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| 1 | Spinal Circuits Transmitting Mechanical Pain and Itch显示文摘In 1905, Henry Head first suggested that transmission of pain-related protopathic information can be negatively modulated by inputs from afferents sensing innocuous touch and temperature. In 1965, Melzak and Wall proposed a more concrete gate control theory of pain that highlights the interaction between unmyelinated C fibers and myelinated A fibers in pain transmission. Here we review the current understanding of the spinal microcircuits transmitting and gating mechanical pain or itch.We also discuss how disruption of the gate control could cause pain or itch evoked by innocuous mechanical stimuli,a hallmark symptom for many chronic pain or itch patients. | Bo Duan Longzhen Cheng Qiufu Ma | 2018 | Neuroscience Bulletin2018，34，1： | 8 |
| 2 | Activation of extrasynaptic GABA_A receptors inhibits cyclothiazideinduced epileptiform activity in hippocampal CA1 neurons显示文摘Extrasynaptic GABA_A receptors(GABA_ARs)-mediated tonic inhibition is reported to involve in the pathogenesis of epilepsy.In this study,we used cyclothiazide(CTZ)-induced in vitro brain slice seizure model to explore the effect of selective activation of extrasynaptic GABA_ARs by 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol(THIP)on the CTZ-induced epileptiform activity in hippocampal neurons.Perfusion with CTZ dose-dependently induced multiple epileptiform peaks of evoked population spikes(PSs)in CA1 pyramidal neurons,and treatment with THIP(5 umol/L)significantly reduced the multiple PS peaks induced by CTZ stimulation.Western blot showed that the 5-subunit of the GABA_AR,an extrasynaptic specific GABA_AR subunit,was also significantly down-regulated in the cell membrane 2h after CTZ treatment.Our results suggest that the CTZ-induced epileptiform activity in hippocampal CA1neurons is suppressed by the activation of extrasynaptic GABA_ARs,and further support the hypothesis that tonic inhibition mediated by extrasynaptic GABA_ARs plays a prominent role in seizure generation. | Li Wan Xu Liu Zheng Wu Wanting Ren Shuzhen Kong Raya Abou Dargham Longzhen Cheng Yun Wang | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 3 | Study on Growth,Serum Biochemical and Antioxidant Enzyme Indices of Juvenile Siganus guttatus Fed with Enteromorpha prolifra and Artificial Feed显示文摘In order to provide reference for using Siganus guttatus to control overgrowth of Enteromorpha prolifra,the growth,serum biochemical and antioxidant enzyme indices of juvenile S.guttatus respectively fed with E.prolifra and artificial feed were studied.One hundred and eighty individuals were cultivated for 90 days in six 2.5 m × 1.5 m × 1.5 m cages (30 ind.per cage) which mesh size were 0.5 mm.The experimental animals were divided into two dietary groups (three cages for each group) that were fed with E.prolifra and artificial feed respectively.During the culture period,temperatures ranged from 23.0 to 26.5℃,p H was between 7.8 and 8.2,dissolved oxygen was more than 5.0 mg/L.The weight gain rate,specific growth rate,relative growth rate,hepato-somatic index of juvenile S.guttatus fed with E.prolifra were significantly lowe than that fed with artificial feed (P<0.05).The total protein (TP),urea nitrogen (UN)and alkaline phosphatase (AKP) of juvenile S.guttatus fed with E.Prolifra were significantly higher than that fed with artificial feed (P<0.05),while glutamic oxalacetic transaminase (AST/GOT) and glutamic-pyruvic transaminase (ALT/GPT) of juvenile S.guttatus fed with E.prolifra were significantly lower than that fed with artificial feed (P<0.05).SOD,GPX and anti-superoxide anion radical activity in liver,kidney,gill and muscle of juvenile S.guttatus fed with E.prolifra were higher than that fed with artificial feed,and these antioxidant enzyme activities in kidney of juvenile S.guttatus fed with E.prolifra was significantly higher than that fed with artificial feed (P<0.05),while CAT and hydroxyl radical-inhibiting activity in liver of juvenile S.guttatus fed with artificial feed were significantly higher than that fed with E.prolifra (P<0.05).Juvenile S.guttatus fed with E.prolifra showed poor growth performance but better antioxidant defense system.S.guttatus is easily raised and has stronger ability of digestion and absorption of E.Prolifra.The technique that uses S.guttatus to control E.prolifra deserves deeply study. | Song Chao Hu Chengshuo Zhang Longzhen Zhao Feng Huang Xiaorong Wang Yu Liu Jianyi | 2016 | Animal Husbandry and Feed Science2016，8，5： | 2 |
| 4 | Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies显示文摘Until now,there has been a lack of standard and effective treatments for patients with recurrent malignant tumors or abdominal and pelvic malignancies with extensive invasion(Morris,2000).Generally,these patients face problems such as inability to undergo surgery or chemotherapy resistance(Combs et al.,2016).Re-radiotherapy has achieved a prominent place in the treatment of patients who have received radiotherapy previously and developed in-field recurrences(Straube et al.,2018).However,re-radiotherapy is very complicated,requiring comprehensive consideration of appropriate radiation dose,interval from first radiotherapy,boundary of the radiotherapy target area,and damage to surrounding normal tissues(Straube et al.,2019).In other words,it is necessary to focus on the protection of surrounding normal tissues while maximizing the eflFicacy of re-radiotherapy in such patients. | Xin WEN Hui QIU Zhiying SHAO Guihong LIU Nianli LIU Aoxing CHEN Xingying ZHANG Xin DING Longzhen ZHANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，9： | 2 |
| 5 | Solid-state cold spraying of FeCoCrNiMn high-entropy alloy:an insight into microstructure evolution and oxidation behavior at 700-900℃显示文摘About 3 mm thick five-element equimolar high-entropy alloy(HEA) FeCoCrNiMn was successfully deposited by solid-state cold spraying(CS).The high-temperature oxidation behavior of the CSed HEA was investigated at 700-900℃.Heat treatment was performed on the CSed HEA before oxidation to heal the incomplete interfaces between the deposited particles.Results show that the microstructure of the CSed HEA is characterized by grain refinement and abundant interparticle incomplete interfaces.Post-spray heat treatment promotes recrystallization and grain growth in the CSed HEA.After oxidation testing,the oxide scales are composed of multi-layers:a Mn_(2)O_(3)(or Mn_(3)O_(4)) outer layer,a Mn-Cr spinel intermediate layer and a Cr_(2)O_(3) inner layer.The CSed HEA exhibits higher parabolic rate constants and more favorable internal oxidation than the bulk HEAs that have similar compositions in the literature.Such a discrepancy becomes pronounced at higher temperatures.The grain refinement and numerous particle boundaries are responsible for such a distinctive performance of the CSed HEA. | Yaxin Xu Weny Li Longzhen Qu Xiawei Yang Bo Song Rocco Lupoi Shuo Yin | 2021 | Journal of Materials Science & Technology2021，，9： | 2 |
| 6 | Controlled growth of three morphological structures of magnesium hydroxide nanoparticles by wet precipitation method显示文摘 | Jianping Lv Longzhen Qiu Baojun Qu | 2004 | Journal of Crystal Growth2004，267，： | 1 |
| 7 | Inflammatory Lesions of Cochlea in Murine Cytomegalovirus-Infected Mice with Hearing Loss显示文摘 | Qiao Yuehua Zhang Longzhen Xu Kailin Zeng Lingyu Meng Lingjian Wang Jun Meng Hong | 2012 | Cell Biochemistry and Biophysics2012，，2： | 1 |
| 8 | Controlled synthesis of magnesium hydroxide nanopariicles with different morphological structures and related properties in flame retardant ethylenevinyl acetate blends 显示文摘 | Jimping Lv Qiu Longzhen Qu Baojun | 2004 | Nanotechnology2004，15，11： | 1 |
| 9 | Preparation and characterization of magnesium hydroxide nanoparticles and flame-retardant property of its nanocomposites with EVA显示文摘 | Qiu Longzhen Xie Rongcai Ding Peng | 2003 | Composite Structures2003，，62： | 1 |
| 10 | Synthesis, characterization and upconversion emission properties of the nanocrystals of Yb^3+/Er^3+ -codoped YF3 -YOF-Y2O3 system 显示文摘 | Li Zhihua Zheng Longzhen Zhang Luning Xiong Leyan | 2007 | Luminescence2007，126，2： | 1 |
| 11 | Controlled growth of three morphological structures of magnesium hydroxide nanoparticles by wet precipitation method 显示文摘 | Jianping Lv Longzhen Qiu Baojun Qu | 2004 | Journal of Crystal Growth2004，，267： | 1 |
| 12 | Preparation and char- acterization of Mg(OH) 2 nanopartical and flame-retardant property of its nanocomposites with EVA 显示文摘 | Qiu Longzhen Xie Rongcai Ding Peng | 2003 | Composite Structures2003，62，： | 1 |
| 13 | Band-gap-tailored random laser显示文摘A band-gap-tailored random laser with a wide tunable range and low threshold through infrared radiation is demonstrated. When fluorescent dyes are doped into the liquid crystal and heavily doped chiral agent system,we demonstrate a wavelength tuning random laser instead of a side-band laser, which is caused by the combined effect of multi-scattering of liquid crystal(LC) and band-gap control. Through rotating the infrared absorbing material on the side of the LC cell, an adjustable range for random lasing of 80 nm by infrared light irradiation was observed. | HONGBO Lu JIAN XING CHENG WEI JIANGYING XIA JUNQING SHA YUNSHENG DING GUOBING ZHANG KANG XIE LONGZHEN QIU ZHIJIA Hu | 2018 | Photonics Research2018，6，5： | 1 |
| 14 | Synthesis of a novel β-cyclodextrin derivative with high solubil- ityand the electrochemical properties of ferrocene-carbonyl-β- cyclodextrininclusion complex as an electron transfer mediator 显示文摘 | LONGZHEN ZHENG LEYAN XIONG JUNHUA LI | 2008 | Electrochemistry Communications2008，10，2： | 1 |
| 15 | Preparation and characterization of Mg(OH)2 nanoparticles and flame retardant property of its nanocomposites with EVA 显示文摘 | Qiu Longzhen Xie Rongcai Ding Peng | 2003 | Composite Struetures2003，，62： | 1 |
| 16 | Controlled growth of three morphological structures of magnesium hydroxide nanoparticles by wet precipitation method显示文摘 | Lv Jianping Qiu Longzhen Qu Baojun | 2004 | Journal of Crystal Growth2004，267，： | 1 |
| 17 | Osmoregulation in juvenile Chinese sturgeon (Acipenser sinensis Gray) during brackish water adaptation 显示文摘 | Xuguang H Ping Z Longzhen Z | 2009 | Fish Physiol Biochem2009，35，2： | 1 |
| 18 | Controlled growth ot three morphological struetures of magnesium hydroxide nanopartieles by wet precipitation method 显示文摘 | Jianping Lv Longzhen Qiu Baojun Qu | 2004 | Journal of Crystal Growth2004，267，： | 1 |
| 19 | Controlled synthesis of magnesium hydroxide nanoparticles with different morphological structures and related properties in flame retardant ethylene-vinyl acetate blends显示文摘 | LU Jianping Q1U Longzhen QU Baojun | 2004 | Nanoteehnology2004，10，15： | 1 |
| 20 | Preparation and characterization of Mg(OH)2 nanoparticles and flame-retardant property of its nanocomposites with EVA 显示文摘 | Qiu Longzhen Xie Rongcai Ding Peng | 2003 | Composite Structures2003，62，34： | 1 |
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