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| 1 | The significance and variation characteristics of interlay water in smectite of hydrocarbon source rocks显示文摘To investigate variation characteristics of interlayer water bound up with organic matter in smectite, organo-clay complexes extracted from grinded source rock samples were determined using thermo-XRD, DTA and PY-GC. The d001 diffraction peak of organo-clay complexes is postponed from 250 to 550°C before reaching 1.00 nm and accompanied by exothermal peaks on DTA and organic matter with abundant C20-C30 carbon detected by PY-GC, which is different from single smectite and indicates the existence of organic matter in the interlayer of smectite. Water desorption characteristics of organo-clay complexes are in consistent with smectite at 100 and 600°C, but different from smectite at 550°C with an additional dehydration peak and a remaining d001 diffraction peak, suggesting the water removed at 550°C is interlayer adsorption water rather than constituent water of clay minerals. Comparing the dehydration order and water loss, we conclude that part of interlayer water of smectite may act as the 'bridge' that binds organic matter and smectite, which results in water-expelled lag beyond 250°C and may provide a good medium for hydrocarbon migration and oil pool formation. | CAI JinGong LU LongFei BAO YuJin FAN Fu XU JinLi | 2012 | Science China Earth Sciences2012，55，3： | 6 |
| 2 | Experimental Study on Dynamic Mechanical Properties of Sprayed Concrete-Surrounding Rock Combined Body显示文摘To investigate the dynamic response problem of the double medium formed by the adherence of sprayed concrete and surrounding rock in the tunnel,a split Hopkinson pressure bar of 75 mm in diameter was adopted at the ages of 3,7 and 10 d.Experimental results showed that dynamic compressive strength and dynamic increase factors(DIF)of the combined bodies increase with the strain rate.With the growth of strain rate,the critical strain of the combined bodies first increases,then deceases.Furthermore,the combined bodies of 3 d reveal the plastic property and brittle property for 7 d and 10 d when the strain rate is over 80/s.The failure characteristic of the sprayed concrete changes from tearing strain damage to crushing damage as the growth of strain rate,and the failure characteristic of rock presents the tensile failure mode as demonstrated by the scanning electron microscope(SEM). | Dongming Guo Pengyang Yan Longfei Fan Yingshi Zhang Xiaoye Wang | 2019 | Journal of Beijing Institute of Technology2019，28，2： | 3 |
| 3 | Human obstructive(postvasectomy)and nonobstructive azoospermia-Insights from scRNA-Seq and transcriptome analysis显示文摘A substantial number of male infertility is caused by azoospermia.However,the underlying etiology and the molecular basis remain largely unknown.Through single-cell(sc)RNA sequencing,we had analyzed testis biopsy samples from two patients with obstructive azoospermia(OA)and nonobstructive azoospermia(NOA).We found only somatic cells in the NOA samples and explored the transcriptional changes in Sertoli cells in response to a loss of interactions with germ cells.Moreover,we observed a germ cell population discrepancy between an OA(postvasectomy)patient and a healthy individual.We confirmed this observation in a secondary study with two datasets at GSM3526588 and GSE124263 for detailed analysis wherein the regulatory mechanisms at the transcriptional level were identified.These findings thus provide valuable information on huma n spermatoge nesis,and we also ide ntified in sightful info rmation for further research on reproducti on-related diseases. | Shitao Chen Geng An Hanshu Wang Xiaolong Wu Ping Ping Longfei Hu Yunmei Chen Jue Fan C.Yan Cheng Fei Sun | 2022 | Genes & Diseases2022，9，3： | 2 |
| 4 | Approaching 19%efficiency and stable binary polymer solar cells enabled by a solidification strategy of solvent additive显示文摘Additives play a crucial role in enhancing the photovoltaic performance of polymer solar cells(PSCs).However,the typical additives used to optimize blend morphology of PSCs are still high boiling-point solvents,while their trace residues may reduce device stability.Herein,an effective strategy of“solidification of solvent additive(SSA)”has been developed to convert additive from liquid to solid,by introducing a covalent bond into low-cost solvent diphenyl sulfide(DPS)to synthesize solid dibenzothiophene(DBT)in one-step,which achieves optimized morphology thus promoting efficiency and device stability.Owing to the fine planarity and volatilization of DBT,the DBT-processed films achieve ordered molecular crystallinity and suitable phase separation compared to the additive-free or DPS-treated ones.Importantly,the DBT-processed device also possesses improved light absorption,enhanced charge transport,and thus a champion efficiency of 17.9%is achieved in the PM6:Y6-based PSCs with an excellent additive component tolerance,reproducibility,and stability.Additionally,the DBT-processed PM6:L8-BO-based PSCs are further fabricated to study the universality of SSA strategy,offering an impressive efficiency approaching19%as one of the highest values in binary PSCs.In conclusion,this article developed a promising strategy named SSA to boost efficiency and improve stability of PSCs. | Manjun Xiao Longfei Liu Yongdie Meng Baobing Fan Wenyan Su Conggui Jin Luocheng Liao Fan Yi Chao Xu Rui Zhang Alex K.-Y.Jen Wei Ma Qunping Fan | 2023 | Science China Chemistry2023，66，5： | 1 |
| 5 | High energy product of isotropic bulk Sm-Co/α-Fe(Co)nanocomposite magnet with multiple hard phases and nanoscale grains显示文摘Nanocomposite magnets consisting of hard and soft magnetic phases have potential applications to be the next generation of permanent magnets with very high energy product and less expensive rare-earth elements.But it is still a big challenge to obtain bulk magnets with ideal microstructure and high performance.In this work,two-step warm processing at relative low temperatures had been adopted to obtain nearly theoretical density bulk nanocomposite magnets from amorphous/nanocrystalline powder precursors.Novel nanostructures consisting of multiple Sm-Co hard phases(SmCo_(5)as main phase,SmCO_(3),SmCo_(7),Sm_(2)Co_(17)as minor phases)and 25 wt%α-Fe(Co)soft phase,nanoscale grain size below 20 nm for both the hard phase and soft phase,and the diffusion of Fe and Co compositions had been obtained in bulk isotropic magnets.Besides the ideal nanostructures,a high coercivity of 5.9 kOe,M_(r)/M_(s)value of 0.78 and a high square degree of demagnetization curve S=0.47 were obtained.All of these factors together brought a new record-high energy product(BH)_(max)of 23.6 MGOe.These results make an important step toward fabricating novel nanostructure with high performance. | Shuo Li Longfei Ma Jinkui Fan Jianping Yang Qiang Zheng Baoru Bian Jian Zhang Juan Du | 2021 | Journal of Materials Science & Technology2021，，29： | 1 |
| 6 | A method to determine the bonded-particle model parameters for simulation of ores显示文摘The bonded-particle model(BPM)is commonly used in the numerical analysis of ore samples.To improve the accuracy of simulating the mechanical process of ore process of ore crushing in a crusher,the parameters of the BPM for the ore must be calibrated.In this study,a calibration method was proposed for the scientific determination of the parameters of the BPM for ore undergoing uniaxial compression.First,physical tests and simulations were conducted to determine the mechanical response(uniaxial compressive strength and macroscopic stiffness)of ore during uniaxial compression.Then,the sensitivity of the mechanical response to the values of microscopic parameters was tested using a Plackett-Burman design.Next,the microscopic parameters with the greatest impact on the response were identified,and the range of parameters that met the target response was determined using a steepest ascent design;Second,a second-order model of the mechanical response was established using the sensitive parameters by combining a Box-Behnken design with response surface methodology to obtain the optimal BPM parameters.Simulation tests showed that the normal stiffness per unit area,critical shear stress,and bonded disk radius had significant effects on the uniaxial compressive strength(UCS)and macroscopic stiffness(MS).To verify the validity of the proposed calibration method,laboratory tests were conducted.The consistency of the simulation results with experimental results indicated that response surface methodology with the Plackett-Burman design,steepest ascent design,and Box-Behnken design can be an effective method for calibrating the BPM of ores. | Shuwei Wu Guoqiang Wang Longfei Fan Wei Guan Jianbo Guo Zhengbin Liu Yukuan Wang | 2024 | Particuology2024，86，3： | 0 |
| 7 | High magnetic energy product in isotropic nanocomposite powders with high percent of soft phase towards ultrastrong magnets显示文摘Nanostructure of magnetically hard and soft materials is fascinating for exploring next-generation ul-trastrong permanent magnets with less expensive rare-earth elements.However,the resulting hard/soft nanocomposites often exhibit a low remanence/energy product due to the challenge in obtaining ideal phase components and appropriate soft phase fraction.In this work,a novel microstructure of multiple phases consisting of 1:5 phase and 1:3 phase as main hard phase,and a high ratio of Fe(Co)(27 wt.%-48 wt.%)as soft phase was obtained in Sm-Co(Fe)/Fe nanocomposite magnet.The grain size of both hard and soft phases below 15 nm was observed.The optimal energy product for Sm-Co(Fe)/Fe(Co)nanocom-posite is 2.1 times(an increment of 107%)of the corresponding single-hard-phase powders without soft phase.It reports that the isotropic nanocomposite powders exhibit a record of magnetic energy product larger than 25 MGOe(the highest value is 28.6 MGOe).The high performance and the microstructure achieved in this work for the isotropic powders will shed light on and provide a good premise for syn-thesizing high performance anisotropic bulk nanocomposite magnets. | Longfei Ma Wei Quan Jinkui Fan Yanbai Chen Qiang Zheng Baoru Bian Jian Zhang Juan Du | 2023 | Journal of Materials Science & Technology2023，，13： | 0 |
| 8 | Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritis in vivo显示文摘Osteoarthritis is a prevalent global joint disease,which is characterized by inflammatory reaction and cartilage degradation.Cyasterone,a sterone derived from the roots of Cyathula officinalis Kuan,exerts protective effect against several inflammationrelated diseases.However,its effect on osteoarthritis remains unclear.The current study was designed to investigate the potential antiosteoarthritis activity of cyasterone.Primary chondrocytes isolated from rats induced by interleukin(IL)-1βand a rat model stimulated by monosodium iodoacetate(MIA)were used for in vitro and in vivo experiments,respectively.The results of in vitro experiments showed that cyasterone apparently counteracted chondrocyte apoptosis,increased the expression of collagen II and aggrecan,and restrained the production of the inflammatory factors inducible nitric oxide synthase(iNOS),cyclooxygenase-2(COX-2),a disintegrin and metalloproteinase with thrombospondin motifs-5(ADAMTS-5),metalloproteinase-3(MMP-3),and metalloproteinase-13(MMP13)induced by IL-1βin chondrocytes.Furthermore,cyasterone ameliorated the inflammation and degenerative progression of osteoarthritis potentially by regulating the nuclear factor kappa B(NF-κB)and mitogen-activated protein kinase(MAPK)pathways.For in vivo experiments,cyasterone significantly alleviated the inflammatory response and cartilage destruction of rats induced by monosodium iodoacetate,where dexamethasone was used as the positive control.Overall,this study laid a theoretical foundation for developing cyasterone as an effective agent for the alleviation of osteoarthritis. | TENG Li SHEN Yue QU Yuhan YANG Longfei YANG Yuting JIAN Xi FAN Shengli ZHANG Lele FU Qiang | 2023 | Chinese Journal of Natural Medicines2023，21，2： | 0 |
| 9 | Synergistic cytotoxicity of binary combinations of inorganic and organic disinfection byproducts assessed by real-time cell analysis显示文摘Chlorine, chlorine dioxide, and ozone are widely used as disinfectants in drinking water treatments. However, the combined use of different disinfectants can result in the formation of various organic and inorganic disinfection byproducts(DBPs). The toxic interactions, including synergism, addition, and antagonism, among the complex DBPs are still unclear. In this study, we established and verified a real-time cell analysis(RTCA) method for cytotoxicity measurement on Chinese hamster ovary(CHO) cell. Using this convenient and accurate method, we assessed the cytotoxicity of a series of binary combinations consisting of one of the 3 inorganic DBPs(chlorite, chlorate, and bromate) and one of the 32 regulated and emerging organic DBPs. The combination index(CI) of each combination was calculated and evaluated by isobolographic analysis to reflect the toxic interactions. The results confirmed the synergistic effect on cytotoxicity in the binary combinations consisting of chlorite and one of the 5 organic DBPs(2 iodinated DBPs(I-DBPs) and 3 brominated DBPs(Br-DBPs)), chlorate and one of the 4 organic DBPs(3 aromatic DBPs and dibromoacetonitrile), and bromate and one of the 3 organic DBPs(2 I-DBPs and dibromoacetic acid). The possible synergism mechanism of organic DBPs on the inorganic ones may be attributed to the influence of organic DBPs on cell membrane and cell antioxidant system. This study revealed the toxic interactions among organic and inorganic DBPs, and emphasized the latent adverse outcomes in the combined use of different disinfectants. | Mengge Fan Longfei Shu Xinran Zhang Miao Yu Yongting Du Junlang Qiu Xin Yang | 2022 | Journal of Environmental Sciences2022，34，7： | 0 |
| 10 | Stepless shape morphing polymer显示文摘To change the situation of shape memory polymers(SMPs)that can only remember very few shapes and enable discretional morphing for practical application,the authors report a reversible stepless multiple SMP derived from ultrahigh molecular weight polyethylene(UHMWPE).As the crystals of semicrystalline polymers are assembled by those with slightly different melting temperatures,and each type of crystal can remember a single shape,the crystalline region of UHMWPE is allowed to remember plenty of temporary shapes after programming.Changing the temperature of the programmed polymer within the melting/crystallization temperature ranges would lead to releasing/recovery of the memorized temporary shapes.Accordingly,multiple shape memory effects can be easily realized without an elaborate design of material structure and training process in advance as before.The temperaturedependent adjustability of the analog capacitor and soft lens with embedded programmed UHMWPE as actuators,characterized by the continuous/random/proportional responsivity,further reveals the utilization prospects of the controllable reversible stepless discretionary morphing effect.Moreover,the maximum work density of the programmed UHMWPE is found to be 210 kJ/m_(3),which is more than 10 times of piezoelectric ceramics,so that it can serve as a proof-of-concept mechanical driver for reversibly pumping of ethanediol-droplet upon heating/cooling. | Lei Min Min Zhu Hanlun Lu Yao Li Longfei Fan Mingqiu Zhang Minzhi Rong | 2023 | SmartMat2023，4，1： | 0 |
| 11 | Industry Competitiveness and Complementarity between China and Eurasian Economic Union Countries under the Background of Strategic Docking between Silk Road Economic Belt and the Union显示文摘The implementation of strategic docking between Silk Road Economic Bclt and the Eurasian Economic Union(the Union)is of great significance to facilitate the stable expansion of bilateral trade volume,diversification in major areas of trade,and the continual improvement of technical content level of trade products.This paper first uses the revealed comparative advantage index to study the competitiveness of industries with different technical levels for China and the Union member countries.Then,the trade complementarity and trade integration between China the Union member countries are studied by using the trade complementarity index and trade intensity index.Based on these results,the paper gives some advice on expanding and deepening the bilateral cconomic and trade cooperation. | Xinxuan Cheng Longfei Fan Jiachen Wang | 2019 | China Finance and Economic Review2019，8，1： | 0 |
| 12 | Human IFN-k Inhibited Respiratory RNA Virus Replication Dependent on Cell-to-Cell Interaction in the Early Phase显示文摘Background:Interferon kappa(IFN-k)is a type I interferon(IFN-I)that inhibits virus replication by evoking interferon-stimulated genes(ISGs).However,as an evolutionarily ancient interferon,IFN-k may function differently from the later emerged interferon-a and b.Methods:Conventional molecular biology methods were used to determine the localization of IFN-k and its structure and function.In addition,we employed RT-PCR,western blot,and RNA-Seq technologies to characterize the ISGs expression profile and antiviral activities exerted by IFN-k or IFN-a2.Results:Human IFN-k exists in two forms upon ectopic expression,one located on the cell membrane and the other secreted outside the cells.The membrane-anchored IFN-k showed the ability to induce ISGs and curtail RNA virus replication,whereas the secreted IFN-k failed to do so.Structural analyses indicated that 1-27aa at the N-terminus was the signal peptide,and 28-37aa was predicted as the transmembrane region.However,our data demonstrated that both of them were not associated with membrane localization of IFN-k;the former influenced the expression and secretion of IFN-k,and the latter had an impact on the induction of ISGs.In addition,prokaryotic purified soluble mature human IFN-k was also capable of inducing ISGs and inhibiting RNA virus replication.Importantly,human IFN-k induced a faster ISG response but with a lower intensity and a shorter half-life than the response of IFN-a2.In contrast,IFN-a2 started to function later but was stronger and more durable than IFN-k.Conclusions:Human IFN-k-induced ISG response and inhibited respiratory RNA virus replication dependent on cell-to-cell interactions.In addition,compared with IFN-a2,IFN-k exerted effects more rapidly in the early phase,with less intensity and a shorter half-life.Therefore,IFN-k may constitute the first line of IFN-I against respiratory virus infections. | Weihui Fu Peng Sun Jun Fan Longfei Ding Songhua Yuan Guanxing Zhai Miaomiao Zhang Chenli Qiu Shuye Zhang Xiaoyan Zhang Jianqing Xu | 2022 | Infectious Diseases & Immunity2022，2，2： | 0 |
| 13 | Influence of geometry on the thermal performance of water pit seasonal heat storages for solar district heating显示文摘The aim of the study is to investigate the influence of geometry on the thermal capacity and stratifications of a water pit heat storage for solar district heating.A TRNSYS component model for a truncated cone water pit was developed based on the coordinate transformation method and validated by experimental results from the water pit heat storage in Huangdicheng in 2018.The thermal performance of 26 water pits with different heights and side wall slopes was calculated for 10 consecutive years.It takes four to six years for the water pit to reach steady-state operation.The operation data from the tenth year was selected to evaluate the thermal performance of each configuration.The results show that because of the thermal insulation on top of the water pit,the height to diameter ratio of a water pit with minimum annual heat loss was always smaller than 1.0.The annual storage efficiency of a water pit increases with side wall slope due to the reduced side wall area.There is an almost linear increase in the thermal stratification number of a water pit with height.With an increase in the height,thermal stratification in water pits with a steeper slope increased more gradually than water pits with a lower slope.The findings in this paper are relevant for the design optimization of water pits as seasonal thermal energy storages. | Yakai Bai Ming Yang Jianhua Fan Xiaoxia Li Longfei Chen Guofeng Yuan Zhifeng Wang | 2021 | Building Simulation2021，14，3： | 0 |
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