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| 1 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 2 | Oxidative DNA damage mediated by copper(Ⅱ),iron(Ⅱ),and nickel(Ⅱ) Fenton reactions:Evidence for site specific mechanisms in the formation of double-strand breaks,8-hydroxydeoxyguanosine,and putative intrastrand cross-links显示文摘 | Loyd D R Phillips D H 1999 | 1999 | Mutat Res1999，424，： | 1 |
| 3 | N2,N2O and O2profiles in a tagus estuary salt marsh estuarine显示文摘 | Cartaxana P Loyd D | 1999 | Coastal and Shelf Science1999，48，6： | 1 |
| 4 | Har Glass Transition and Caking of Spray-Dried Lactose显示文摘 | RECHARD J LOYD X CHEN D | | 0，，： | 1 |
| 5 | Membrane distillation 1 module design and performance evaluation using vacuum membrane distillation显示文摘 | LAWSON K W LOYD D R | 1996 | J Membr Sci1996，120，： | 1 |
| 6 | Mold performance of some construction products with and without borates 显示文摘 | Fogel J L Loyd J D | 2002 | Forest Products Jour- nal2002，52，2： | 1 |
| 7 | Acoustics of gas-bear ing sediments显示文摘 | Auhrey L Anderson Loyd D Hampton | 1980 | Journal of the Acoustical Society of America1980，67，6： | 1 |
| 8 | Development of a monoclonal -based enzyme -linked immunosorbent assay for the coccidiostat salinomycin显示文摘 | Marcel H E Ross C B Loyd D R | 1993 | J Agric Food Chem1993，41，： | 1 |
| 9 | Lower Silurian 'hot shales' in North Africa and Arabia:regional distribution and depositional model显示文摘 | Luning S Craig J LoydelI D K | | 0，，01： | 1 |
| 10 | Analysis of different methods of assessing the stenotic mitral valve area with emphasis on the pressure gradient half-time concept 显示文摘 | Wranne B Ask P Loyd D | 1990 | Am J Cardiol1990，66，： | 1 |
| 11 | Levopimaric acid显示文摘 | Loyd W D Hedrick G W | 1965 | Organic Synthe-size1965，45，： | 1 |
| 12 | Formation of PLA microfiltra?tion membranes via themally induced phase separation显示文摘 | Tanaka T Loyd D R | 2004 | J Membr Sci2004，238，： | 1 |
| 13 | Germsite of bovine slein显示文摘 | Loyd D H | 1989 | Brit Vet J1989，135，6： | 1 |
| 14 | Membrane distillation显示文摘 | LAWSON K W LOYD D R | 1997 | Journal of Membrane Science1997，124，： | 1 |
| 15 | Thermostatic mixing valvesmodeling and simulation of the thermostat under real operating conditions显示文摘 | Wren J Persson P Loyd D | 2006 | WSEAS Transactions on Heat and Mass Transfer2006，1，1： | 1 |
| 16 | Vertical Equating Using the Rasch Model 显示文摘 | Loyd B H & Hoover H D | 1980 | Journal of Educational Measurement1980，17，： | 1 |
| 17 | The genetics of pulmonary arterial hypertension 显示文摘 | Austin E D Loyd J E | 2014 | Ore Res2014，115，1： | 1 |
| 18 | Removal of basic blue 41 dye from aqueous solutions by adsorption by linseed cake显示文摘 | LIVERSIDEG R M LOYD G J WASE D A J | | 0，，06： | 1 |
| 19 | Assessing the effect of integrating eleva- tion data into the estimation of monthly precipitation in great Britain显示文摘 | Loyd C D | 2005 | Journal of Hydrology2005，，308： | 1 |
| 20 | When surface and deep-level diversitycollide the effects on dissenting group members 显示文摘 | PHILLIP S KW LOYD D L | 2006 | Organizational Behavior and Human Decision Proces- ses2006，99，2： | 1 |
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