|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 2 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 3 | A case study of geotextile-reinforced embankment on soft ground显示文摘 | Dennes T Bergado Pham V Long B.R Srinivasa Murthy | 2002 | Geotextiles and Geomembranes2002，，6： | 2 |
| 4 | The potential for resistance to Botrytis cinerea by kiwifruit显示文摘 | Wurms K V Long P G Sharrock K R | 1999 | Crop Protection1999，18，： | 1 |
| 5 | Masculinity, Femininity, and Women Scients'self-esteem and self-acceptance显示文摘 | Long V O | 1990 | The Journal of Psychology1990，125，3： | 1 |
| 6 | Investigation of factors af- fecting the diffusion of mobile telephone services: An empirical analysis for Vietnam显示文摘 | Hwang J Cho Y Long N V | 2009 | Telecommunications Policy2009，33，： | 1 |
| 7 | Trade,Wage Gapsand Specific Human Capital Accumulation显示文摘 | Long N V Riezman R Soubeyran A | 2007 | Review ofInternational Economics2007，15，6： | 1 |
| 8 | Monitoring electrical resistance of concretes containing alternative cementitious materials to assess their resistance to chloride penetration显示文摘 | Basheer P A M Gilleece P R V Long A E | 2002 | Cement and Concrete Composites2002，24，5： | 1 |
| 9 | LANA-1 ,Bcl-2,Mcl-1 and HIF-I alpha protein expression in HIV-associated Kaposi sarcoma 显示文摘 | Long E fllie M Hofman V | 2009 | Virchows Arch2009，455，2： | 1 |
| 10 | Group 4 metal olefin polymerization catalysts stabilized by bidentate O,Pligands显示文摘 | Long R J Gibson V C White A J P | | 0，，： | 1 |
| 11 | Nivolumab in Previously Un- treated Melanoma without BRAF Mutation显示文摘 | Robert C Long G V Brady B | 2015 | N Engl J Med2015，372，4： | 1 |
| 12 | Nivolumab in previously untreated melanoma without BRAF mutation 显示文摘 | Robert C Long G V Brady B | 2015 | N Engl J Med2015，372，4： | 1 |
| 13 | Solvent dependence of the rtsonance raman spectra of azobenzene, 4-aminoazobenzene, 4-meth- ylaminoazobenzene and 4-mimethylaminoazobenzene 显示文摘 | BARKER I K FAWCErlT V LONG D A | 1987 | Journal of Raman Spectroscopy1987，18，： | 1 |
| 14 | Identification of voltage collapse through direct equilibrium tracing显示文摘 | Feng Z H Ajjarapu V Long B | 2000 | IEEE Trans on Power Systems2000，15，1： | 1 |
| 15 | Endocrine-disrupting potential of bisphe- nol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: new data and a brief review 显示文摘 | BONEFELD-JORGENSEN E C LONG M HOFMEISTER M V | 2007 | Environmental Health Perspectives2007，，： | 1 |
| 16 | Measuring the contribution of tumor biobanks to research in oncology:surrogate indicators and bibliographic output显示文摘 | Hofman V Ilie M Long E | 2013 | Biopreserv Biobank2013，11，4： | 1 |
| 17 | The effect of pre-slaughter showering and post-slaughter rapid chilling on meat quality in intact pork side 显示文摘 | Long V P Tarrant P V | 1990 | Meat Science1990，27，： | 1 |
| 18 | Gender and tuberculosis control: Perspectives on health seeking be- haviour among men and women in Vietnam 显示文摘 | Johansson E Long N H Diwan V K | 2000 | Health Policy2000，52，1： | 1 |
| 19 | Inorganic Salts as Additives in Accelerating the Photografting of Styrene to Cellulose and Polyethylene显示文摘 | Garnett J L Jankiewicz S V Long M A Sangster D F | 1986 | Journal of Polymer Science Part C-Polymer Letters1986，24，3： | 1 |
| 20 | The cathodolumenence of minerals in thin section显示文摘 | Long J V P Agrell S O | 1965 | Miner Mag1965，34，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员