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| 1 | Effects of gastric pacing on gastric emptying and plasma motilin显示文摘AIM:To investigate the effects of gastric pacing on gastric emptying and plasma motilin level in a canine model of gastric motility disorders and the correlation between gastric emptying and plasma motilin level.METHODS: Ten healthy Mongrel dogs were divided into:experimental group of six dogs and control group of four dogs. A model of gastric motility disorders was established in the experimental group undergone truncal vagotomy combined with injection of glucagon. Gastric half-emptying time (GEt1/2) was monitored with single photon emission computerized tornography (SPECT), and the half-solid test meal was labeled with an isotope-^99mTc sulfur colloid. Plasma motilin concentration was measured with radioimmunoassay (RIA) kit. Surface gastric pacing at 1.1-1.2 times the intrinsic slow-wave frequency and a superimposed series of high frequency pulses (10-30Hz) was performed for 45min daily for a month in conscious dogs.RESULTS:After surgery, GEt1/2 in dogs undergone truncal vagotorny was increased significantly from 56.35±2.99min to 79.42±1.91min (P<0.001), but surface gastric pacing markedly accelerated gastric emptying and significantly decreased GEt1/2 to 64.94±1.75min (P<0.001) in animals undergone vagotomy. There was a significant increase of plasma level of motilin at the phase of IMCⅢ (interdigestive myoelectrical complex, IMCⅢ) in the dogs undergone bilateral truncal vagotomy (baseline vsvagotomy, 184.29±9.81pg/ml vs 242.09±17.22pg/ml;P<0.01).But plasma motilin concentration (212.55±11.20pg/ml; P<0.02) was decreased significantly after a long-term treatment with gastric pacing.Before gastric padng, GEt1/2 and plasma motilin concentration of the dogs undergone vagotomy showed a positive correlation (r=0.867, P<0.01), but after a long-term gastric pacing, GEt1/2 and motilin level showed a negative correlation (r=-0.733, P<0.04).CONCLUSION: Surface gastric pacing with optimal pacing parameters can improve gastric emptying parameters and significantly accelerate gastric emptying and can resume or alter motor function in a canine model of motility disorders. Gastric emptying is correlated well with plasma motilin level before and after padng, which suggests that motilin can modulate the mechanism of gastric pacing byaltering gastric motility.motilin can modulate the mechanism of gastric pacing by altering gastric motility. | MinYang Dian-ChunFang Qian-weiLi Nian-XuSun Qing-LinLong Jian-FengSui LuGan | 2004 | World Journal of Gastroenterology2004，10，3： | 27 |
| 2 | Screening of differentially expressed microRNA in ulcerative colitis related colorectal cancer显示文摘Objective:To investigate the differential expression of microRNA(miRNA)in colon between ulcerative colitis(UC)and ulcerative colitis related colorectal cancer(UCRCC).Methods:An UC mouse model was built by dextran sodium sulfate,and an UCRCC mouse model by dextran sodium sulfate and 1,2-diformylhydrazine.RNAs were extracted from the colon,purified and hybridized with fluorescence-labeled miRNA oligonucleotide gene chip.Real-time fluorescence quantitative PCR was used to verity the expression variation of miRNA.SAM was employed for the data analysis.Results:The up-regulated miRNA in colon cancer included has-miR-194,hasmiR-215,has-miR-93,has-miR-192,has-miR-92a,has-miR-29b,and has-miR-20a(median false discovery rate<5%),while the down-regulated miRNAs were has-miR-1231,has-miR-195,has-miR-143,and has-miR-145(median false discovery rate<5%).Conclusions:Significant differential expression of miRNA was found between the UC mouse and UCRCC mouse,which may be related to the onset,erosion and transfer of colorectal cancer. | Yong-GangTan Yong-FengZhang Chang-JunGuo MinYang Man-YinChen | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，12： | 7 |
| 3 | The Hippo signalling pathway and its implications in human health and diseases显示文摘As an evolutionarily conserved signalling network,the Hippo pathway plays a crucial role in the regulation of numerous biological processes.Thus,substantial efforts have been made to understand the upstream signals that influence the activity of the Hippo pathway,as well as its physiological functions,such as cell proliferation and differentiation,organ growth,embryogenesis,and tissue regeneration/wound healing.However,dysregulation of the Hippo pathway can cause a variety of diseases,including cancer,eye diseases,cardiac diseases,pulmonary diseases,renal diseases,hepatic diseases,and immune dysfunction.Therefore,therapeutic strategies that target dysregulated Hippo components might be promising approaches for the treatment of a wide spectrum of diseases.Here,we review the key components and upstream signals of the Hippo pathway,as well as the critical physiological functions controlled by the Hippo pathway.Additionally,diseases associated with alterations in the Hippo pathway and potential therapies targeting Hippo components will be discussed. | Minyang Fu Yuan Hu Tianxia Lan Kun-Liang Guan Ting Luo Min Luo | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 5 |
| 4 | Multifunctional regulatory protein connective tissue growth factor (CTGF):A potential therapeutic target for diverse diseases显示文摘Connective tissue growth factor(CTGF),a multifunctional protein of the CCN family,regulates cell proliferation,differentiation,adhesion,and a variety of other biological processes.It is involved in the disease-related pathways such as the Hippo pathway,p53 and nuclear factor kappa-B(NF-κB)pathways and thus contributes to the developments of inflammation,fibrosis,cancer and other diseases as a downstream effector.Therefore,CTGF might be a potential therapeutic target for treating various diseases.In recent years,the research on the potential of CTGF in the treatment of diseases has also been paid more attention.Several drugs targeting CTGF(monoclonal antibodies FG3149 and FG3019)are being assessed by clinical or preclinical trials and have shown promising outcomes.In this review,the cellular events regulated by CTGF,and the relationships between CTGF and pathogenesis of diseases are systematically summarized.In addition,we highlight the current researches,focusing on the preclinical and clinical trials concerned with CTGF as the therapeutic target. | Minyang Fu Dandan Peng Tianxia Lan Yuquan Wei Xiawei Wei | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 5 |
| 5 | A high-quality genome assembly of Morinda officinalis,a famous native southern herb in the Lingnan region of southern China显示文摘Morinda officinalis is a well-known medicinal and edible plant that is widely cultivated in the Lingnan region of southern China.Its dried roots(called bajitian in traditional Chinese medicine)are broadly used to treat various diseases,such as impotence and rheumatism.Here,we report a high-quality chromosome-scale genome assembly of M.officinalis using Nanopore single-molecule sequencing and Hi-C technology.The assembled genome size was 484.85Mb with a scaffold N50 of 40.97 Mb,and 90.77%of the assembled sequences were anchored on eleven pseudochromosomes.The genome includes 27,698 protein-coding genes,and most of the assemblies are repetitive sequences.Genome evolution analysis revealed that M.officinalis underwent core eudicotγgenome triplication events but no recent whole-genome duplication(WGD).Likewise,comparative genomic analysis showed no large-scale structural variation after species divergence between M.officinalis and Coffea canephora.Moreover,gene family analysis indicated that gene families associated with plant–pathogen interactions and sugar metabolism were significantly expanded in M.officinalis.Furthermore,we identified many candidate genes involved in the biosynthesis of major active components such as anthraquinones,iridoids and polysaccharides.In addition,we also found that the DHQS,GGPPS,TPS-Clin,TPS04,sacA,and UGDH gene families—which include the critical genes for active component biosynthesis—were expanded in M.officinalis.This study provides a valuable resource for understanding M.officinalis genome evolution and active component biosynthesis.This work will facilitate genetic improvement and molecular breeding of this commercially important plant. | Jihua Wang Shiqiang Xu Yu Mei Shike Cai Yan Gu Minyang Sun Zhan Liang Yong Xiao Muqing Zhang Shaohai Yang | 2021 | Horticulture Research2021，8，1： | 4 |
| 6 | Efficient and Quick Inactivation of SARS Coronavirus and Other Microbes Exposed to the Surfaces of Some Metal Catalysts显示文摘Objective To study the two metal catalysts Ag/Al2O3 and Cu/Al2O3 that interdict the transmission pathway for SARS and other respiratory infectious diseases. Methods Two metal catalysts Ag/Al2O3 and Cu/Al2O3 were pressed into wafers. One hundred μL 106 TCID50/mL SARS-CoV, 100 μL 106 PFU/mL recombinant baculovirus expressing hamster’s prion protein (haPrP) protein and roughly 106 E. coli were slowly dropped onto the surfaces of the catalyst wafers and exposed for 5 and 20 min, respectively. After eluted from the surfaces of wafers, the infectivity of viruses and propagation of bacteria were measured. The expression of PrP protein was determined by Western blot. The morphological changes of bacteria were observed by electronic microscopy. Results After exposure to the catalysts surfaces for 5 and 20 min, the infectivity of SARS-CoV in Vero cells and baculovirus in Sf9 cells dropped down to a very low and undetectable level, and no colony was detected using bacteria culture method. The expression of haPrP protein reduced to 21.8% in the preparation of Sf9 cells infected with recombinant baculovirus exposed for 5 min and was undetectable exposed for 20 min. Bacterial membranes seemed to be cracked and the cytoplasm seemed to be effluent from cell bodies. Conclusion Exposures to the surfaces of Ag/Al2O3 and Cu/Al2O3 destroy the replication and propagation abilities of SARS-CoV, baculovirus and E. coli. Inactivation ability of metal catalysts needs to interact with air, utilizing oxygen molecules in air. Efficiently killing viruses and bacteria on the surfaces of the two metal catalysts has a promising potential for air-disinfection in hospitals, communities, and households. | JUNHAN LANCHEN SHU-MINDUAN QING-XIANGYANG MINYANG CHENGAO BAO-YUNZHANG HONGHE XIAO-PINGDONG | 2005 | Biomedical and Environmental Sciences2005，18，3： | 4 |
| 7 | Author correction to‘Multifunctional regulatory protein connective tissue growth factor(CTGF):A potential therapeutic target for diverse diseases’[Acta pharmaceutica sinica B 12(2022)1740-1760]显示文摘The authors regret that there was an error in 7.Conclusion and prospect section of the article.The last paragraph of this section‘Under particular external…integrins interact with CT domain’is supposed to be the content of the figure legend(Fig.1).It is superfluous in this part and should be deleted.The revision does not affect any conclusions of this work. | Minyang Fu Dandan Peng Tianxia Lan Yuquan Wei Xiawei Wei | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 3 |
| 8 | The role of personality,social economic and prevention strategy effects on health-related quality of life among people living with HIV/AIDS显示文摘Background::HIV/AIDS has transformed into a chronic controllable but not yet curable infectious disease as other chronic diseases to some extent.The additional of so called fourth 90%that included the improved health-related quality of life(HRQoL)for people living with HIV(PLWHIV)required solutions beyond antiretroviral therapy and viral load suppression.This study will explore the role of personality,social economic and prevention strategy effection on HRQoL among people living with HIV/AIDS.Methods::A cross-sectional study was conducted among PLWHIV aged more than 16 years old in the 10 municipalities in Yunnan Province,China from October 2019 to May 2020,enrolling total 1997 participants.Individual-level HRQoL data were measured by 12-item Short Form Health Survey(SF-12)and EuroQol Five Dimensions Questionnaire(EQ-5D-5L).We assembled municipal-level data about social economic from Yunnan Statistical Yearbook in 2020 and strategy practice information from the self-evaluation system.We used the principal component analysis to build the social economic and strategy effect on each area respectively and one-way ANOVA was used to perform univariate analysis to identify the predictors with significant differences.Finally we used multi-level model(MLM)to explore the personality,social economic and strategy effects in health-related quality of life among PLWHIV.Results::The global score for quality of life measured using EQ-5D-5L had an estimated mean score(standard deviation,SD)of 0.901±0.146.The HRQoL score measured using PCS-12 had an estimated mean score(SD)of 46.62±8.55.The mean MCS-12 score(SD)was estimated to be 47.80±9.71.The area-level predictors explained a proportion of 13.6-17.2%for the between-area variation of the HRQoL scores,regardless of the total HRQoL,physical component and mental component.The impacts of stigma(P<0.01),social support(P<0.001),anxiety(P<0.001),depression(P<0.05)and social economic status(P<0.05)on HRQoL at the individual-level were significantly different.The plots visualized the impact of individual-level factors on a respondent’s HRQoL was modified by the area-level characteristics.Conclusions::The study identified the possible strategy determinant of individual HRQoL of PLWHIV and also the area effect on HRQoL.Stigma,social support,anxiety,depression and social economic status were the individual-level determinants on HRQoL.These could be a valuable resource for evaluating the overall health of the areas and help improve local decision making. | Xiaowen Wang Hongbing Luo Enlong Yao RenhaiTang Wenbin Dong Fuyong Liu Jun Liang Huilan Li Minyang Xiao Zuyang Zhang Jin Niu Lijun Song Liru Fu Xuehua Li Shicong Qian Qing Guo Zhizhong Song | 2021 | Infectious Diseases of Poverty2021，10，4： | 3 |
| 9 | Discussion on the Mechanism of Boric Acid and Phosphoric Acid to Improve the Hardening of Complex Calcium Lubricating Grease显示文摘In order to solve the hardening problem of complex calcium lubricating grease, the water absorption test of several calcium salts was carried out, and it was found that calcium 12-hydroxystearate did not absorb water, and calcium acetate, calcium phosphate and calcium borate had different degrees of water absorption. Calcium acetate has the highest water absorption rate, while calcium phosphate and calcium borate show comparable water absorption rates. Upon using the molecular simulation technology, it is found that in the complex calcium grease system, calcium phosphate and calcium borate tend to combine with water, which inhibits the water absorption of calcium acetate and alleviate the hardening problem. | Zheng Hui Sun Hongwei He Yifeng Su Shuo Zhuang Minyang Liu Xinyang | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，4： | 3 |
| 10 | Nutrient Accumulation and Distribution of Mature Pinus massoniana Plantation in Northwestern Guangxi显示文摘[Objectives]This study was conducted to reveal the characteristics of nutrient absorption and accumulation in Pinus massoniana plantations in Northwestern Guangxi.[Methods]Based on field investigation and indoor analysis,the contents,accumulation and annual net accumulation of five nutrient elements(N,P,K,Ca and Mg)in a mature P.massoniana plantation(26-year-old)in Nandan County,Guangxi Province were studied.[Results]The contents of nutrient elements in different organs of the mature P.massoniana plantation were the highest in the leaves,followed by the bark,branch and root,and the lowest in the stem.In general,among the contents of the five elements in different organs,N content was the highest,followed by K or Ca,and P and Mg were the lowest.The total accumulation of nutrient elements in the 26-year-old mature P.massoniana plantation in northwestern Guangxi was 1 384.05 kg/hm^2.Among the different structural levels of the stand,the tree layer had the highest accumulation of nutrient elements,which was 1 198.41 kg/hm^2,accounting for 86.59%of the total accumulation of nutrients in the plantation,and the accumulation of nutrients in other layers from the largest to the smallest was the litter layer(91.97 kg/hm^2),herb layer(49.86 kg/hm^2)and shrub layer(43.92 kg/hm^2),accounting for 3.17%,3.60%and 6.64%of the total nutrient accumulation of the plantation,respectively.The annual net accumulation of nutrient elements in the tree layer of the mature P.massoniana plantation was 46.09 kg/(hm^2·a),and the order of the annual net accumulation of different nutrient elements followed N>K>Ca>Mg>P;and the accumulation of 1 t of dry matter needed 6.37 kg of the five nutrients.[Conclusions]This study provides a scientific basis for the rational management of P.massoniana plantations,especially forest soil management. | Minyang XIE Zhenge HUANG Mingbao WEI Bin HE Shaozhuang MO Gang ZHOU JI LIANG | 2019 | Agricultural Biotechnology2019，8，4： | 2 |
| 11 | The benefits of using instantaneous energy to monitor the transient state of the wire-EDM process 显示文摘 | Kwon S Yang Minyang | 2006 | The International Journal of Advanced Manufacturing Technology2006，27，910： | 1 |
| 12 | A study on a generalized parametric interpolator with real-time jerk-limited acceleration显示文摘 | NAM S H YANG Minyang | 2004 | Computer-Aided Design2004，36，1： | 1 |
| 13 | A study on a generalized parametric interpolator with real - time jerk - limited acce|eration 显示文摘 | Nam Sung- Ho Yang Minyang | 2003 | Comput Aided Des2003，36，1： | 1 |
| 14 | A set of miRNAs from Brassica napus in response to sulphate deficiency and cadmium stress显示文摘 | Si QiHuang An LingXiang Li LingChe SongChen HuiLi Jian BoSong Zhi MinYang | 2010 | Plant Biotechnology Journal2010，，8： | 1 |
| 15 | NC verification of numerically controlled machining programs显示文摘 | YANG Minyang LEE Eungki | 1996 | The Visual Computer1996，28，9： | 1 |
| 16 | A tool condition recognition system using image processing 显示文摘 | Minyang Yang Oh Dal Kwan | 1998 | Control Engineering Practice1998，，6： | 1 |
| 17 | Development of a real-time trajectory generator for NURBS interpolation based on the two-stage interpolation method显示文摘 | Jinho Park Sungho Nam Minyang Yang | 2005 | The International Journal of Advanced Manufacturing Technology2005，，4： | 1 |
| 18 | The prediction of cutting force in ball end milling显示文摘 | Minyang Yang Heeduck Park | 1991 | International Journal of Machine Tool Design and Research1991，31，1： | 1 |
| 19 | LRIG1, a candidate tumour‐suppressor gene in human bladder cancer cell line BIU87显示文摘 | Wei‐MinYang Ze‐JunYan Zhang‐QunYe Dong‐ShengGuo | 2006 | BJU International2006，，4： | 1 |
| 20 | Experimental Study of Surface Integrity during End Milling of AI/SiC Particulate Metal - matrix Composites 显示文摘 | Suresh Kumar Reddy N Shin Kwang Sup Yang Minyang | 2008 | Journal of Materials Pro cessing Technology2008，201，13： | 1 |
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