| 1 | Current and future circulating biomarkers for cardiac amyloidosis显示文摘心脏的淀粉样变性病(CA ) 包括影响心肌层的医药条件的一个异构的组。它与严厉,流行和进化的可变的度与 proteinaceous 介绍渗入。尽管有这异质,错误的蛋白质合拢是普通 pathophysiologic 过程,产出日益增多地发展并且最终形成淀粉的纤维的单个错误褶层蛋白质(单体) 的形成。由从起源的机关外面播种,另外,称为 oligomers 的中介转移并且重启这个过程。如此的自我回应的行为象主要的一样使第二等的影响机关重要。不幸地, CA 能在它的自然历史的一个迟了的阶段临床上挑战性、仅仅暗示,让一扇狭窄的治疗学的时间窗户可得到。考虑到淀粉样变性病的进化性质,这里,我们越过 CA 子类型与不同特性和适用性基于时间舞台建议当前使用的 biomarkers 的一个新分类。早标记(免费的轻链,浆液淀粉的 A, 2-microglobulin, osteopontin 和 osteoprotegerin ) 能为疾病察觉被采用。中间的标记[tumorigenicity 的可溶的抑制 2 (sST-2 ) , midregional proadrenomedullin (MR-proADM ) , von Willebrand 因素(vWF ) , hepatocyte 生长因素(HGF ) ,矩阵 metalloproteinases (MMP ) 和织物禁止者 metalloproteinases (TIMP )] 能在心肌的损坏的生物机制上提供信息。作为在心失败,迟了阶段的 biomarkers (troponins 和 natriuretic 肽) 能在 CA 帮助临床医生做好预后和治疗学的反应评估。如此的调查结果在 CA 上为我们的当前的知识产生了一个显著基础。不过,我们想象目标为能够检测合拢缺点的在上游的事件的 biomarkers 的一个未来班,它将最终扩展治疗学的窗户。 | Marco LUCIANI Luca TRONCONE Federica DEL MONTE | 2018 | Acta Pharmacologica Sinica2018，39，7： | 3 |
| 4 | The western Durkan Complex(Makran Accretionary Prism,SE Iran):A Late Cretaceous tectonically disrupted seamounts chain and its role in controlling deformation style显示文摘The Durkan Complex is a key tectonic element of the Makran accretionary prism(SE Iran)and it has been interpreted as representing a continental margin succession.We present here a multidisciplinary study of the western Durkan Complex,which is based on new geological,stratigraphic,biostratigraphic data,as well as geochemical data of the volcanic and meta-volcanic rocks forming this complex.Our data show that this complex consists of distinct tectonic slices showing both non-metamorphic and very low-grade metamorphic deformed successions.Stratigraphic and biostratigraphic data allow us to recognize three types of successions.Type-Ⅰis composed by a Coniacian-early Campanian pelagic succession with intercalation of pillow lavas and minor volcaniclastic rocks.Type-Ⅱsuccession includes a volcanic sequence passing to a volcano-sedimentary sequence with Cenomanian pelagic limestones,followed by a hemipelagic sequence.This succession is characterized by abundant mass-transport deposits.Type-Ⅲsuccession includes volcanic and volcano-sedimentary sequences,which are stratigraphically covered by a Cenomanian platform succession.The latter is locally followed by a hemipelagic sequence.The volcanic rocks in the different successions show alkaline geochemical affinity,suggesting an origin from an oceanic within-plate setting.Our new results indicate that the western Durkan Complex represents fragments of seamounts tectonically incorporated in the Makran accretionary wedge during the latest Late Cretaceous-Paleocene.We propose that incorporation of seamounts in the frontal prism caused a shortening of the whole convergent margin and possibly contributed to controlling the deformation style in the Makran Accretionary Wedge during Late Cretaceous-Paleocene times. | Edoardo Barbero Luca Pandolfi Morteza Delavari Asghar Dolati Emilio Saccani Rita Catanzariti Valeria Luciani Marco Chiari Michele Marroni | 2021 | Geoscience Frontiers2021，12，3： | 0 |
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