012，5，6： | 2 |
| 8 | Effect of climate and altitude on plant community composition and richness in Brazilian inselbergs显示文摘Plant communities are shaped by multiple factors along environmental gradients;however,studies are limited on how environmental filtering drives community composition and species richness on tropical inselbergs.We evaluate the influence of altitude and climatic variables related to temperature and precipitation on plant community composition and species richness on Brazilian inselbergs.We assume as a premise that both climate and altitude would induce changes on plant community composition and species richness at the local level.We used plant inventory data from 370 sampling units across four inselberg sites in the Atlantic Forest of Espírito Santo State,south-eastern Brazil.We tested the univariate and multivariate effects of altitude and climate variables on community composition and species richness with multiple models.Differences in species richness between inselbergs were evaluated using sample-based data to estimate rarefaction and extrapolation curves.In addition,differences in species composition and taxonomic beta diversity were examined via novel frequency-based metrics.A contrasting climate pattern was observed between the inselberg sites,with south sites being wet compared to the dry conditions found in northern sites.Species richness by rarefaction showed a similar pattern within regional sites;however,there were marked differences between regions.Species richness and beta diversity showed significant differences among sites,with higher values in southern sites than in northern sites.In a multi-model comparison between inselberg sites,altitude significantly influenced community composition and species richness and explained more variance than climate models.This finding suggested that climate could act to some extent on these tropical inselbergs;however,altitude was a better predictor of plant community composition and species richness at the local level. | Herval Vieira PINTO-JUNIOR Pedro Manuel VILLA Luis Fernando Tavares de MENEZES Miriam Cristina Alvarez PEREIRA | 2020 | Journal of Mountain Science2020，17，8： | 2 |
| 9 | Optimal exit and valuation under demand uncertainty:A real option approach显示文摘 | Alvarez Luis H R | 1999 | European Journal of Operation Research1999，114，2： | 1 |
| 10 | Optimal exit and valuation under demand uncertainty:A real options approach显示文摘 | Luis H R Alvarez | 1999 | Journal of Mathematical Economics1999，，114： | 1 |
| 11 | The market ori- entation concept in the private nonprofit organisation domain显示文摘 | LUIS 1GNACIO ALVAREZ GONZALEZ Maria LETIC1A SANTOS VIJANDE RODOLFO VAZQUEZ CASIELLES | 2002 | lnternational Journal of Nonprofit and Voluntary Sector Marketing2002，，7： | 1 |
| 12 | Analyses of genetic diversity in Cuban rice varieties using isozyme, RAPD and AFLP markers显示文摘 | Jorge Luis Fuentes Fabio Escobar Alba Alvarez Geraldo Gallego Miriam Cristina Duque Mirle Ferrer Juan Enrrique Deus Joe M. Tohme | 1999 | Euphytica1999，，2： | 1 |
| 13 | Application of proteomics for fast identification of species - specific peptides from marine species 显示文摘 | Jose Luis Lopez Anabel Marina Gonzalo alvarez | 2002 | Proteomics2002，2，： | 1 |
| 14 | An algebraic approach to lens distortion by line rectification 显示文摘 | Luis Alvarez Luis Gomez J Rafael Sendra | 2009 | J Math Imaging Vis2009，35，1： | 1 |
| 15 | Pathophysiologic mechanisms of cardiovascular disease inobstructive sleep apnea syndrome显示文摘 | Carlos Zamarron Luis Valdes Cuadrado Rodolfo Alvarez -Sala | 2013 | Pulm Med2013，2013，52： | 1 |
| 16 | Adoption of Uncertain Multistage Technol- ogy Projects: A Real Options Approach显示文摘 | Luis H R Alvarez R S | 2001 | Journal of Mathemati- cal Economics2001，35，1： | 1 |
| 17 | Duodenal biopsy may be avoided when high transglutaminase antibody titers are present显示文摘AIM:To evaluate the predictive value of tissue transglutaminase (tTG) antibodies for villous atrophy in adult and pediatric populations to determine if duodenal biopsy can be avoided.METHODS: A total of 324 patients with celiac disease (CD; 97 children and 227 adults) were recruited prospectively at two tertiary centers. Human IgA class anti-tTG antibody measurement and upper gastrointestinal endoscopy were performed at diagnosis. A second biopsy was performed in 40 asymptomatic adults on a gluten-free diet (GFD) and with normal tTG levels.RESULTS: Adults showed less severe histopathology (26% vs 63%, P<0.0001) and lower tTG antibody titers than children. Levels of tTG antibody correlated with Marsh type in both populations (r=0.661, P<0.0001). Multiple logistic regression revealed that only tTG antibody was an independent predictor for Marsh type 3 lesions, but clinical presentation type and age were not. A cut-off point of 30 U tTG antibody yielded the highest area under the receiver operating characteristic curve (0.854). Based on the predictive value of this cut-off point, up to 95% of children and 53% of adults would be correctly diagnosed without biopsy. Despite GFDs and decreased tTG antibody levels, 25% of the adults did not recover from villous atrophy during the second year after diagnosis.CONCLUSION: Strongly positive tTG antibody titers might be sufficient for CD diagnosis in children. However, duodenal biopsy cannot be avoided in adults because disease presentation and monitoring are different. | Santiago Vivas Jose G Ruiz de Morales Sabino Riestra Laura Arias Dolores Fuentes Noemi Alvarez Sara Calleja Mercedes Hernando Blanca Herrero Javier Casqueiro Luis Rodrigo | 2009 | World Journal of Gastroenterology2009，15，38： | 1 |
| 18 | Adaptive emergency brak- ing control with underestimation of friction coefficient 显示文摘 | YI J G LUIS ALVAREZ R HOROWITZ | 2002 | IEEE Transactions on Control Systems Technology2002，10，3： | 1 |
| 19 | Takeover Timing, Implementation Uncertainty, and Embedded Divestment Options显示文摘 | Luis H. R. Alvarez Rune Stenbacka | 2006 | Review of Finance2006，，3： | 1 |
| 20 | Evolution of methicillin-resistant Staphylococcus aureus clones in Latin America显示文摘 | Eduardo Rodríguez-Noriega Carlos Seas Manuel Guzmán-Blanco Carlos Mejía Carlos Alvarez Luis Bavestrello Jeannete Zurita Jaime Labarca Carlos M. Luna Mauro J.C. Salles Eduardo Gotuzzo | 2009 | International Journal of Infectious Diseases2009，，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员