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| 1 | 探寻预测急性卒中事件后发生癫痫的生物标记物显示文摘血液生物标记物在卒中后癫痫中的作用尚未得到广泛研究。本研究旨在研究急性卒中的临床因素和生物标记物,并经过较长时间的观察分析它们与卒中癫痫发生的关系。对缺血性和出血性卒中的患者进行14个血液生物标记物的检测。用Z-scores对生物标记物进行规范化和标准化。同时还评估了卒中和癫痫相关变量:卒中严重程度(依据美国国立卫生研究院卒中量表NIHSS评分)、卒中类型和病因、从卒中到迟发性癫痫发作的时间以及癫痫发作类型。使用多因素Cox回归分析来确定与癫痫相关的独立的临床变量和生物标记物。从1115例患者队列中纳入895例。平均年龄为(72.0±13.1)岁,其中有57.8%的患者为男性。51例患者(5.7%)发展为迟发性癫痫,中位时间为232天[四分位数间距IQR(86~491)]。NIHSS分数≥8[P<0.001,HR=4.013,95%CI(2.123,7.586)]和早发性癫痫发作的病史[P<0.001,HR=4.038,95%CI(1.802,9.045)]是与癫痫发展风险相关的独立因素。预测癫痫的独立生物标记物有:高水平的内皮抑素>1.203[P=0.046,HR=4.300,95%CI(1.028,17.996)]、低水平的70 kDa热休克蛋白8(Hsc70)<2.496[P=0.006,HR=3.795,95%CI(1.476,9.760)]和S100B<1.364[P=0.001,HR=2.955,95%CI(1.534,5.491)]。当这些生物标记物共同存在时,癫痫风险上升至17%。临床变量和血液生物标记物联合使用时,预测模型中受试者工作特性(ROC)曲线下的面积比单独一个存在时[68.9%,95%CI(60.3%,77.6%)]的面积大,为[74.3%,95%CI(65.2%,83.3%)]。S100B和Hsc70的下降及内皮抑制素的升高可能有助于预测卒中后癫痫,这为临床危险因素提供了额外信息。此外,这些数据为癫痫发生假说过程提供了一定依据。 | Abraira L Santamarina E Cazorla S 郭雅静(译) 孟永玲(译) 薛国芳(审) | 2021 | 癫痫杂志2021，7，6： | 2 |
| 2 | Involvment of transcriptional mechanisms in the inhibition of iNOS expression by dexamethasone in rat mesangial cells显示文摘 | Zaragoza C Diaz Cazorla M | 1998 | Kidney Int1998，53，1： | 1 |
| 3 | Development of a sky imager for cloud cover assessment 显示文摘 | Cazorla A Olmo F J Alados-Arboledas L | 2008 | Journal of the Optical Society of America A2008，25，1： | 1 |
| 4 | Breast Milk as a Possible Route of Vertical Transmission of Dengue Virus?显示文摘 | Anne Barthel Ann-Claire Gourinat Cécile Cazorla Corinne Joubert Myrielle Dupont-Rouzeyrol Elodie Descloux | 2013 | Clinical Infectious Diseases2013，，3： | 1 |
| 5 | Age structure of the population of weakfish Cynoscion guatucupa (Cuvier) in the Bahia Blanca waters,Argentina显示文摘 | Cazorla A L | 2000 | Fish Res2000，46，： | 1 |
| 6 | Molecular characterization and oenological properties of wine yeasts isolated during spontaneous fermentation of six varieties of grape must 显示文摘 | Josefa Maria Clemente Jimenez Lydia Mingorance Cazorla Sergio Martinez Rodriguez | 2004 | Food Microbiology2004，，21： | 1 |
| 7 | Acquired immunodeficiency syndrome-associated Kaposi′s sarcoma and human herpesvirus 8 DNA detection in serial peripheral blood mononuclear cell samples显示文摘 | Dupon M Masquelier B Cazorla C | 1997 | Res Virol1997，148，6： | 1 |
| 8 | The biological and metabolic adaptations to 12 months training in elite rowers显示文摘 | Petibois C Cazorla G Deleris G | 2003 | Int J Sports Med2003，24，1： | 1 |
| 9 | Feature selection,mutual information,and the classification of high-dimensional patterns显示文摘 | BONEV B ESCALANO F CAZORLA M | 2008 | Pattern Analysis and Applications2008，11，34： | 1 |
| 10 | Application of FT-IRspectrometry to determine the global metabolic adapta-tions to physical conditioning in sportsmen显示文摘 | Petibois C Cazorla G Cassaigne A | 2002 | ApplSpectrosc2002，56，： | 1 |
| 11 | Constraints on the phase diagram of molybdenum from first-principles free- energy calculations 显示文摘 | CAZORLA C ALFl~ D GILLAN M J | 2012 | Phys Rev B2012，85，06： | 1 |
| 12 | Biochemical aspects of the metabolism alteration process syndrome显示文摘 | Petibois C Cazorla G Poortmans overtraining in endurance sporls J R | 2003 | Sports Med2003，33，2： | 1 |
| 13 | Influence of pore structure and surface chemistry on electric double layer capacitance in non-aqueous electrolyte显示文摘 | Lozano Castello D Cazorla Amoro D Linares Solano A | | 0，，09： | 1 |
| 14 | Calcium-carbon interaction study:its importance in the carbongas reactions显示文摘 | Cazorla A D Linares S A Salinas M D L C | 1991 | Carbon1991，29，3： | 1 |
| 15 | Pseudomonas syringae diseases of fruit trees: progress toward understanding and control 显示文摘 | Kennelly M M Cazorla F M de Vicente A | 2007 | Plant Disease2007，91，1： | 1 |
| 16 | Biochemical aspects of overtraining in endurance sports显示文摘 | Cyril Petibois Georges Cazorla Jacques Poortmans | | 0，，13： | 1 |
| 17 | Oxygen-vacancy induced magnetic phase transitions in multiferroic thin films显示文摘Multiferroics in which giant ferroelectric polarization and magnetism coexist are of tremendous potential for engineering disruptive applications in information storage and energy conversion.Yet the functional properties of multiferroics are thought to be affected detrimentally by the presence of point defects,which may be abundant due to the volatile nature of some constituent atoms and the high temperatures involved in the synthesis of materials.Here,we demonstrate with theoretical methods that oxygen vacancies may enhance the functionality of multiferroics by radically changing their magnetic interactions in thin films.Specifically,oxygen vacancies may restore missing magnetic super-exchange interactions in large axial ratio phases,leading to full antiferromagnetic spin ordering,and induce the stabilization of ferrimagnetic states with considerable net magnetizations.Our theoretical study should help to clarify the origins of long-standing controversies in bismuth ferrite and improve the design of technological applications based on multiferroics. | César Menéndez Dewei Chu Claudio Cazorla | 2020 | npj Computational Materials2020，，1： | 1 |
| 18 | Immunohistochemistry for the differential diagnosis ofrenal tumors with oncocytic features显示文摘 | Fernandez-Acenero M J Cazorla A Manzarbeitia F | 2011 | Urol Oncol2011，29，5： | 1 |
| 19 | ModelChecking Wireless Sensor Network Security Protocols : TinySec +LEAP显示文摘 | Llanos Tobarra Diego Cazorla Fernando Cuartero | 2007 | IFIP International Federation for Information Processing2007，248，： | 1 |
| 20 | Proartis:Probabilistically analyzable real-time systems显示文摘 | Cazorla F J Quinones E Vardanega T | 2013 | ACM Transactions on Embedded Computing Systems(TECS)2013，12，2： | 1 |
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