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| 1 | Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients显示文摘T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease progression.Pro-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell function.Constitutive STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune diseases.We characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for M.tuberculosis-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 expression.Lentiviral modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after M.tuberculosis-specific stimulation compared to healthy contacts.In addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy contacts.Notably,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in T-cells.Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.SOCS3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 phosphorylation.SOCS3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 phosphorylation.We conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients. | Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 2 | Age,smoking and overweight contribute to the development of intestinal metaplasia of the cardia显示文摘AIM:To assess the role of Helicobacter pylori(H.pylori),gastroesophageal reflux disease(GERD),age,smoking and body weight on the development of intestinal metaplasia of the gastric cardia(IMC).METHODS:Two hundred and seventeen patients scheduled for esophagogastroduodenoscopy were enrolled in this study.Endoscopic biopsies from the esophagus,gastroesophageal junction and stomach were evaluated for inflammation,the presence of H.pylori and intestinal metaplasia.The correlation of these factors with the presence of IMC was assessed using logistic regression.RESULTS:IMC was observed in 42% of the patients.Patient age,smoking habit and body mass index(BMI) were found as potential contributors to IMC.The risk of developing IMC can be predicted in theory by combining these factors according to the following formula:Risk of IMC = a + s-2B where a = 2,…6 decade of age,s = 0 for non-smokers or ex-smokers,1 for < 10 cigarettes/d,2 for > 10 cigarettes/d and B = 0 for BMI < 25 kg/m2(BMI < 27 kg/m2 in females),1 for BMI > 25 kg/m2(BMI > 27 kg/m2 in females).Among potential factors associated with IMC,H.pylori had borderline signif icance(P = 0.07),while GERD showed no signif icance.CONCLUSION:Age,smoking and BMI are potential factors associated with IMC,while H.pylori and GERD show no significant association.IMC can be predicted in theory by logistic regression analysis. | Christian Felley Hanifa Bouzourene Marianne Bründler G VanMelle Antoine Hadengue Pierre Michetti Gian Dorta Laurent Spahr Emiliano Giostra Jean Louis Frossard | 2012 | World Journal of Gastroenterology2012，18，17： | 5 |
| 3 | Saccharomyces boulardii Does Not Prevent Relapse of Crohn’s Disease显示文摘 | Arnaud Bourreille Guillaume Cadiot Gérard Le Dreau David Laharie Laurent Beaugerie Jean–Louis Dupas Philippe Marteau Patrick Rampal Dominique Moyse Ashraf Saleh Marie–Emmanuelle Le Guern Jean–Paul Galmiche | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 3 |
| 4 | Emergence and epidemic occurrence of enterovirus 68 respiratory infections in The Netherlands in 2010显示文摘 | Adam Meijer Sabine van der Sanden Bianca E.P. Snijders Giovanna Jaramillo-Gutierrez Louis Bont Cornelis K. van der Ent Pieter Overduin Shireen L. Jenny Edin Jusic Harrie G.A.M. van der Avoort Gavin J.D. Smith Gé A. Donker Marion P.G. Koopmans | 2011 | Virology2011，，1： | 2 |
| 5 | Synthesis of electrically conducting organic polymers: halogen derivatives of polyacetylene, (CH)x 显示文摘 | Shirakawa H Louis E J MacDiarmid A G | 1977 | Chemical Communication1977，，： | 2 |
| 6 | Anti-inflammatory and analgesic activities of Melanthera scandens显示文摘Objective:To evaluate the anti-inflammatory and analgesic activities of leaf extract of Melanthera scandens(M.scandens).Methods:The crude leaf extract(39-111 mg/kg)of M.scandens was investigated for anti-inflammatory and analgesic activities using various experimental models.The anti-inflammatory activity was investigated using carragenin,egg-albumin induced oedema models,while acetic acid,formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive property.Results:The extract caused a significant(P<0.05-0.001)dose-dependent reduction of inflammation and pains induced by different agents used.Conclusions:The leaf extract possesses anti-inflammatory and analgesic effects which may be mediated through the phytochemical constituents of the plant. | Jude E Okokon Anwanga E Udoh Samuel G Frank Louis U Amazu | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 2 |
| 7 | Randomized Comparison of Strategies for Type B Aortic Dissection: The INvestigation of STEnt Grafts in Aortic Dissection (INSTEAD) Trial显示文摘 | Christoph A. Nienaber Hervé Rousseau Holger Eggebrecht Stephan Kische Rossella Fattori Tim C. Rehders Günther Kundt Dierk Scheinert Martin Czerny Tilo Kleinfeldt Burkhart Zipfel Louis Labrousse Hüseyin Ince | 2009 | Circulation2009，，25： | 2 |
| 8 | Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus:A pilot ex-vivo study显示文摘AIM:To investigate a classification of endocytoscopy(ECS)images in Barrett’s esophagus(BE)and evaluate its diagnostic performance and interobserver variability.METHODS:ECS was applied to surveillance endoscopic mucosal resection(EMR)specimens of BE ex-vivo.The mucosal surface of specimen was stained with 1%methylene blue and surveyed with a catheter-type endocytoscope.We selected still images that were most representative of the endoscopically suspect lesion and matched with the final histopathological diagnosis to accomplish accurate correlation.The diagnostic performance and inter-observer variability of the new classification scheme were assessed in a blinded fashion by physicians with expertise in both BE and ECS and inexperienced physicians with no prior exposure to ECS.RESULTS:Three staff physicians and 22 gastroenterology fellows classified eight randomly assigned unknown still ECS pictures(two images per each classification)into one of four histopathologic categories as follows:(1)BEC1-squamous epithelium;(2)BEC2-BE without dysplasia;(3)BEC3-BE with dysplasia;and(4)BEC4-esophageal adenocarcinoma(EAC)in BE.Accuracy of diagnosis in staff physicians and clinical fellows were,respectively,100%and 99.4%for BEC1,95.8%and83.0%for BEC2,91.7%and 83.0%for BEC3,and95.8%and 98.3%for BEC4.Interobserver agreement of the faculty physicians and fellows in classifying each category were 0.932 and 0.897,respectively.CONCLUSION:This is the first study to investigate classification system of ECS in BE.This ex-vivo pilot study demonstrated acceptable diagnostic accuracy and excellent interobserver agreement. | Yutaka Tomizawa Prasad G Iyer Louis M Wongkeesong Navtej S Buttar Lori S Lutzke Tsung-Teh Wu Kenneth K Wang | 2013 | World Journal of Gastroenterology2013，19，46： | 2 |
| 9 | The matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients显示文摘 | Fernandez CA Yan L Louis G | 2005 | Clin Cancer Res2005，11，： | 1 |
| 10 | Characterization of the microstructure of a commerical Al-Cu alloy (2011) by differential scanning calorimetry (DSC)显示文摘 | Cordovilla C G Louis E | 1984 | J Material Science1984，19，： | 1 |
| 11 | Review: Membranes for haemo- dialysis显示文摘 | Peter G Kerr Louis Huang | 2010 | Nephrology2010，15，： | 1 |
| 12 | A review of volatile analytical methods for determining the botanical origin of honey 显示文摘 | Luis F C G Jorge A P Louis S S | 2007 | Food Chem2007，103，： | 1 |
| 13 | Synthesis and characterization of mesostructured titania-based materials through evaporation-induced self-assembly显示文摘 | G J de A A Soler-Illia A Louis C Sanchez | 2002 | Chemistry of Materials2002，14，2： | 1 |
| 14 | The 2016World Health Organization Classification of Tumors of the CentralNervous System: a summary 显示文摘 | LOUIS DN PERRY A REIFENBERGER G | 2016 | Acta Neuropathol2016，131，6： | 1 |
| 15 | Long-term changes in marsh veg-etation in Sanjiang Plain, northeast China显示文摘 | LouY Zhao K Wang G | 2015 | Journal of Vegeta-tion Science2015，26，4： | 1 |
| 16 | Using real- world data tbr coverage and payment decisions: the ISPOR real- world data task force report 显示文摘 | LOUIS P G J PETER J N PENNIFER E | 2007 | Value Health2007，10，5： | 1 |
| 17 | Tracheostomal stenosis following laryngectomy显示文摘 | MYERS E N LOUIS J G | 1982 | Ann Otol Rhinol Laryngol1982，91，4： | 1 |
| 18 | The association of incident dementia with mortality in PD显示文摘 | Levy G Tang MX Louis ED et ai | 2002 | Neurology2002，59，： | 1 |
| 19 | Pulse pressure and cardiovascular mortality in normotensive and hypertensive subjects显示文摘 | Annie R Michel S Louis G | 1998 | Hypertension1998，32，： | 1 |
| 20 | Inhibition of the mammalian β-lactamase renal dipeptidase(Dehydropeptiolase-Ⅰ)by(Z)-2-(aeylamino)-3-substituted-propenonie acids显示文摘 | Donald W G Wallace T A Louis B | 1987 | J Med Chem1987，30，6： | 1 |
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