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您的检索式：作者名="Lucile Alexandre"
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| 1 | Root osmotic sensing from local perception to systemic responses显示文摘Plants face a constantly changing environment,requiring fine tuning of their growth and development.Plants have therefore developed numerous mechanisms to cope with environmental stress conditions.One striking exam-ple is root response to water deficit.Upon drought(which causes osmotic stress to cells),plants can among other responses alter locally their root system architecture(hydropatterning)or orientate their root growth to optimize water uptake(hydrotropism).They can also modify their hydraulic properties,metabolism and development coordi-nately at the whole root and plant levels.Upstream of these developmental and physiological changes,plant roots must perceive and transduce signals for water availability.Here,we review current knowledge on plant osmotic per-ception and discuss how long distance signaling can play a role in signal integration,leading to the great phenotypic plasticity of roots and plant development. | Lucille Gorgues Xuelian Li Christophe Maurel Alexandre Martiniere Philippe Nacry | 2022 | Stress Biology2022，2，1： | 1 |
| 2 | Peg-IFNα/ribavirin/protease inhibitor combination in severe hepatitis C virus-associated mixed cryoglobulinemia vasculitis显示文摘 | David Saadoun Matthieu Resche Rigon Stanislas Pol Vincent Thibault Fran?ois Blanc Gilles Pialoux Alexandre Karras Dorothée Bazin-Kara Cécile Cazorla Daniel Vittecoq Lucile Musset Julie Peltier Olivier Decaux Jean-Marc Ziza Olivier Lambotte Patrice Cacoub | 2014 | Journal of Hepatology2014，，： | 1 |
| 3 | High-throughput extraction on a dynamic solid phase for low-abundance biomarker isolation from biological samples显示文摘Liquid biopsy,in particular circulating tumor DNA(ctDNA)analysis,has paved the way for a new noninvasive approach to cancer diagnosis,treatment selection and follow-up.As a crucial step in the analysis,the extraction of the genetic material from a complex matrix needs to meet specific requirements such as high specificity and low loss of target.Here,we developed a new generation of microfluidic fluidized beds(FBs)that enable the efficient extraction and preconcentration of specific ctDNA sequences from human serum with flow rates up to 15µL/min.We first demonstrated that implementation of a vibration system inducing flow rate fluctuations combined with a mixture of different bead sizes significantly enhanced bead homogeneity,thereby increasing capture efficiency.Taking advantage of this new generation of high-throughput magnetic FBs,we then developed a new method to selectively capture a double-stranded(dsDNA)BRAF mutated DNA sequence in complex matrices such as patient serum.Finally,as proof of concept,ligation chain reaction(LCR)assays were performed to specifically amplify a mutated BRAF sequence,allowing the detection of concentrations as low as 6×104 copies/µL of the mutated DNA sequence in serum. | Lucile Alexandre Monica Araya-Farias Manh-Louis Nguyen Nikoletta Naoumi Giacomo Gropplero Electra Gizeli Laurent Malaquin Stéphanie Descroix | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
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