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| 1 | Effects of gastric pacing on gastric emptying and plasma motilin显示文摘AIM:To investigate the effects of gastric pacing on gastric emptying and plasma motilin level in a canine model of gastric motility disorders and the correlation between gastric emptying and plasma motilin level.METHODS: Ten healthy Mongrel dogs were divided into:experimental group of six dogs and control group of four dogs. A model of gastric motility disorders was established in the experimental group undergone truncal vagotomy combined with injection of glucagon. Gastric half-emptying time (GEt1/2) was monitored with single photon emission computerized tornography (SPECT), and the half-solid test meal was labeled with an isotope-^99mTc sulfur colloid. Plasma motilin concentration was measured with radioimmunoassay (RIA) kit. Surface gastric pacing at 1.1-1.2 times the intrinsic slow-wave frequency and a superimposed series of high frequency pulses (10-30Hz) was performed for 45min daily for a month in conscious dogs.RESULTS:After surgery, GEt1/2 in dogs undergone truncal vagotorny was increased significantly from 56.35±2.99min to 79.42±1.91min (P<0.001), but surface gastric pacing markedly accelerated gastric emptying and significantly decreased GEt1/2 to 64.94±1.75min (P<0.001) in animals undergone vagotomy. There was a significant increase of plasma level of motilin at the phase of IMCⅢ (interdigestive myoelectrical complex, IMCⅢ) in the dogs undergone bilateral truncal vagotomy (baseline vsvagotomy, 184.29±9.81pg/ml vs 242.09±17.22pg/ml;P<0.01).But plasma motilin concentration (212.55±11.20pg/ml; P<0.02) was decreased significantly after a long-term treatment with gastric pacing.Before gastric padng, GEt1/2 and plasma motilin concentration of the dogs undergone vagotomy showed a positive correlation (r=0.867, P<0.01), but after a long-term gastric pacing, GEt1/2 and motilin level showed a negative correlation (r=-0.733, P<0.04).CONCLUSION: Surface gastric pacing with optimal pacing parameters can improve gastric emptying parameters and significantly accelerate gastric emptying and can resume or alter motor function in a canine model of motility disorders. Gastric emptying is correlated well with plasma motilin level before and after padng, which suggests that motilin can modulate the mechanism of gastric pacing byaltering gastric motility.motilin can modulate the mechanism of gastric pacing by altering gastric motility. | MinYang Dian-ChunFang Qian-weiLi Nian-XuSun Qing-LinLong Jian-FengSui LuGan | 2004 | World Journal of Gastroenterology2004，10，3： | 27 |
| 2 | Metabolome and water homeostasis analysis of Thellungiella salsuginea suggests that dehydration tolerance is a key response to osmotic stress in this halophyte显示文摘 | Lugan R Niogret MF Leport L | | 0，，02： | 1 |
| 3 | Solid-State Luminescence and π-Stacking in Crystalline Uranyl Dipicolinates 显示文摘 | Harrowfield J M Lugan N Shahverdizadeh G H | 2006 | Eur J Inorg Chem2006，，： | 1 |
| 4 | Sleep laboratory investigations on hypnotic properties of melaronin显示文摘 | Waldhauser F Saletu B Trinchard Lugan I | 1990 | Psychopharmacology1990，100，： | 1 |
| 5 | Metabolome and water homeostasis analysis of TheUungiella salsuginea suggests that dehydration tolerance is a key response to osmotic stress in this halophyte 显示文摘 | Lugan R Niogret MF Leport L | 2010 | The Plant Journal2010，64，2： | 1 |
| 6 | Bioequivalence of liquid and freeze-dried recombinant human follicle-stimulating hormone 显示文摘 | LUGAN I FEBBRARO S LECUELLE H | 2005 | Curr Med Res Opin2005，21，1： | 1 |
| 7 | Bioequivalence of liquid and freeze-dried recombinant human follicle-stimulating hormone显示文摘 | Lugan I Febbraro S Lecuelle H | 2005 | Curr Med Res Opin2005，21，： | 1 |
| 8 | Metabolome and water homeostasis analysis of Thellungiella salsuginea suggests that dehydra- tion tolerance is a key response to osmotic stress in this halophyte 显示文摘 | LUGAN R NIOG RET M F LEPORT L | 2010 | The Plant Journal2010，64，2： | 1 |
| 9 | 查看详情显示文摘 | J Billy V Josse Z Zuo A Bernard B Hambrecht P Lugan D C1éent L Sanchez-Palencia P Bouyer and A Aspect | | 0，，7197： | 1 |
| 10 | Metabolome and water home- ostasis analysis of Thellungiella salsuginea suggests that dehydration tolerance is a key response to osmotic stress in this halophyte 显示文摘 | Lugan R Niogret M F Leport L | 2010 | The Plant Journal2010，64，2： | 1 |
| 11 | 查看详情显示文摘 | J Billy V Josse Z Zuo A Bernard B Hambrecht P Lugan D Clément L Sanchez-Palencia P Bouyer and A Aspect | | 0，，7197： | 1 |
| 12 | Structural, func- tional, and evolutionary analysis of the unusually large stilbene synthase gene family in grapevine显示文摘 | PARAGE C TAVARES R RETY S BALTENWECK- GUYOT R POUTARAUD A RENAULT L HEINTZ D LUGAN R MARAIS G AUBOURG S HUGUENEY P | 2012 | Plant Physiology2012，160，3： | 1 |
| 13 | Characteristics and variation law of wind-blown sand delivered to the NingxiaeInner Mongolia reach of the Yellow River under a changing environment显示文摘Wind-blown sand is one of the key factors affecting the evolution of sediment transport,erosion,and deposition in rivers crossing desert areas.However,the differences and complex variations in the spatial and temporal distribution of the underlying surface conditions are seldom considered in research on the river inflow of wind-blown sand over a long time period.The Yellow River contains a large amount of sediment.The NingxiaeInner Mongolia reach of the Yellow River was selected as the research area of the current study.The reach flows out of Heishanxia and then flows through the Tengger,Hedong,Ulan Buh,and Kubuqi Deserts.In the current study,the wind speed,vegetation coverage,and sand matter on the river basin's surface were analyzed from the perspectives of the river basin surface and riverbank line.The vegetation coverage of the river basin's surface was calculated using the normalized difference vegetation index.Based on the types of sand matter,vegetation coverage,and other underlying surface conditions,the loose particle sediment transport efficiency was determined,the Lettau and Lettau formula for the sediment transport rate was modified,a surface wind-erosion sand flux model was established,and the amount of wind-blown sand transported into the NingxiaeInner Mongolia reach was calculated.The results show that,from 1981 to 2014,the annual average amount of wind-blown sand transported into the main stream and tributaries of the NingxiaeInner Mongolia reach of the Yellow River were 7,310,000 and 13,190,000 t,respectively.The ShizuishaneBayangole reach received 51%of the total wind-blown sand that transported into the main stream,while the tributaries in the Shidakongdui area were the most important source wind-blown sand,providing 74%of the total windblown sand inflow from the tributaries.In recent years,the amount of sand transported into the river of the mainstream and tributaries of the NingxiaeInner Mongolia reach of the Yellow River has significantly decreased from 1981 to 2002,particularly in 1993e2002,which is mainly the result of the weakening wind speed,increasing vegetation coverage,and embankment construction.More specifically,environmental protection policies led by the government,such as“returning farmland to forest”,have played an important and positive role.Therefore,when regulating the water and sediment in the NingxiaeInner Mongolia reach of the Yellow River,the issue of wind-blown sand deposition into the river should be fully considered in water and sediment regulation. | Zhichun Yue Ximin Yuan Lugan Cao Fuchang Tian Chao Han Hongwu Zhang | 2022 | International Journal of Sediment Research2022，37，2： | 1 |
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